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Protein

C-C motif chemokine 25

Gene

Ccl25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene namesi
Name:Ccl25
Synonyms:Scya25, Teck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1099448. Ccl25.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 144121C-C motif chemokine 25PRO_0000005236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO35903.

PTM databases

PhosphoSiteiO35903.

Expressioni

Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

CleanExiMM_CCL25.
ExpressionAtlasiO35903. baseline and differential.

Interactioni

Protein-protein interaction databases

DIPiDIP-5885N.
IntActiO35903. 1 interaction.
MINTiMINT-106264.
STRINGi10090.ENSMUSP00000024004.

Structurei

3D structure databases

ProteinModelPortaliO35903.
SMRiO35903. Positions 23-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiO35903.
KOiK13072.
OMAiQGVFEDC.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35903-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWLFACLV ACFVGAWMPV VHAQGAFEDC CLGYQHRIKW NVLRHARNYH
60 70 80 90 100
QQEVSGSCNL RAVRFYFRQK VVCGNPEDMN VKRAMRILTA RKRLVHWKSA
110 120 130 140
SDSQTERKKS NHMKSKVENP NSTSVRSATL GHPRMVMMPR KTNN
Length:144
Mass (Da):16,733
Last modified:September 18, 2013 - v2
Checksum:iCEC1924B320B4408
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851M → I in AAB69982 (PubMed:9285413).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86357 mRNA. Translation: AAB69982.1.
AJ249480 mRNA. Translation: CAB55762.1.
DQ158256 mRNA. Translation: AAZ99719.1.
AK134138 mRNA. Translation: BAE22030.1.
AC155164 Genomic DNA. No translation available.
BC117033 mRNA. Translation: AAI17034.1.
BC117037 mRNA. Translation: AAI17038.1.
CCDSiCCDS22085.1.
RefSeqiNP_033164.1. NM_009138.3.
UniGeneiMm.7275.

Genome annotation databases

EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235.
GeneIDi20300.
KEGGimmu:20300.
UCSCiuc009ktw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86357 mRNA. Translation: AAB69982.1.
AJ249480 mRNA. Translation: CAB55762.1.
DQ158256 mRNA. Translation: AAZ99719.1.
AK134138 mRNA. Translation: BAE22030.1.
AC155164 Genomic DNA. No translation available.
BC117033 mRNA. Translation: AAI17034.1.
BC117037 mRNA. Translation: AAI17038.1.
CCDSiCCDS22085.1.
RefSeqiNP_033164.1. NM_009138.3.
UniGeneiMm.7275.

3D structure databases

ProteinModelPortaliO35903.
SMRiO35903. Positions 23-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5885N.
IntActiO35903. 1 interaction.
MINTiMINT-106264.
STRINGi10090.ENSMUSP00000024004.

PTM databases

PhosphoSiteiO35903.

Proteomic databases

PRIDEiO35903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235.
GeneIDi20300.
KEGGimmu:20300.
UCSCiuc009ktw.2. mouse.

Organism-specific databases

CTDi6370.
MGIiMGI:1099448. Ccl25.

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiO35903.
KOiK13072.
OMAiQGVFEDC.
TreeFamiTF353160.

Enzyme and pathway databases

ReactomeiREACT_288802. Chemokine receptors bind chemokines.
REACT_331048. G alpha (i) signalling events.

Miscellaneous databases

NextBioi298037.
PROiO35903.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CCL25.
ExpressionAtlasiO35903. baseline and differential.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
    Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
    Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9."
    Wurbel M.A., Philippe J.-M., Nguyen C., Victorero G., Freeman T., Wooding P., Miazek A., Mattei M.-G., Malissen M., Jordan B.R., Malissen B., Carrier A., Naquet P.
    Eur. J. Immunol. 30:262-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors."
    Ericsson A., Kotarsky K., Svensson M., Sigvardsson M., Agace W.
    J. Immunol. 176:3642-3651(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Small intestine.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCL25_MOUSE
AccessioniPrimary (citable) accession number: O35903
Secondary accession number(s): Q9QYY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 18, 2013
Last modified: June 24, 2015
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.