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O35903

- CCL25_MOUSE

UniProt

O35903 - CCL25_MOUSE

Protein

C-C motif chemokine 25

Gene

Ccl25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

    GO - Molecular functioni

    1. chemokine activity Source: MGI
    2. chemokine receptor binding Source: UniProtKB
    3. protein binding Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. chemotaxis Source: MGI
    3. immune response Source: InterPro
    4. inflammatory response Source: UniProtKB-KW
    5. leukocyte migration Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 25
    Alternative name(s):
    Chemokine TECK
    Small-inducible cytokine A25
    Thymus-expressed chemokine
    Gene namesi
    Name:Ccl25
    Synonyms:Scya25, Teck
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1099448. Ccl25.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 144121C-C motif chemokine 25PRO_0000005236Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 58By similarity
    Disulfide bondi31 ↔ 73By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiO35903.

    PTM databases

    PhosphoSiteiO35903.

    Expressioni

    Tissue specificityi

    Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

    Gene expression databases

    CleanExiMM_CCL25.
    GenevestigatoriO35903.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5885N.
    IntActiO35903. 1 interaction.
    MINTiMINT-106264.
    STRINGi10090.ENSMUSP00000024004.

    Structurei

    3D structure databases

    ProteinModelPortaliO35903.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39655.
    GeneTreeiENSGT00510000049257.
    HOGENOMiHOG000293281.
    HOVERGENiHBG050832.
    InParanoidiO35903.
    KOiK13072.
    OMAiMACSTER.
    TreeFamiTF353160.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLWLFACLV ACFVGAWMPV VHAQGAFEDC CLGYQHRIKW NVLRHARNYH    50
    QQEVSGSCNL RAVRFYFRQK VVCGNPEDMN VKRAMRILTA RKRLVHWKSA 100
    SDSQTERKKS NHMKSKVENP NSTSVRSATL GHPRMVMMPR KTNN 144
    Length:144
    Mass (Da):16,733
    Last modified:September 18, 2013 - v2
    Checksum:iCEC1924B320B4408
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851M → I in AAB69982. (PubMed:9285413)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86357 mRNA. Translation: AAB69982.1.
    AJ249480 mRNA. Translation: CAB55762.1.
    DQ158256 mRNA. Translation: AAZ99719.1.
    AK134138 mRNA. Translation: BAE22030.1.
    AC155164 Genomic DNA. No translation available.
    BC117033 mRNA. Translation: AAI17034.1.
    BC117037 mRNA. Translation: AAI17038.1.
    CCDSiCCDS22085.1.
    RefSeqiNP_033164.1. NM_009138.3.
    UniGeneiMm.7275.

    Genome annotation databases

    EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235.
    GeneIDi20300.
    KEGGimmu:20300.
    UCSCiuc009ktw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86357 mRNA. Translation: AAB69982.1 .
    AJ249480 mRNA. Translation: CAB55762.1 .
    DQ158256 mRNA. Translation: AAZ99719.1 .
    AK134138 mRNA. Translation: BAE22030.1 .
    AC155164 Genomic DNA. No translation available.
    BC117033 mRNA. Translation: AAI17034.1 .
    BC117037 mRNA. Translation: AAI17038.1 .
    CCDSi CCDS22085.1.
    RefSeqi NP_033164.1. NM_009138.3.
    UniGenei Mm.7275.

    3D structure databases

    ProteinModelPortali O35903.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5885N.
    IntActi O35903. 1 interaction.
    MINTi MINT-106264.
    STRINGi 10090.ENSMUSP00000024004.

    PTM databases

    PhosphoSitei O35903.

    Proteomic databases

    PRIDEi O35903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024004 ; ENSMUSP00000024004 ; ENSMUSG00000023235 .
    GeneIDi 20300.
    KEGGi mmu:20300.
    UCSCi uc009ktw.2. mouse.

    Organism-specific databases

    CTDi 6370.
    MGIi MGI:1099448. Ccl25.

    Phylogenomic databases

    eggNOGi NOG39655.
    GeneTreei ENSGT00510000049257.
    HOGENOMi HOG000293281.
    HOVERGENi HBG050832.
    InParanoidi O35903.
    KOi K13072.
    OMAi MACSTER.
    TreeFami TF353160.

    Miscellaneous databases

    ChiTaRSi CCL25. mouse.
    NextBioi 298037.
    PROi O35903.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CCL25.
    Genevestigatori O35903.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
      Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
      Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9."
      Wurbel M.A., Philippe J.-M., Nguyen C., Victorero G., Freeman T., Wooding P., Miazek A., Mattei M.-G., Malissen M., Jordan B.R., Malissen B., Carrier A., Naquet P.
      Eur. J. Immunol. 30:262-271(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors."
      Ericsson A., Kotarsky K., Svensson M., Sigvardsson M., Agace W.
      J. Immunol. 176:3642-3651(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Small intestine.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCCL25_MOUSE
    AccessioniPrimary (citable) accession number: O35903
    Secondary accession number(s): Q9QYY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3