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O35903

- CCL25_MOUSE

UniProt

O35903 - CCL25_MOUSE

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Protein

C-C motif chemokine 25

Gene

Ccl25

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

GO - Molecular functioni

  1. chemokine activity Source: MGI
  2. chemokine receptor binding Source: UniProtKB

GO - Biological processi

  1. cell chemotaxis Source: GOC
  2. chemotaxis Source: MGI
  3. immune response Source: InterPro
  4. inflammatory response Source: UniProtKB-KW
  5. leukocyte migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 25
Alternative name(s):
Chemokine TECK
Small-inducible cytokine A25
Thymus-expressed chemokine
Gene namesi
Name:Ccl25
Synonyms:Scya25, Teck
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1099448. Ccl25.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 144121C-C motif chemokine 25PRO_0000005236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiO35903.

PTM databases

PhosphoSiteiO35903.

Expressioni

Tissue specificityi

Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.

Gene expression databases

CleanExiMM_CCL25.
ExpressionAtlasiO35903. baseline and differential.
GenevestigatoriO35903.

Interactioni

Protein-protein interaction databases

DIPiDIP-5885N.
IntActiO35903. 1 interaction.
MINTiMINT-106264.
STRINGi10090.ENSMUSP00000024004.

Structurei

3D structure databases

ProteinModelPortaliO35903.
SMRiO35903. Positions 23-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39655.
GeneTreeiENSGT00510000049257.
HOGENOMiHOG000293281.
HOVERGENiHBG050832.
InParanoidiO35903.
KOiK13072.
OMAiMACSTER.
TreeFamiTF353160.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLWLFACLV ACFVGAWMPV VHAQGAFEDC CLGYQHRIKW NVLRHARNYH
60 70 80 90 100
QQEVSGSCNL RAVRFYFRQK VVCGNPEDMN VKRAMRILTA RKRLVHWKSA
110 120 130 140
SDSQTERKKS NHMKSKVENP NSTSVRSATL GHPRMVMMPR KTNN
Length:144
Mass (Da):16,733
Last modified:September 18, 2013 - v2
Checksum:iCEC1924B320B4408
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851M → I in AAB69982. (PubMed:9285413)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86357 mRNA. Translation: AAB69982.1.
AJ249480 mRNA. Translation: CAB55762.1.
DQ158256 mRNA. Translation: AAZ99719.1.
AK134138 mRNA. Translation: BAE22030.1.
AC155164 Genomic DNA. No translation available.
BC117033 mRNA. Translation: AAI17034.1.
BC117037 mRNA. Translation: AAI17038.1.
CCDSiCCDS22085.1.
RefSeqiNP_033164.1. NM_009138.3.
UniGeneiMm.7275.

Genome annotation databases

EnsembliENSMUST00000024004; ENSMUSP00000024004; ENSMUSG00000023235.
GeneIDi20300.
KEGGimmu:20300.
UCSCiuc009ktw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86357 mRNA. Translation: AAB69982.1 .
AJ249480 mRNA. Translation: CAB55762.1 .
DQ158256 mRNA. Translation: AAZ99719.1 .
AK134138 mRNA. Translation: BAE22030.1 .
AC155164 Genomic DNA. No translation available.
BC117033 mRNA. Translation: AAI17034.1 .
BC117037 mRNA. Translation: AAI17038.1 .
CCDSi CCDS22085.1.
RefSeqi NP_033164.1. NM_009138.3.
UniGenei Mm.7275.

3D structure databases

ProteinModelPortali O35903.
SMRi O35903. Positions 23-91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5885N.
IntActi O35903. 1 interaction.
MINTi MINT-106264.
STRINGi 10090.ENSMUSP00000024004.

PTM databases

PhosphoSitei O35903.

Proteomic databases

PRIDEi O35903.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024004 ; ENSMUSP00000024004 ; ENSMUSG00000023235 .
GeneIDi 20300.
KEGGi mmu:20300.
UCSCi uc009ktw.2. mouse.

Organism-specific databases

CTDi 6370.
MGIi MGI:1099448. Ccl25.

Phylogenomic databases

eggNOGi NOG39655.
GeneTreei ENSGT00510000049257.
HOGENOMi HOG000293281.
HOVERGENi HBG050832.
InParanoidi O35903.
KOi K13072.
OMAi MACSTER.
TreeFami TF353160.

Miscellaneous databases

ChiTaRSi CCL25. mouse.
NextBioi 298037.
PROi O35903.
SOURCEi Search...

Gene expression databases

CleanExi MM_CCL25.
ExpressionAtlasi O35903. baseline and differential.
Genevestigatori O35903.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development."
    Vicari A.P., Figueroa D.J., Hedrick J.A., Foster J.S., Singh K.P., Menon S., Copeland N.G., Gilbert D.J., Jenkins N.A., Bacon K.B., Zlotnik A.
    Immunity 7:291-301(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9."
    Wurbel M.A., Philippe J.-M., Nguyen C., Victorero G., Freeman T., Wooding P., Miazek A., Mattei M.-G., Malissen M., Jordan B.R., Malissen B., Carrier A., Naquet P.
    Eur. J. Immunol. 30:262-271(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Functional characterization of the CCL25 promoter in small intestinal epithelial cells suggests a regulatory role for caudal-related homeobox (Cdx) transcription factors."
    Ericsson A., Kotarsky K., Svensson M., Sigvardsson M., Agace W.
    J. Immunol. 176:3642-3651(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Small intestine.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCCL25_MOUSE
AccessioniPrimary (citable) accession number: O35903
Secondary accession number(s): Q9QYY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3