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O35902 (DSG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Desmoglein-3
Alternative name(s):
130 kDa pemphigus vulgaris antigen homolog
Gene names
Name:Dsg3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length993 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity.

Tissue specificity

Expressed in epidermis. Ref.3

Developmental stage

Expressed in embryo at 7 to 17 dpc. Ref.3

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 4 cadherin domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O35902-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O35902-2)

The sequence of this isoform differs from the canonical sequence as follows:
     876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
     930-993: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 4926 Potential
PRO_0000003853
Chain50 – 993944Desmoglein-3
PRO_0000003854

Regions

Topological domain50 – 617568Extracellular Potential
Transmembrane618 – 63821Helical; Potential
Topological domain639 – 993355Cytoplasmic Potential
Domain50 – 157108Cadherin 1
Domain158 – 267110Cadherin 2
Domain268 – 388121Cadherin 3
Domain384 – 495112Cadherin 4
Repeat905 – 93026Desmoglein repeat 1
Repeat931 – 96131Desmoglein repeat 2

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation4591N-linked (GlcNAc...) Potential
Glycosylation5461N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence876 – 92954YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2.
VSP_012905
Alternative sequence930 – 99364Missing in isoform 2.
VSP_012906

Experimental info

Sequence conflict8161G → A in BAC26246. Ref.2
Sequence conflict8161G → A in BAC29718. Ref.2
Sequence conflict9411P → H in BAC29718. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: DB6CC526ABFB179A

FASTA993107,889
        10         20         30         40         50         60 
MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE WVKFAKPCRE 

        70         80         90        100        110        120 
REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF VVDPNNGDIN ITAIVDREET 

       130        140        150        160        170        180 
PSFLITCRAL NALGQDVERP LILTVKILDV NDNPPIFSQT IFKGEIEENS ASNSLVMILN 

       190        200        210        220        230        240 
ATDADEPNHM NSKIAFKIVS QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA 

       250        260        270        280        290        300 
DNDGTGLSTQ CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN 

       310        320        330        340        350        360 
WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR NKAEFHQSVI 

       370        380        390        400        410        420 
SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK LVGYILGTYQ ATDEDTGKAA 

       430        440        450        460        470        480 
SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI DRDSTFIVNK TISAEVLAID ENTGKTSTGT 

       490        500        510        520        530        540 
IYVEVPSFNE NCPSVVLEKK DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW 

       550        560        570        580        590        600 
TITTLNATSA LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI 

       610        620        630        640        650        660 
PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA ATGGFIPVPD 

       670        680        690        700        710        720 
GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS EVCTNTYAGG TMVEGASGME 

       730        740        750        760        770        780 
MITKLGGATG ATAALGPCSL GYSGTMRTRH STGGTLKDYA APVNMTFLGS YFSQKSLAYA 

       790        800        810        820        830        840 
EEEDEREVND CLLIYDDEGE DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG 

       850        860        870        880        890        900 
IDDEAKQAKP GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ 

       910        920        930        940        950        960 
ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV TQNVTVTERV 

       970        980        990 
ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL 

« Hide

Isoform 2 [UniParc].

Checksum: 0B3A2C36DE9E2614
Show »

FASTA929101,344

References

« Hide 'large scale' references
[1]"cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen."
Ishikawa H., Silos S.A., Tamai K., Copeland N.G., Gilbert D.J., Jenkins N.A., Uitto J.
Mamm. Genome 5:803-804(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Skin and Vagina.
[3]"Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
Whittock N.V.
J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U86016 mRNA. Translation: AAB65091.1.
AK029018 mRNA. Translation: BAC26246.1.
AK037142 mRNA. Translation: BAC29718.1.
UniGeneMm.106811.

3D structure databases

ProteinModelPortalO35902.
SMRO35902. Positions 34-591, 768-841.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO35902.

Proteomic databases

PRIDEO35902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:99499. Dsg3.

Phylogenomic databases

eggNOGNOG290138.
HOGENOMHOG000236266.
HOVERGENHBG005532.
InParanoidO35902.
PhylomeDBO35902.

Gene expression databases

CleanExMM_DSG3.
GenevestigatorO35902.

Family and domain databases

Gene3D2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERPTHR24025. PTHR24025. 1 hit.
PfamPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTSM00112. CA. 4 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 4 hits.
PROSITEPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

PROO35902.
SOURCESearch...

Entry information

Entry nameDSG3_MOUSE
AccessionPrimary (citable) accession number: O35902
Secondary accession number(s): Q8CB02, Q8CE48
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot