O35902 (DSG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Desmoglein-3

Alternative name(s):
130 kDa pemphigus vulgaris antigen homolog

Gene names

Name:

Dsg3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	993 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity. Cell junction › desmosome By similarity.
Tissue specificity	Expressed in epidermis. Ref.3
Developmental stage	Expressed in embryo at 7 to 17 dpc. Ref.3
Domain	Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.
Sequence similarities	Contains 4 cadherin domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium Metal-binding
PTM	Cleavage on pair of basic residues Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement PubMed 10949543. Source: MGI homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	desmosome Traceable author statement PubMed 12705872. Source: MGI integral to plasma membrane Traceable author statement PubMed 10949543. Source: MGI spot adherens junction Traceable author statement PubMed 10949543. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O35902-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O35902-2)

The sequence of this isoform differs from the canonical sequence as follows:
     876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
     930-993: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Propeptide	24 – 49	26	Potential		PRO_0000003853
	Chain	50 – 993	944	Desmoglein-3		PRO_0000003854
Regions
	Topological domain	50 – 617	568	Extracellular Potential
	Transmembrane	618 – 638	21	Helical; Potential
	Topological domain	639 – 993	355	Cytoplasmic Potential
	Domain	50 – 157	108	Cadherin 1
	Domain	158 – 267	110	Cadherin 2
	Domain	268 – 388	121	Cadherin 3
	Domain	384 – 495	112	Cadherin 4
	Repeat	905 – 930	26	Desmoglein repeat 1
	Repeat	931 – 961	31	Desmoglein repeat 2
Amino acid modifications
	Glycosylation	110	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	459	1	N-linked (GlcNAc...) Potential
	Glycosylation	546	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	876 – 929	54	YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2.		VSP_012905
	Alternative sequence	930 – 993	64	Missing in isoform 2.		VSP_012906
Experimental info
	Sequence conflict	816	1	G → A in BAC26246. Ref.2
	Sequence conflict	816	1	G → A in BAC29718. Ref.2
	Sequence conflict	941	1	P → H in BAC29718. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: DB6CC526ABFB179A	FASTA	993	107,889
	10 20 30 40 50 60 MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE WVKFAKPCRE 70 80 90 100 110 120 REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF VVDPNNGDIN ITAIVDREET 130 140 150 160 170 180 PSFLITCRAL NALGQDVERP LILTVKILDV NDNPPIFSQT IFKGEIEENS ASNSLVMILN 190 200 210 220 230 240 ATDADEPNHM NSKIAFKIVS QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA 250 260 270 280 290 300 DNDGTGLSTQ CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN 310 320 330 340 350 360 WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR NKAEFHQSVI 370 380 390 400 410 420 SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK LVGYILGTYQ ATDEDTGKAA 430 440 450 460 470 480 SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI DRDSTFIVNK TISAEVLAID ENTGKTSTGT 490 500 510 520 530 540 IYVEVPSFNE NCPSVVLEKK DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW 550 560 570 580 590 600 TITTLNATSA LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI 610 620 630 640 650 660 PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA ATGGFIPVPD 670 680 690 700 710 720 GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS EVCTNTYAGG TMVEGASGME 730 740 750 760 770 780 MITKLGGATG ATAALGPCSL GYSGTMRTRH STGGTLKDYA APVNMTFLGS YFSQKSLAYA 790 800 810 820 830 840 EEEDEREVND CLLIYDDEGE DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG 850 860 870 880 890 900 IDDEAKQAKP GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ 910 920 930 940 950 960 ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV TQNVTVTERV 970 980 990 ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL
	Isoform 2 [UniParc]. Checksum: 0B3A2C36DE9E2614	FASTA	929	101,344
	10 20 30 40 50 60 MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE WVKFAKPCRE 70 80 90 100 110 120 REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF VVDPNNGDIN ITAIVDREET 130 140 150 160 170 180 PSFLITCRAL NALGQDVERP LILTVKILDV NDNPPIFSQT IFKGEIEENS ASNSLVMILN 190 200 210 220 230 240 ATDADEPNHM NSKIAFKIVS QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA 250 260 270 280 290 300 DNDGTGLSTQ CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN 310 320 330 340 350 360 WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR NKAEFHQSVI 370 380 390 400 410 420 SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK LVGYILGTYQ ATDEDTGKAA 430 440 450 460 470 480 SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI DRDSTFIVNK TISAEVLAID ENTGKTSTGT 490 500 510 520 530 540 IYVEVPSFNE NCPSVVLEKK DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW 550 560 570 580 590 600 TITTLNATSA LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI 610 620 630 640 650 660 PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA ATGGFIPVPD 670 680 690 700 710 720 GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS EVCTNTYAGG TMVEGASGME 730 740 750 760 770 780 MITKLGGATG ATAALGPCSL GYSGTMRTRH STGGTLKDYA APVNMTFLGS YFSQKSLAYA 790 800 810 820 830 840 EEEDEREVND CLLIYDDEGE DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG 850 860 870 880 890 900 IDDEAKQAKP GPKDSGSGAD TCARSMEVPQ SGSNRQYLFL LLPSNEEAGA RIHRAPSTNP 910 920 RLLLLCLVHS EQRSVHSQYG SDAQGMNTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen." Ishikawa H., Silos S.A., Tamai K., Copeland N.G., Gilbert D.J., Jenkins N.A., Uitto J. Mamm. Genome 5:803-804(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Skin and Vagina.
[3]	"Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6." Whittock N.V. J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U86016 mRNA. Translation: AAB65091.1. AK029018 mRNA. Translation: BAC26246.1. AK037142 mRNA. Translation: BAC29718.1.
IPI	IPI00316674. IPI00756879.
UniGene	Mm.106811.
3D structure databases
ProteinModelPortal	O35902.
SMR	O35902. Positions 48-591.
ModBase	Search...
PTM databases
PhosphoSite	O35902.
Proteomic databases
PRIDE	O35902.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:99499. Dsg3.
Phylogenomic databases
eggNOG	NOG290138.
HOGENOM	HOG000236266.
HOVERGEN	HBG005532.
InParanoid	O35902.
OrthoDB	EOG4ZS92C.
Gene expression databases
CleanEx	MM_DSG3.
Genevestigator	O35902.
Family and domain databases
Gene3D	2.60.40.60. 4 hits. 4.10.900.10. 1 hit.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR000233. Cadherin_cytoplasmic-dom. IPR027397. Catenin_binding_dom. IPR009123. Desmoglein. IPR009122. Desmosomal_cadherin. [Graphical view]
PANTHER	PTHR24025. PTHR24025. 1 hit.
Pfam	PF00028. Cadherin. 4 hits. PF01049. Cadherin_C. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN. PR01818. DESMOCADHERN. PR01819. DESMOGLEIN.
SMART	SM00112. CA. 4 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 4 hits.
PROSITE	PS00232. CADHERIN_1. 2 hits. PS50268. CADHERIN_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

DSG3_MOUSE

Accession

Primary (citable) accession number: O35902
Secondary accession number(s): Q8CB02, Q8CE48

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	January 1, 1998
Last modified:	May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program