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O35902

- DSG3_MOUSE

UniProt

O35902 - DSG3_MOUSE

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Protein

Desmoglein-3

Gene

Dsg3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: MGI
  2. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-3
Alternative name(s):
130 kDa pemphigus vulgaris antigen homolog
Gene namesi
Name:Dsg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:99499. Dsg3.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 617568ExtracellularSequence AnalysisAdd
BLAST
Transmembranei618 – 63821HelicalSequence AnalysisAdd
BLAST
Topological domaini639 – 993355CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. desmosome Source: MGI
  2. integral component of plasma membrane Source: MGI
  3. spot adherens junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 4926CuratedPRO_0000003853Add
BLAST
Chaini50 – 993944Desmoglein-3PRO_0000003854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiO35902.

PTM databases

PhosphoSiteiO35902.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc.1 Publication

Gene expression databases

CleanExiMM_DSG3.
GenevestigatoriO35902.

Structurei

3D structure databases

ProteinModelPortaliO35902.
SMRiO35902. Positions 48-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 157108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini158 – 267110Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini268 – 388121Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 495112Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Repeati905 – 93026Desmoglein repeat 1Add
BLAST
Repeati931 – 96131Desmoglein repeat 2Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290138.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO35902.
PhylomeDBiO35902.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35902-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE
60 70 80 90 100
WVKFAKPCRE REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF
110 120 130 140 150
VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV
160 170 180 190 200
NDNPPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS
210 220 230 240 250
QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA DNDGTGLSTQ
260 270 280 290 300
CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR
360 370 380 390 400
NKAEFHQSVI SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK
410 420 430 440 450
LVGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI
460 470 480 490 500
DRDSTFIVNK TISAEVLAID ENTGKTSTGT IYVEVPSFNE NCPSVVLEKK
510 520 530 540 550
DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW TITTLNATSA
560 570 580 590 600
LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI
610 620 630 640 650
PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA
660 670 680 690 700
ATGGFIPVPD GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS
710 720 730 740 750
EVCTNTYAGG TMVEGASGME MITKLGGATG ATAALGPCSL GYSGTMRTRH
760 770 780 790 800
STGGTLKDYA APVNMTFLGS YFSQKSLAYA EEEDEREVND CLLIYDDEGE
810 820 830 840 850
DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG IDDEAKQAKP
860 870 880 890 900
GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ
910 920 930 940 950
ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV
960 970 980 990
TQNVTVTERV ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL
Length:993
Mass (Da):107,889
Last modified:January 1, 1998 - v1
Checksum:iDB6CC526ABFB179A
GO
Isoform 2 (identifier: O35902-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
     930-993: Missing.

Show »
Length:929
Mass (Da):101,344
Checksum:i0B3A2C36DE9E2614
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti816 – 8161G → A in BAC26246. (PubMed:16141072)Curated
Sequence conflicti816 – 8161G → A in BAC29718. (PubMed:16141072)Curated
Sequence conflicti941 – 9411P → H in BAC29718. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei876 – 92954YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2. 1 PublicationVSP_012905Add
BLAST
Alternative sequencei930 – 99364Missing in isoform 2. 1 PublicationVSP_012906Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86016 mRNA. Translation: AAB65091.1.
AK029018 mRNA. Translation: BAC26246.1.
AK037142 mRNA. Translation: BAC29718.1.
CCDSiCCDS29083.1. [O35902-1]
UniGeneiMm.106811.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86016 mRNA. Translation: AAB65091.1 .
AK029018 mRNA. Translation: BAC26246.1 .
AK037142 mRNA. Translation: BAC29718.1 .
CCDSi CCDS29083.1. [O35902-1 ]
UniGenei Mm.106811.

3D structure databases

ProteinModelPortali O35902.
SMRi O35902. Positions 48-591.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35902.

Proteomic databases

PRIDEi O35902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:99499. Dsg3.

Phylogenomic databases

eggNOGi NOG290138.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi O35902.
PhylomeDBi O35902.

Miscellaneous databases

PROi O35902.
SOURCEi Search...

Gene expression databases

CleanExi MM_DSG3.
Genevestigatori O35902.

Family and domain databases

Gene3Di 2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 4 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen."
    Ishikawa H., Silos S.A., Tamai K., Copeland N.G., Gilbert D.J., Jenkins N.A., Uitto J.
    Mamm. Genome 5:803-804(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Skin and Vagina.
  3. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
    Whittock N.V.
    J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDSG3_MOUSE
AccessioniPrimary (citable) accession number: O35902
Secondary accession number(s): Q8CB02, Q8CE48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3