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O35902

- DSG3_MOUSE

UniProt

O35902 - DSG3_MOUSE

Protein

Desmoglein-3

Gene

Dsg3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: MGI
    2. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoglein-3
    Alternative name(s):
    130 kDa pemphigus vulgaris antigen homolog
    Gene namesi
    Name:Dsg3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:99499. Dsg3.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctiondesmosome By similarity

    GO - Cellular componenti

    1. desmosome Source: MGI
    2. integral component of plasma membrane Source: MGI
    3. spot adherens junction Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323CuratedAdd
    BLAST
    Propeptidei24 – 4926CuratedPRO_0000003853Add
    BLAST
    Chaini50 – 993944Desmoglein-3PRO_0000003854Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi546 – 5461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PRIDEiO35902.

    PTM databases

    PhosphoSiteiO35902.

    Expressioni

    Tissue specificityi

    Expressed in epidermis.1 Publication

    Developmental stagei

    Expressed in embryo at 7 to 17 dpc.1 Publication

    Gene expression databases

    CleanExiMM_DSG3.
    GenevestigatoriO35902.

    Structurei

    3D structure databases

    ProteinModelPortaliO35902.
    SMRiO35902. Positions 48-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini50 – 617568ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini639 – 993355CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei618 – 63821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 157108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini158 – 267110Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 388121Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 495112Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati905 – 93026Desmoglein repeat 1Add
    BLAST
    Repeati931 – 96131Desmoglein repeat 2Add
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290138.
    HOGENOMiHOG000236266.
    HOVERGENiHBG005532.
    InParanoidiO35902.
    PhylomeDBiO35902.

    Family and domain databases

    Gene3Di2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 4 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O35902-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE    50
    WVKFAKPCRE REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF 100
    VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV 150
    NDNPPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS 200
    QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA DNDGTGLSTQ 250
    CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN 300
    WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR 350
    NKAEFHQSVI SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK 400
    LVGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI 450
    DRDSTFIVNK TISAEVLAID ENTGKTSTGT IYVEVPSFNE NCPSVVLEKK 500
    DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW TITTLNATSA 550
    LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI 600
    PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA 650
    ATGGFIPVPD GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS 700
    EVCTNTYAGG TMVEGASGME MITKLGGATG ATAALGPCSL GYSGTMRTRH 750
    STGGTLKDYA APVNMTFLGS YFSQKSLAYA EEEDEREVND CLLIYDDEGE 800
    DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG IDDEAKQAKP 850
    GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ 900
    ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV 950
    TQNVTVTERV ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL 993
    Length:993
    Mass (Da):107,889
    Last modified:January 1, 1998 - v1
    Checksum:iDB6CC526ABFB179A
    GO
    Isoform 2 (identifier: O35902-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
         930-993: Missing.

    Show »
    Length:929
    Mass (Da):101,344
    Checksum:i0B3A2C36DE9E2614
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti816 – 8161G → A in BAC26246. (PubMed:16141072)Curated
    Sequence conflicti816 – 8161G → A in BAC29718. (PubMed:16141072)Curated
    Sequence conflicti941 – 9411P → H in BAC29718. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei876 – 92954YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2. 1 PublicationVSP_012905Add
    BLAST
    Alternative sequencei930 – 99364Missing in isoform 2. 1 PublicationVSP_012906Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86016 mRNA. Translation: AAB65091.1.
    AK029018 mRNA. Translation: BAC26246.1.
    AK037142 mRNA. Translation: BAC29718.1.
    CCDSiCCDS29083.1. [O35902-1]
    UniGeneiMm.106811.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U86016 mRNA. Translation: AAB65091.1 .
    AK029018 mRNA. Translation: BAC26246.1 .
    AK037142 mRNA. Translation: BAC29718.1 .
    CCDSi CCDS29083.1. [O35902-1 ]
    UniGenei Mm.106811.

    3D structure databases

    ProteinModelPortali O35902.
    SMRi O35902. Positions 48-591.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O35902.

    Proteomic databases

    PRIDEi O35902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:99499. Dsg3.

    Phylogenomic databases

    eggNOGi NOG290138.
    HOGENOMi HOG000236266.
    HOVERGENi HBG005532.
    InParanoidi O35902.
    PhylomeDBi O35902.

    Miscellaneous databases

    PROi O35902.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DSG3.
    Genevestigatori O35902.

    Family and domain databases

    Gene3Di 2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 4 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 4 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen."
      Ishikawa H., Silos S.A., Tamai K., Copeland N.G., Gilbert D.J., Jenkins N.A., Uitto J.
      Mamm. Genome 5:803-804(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Skin and Vagina.
    3. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
      Whittock N.V.
      J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiDSG3_MOUSE
    AccessioniPrimary (citable) accession number: O35902
    Secondary accession number(s): Q8CB02, Q8CE48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3