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Protein

Desmoglein-3

Gene

Dsg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-3
Alternative name(s):
130 kDa pemphigus vulgaris antigen homolog
Gene namesi
Name:Dsg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99499. Dsg3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 617ExtracellularSequence analysisAdd BLAST568
Transmembranei618 – 638HelicalSequence analysisAdd BLAST21
Topological domaini639 – 993CytoplasmicSequence analysisAdd BLAST355

GO - Cellular componenti

  • desmosome Source: MGI
  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: MGI
  • spot adherens junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23CuratedAdd BLAST23
PropeptideiPRO_000000385324 – 49CuratedAdd BLAST26
ChainiPRO_000000385450 – 993Desmoglein-3Add BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiO35902.
PaxDbiO35902.
PeptideAtlasiO35902.
PRIDEiO35902.

PTM databases

iPTMnetiO35902.
PhosphoSitePlusiO35902.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc.1 Publication

Gene expression databases

CleanExiMM_DSG3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064718.

Structurei

3D structure databases

ProteinModelPortaliO35902.
SMRiO35902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini158 – 267Cadherin 2PROSITE-ProRule annotationAdd BLAST110
Domaini268 – 388Cadherin 3PROSITE-ProRule annotationAdd BLAST121
Domaini384 – 495Cadherin 4PROSITE-ProRule annotationAdd BLAST112
Repeati905 – 930Desmoglein repeat 1Add BLAST26
Repeati931 – 961Desmoglein repeat 2Add BLAST31

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO35902.
KOiK07598.
PhylomeDBiO35902.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O35902-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE
60 70 80 90 100
WVKFAKPCRE REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF
110 120 130 140 150
VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV
160 170 180 190 200
NDNPPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS
210 220 230 240 250
QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA DNDGTGLSTQ
260 270 280 290 300
CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN
310 320 330 340 350
WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR
360 370 380 390 400
NKAEFHQSVI SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK
410 420 430 440 450
LVGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI
460 470 480 490 500
DRDSTFIVNK TISAEVLAID ENTGKTSTGT IYVEVPSFNE NCPSVVLEKK
510 520 530 540 550
DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW TITTLNATSA
560 570 580 590 600
LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI
610 620 630 640 650
PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA
660 670 680 690 700
ATGGFIPVPD GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS
710 720 730 740 750
EVCTNTYAGG TMVEGASGME MITKLGGATG ATAALGPCSL GYSGTMRTRH
760 770 780 790 800
STGGTLKDYA APVNMTFLGS YFSQKSLAYA EEEDEREVND CLLIYDDEGE
810 820 830 840 850
DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG IDDEAKQAKP
860 870 880 890 900
GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ
910 920 930 940 950
ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV
960 970 980 990
TQNVTVTERV ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL
Length:993
Mass (Da):107,889
Last modified:January 1, 1998 - v1
Checksum:iDB6CC526ABFB179A
GO
Isoform 2 (identifier: O35902-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
     930-993: Missing.

Show »
Length:929
Mass (Da):101,344
Checksum:i0B3A2C36DE9E2614
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti816G → A in BAC26246 (PubMed:16141072).Curated1
Sequence conflicti816G → A in BAC29718 (PubMed:16141072).Curated1
Sequence conflicti941P → H in BAC29718 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012905876 – 929YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_012906930 – 993Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86016 mRNA. Translation: AAB65091.1.
AK029018 mRNA. Translation: BAC26246.1.
AK037142 mRNA. Translation: BAC29718.1.
CCDSiCCDS29083.1. [O35902-1]
RefSeqiNP_085099.2. NM_030596.4.
UniGeneiMm.106811.

Genome annotation databases

GeneIDi13512.
KEGGimmu:13512.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86016 mRNA. Translation: AAB65091.1.
AK029018 mRNA. Translation: BAC26246.1.
AK037142 mRNA. Translation: BAC29718.1.
CCDSiCCDS29083.1. [O35902-1]
RefSeqiNP_085099.2. NM_030596.4.
UniGeneiMm.106811.

3D structure databases

ProteinModelPortaliO35902.
SMRiO35902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064718.

PTM databases

iPTMnetiO35902.
PhosphoSitePlusiO35902.

Proteomic databases

MaxQBiO35902.
PaxDbiO35902.
PeptideAtlasiO35902.
PRIDEiO35902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13512.
KEGGimmu:13512.

Organism-specific databases

CTDi1830.
MGIiMGI:99499. Dsg3.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO35902.
KOiK07598.
PhylomeDBiO35902.

Miscellaneous databases

PROiO35902.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DSG3.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSG3_MOUSE
AccessioniPrimary (citable) accession number: O35902
Secondary accession number(s): Q8CB02, Q8CE48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.