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O35902

- DSG3_MOUSE

UniProt

O35902 - DSG3_MOUSE

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Protein

Desmoglein-3

Gene
Dsg3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: MGI
  2. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-3
Alternative name(s):
130 kDa pemphigus vulgaris antigen homolog
Gene namesi
Name:Dsg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:99499. Dsg3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 617568Extracellular Reviewed predictionAdd
BLAST
Transmembranei618 – 63821Helical; Reviewed predictionAdd
BLAST
Topological domaini639 – 993355Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. desmosome Source: MGI
  2. integral component of plasma membrane Source: MGI
  3. spot adherens junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Propeptidei24 – 4926 Reviewed predictionPRO_0000003853Add
BLAST
Chaini50 – 993944Desmoglein-3PRO_0000003854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi546 – 5461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PRIDEiO35902.

PTM databases

PhosphoSiteiO35902.

Expressioni

Tissue specificityi

Expressed in epidermis.1 Publication

Developmental stagei

Expressed in embryo at 7 to 17 dpc.1 Publication

Gene expression databases

CleanExiMM_DSG3.
GenevestigatoriO35902.

Structurei

3D structure databases

ProteinModelPortaliO35902.
SMRiO35902. Positions 48-591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 157108Cadherin 1Add
BLAST
Domaini158 – 267110Cadherin 2Add
BLAST
Domaini268 – 388121Cadherin 3Add
BLAST
Domaini384 – 495112Cadherin 4Add
BLAST
Repeati905 – 93026Desmoglein repeat 1Add
BLAST
Repeati931 – 96131Desmoglein repeat 2Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 4 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290138.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiO35902.
PhylomeDBiO35902.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O35902-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTCLFPRALG SLALLMVVLL VQGELHVKPG GQHREDGTAL QLAKRRYKRE    50
WVKFAKPCRE REDNSRRNPI AKITSDFQKN QKITYRISGV GIDQPPFGIF 100
VVDPNNGDIN ITAIVDREET PSFLITCRAL NALGQDVERP LILTVKILDV 150
NDNPPIFSQT IFKGEIEENS ASNSLVMILN ATDADEPNHM NSKIAFKIVS 200
QEPAGMSMFL ISRNTGEVRT LTSSLDREQI SSYHLVVSGA DNDGTGLSTQ 250
CECSIKIKDV NDNFPVLRES QYSARIEENT LNAELLRFQV TDWDEEYTDN 300
WLAVYFFTSG NEGNWFEIET DPRTNEGILK VVKALDYEQV QSMQFSIAVR 350
NKAEFHQSVI SQYRVQSTPV TIQVIDVREG ISFRPPSKTF TVQRGVSTNK 400
LVGYILGTYQ ATDEDTGKAA SSVRYVLGRN DGGLLVIDSK TAQIKFVKNI 450
DRDSTFIVNK TISAEVLAID ENTGKTSTGT IYVEVPSFNE NCPSVVLEKK 500
DICTSSPSVT LSVRTLDRGK YTGPYTVSLE EQPLKLPVMW TITTLNATSA 550
LLQAQQQVSP GVYNVPVIVK DNQDGLCDTP ESLTLTVCQC DDRSMCRAPI 600
PSREPNTYGE SSWRLGPAAI GLILLGLLML LLAPLLLLTC DCGSGPIGGA 650
ATGGFIPVPD GSEGTIHQWG IEGAQPEDKE ITNICVPPVT TNGADFMESS 700
EVCTNTYAGG TMVEGASGME MITKLGGATG ATAALGPCSL GYSGTMRTRH 750
STGGTLKDYA APVNMTFLGS YFSQKSLAYA EEEDEREVND CLLIYDDEGE 800
DAAPHSPTLS SCSIFGDDLD DNFLDSLGPK FKKLAEICLG IDDEAKQAKP 850
GPKDSGSGAD TCARSMEVPQ SGSNRYQTLP GSLEVTQTGS KICHTLSGNQ 900
ETSVMSTSGS VHPAVAIPDP LQLGNYLLTE TYSTSGSFAQ PTTVTFDPHV 950
TQNVTVTERV ICPLPSASSS IVAPTELRGS YNMLYTKETC SHL 993
Length:993
Mass (Da):107,889
Last modified:January 1, 1998 - v1
Checksum:iDB6CC526ABFB179A
GO
Isoform 2 (identifier: O35902-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     876-929: YQTLPGSLEV...PLQLGNYLLT → QYLFLLLPSN...GSDAQGMNTL
     930-993: Missing.

Show »
Length:929
Mass (Da):101,344
Checksum:i0B3A2C36DE9E2614
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei876 – 92954YQTLP…NYLLT → QYLFLLLPSNEEAGARIHRA PSTNPRLLLLCLVHSEQRSV HSQYGSDAQGMNTL in isoform 2. VSP_012905Add
BLAST
Alternative sequencei930 – 99364Missing in isoform 2. VSP_012906Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti816 – 8161G → A in BAC26246. 1 Publication
Sequence conflicti816 – 8161G → A in BAC29718. 1 Publication
Sequence conflicti941 – 9411P → H in BAC29718. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86016 mRNA. Translation: AAB65091.1.
AK029018 mRNA. Translation: BAC26246.1.
AK037142 mRNA. Translation: BAC29718.1.
CCDSiCCDS29083.1. [O35902-1]
UniGeneiMm.106811.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U86016 mRNA. Translation: AAB65091.1 .
AK029018 mRNA. Translation: BAC26246.1 .
AK037142 mRNA. Translation: BAC29718.1 .
CCDSi CCDS29083.1. [O35902-1 ]
UniGenei Mm.106811.

3D structure databases

ProteinModelPortali O35902.
SMRi O35902. Positions 48-591.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O35902.

Proteomic databases

PRIDEi O35902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:99499. Dsg3.

Phylogenomic databases

eggNOGi NOG290138.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi O35902.
PhylomeDBi O35902.

Miscellaneous databases

PROi O35902.
SOURCEi Search...

Gene expression databases

CleanExi MM_DSG3.
Genevestigatori O35902.

Family and domain databases

Gene3Di 2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 4 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 4 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and chromosomal assignment of the mouse gene for desmoglein 3 (Dsg3), the pemphigus vulgaris antigen."
    Ishikawa H., Silos S.A., Tamai K., Copeland N.G., Gilbert D.J., Jenkins N.A., Uitto J.
    Mamm. Genome 5:803-804(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Skin and Vagina.
  3. "Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6."
    Whittock N.V.
    J. Invest. Dermatol. 120:970-980(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDSG3_MOUSE
AccessioniPrimary (citable) accession number: O35902
Secondary accession number(s): Q8CB02, Q8CE48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi