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Protein

U6 snRNA-associated Sm-like protein LSm2

Gene

Lsm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • protein kinase binding Source: MGI
  • Ral GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm2
Alternative name(s):
Protein G7b
snRNP core Sm-like protein Sm-x5
Gene namesi
Name:Lsm2
Synonyms:G7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:90676. Lsm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595U6 snRNA-associated Sm-like protein LSm2PRO_0000125557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35900.
PaxDbiO35900.
PeptideAtlasiO35900.
PRIDEiO35900.

2D gel databases

REPRODUCTION-2DPAGEO35900.

PTM databases

iPTMnetiO35900.
PhosphoSiteiO35900.

Expressioni

Gene expression databases

BgeeiO35900.
ExpressionAtlasiO35900. baseline and differential.
GenevisibleiO35900. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • Ral GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi205506. 1 interaction.
STRINGi10090.ENSMUSP00000007266.

Structurei

3D structure databases

ProteinModelPortaliO35900.
SMRiO35900. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3448. Eukaryota.
COG1958. LUCA.
HOVERGENiHBG000486.
InParanoidiO35900.
KOiK12621.
OrthoDBiEOG7DNNXM.
PhylomeDBiO35900.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR016654. U6_snRNA_Lsm2.
[Graphical view]
PANTHERiPTHR13829. PTHR13829. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

O35900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK
60 70 80 90
YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
Length:95
Mass (Da):10,835
Last modified:January 1, 1998 - v1
Checksum:i623591A09A6ABACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85207 Genomic DNA. Translation: AAB72037.1.
AF397035 Genomic DNA. Translation: AAL14450.1.
AF397036 Genomic DNA. Translation: AAL14458.1.
BC014288 mRNA. Translation: AAH14288.1.
CCDSiCCDS50081.1.
RefSeqiNP_001103571.1. NM_001110101.2.
UniGeneiMm.165735.

Genome annotation databases

EnsembliENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050.
GeneIDi27756.
KEGGimmu:27756.
UCSCiuc008cer.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85207 Genomic DNA. Translation: AAB72037.1.
AF397035 Genomic DNA. Translation: AAL14450.1.
AF397036 Genomic DNA. Translation: AAL14458.1.
BC014288 mRNA. Translation: AAH14288.1.
CCDSiCCDS50081.1.
RefSeqiNP_001103571.1. NM_001110101.2.
UniGeneiMm.165735.

3D structure databases

ProteinModelPortaliO35900.
SMRiO35900. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205506. 1 interaction.
STRINGi10090.ENSMUSP00000007266.

PTM databases

iPTMnetiO35900.
PhosphoSiteiO35900.

2D gel databases

REPRODUCTION-2DPAGEO35900.

Proteomic databases

EPDiO35900.
PaxDbiO35900.
PeptideAtlasiO35900.
PRIDEiO35900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050.
GeneIDi27756.
KEGGimmu:27756.
UCSCiuc008cer.3. mouse.

Organism-specific databases

CTDi57819.
MGIiMGI:90676. Lsm2.

Phylogenomic databases

eggNOGiKOG3448. Eukaryota.
COG1958. LUCA.
HOVERGENiHBG000486.
InParanoidiO35900.
KOiK12621.
OrthoDBiEOG7DNNXM.
PhylomeDBiO35900.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiO35900.
SOURCEiSearch...

Gene expression databases

BgeeiO35900.
ExpressionAtlasiO35900. baseline and differential.
GenevisibleiO35900. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR016654. U6_snRNA_Lsm2.
[Graphical view]
PANTHERiPTHR13829. PTHR13829. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC."
    Bedian V., Adams T., Geiger E.A., Bailey L.C., Gasser D.L.
    Immunogenetics 46:427-430(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "Genotype versus phenotype: conflicting results in mapping a lung tumor susceptibility locus to the G7c recombination interval in the mouse MHC class III region."
    van Kooij M., de Groot K., van Vugt H., Aten J., Snoek M.
    Immunogenetics 53:656-661(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: B10.A.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLSM2_MOUSE
AccessioniPrimary (citable) accession number: O35900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.