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Protein

U6 snRNA-associated Sm-like protein LSm2

Gene

Lsm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing (By similarity).By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • protein kinase binding Source: MGI
  • Ral GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm2
Alternative name(s):
Protein G7b
snRNP core Sm-like protein Sm-x5
Gene namesi
Name:Lsm2
Synonyms:G7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:90676. Lsm2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595U6 snRNA-associated Sm-like protein LSm2PRO_0000125557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO35900.
PaxDbiO35900.
PeptideAtlasiO35900.
PRIDEiO35900.

2D gel databases

REPRODUCTION-2DPAGEO35900.

PTM databases

iPTMnetiO35900.
PhosphoSiteiO35900.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007050.
ExpressionAtlasiO35900. baseline and differential.
GenevisibleiO35900. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • Ral GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi205506. 1 interaction.
STRINGi10090.ENSMUSP00000007266.

Structurei

3D structure databases

ProteinModelPortaliO35900.
SMRiO35900. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3448. Eukaryota.
COG1958. LUCA.
HOVERGENiHBG000486.
InParanoidiO35900.
KOiK12621.
PhylomeDBiO35900.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR016654. U6_snRNA_Lsm2.
[Graphical view]
PANTHERiPTHR13829. PTHR13829. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

O35900-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK
60 70 80 90
YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
Length:95
Mass (Da):10,835
Last modified:January 1, 1998 - v1
Checksum:i623591A09A6ABACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85207 Genomic DNA. Translation: AAB72037.1.
AF397035 Genomic DNA. Translation: AAL14450.1.
AF397036 Genomic DNA. Translation: AAL14458.1.
BC014288 mRNA. Translation: AAH14288.1.
CCDSiCCDS50081.1.
RefSeqiNP_001103571.1. NM_001110101.2.
UniGeneiMm.165735.

Genome annotation databases

EnsembliENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050.
GeneIDi27756.
KEGGimmu:27756.
UCSCiuc008cer.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85207 Genomic DNA. Translation: AAB72037.1.
AF397035 Genomic DNA. Translation: AAL14450.1.
AF397036 Genomic DNA. Translation: AAL14458.1.
BC014288 mRNA. Translation: AAH14288.1.
CCDSiCCDS50081.1.
RefSeqiNP_001103571.1. NM_001110101.2.
UniGeneiMm.165735.

3D structure databases

ProteinModelPortaliO35900.
SMRiO35900. Positions 1-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205506. 1 interaction.
STRINGi10090.ENSMUSP00000007266.

PTM databases

iPTMnetiO35900.
PhosphoSiteiO35900.

2D gel databases

REPRODUCTION-2DPAGEO35900.

Proteomic databases

EPDiO35900.
PaxDbiO35900.
PeptideAtlasiO35900.
PRIDEiO35900.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114011; ENSMUSP00000109644; ENSMUSG00000007050.
GeneIDi27756.
KEGGimmu:27756.
UCSCiuc008cer.3. mouse.

Organism-specific databases

CTDi57819.
MGIiMGI:90676. Lsm2.

Phylogenomic databases

eggNOGiKOG3448. Eukaryota.
COG1958. LUCA.
HOVERGENiHBG000486.
InParanoidiO35900.
KOiK12621.
PhylomeDBiO35900.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiO35900.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007050.
ExpressionAtlasiO35900. baseline and differential.
GenevisibleiO35900. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR016654. U6_snRNA_Lsm2.
[Graphical view]
PANTHERiPTHR13829. PTHR13829. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM2_MOUSE
AccessioniPrimary (citable) accession number: O35900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.