Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calumenin

Gene

Calu

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi81 – 92121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi117 – 128122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi164 – 175123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi201 – 212124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi242 – 253125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi278 – 289126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • enzyme inhibitor activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
Gene namesi
Name:Calu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097158. Calu.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity
  • Golgi apparatus By similarity
  • Secreted By similarity
  • Melanosome By similarity
  • Sarcoplasmic reticulum lumen By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 315296CalumeninPRO_0000004154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei47 – 471PhosphotyrosineBy similarity
Modified residuei65 – 651PhosphothreonineBy similarity
Modified residuei69 – 691PhosphoserineCombined sources
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence analysis
Modified residuei165 – 1651N6-acetyllysineCombined sources
Modified residuei254 – 2541PhosphothreonineBy similarity
Modified residuei261 – 2611PhosphoserineBy similarity
Modified residuei277 – 2771PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35887.
PaxDbiO35887.
PeptideAtlasiO35887.
PRIDEiO35887.
TopDownProteomicsiO35887.

PTM databases

iPTMnetiO35887.
PhosphoSiteiO35887.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029767.
CleanExiMM_CALU.
ExpressionAtlasiO35887. baseline and differential.
GenevisibleiO35887. MM.

Interactioni

Subunit structurei

Interacts with GGCX.By similarity

Protein-protein interaction databases

BioGridi198460. 7 interactions.
IntActiO35887. 11 interactions.
MINTiMINT-1726881.
STRINGi10090.ENSMUSP00000031779.

Structurei

3D structure databases

ProteinModelPortaliO35887.
SMRiO35887. Positions 47-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 10336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini104 – 13936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 18636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini188 – 22336EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 26436EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 30036EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi312 – 3154Prevents secretion from ER

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiO35887.
PhylomeDBiO35887.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKS FDQLTPEESK ERLGKIVSKI DDDKDGFVTV DELKGWIKFA
110 120 130 140 150
QKRWIHEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK
160 170 180 190 200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI
210 220 230 240 250
DKNADGFIDL EEYIGDMYSH DGNADEPEWV KTEREQFVEF RDKNRDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,064
Last modified:January 1, 1998 - v1
Checksum:i742361814171E273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81829 mRNA. Translation: AAC53316.1.
BC051423 mRNA. Translation: AAH51423.1.
CCDSiCCDS19957.1.
RefSeqiNP_031620.1. NM_007594.4.
UniGeneiMm.392075.

Genome annotation databases

EnsembliENSMUST00000031779; ENSMUSP00000031779; ENSMUSG00000029767.
GeneIDi12321.
KEGGimmu:12321.
UCSCiuc009bdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81829 mRNA. Translation: AAC53316.1.
BC051423 mRNA. Translation: AAH51423.1.
CCDSiCCDS19957.1.
RefSeqiNP_031620.1. NM_007594.4.
UniGeneiMm.392075.

3D structure databases

ProteinModelPortaliO35887.
SMRiO35887. Positions 47-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198460. 7 interactions.
IntActiO35887. 11 interactions.
MINTiMINT-1726881.
STRINGi10090.ENSMUSP00000031779.

PTM databases

iPTMnetiO35887.
PhosphoSiteiO35887.

Proteomic databases

EPDiO35887.
PaxDbiO35887.
PeptideAtlasiO35887.
PRIDEiO35887.
TopDownProteomicsiO35887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031779; ENSMUSP00000031779; ENSMUSG00000029767.
GeneIDi12321.
KEGGimmu:12321.
UCSCiuc009bdg.2. mouse.

Organism-specific databases

CTDi813.
MGIiMGI:1097158. Calu.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiO35887.
PhylomeDBiO35887.
TreeFamiTF314849.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiCalu. mouse.
PROiO35887.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029767.
CleanExiMM_CALU.
ExpressionAtlasiO35887. baseline and differential.
GenevisibleiO35887. MM.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALU_MOUSE
AccessioniPrimary (citable) accession number: O35887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.