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Protein

Calumenin

Gene

Calu

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi81 – 921PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi117 – 1282PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi164 – 1753; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi201 – 2124PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi242 – 2535PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi278 – 2896PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
Gene namesi
Name:Calu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097158. Calu.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity
  • Golgi apparatus By similarity
  • Secreted By similarity
  • Melanosome By similarity
  • Sarcoplasmic reticulum lumen By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000000415420 – 315CalumeninAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphotyrosineBy similarity1
Modified residuei65PhosphothreonineBy similarity1
Modified residuei69PhosphoserineCombined sources1
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei254PhosphothreonineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35887.
PaxDbiO35887.
PeptideAtlasiO35887.
PRIDEiO35887.
TopDownProteomicsiO35887.

PTM databases

iPTMnetiO35887.
PhosphoSitePlusiO35887.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029767.
CleanExiMM_CALU.
ExpressionAtlasiO35887. baseline and differential.
GenevisibleiO35887. MM.

Interactioni

Subunit structurei

Interacts with GGCX.By similarity

Protein-protein interaction databases

BioGridi198460. 7 interactors.
IntActiO35887. 11 interactors.
MINTiMINT-1726881.
STRINGi10090.ENSMUSP00000031779.

Structurei

3D structure databases

ProteinModelPortaliO35887.
SMRiO35887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 103EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini104 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini188 – 223EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini229 – 264EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini265 – 300EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 315Prevents secretion from ER4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiO35887.
PhylomeDBiO35887.
TreeFamiTF314849.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKS FDQLTPEESK ERLGKIVSKI DDDKDGFVTV DELKGWIKFA
110 120 130 140 150
QKRWIHEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK
160 170 180 190 200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI
210 220 230 240 250
DKNADGFIDL EEYIGDMYSH DGNADEPEWV KTEREQFVEF RDKNRDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,064
Last modified:January 1, 1998 - v1
Checksum:i742361814171E273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81829 mRNA. Translation: AAC53316.1.
BC051423 mRNA. Translation: AAH51423.1.
CCDSiCCDS19957.1.
RefSeqiNP_031620.1. NM_007594.4.
UniGeneiMm.392075.

Genome annotation databases

EnsembliENSMUST00000031779; ENSMUSP00000031779; ENSMUSG00000029767.
GeneIDi12321.
KEGGimmu:12321.
UCSCiuc009bdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81829 mRNA. Translation: AAC53316.1.
BC051423 mRNA. Translation: AAH51423.1.
CCDSiCCDS19957.1.
RefSeqiNP_031620.1. NM_007594.4.
UniGeneiMm.392075.

3D structure databases

ProteinModelPortaliO35887.
SMRiO35887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198460. 7 interactors.
IntActiO35887. 11 interactors.
MINTiMINT-1726881.
STRINGi10090.ENSMUSP00000031779.

PTM databases

iPTMnetiO35887.
PhosphoSitePlusiO35887.

Proteomic databases

EPDiO35887.
PaxDbiO35887.
PeptideAtlasiO35887.
PRIDEiO35887.
TopDownProteomicsiO35887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031779; ENSMUSP00000031779; ENSMUSG00000029767.
GeneIDi12321.
KEGGimmu:12321.
UCSCiuc009bdg.2. mouse.

Organism-specific databases

CTDi813.
MGIiMGI:1097158. Calu.

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiO35887.
PhylomeDBiO35887.
TreeFamiTF314849.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiCalu. mouse.
PROiO35887.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029767.
CleanExiMM_CALU.
ExpressionAtlasiO35887. baseline and differential.
GenevisibleiO35887. MM.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR027239. Calumenin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF34. PTHR10827:SF34. 1 hit.
PfamiPF13202. EF-hand_5. 2 hits.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALU_MOUSE
AccessioniPrimary (citable) accession number: O35887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.