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Protein

Calumenin

Gene

Calu

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi81 – 921PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi117 – 1282PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi164 – 1753; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi201 – 2124PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi242 – 2535PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi278 – 2896PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • enzyme binding Source: MGI
  • enzyme inhibitor activity Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Calumenin
Alternative name(s):
Crocalbin
Gene namesi
Name:Calu
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1097158 Calu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane, Sarcoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000000415420 – 315CalumeninAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphotyrosineBy similarity1
Modified residuei65PhosphothreonineBy similarity1
Modified residuei69PhosphoserineCombined sources1
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei254PhosphothreonineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei277PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35887
PaxDbiO35887
PeptideAtlasiO35887
PRIDEiO35887
TopDownProteomicsiO35887

PTM databases

iPTMnetiO35887
PhosphoSitePlusiO35887

Expressioni

Gene expression databases

BgeeiENSMUSG00000029767
CleanExiMM_CALU
ExpressionAtlasiO35887 baseline and differential
GenevisibleiO35887 MM

Interactioni

Subunit structurei

Interacts with GGCX.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198460, 8 interactors
IntActiO35887, 11 interactors
MINTiO35887
STRINGi10090.ENSMUSP00000031779

Structurei

3D structure databases

ProteinModelPortaliO35887
SMRiO35887
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 103EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini104 – 139EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini151 – 186EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini188 – 223EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini229 – 264EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini265 – 300EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 315Prevents secretion from ER4

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223 Eukaryota
ENOG410XRVE LUCA
GeneTreeiENSGT00550000074546
HOGENOMiHOG000230934
HOVERGENiHBG002834
InParanoidiO35887
PhylomeDBiO35887
TreeFamiTF314849

Family and domain databases

InterProiView protein in InterPro
IPR027239 Calumenin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR10827:SF70 PTHR10827:SF70, 1 hit
PfamiView protein in Pfam
PF13202 EF-hand_5, 2 hits
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35887-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRQFLMCL SLCTAFALSK PTEKKDRVHH EPQLSDKVHN DAQNFDYDHD
60 70 80 90 100
AFLGAEEAKS FDQLTPEESK ERLGKIVSKI DDDKDGFVTV DELKGWIKFA
110 120 130 140 150
QKRWIHEDVE RQWKGHDLNE DGLVSWEEYK NATYGYVLDD PDPDDGFNYK
160 170 180 190 200
QMMVRDERRF KMADKDGDLI ATKEEFTAFL HPEEYDYMKD IVVQETMEDI
210 220 230 240 250
DKNADGFIDL EEYIGDMYSH DGNADEPEWV KTEREQFVEF RDKNRDGKMD
260 270 280 290 300
KEETKDWILP SDYDHAEAEA RHLVYESDQN KDGKLTKEEI VDKYDLFVGS
310
QATDFGEALV RHDEF
Length:315
Mass (Da):37,064
Last modified:January 1, 1998 - v1
Checksum:i742361814171E273
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81829 mRNA Translation: AAC53316.1
BC051423 mRNA Translation: AAH51423.1
CCDSiCCDS19957.1
RefSeqiNP_031620.1, NM_007594.4
UniGeneiMm.392075

Genome annotation databases

EnsembliENSMUST00000031779; ENSMUSP00000031779; ENSMUSG00000029767
GeneIDi12321
KEGGimmu:12321
UCSCiuc009bdg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCALU_MOUSE
AccessioniPrimary (citable) accession number: O35887
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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