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Protein

Achaete-scute homolog 2

Gene

Ascl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of Schwann cell proliferation Source: Ensembl
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • placenta development Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to hypoxia Source: Ensembl
  • somatic stem cell population maintenance Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 2
Short name:
ASH-2
Short name:
mASH-2
Short name:
mASH2
Gene namesi
Name:Ascl2
Synonyms:Mash2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96920. Ascl2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Achaete-scute homolog 2PRO_0000127131Add
BLAST

Proteomic databases

PaxDbiO35885.
PRIDEiO35885.

PTM databases

PhosphoSiteiO35885.

Expressioni

Gene expression databases

BgeeiO35885.
CleanExiMM_ASCL2.
ExpressionAtlasiO35885. baseline and differential.
GenevisibleiO35885. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009392.

Structurei

3D structure databases

ProteinModelPortaliO35885.
SMRiO35885. Positions 127-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 17053bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi104 – 1074Poly-Arg
Compositional biasi114 – 1174Poly-Ser

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISUZ. Eukaryota.
ENOG410Y0IE. LUCA.
HOGENOMiHOG000013056.
HOVERGENiHBG050590.
InParanoidiO35885.
KOiK09067.
OMAiGCEGELS.
PhylomeDBiO35885.
TreeFamiTF322889.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHLDWYGV PGLQEASDAC PRESCSSALP EAREGANVHF PPHPVPREHF
60 70 80 90 100
SCAAPELVAG AQGLNASLMD GGALPRLMPT SSGVAGACAA RRRQASPELL
110 120 130 140 150
RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA
160 170 180 190 200
NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALAGGLLT PATPPSDECA
210 220 230 240 250
QPSASPASAS LSCASTSPSP DRLGCSEPTS PRSAYSSEES SCEGELSPME
260
QELLDFSSWL GGY
Length:263
Mass (Da):27,784
Last modified:March 25, 2003 - v2
Checksum:i9FA907B436E1BA2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191A → S in AAB86992 (PubMed:9175731).Curated
Sequence conflicti179 – 1791A → T in AAB86992 (PubMed:9175731).Curated
Sequence conflicti182 – 1821A → P in AAB86992 (PubMed:9175731).Curated
Sequence conflicti200 – 2001A → T in AAB86992 (PubMed:9175731).Curated
Sequence conflicti209 – 2091A → G in AAB86992 (PubMed:9175731).Curated
Sequence conflicti220 – 2223PDR → RT in AAB86992 (PubMed:9175731).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77628 Genomic DNA. Translation: AAB86992.1.
AF139595 Genomic DNA. Translation: AAD33794.1.
AJ251835 Genomic DNA. Translation: CAB94773.1.
BC019520 mRNA. Translation: AAH19520.1.
CCDSiCCDS40194.1.
RefSeqiNP_032580.2. NM_008554.3.
XP_006508561.1. XM_006508498.2.
XP_011240286.1. XM_011241984.1.
XP_011240287.1. XM_011241985.1.
UniGeneiMm.196417.

Genome annotation databases

EnsembliENSMUST00000009392; ENSMUSP00000009392; ENSMUSG00000009248.
GeneIDi17173.
KEGGimmu:17173.
UCSCiuc009koj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77628 Genomic DNA. Translation: AAB86992.1.
AF139595 Genomic DNA. Translation: AAD33794.1.
AJ251835 Genomic DNA. Translation: CAB94773.1.
BC019520 mRNA. Translation: AAH19520.1.
CCDSiCCDS40194.1.
RefSeqiNP_032580.2. NM_008554.3.
XP_006508561.1. XM_006508498.2.
XP_011240286.1. XM_011241984.1.
XP_011240287.1. XM_011241985.1.
UniGeneiMm.196417.

3D structure databases

ProteinModelPortaliO35885.
SMRiO35885. Positions 127-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009392.

PTM databases

PhosphoSiteiO35885.

Proteomic databases

PaxDbiO35885.
PRIDEiO35885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009392; ENSMUSP00000009392; ENSMUSG00000009248.
GeneIDi17173.
KEGGimmu:17173.
UCSCiuc009koj.2. mouse.

Organism-specific databases

CTDi430.
MGIiMGI:96920. Ascl2.

Phylogenomic databases

eggNOGiENOG410ISUZ. Eukaryota.
ENOG410Y0IE. LUCA.
HOGENOMiHOG000013056.
HOVERGENiHBG050590.
InParanoidiO35885.
KOiK09067.
OMAiGCEGELS.
PhylomeDBiO35885.
TreeFamiTF322889.

Miscellaneous databases

PROiO35885.
SOURCEiSearch...

Gene expression databases

BgeeiO35885.
CleanExiMM_ASCL2.
ExpressionAtlasiO35885. baseline and differential.
GenevisibleiO35885. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR015660. Achaete-scute-rel.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR13935. PTHR13935. 1 hit.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human Achaete-Scute homologue 2 (ASCL2,HASH2) maps to chromosome 11p15.5, close to IGF2 and is expressed in extravillus trophoblasts."
    Alders M., Hodges M., Hadjantonakis A.-K., Postmus J., van Wijk I.J., Bliek J., de Meulemeester M., Westerveld A., Guillemot F., Oudejans C.B., Little P., Mannens M.
    Hum. Mol. Genet. 6:859-867(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation."
    Tanaka M., Puchyr M., Gertsenstein M., Harpal K., Jaenisch R., Rossant J., Nagy A.
    Mech. Dev. 87:129-142(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse."
    Paulsen M., El-Maarri O., Engemann S., Stroedicke M., Franck O., Davies K., Reinhardt R., Reik W., Walter J.
    Hum. Mol. Genet. 9:1829-1841(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiASCL2_MOUSE
AccessioniPrimary (citable) accession number: O35885
Secondary accession number(s): Q9WUJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 25, 2003
Last modified: June 8, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.