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Protein

Achaete-scute homolog 2

Gene

Ascl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of Schwann cell proliferation Source: Ensembl
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • placenta development Source: MGI
  • regulation of neurogenesis Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: MGI
  • response to hypoxia Source: Ensembl
  • somatic stem cell population maintenance Source: MGI
  • spongiotrophoblast differentiation Source: MGI
  • transcription, DNA-templated Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Achaete-scute homolog 2
Short name:
ASH-2
Short name:
mASH-2
Short name:
mASH2
Gene namesi
Name:Ascl2
Synonyms:Mash2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96920 Ascl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271311 – 263Achaete-scute homolog 2Add BLAST263

Proteomic databases

PaxDbiO35885
PRIDEiO35885

PTM databases

PhosphoSitePlusiO35885

Expressioni

Gene expression databases

BgeeiENSMUSG00000009248
CleanExiMM_ASCL2
ExpressionAtlasiO35885 baseline and differential
GenevisibleiO35885 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009392

Structurei

3D structure databases

ProteinModelPortaliO35885
SMRiO35885
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 170bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi104 – 107Poly-Arg4
Compositional biasi114 – 117Poly-Ser4

Phylogenomic databases

eggNOGiENOG410ISUZ Eukaryota
ENOG410Y0IE LUCA
GeneTreeiENSGT00530000063321
HOGENOMiHOG000013056
HOVERGENiHBG050590
InParanoidiO35885
KOiK09067
OMAiACPRESC
OrthoDBiEOG091G0OB6
PhylomeDBiO35885
TreeFamiTF322889

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR015660 MASH1/Ascl1a-like
PANTHERiPTHR13935 PTHR13935, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O35885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHLDWYGV PGLQEASDAC PRESCSSALP EAREGANVHF PPHPVPREHF
60 70 80 90 100
SCAAPELVAG AQGLNASLMD GGALPRLMPT SSGVAGACAA RRRQASPELL
110 120 130 140 150
RCSRRRRSGA TEASSSSAAV ARRNERERNR VKLVNLGFQA LRQHVPHGGA
160 170 180 190 200
NKKLSKVETL RSAVEYIRAL QRLLAEHDAV RAALAGGLLT PATPPSDECA
210 220 230 240 250
QPSASPASAS LSCASTSPSP DRLGCSEPTS PRSAYSSEES SCEGELSPME
260
QELLDFSSWL GGY
Length:263
Mass (Da):27,784
Last modified:March 25, 2003 - v2
Checksum:i9FA907B436E1BA2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119A → S in AAB86992 (PubMed:9175731).Curated1
Sequence conflicti179A → T in AAB86992 (PubMed:9175731).Curated1
Sequence conflicti182A → P in AAB86992 (PubMed:9175731).Curated1
Sequence conflicti200A → T in AAB86992 (PubMed:9175731).Curated1
Sequence conflicti209A → G in AAB86992 (PubMed:9175731).Curated1
Sequence conflicti220 – 222PDR → RT in AAB86992 (PubMed:9175731).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77628 Genomic DNA Translation: AAB86992.1
AF139595 Genomic DNA Translation: AAD33794.1
AJ251835 Genomic DNA Translation: CAB94773.1
BC019520 mRNA Translation: AAH19520.1
CCDSiCCDS40194.1
RefSeqiNP_032580.2, NM_008554.3
XP_006508561.1, XM_006508498.3
XP_011240286.1, XM_011241984.2
UniGeneiMm.196417

Genome annotation databases

EnsembliENSMUST00000009392; ENSMUSP00000009392; ENSMUSG00000009248
GeneIDi17173
KEGGimmu:17173
UCSCiuc009koj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiASCL2_MOUSE
AccessioniPrimary (citable) accession number: O35885
Secondary accession number(s): Q9WUJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: March 25, 2003
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health