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Protein

P2Y purinoceptor 14

Gene

P2ry14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for UDP-glucose coupled to G-proteins.By similarity

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: RGD
  • immune response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 14
Short name:
P2Y14
Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor
VTR 15-20
Gene namesi
Name:P2ry14
Synonyms:Gpr105
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70912. P2ry14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence analysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 555CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9620ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13922CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 18828ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 23425CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 27823ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini300 – 3056CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305P2Y purinoceptor 14PRO_0000070046Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO35881.

PTM databases

PhosphoSiteiO35881.

Structurei

3D structure databases

ProteinModelPortaliO35881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108228.
InParanoidiO35881.
KOiK04299.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNTTTTEPP KQPCTRNTLI TQQIIPMLYC VVFITGVLLN GISGWIFFYV
60 70 80 90 100
PSSKSFIIYL KNIVVADFLM GLTFPFKVLS DSGLGPWQLN VFVFRVSAVI
110 120 130 140 150
FYVNMYVSIA FFGLISFDRY YKIVKPLLVS IVQSVNYSKV LSVLVWVLML
160 170 180 190 200
LLAVPNIILT NQSVKDVTNI QCMELKNELG RKWHKASNYV FVSIFWIVFL
210 220 230 240 250
LLTVFYMAIT RKIFKSHLKS RKNSISVKRK SSRNIFSIVL AFVACFAPYH
260 270 280 290 300
VARIPYTKSQ TEGHYSCQAK ETLLYTKEFT LLLSAANVCL DPISISSYAS

RLEKS
Length:305
Mass (Da):34,800
Last modified:January 1, 1998 - v1
Checksum:i640646A68ECCC7A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76206 mRNA. Translation: AAB71745.1.
RefSeqiNP_598261.1. NM_133577.1.
UniGeneiRn.234376.
Rn.87082.

Genome annotation databases

GeneIDi171108.
KEGGirno:171108.
UCSCiRGD:70912. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76206 mRNA. Translation: AAB71745.1.
RefSeqiNP_598261.1. NM_133577.1.
UniGeneiRn.234376.
Rn.87082.

3D structure databases

ProteinModelPortaliO35881.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi330.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO35881.

Proteomic databases

PRIDEiO35881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171108.
KEGGirno:171108.
UCSCiRGD:70912. rat.

Organism-specific databases

CTDi9934.
RGDi70912. P2ry14.

Phylogenomic databases

HOVERGENiHBG108228.
InParanoidiO35881.
KOiK04299.

Miscellaneous databases

PROiO35881.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge."
    Charlton M.E., Williams A.S., Fogliano M., Sweetnam P.M., Duman R.S.
    Brain Res. 764:141-148(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiP2Y14_RAT
AccessioniPrimary (citable) accession number: O35881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.