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Protein

Heat shock protein beta-2

Gene

Hspb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May regulate the kinase DMPK.By similarity

GO - Molecular functioni

GO - Biological processi

  • response to heat Source: RGD
  • somatic muscle development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-2
Short name:
HspB2
Gene namesi
Name:Hspb2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi70914. Hspb2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Localizes to nuclear foci.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182Heat shock protein beta-2PRO_0000125935Add
BLAST

Proteomic databases

PaxDbiO35878.

PTM databases

PhosphoSiteiO35878.

Expressioni

Gene expression databases

GenevisibleiO35878. RN.

Interactioni

Subunit structurei

Interacts with DMPK; may enhance its kinase activity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013960.

Structurei

3D structure databases

ProteinModelPortaliO35878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiO35878.
KOiK09543.
OMAiANPSKIY.
OrthoDBiEOG7WHHBK.
PhylomeDBiO35878.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRTVPHAH PATAEYEFAN PSRLGEQRFG EGLLPEEILT PTLYHGYYVR
60 70 80 90 100
PRAARAGEGG RAGASELRLS EGKFQAFLDV SHFTPDEVTV RTVDNLLEVS
110 120 130 140 150
ARHPQRLDRH GFVSREFCRT YVLPADVDPW RVRAALSHDG ILNLEAPRGG
160 170 180
RHLDTEVNEV YISLLPAPPD PEEEEEVARV EP
Length:182
Mass (Da):20,347
Last modified:January 1, 1998 - v1
Checksum:i4547E53EED9AEA39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75899 Genomic DNA. Translation: AAB82758.1.
RefSeqiNP_569115.1. NM_130431.1.
UniGeneiRn.22486.

Genome annotation databases

EnsembliENSRNOT00000013960; ENSRNOP00000013960; ENSRNOG00000010402.
GeneIDi161476.
KEGGirno:161476.
UCSCiRGD:70914. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75899 Genomic DNA. Translation: AAB82758.1.
RefSeqiNP_569115.1. NM_130431.1.
UniGeneiRn.22486.

3D structure databases

ProteinModelPortaliO35878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013960.

PTM databases

PhosphoSiteiO35878.

Proteomic databases

PaxDbiO35878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013960; ENSRNOP00000013960; ENSRNOG00000010402.
GeneIDi161476.
KEGGirno:161476.
UCSCiRGD:70914. rat.

Organism-specific databases

CTDi3316.
RGDi70914. Hspb2.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiO35878.
KOiK09543.
OMAiANPSKIY.
OrthoDBiEOG7WHHBK.
PhylomeDBiO35878.
TreeFamiTF105049.

Miscellaneous databases

NextBioi620979.
PROiO35878.

Gene expression databases

GenevisibleiO35878. RN.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of the gene encoding a new member of the alpha-crystallin/small hsp family, closely linked to the alphaB-crystallin gene in a head-to-head manner."
    Iwaki A., Nagano T., Nakagawa M., Iwaki T., Fukumaki Y.
    Genomics 45:386-394(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiHSPB2_RAT
AccessioniPrimary (citable) accession number: O35878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 11, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.