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O35874

- SATT_MOUSE

UniProt

O35874 - SATT_MOUSE

Protein

Neutral amino acid transporter A

Gene

Slc1a4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence By similarity.By similarity

    GO - Molecular functioni

    1. chloride channel activity Source: Ensembl
    2. L-alanine transmembrane transporter activity Source: Ensembl
    3. L-cystine transmembrane transporter activity Source: Ensembl
    4. L-hydroxyproline transmembrane transporter activity Source: Ensembl
    5. L-proline transmembrane transporter activity Source: Ensembl
    6. L-serine transmembrane transporter activity Source: Ensembl
    7. L-threonine transmembrane transporter activity Source: Ensembl
    8. neutral amino acid transmembrane transporter activity Source: MGI
    9. sodium:dicarboxylate symporter activity Source: InterPro

    GO - Biological processi

    1. cognition Source: Ensembl

    Keywords - Biological processi

    Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neutral amino acid transporter A
    Alternative name(s):
    Alanine/serine/cysteine/threonine transporter 1
    Short name:
    ASCT-1
    SATT
    Solute carrier family 1 member 4
    Gene namesi
    Name:Slc1a4
    Synonyms:Asct1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2135601. Slc1a4.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Melanosome By similarity

    GO - Cellular componenti

    1. dendrite Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. intermediate filament Source: MGI
    4. melanosome Source: UniProtKB-SubCell
    5. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Neutral amino acid transporter APRO_0000202080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Glycosylationi177 – 1771N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi182 – 1821N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi201 – 2011N-linked (GlcNAc...)2 Publications
    Glycosylationi206 – 2061N-linked (GlcNAc...)2 Publications
    Modified residuei507 – 5071PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiO35874.
    PRIDEiO35874.

    PTM databases

    PhosphoSiteiO35874.

    Expressioni

    Gene expression databases

    ArrayExpressiO35874.
    BgeeiO35874.
    GenevestigatoriO35874.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000105223.

    Structurei

    3D structure databases

    ProteinModelPortaliO35874.
    SMRiO35874. Positions 51-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini140 – 21677ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei298 – 31821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1301.
    HOGENOMiHOG000208776.
    HOVERGENiHBG000080.
    InParanoidiO35874.
    KOiK05615.
    OMAiFRSYATD.
    PhylomeDBiO35874.
    TreeFamiTF315206.

    Family and domain databases

    Gene3Di1.10.3860.10. 2 hits.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11958. PTHR11958. 1 hit.
    PfamiPF00375. SDF. 1 hit.
    [Graphical view]
    PRINTSiPR00173. EDTRNSPORT.
    SUPFAMiSSF118215. SSF118215. 2 hits.
    PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35874-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKSGETNGY LDGTQAEPAA GPRTPETAMG KSQRCASFFR RHALVLLTVS    50
    GVLVGAGMGA ALRGLQLTRT QITYLAFPGE MLLRMLRMII LPLVVCSLVS 100
    GAASLDASSL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGAGAQTLQS 150
    SSLGLENSGP PPVSKETVDS FLDLLRNLFP SNLVVAAFTT SATDYTVVTH 200
    NTSSGNVTKE KIPVVTDVEG MNILGLVLFA LVLGVALKKL GPEGEDLIRF 250
    FNSFNEATMV LVSWIMWYVP IGIMFLIGSK IVEMKDIVML VTSLGKYIFA 300
    SMLGHVIHGG IVLPLVYFAF TRKNPFTFLL GLLTPFATAF ATCSSSATLP 350
    SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVD 400
    LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLSLILA 450
    VDWIVDRTTT VVNVEGDALG AGILNHLNQK VVKKGEQELQ EVKVEAIPNS 500
    KSEEETSPLV THQNPAGPVA IAPELESKES VL 532
    Length:532
    Mass (Da):56,062
    Last modified:January 1, 1998 - v1
    Checksum:i99DD9E43C5DB55D7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75215 mRNA. Translation: AAB71740.1.
    BC052733 mRNA. Translation: AAH52733.1.
    CCDSiCCDS24457.1.
    RefSeqiNP_061349.3. NM_018861.3.
    UniGeneiMm.6379.

    Genome annotation databases

    EnsembliENSMUST00000109594; ENSMUSP00000105223; ENSMUSG00000020142.
    GeneIDi55963.
    KEGGimmu:55963.
    UCSCiuc007idb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75215 mRNA. Translation: AAB71740.1 .
    BC052733 mRNA. Translation: AAH52733.1 .
    CCDSi CCDS24457.1.
    RefSeqi NP_061349.3. NM_018861.3.
    UniGenei Mm.6379.

    3D structure databases

    ProteinModelPortali O35874.
    SMRi O35874. Positions 51-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000105223.

    PTM databases

    PhosphoSitei O35874.

    Proteomic databases

    PaxDbi O35874.
    PRIDEi O35874.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109594 ; ENSMUSP00000105223 ; ENSMUSG00000020142 .
    GeneIDi 55963.
    KEGGi mmu:55963.
    UCSCi uc007idb.2. mouse.

    Organism-specific databases

    CTDi 6509.
    MGIi MGI:2135601. Slc1a4.

    Phylogenomic databases

    eggNOGi COG1301.
    HOGENOMi HOG000208776.
    HOVERGENi HBG000080.
    InParanoidi O35874.
    KOi K05615.
    OMAi FRSYATD.
    PhylomeDBi O35874.
    TreeFami TF315206.

    Miscellaneous databases

    ChiTaRSi SLC1A4. mouse.
    NextBioi 311666.
    PROi O35874.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35874.
    Bgeei O35874.
    Genevestigatori O35874.

    Family and domain databases

    Gene3Di 1.10.3860.10. 2 hits.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11958. PTHR11958. 1 hit.
    Pfami PF00375. SDF. 1 hit.
    [Graphical view ]
    PRINTSi PR00173. EDTRNSPORT.
    SUPFAMi SSF118215. SSF118215. 2 hits.
    PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Peng J.-B., Guo L.-H.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-177; ASN-182; ASN-201 AND ASN-206.
      Tissue: Myoblast.
    5. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-201 AND ASN-206.

    Entry informationi

    Entry nameiSATT_MOUSE
    AccessioniPrimary (citable) accession number: O35874
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3