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Protein

Neutral amino acid transporter A

Gene

Slc1a4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter A
Alternative name(s):
Alanine/serine/cysteine/threonine transporter 1
Short name:
ASCT-1
SATT
Solute carrier family 1 member 4
Gene namesi
Name:Slc1a4
Synonyms:Asct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2135601. Slc1a4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 216ExtracellularSequence analysisAdd BLAST77
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020801 – 532Neutral amino acid transporter AAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi177N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi182N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi201N-linked (GlcNAc...)2 Publications1
Glycosylationi206N-linked (GlcNAc...)2 Publications1
Modified residuei507PhosphoserineBy similarity1
Modified residuei527PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO35874.
PaxDbiO35874.
PeptideAtlasiO35874.
PRIDEiO35874.

PTM databases

iPTMnetiO35874.
PhosphoSitePlusiO35874.
SwissPalmiO35874.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020142.
ExpressionAtlasiO35874. baseline and differential.
GenevisibleiO35874. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105223.

Structurei

3D structure databases

ProteinModelPortaliO35874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35874.
KOiK05615.
OMAiCMAAVFI.
OrthoDBiEOG091G0UCE.
PhylomeDBiO35874.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSGETNGY LDGTQAEPAA GPRTPETAMG KSQRCASFFR RHALVLLTVS
60 70 80 90 100
GVLVGAGMGA ALRGLQLTRT QITYLAFPGE MLLRMLRMII LPLVVCSLVS
110 120 130 140 150
GAASLDASSL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGAGAQTLQS
160 170 180 190 200
SSLGLENSGP PPVSKETVDS FLDLLRNLFP SNLVVAAFTT SATDYTVVTH
210 220 230 240 250
NTSSGNVTKE KIPVVTDVEG MNILGLVLFA LVLGVALKKL GPEGEDLIRF
260 270 280 290 300
FNSFNEATMV LVSWIMWYVP IGIMFLIGSK IVEMKDIVML VTSLGKYIFA
310 320 330 340 350
SMLGHVIHGG IVLPLVYFAF TRKNPFTFLL GLLTPFATAF ATCSSSATLP
360 370 380 390 400
SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVD
410 420 430 440 450
LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLSLILA
460 470 480 490 500
VDWIVDRTTT VVNVEGDALG AGILNHLNQK VVKKGEQELQ EVKVEAIPNS
510 520 530
KSEEETSPLV THQNPAGPVA IAPELESKES VL
Length:532
Mass (Da):56,062
Last modified:January 1, 1998 - v1
Checksum:i99DD9E43C5DB55D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75215 mRNA. Translation: AAB71740.1.
BC052733 mRNA. Translation: AAH52733.1.
CCDSiCCDS24457.1.
RefSeqiNP_061349.3. NM_018861.3.
UniGeneiMm.6379.

Genome annotation databases

EnsembliENSMUST00000109594; ENSMUSP00000105223; ENSMUSG00000020142.
GeneIDi55963.
KEGGimmu:55963.
UCSCiuc007idb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75215 mRNA. Translation: AAB71740.1.
BC052733 mRNA. Translation: AAH52733.1.
CCDSiCCDS24457.1.
RefSeqiNP_061349.3. NM_018861.3.
UniGeneiMm.6379.

3D structure databases

ProteinModelPortaliO35874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105223.

PTM databases

iPTMnetiO35874.
PhosphoSitePlusiO35874.
SwissPalmiO35874.

Proteomic databases

EPDiO35874.
PaxDbiO35874.
PeptideAtlasiO35874.
PRIDEiO35874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109594; ENSMUSP00000105223; ENSMUSG00000020142.
GeneIDi55963.
KEGGimmu:55963.
UCSCiuc007idb.2. mouse.

Organism-specific databases

CTDi6509.
MGIiMGI:2135601. Slc1a4.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiO35874.
KOiK05615.
OMAiCMAAVFI.
OrthoDBiEOG091G0UCE.
PhylomeDBiO35874.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

ChiTaRSiSlc1a4. mouse.
PROiO35874.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020142.
ExpressionAtlasiO35874. baseline and differential.
GenevisibleiO35874. MM.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSATT_MOUSE
AccessioniPrimary (citable) accession number: O35874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.