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Protein

Fanconi anemia group C protein homolog

Gene

Fancc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group C protein homolog
Short name:
Protein FACC
Gene namesi
Name:Fancc
Synonyms:Facc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2593 Fancc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000871861 – 557Fanconi anemia group C protein homologAdd BLAST557

Proteomic databases

PaxDbiO35870
PRIDEiO35870

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022884

Structurei

3D structure databases

SMRiO35870
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IK3Y Eukaryota
ENOG411225E LUCA
HOGENOMiHOG000043097
HOVERGENiHBG051548
InParanoidiO35870
PhylomeDBiO35870

Family and domain databases

InterProiView protein in InterPro
IPR000686 Fanconi
PANTHERiPTHR16798 PTHR16798, 1 hit
PfamiView protein in Pfam
PF02106 Fanconi_C, 1 hit
PIRSFiPIRSF018417 FACC_protein, 1 hit
PRINTSiPR00494 FANCONICGENE

Sequencei

Sequence statusi: Complete.

O35870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEPADLAS DYQFWLQKLS AWEQASSKET QRDTCLHLSR FQEFLRQMYE
60 70 80 90 100
LLKEMDSDAI LERFPSIGQL LAKTCWNPLI LAYDESQKIV IWCLCCLMNK
110 120 130 140 150
APRTSAESGR NSWIQGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL
160 170 180 190 200
LKNMVLSLVS ELRGSHLNGL NTQSRMAPER MMSLSQVCVP LVTLPDIEPL
210 220 230 240 250
VEALLTYHGH EPQEVLSAEF FEAVTEAFLS EKVVLPTSSV VSLWFRHLPS
260 270 280 290 300
LEKATLHLFE KLFSSKRNCL RRMECCIKES LLPQAACQPA IFRIVDEMFR
310 320 330 340 350
FVLLETDGAP AVLAALQIFT SCLVEALRKE NKQLKFALKT YFPYSAPCLT
360 370 380 390 400
AALSQQPEAI PQGHRLQPLL HISQLLREAV EDCTDGSHRN PFESWFLFVH
410 420 430 440 450
FGGWVDLAVE ELLLREEAEP PAGLLWLLVF YYSPQDRSQQ REQSMVELKV
460 470 480 490 500
LVNRLLKLLR SGPLSAMDLL EAAESPREDP RPVCGQLVRR LLLSLLFWTP
510 520 530 540 550
EGHAIVWEAV THMAHTDAVT HEIVGFLDQT LYRSHHLCVE ASRKLARELL

KDLQAQV
Length:557
Mass (Da):63,592
Last modified:January 1, 1998 - v1
Checksum:i891658AE09056902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73586 mRNA Translation: AAB66675.1
UniGeneiRn.10798

Genome annotation databases

UCSCiRGD:2593 rat

Similar proteinsi

Entry informationi

Entry nameiFANCC_RAT
AccessioniPrimary (citable) accession number: O35870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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