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Protein

Fanconi anemia group C protein homolog

Gene

Fancc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group C protein homolog
Short name:
Protein FACC
Gene namesi
Name:Fancc
Synonyms:Facc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2593. Fancc.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: The major form is nuclear. The minor form is cytoplasmic.

GO - Cellular componenti

  • chromatin Source: RGD
  • cytoplasm Source: UniProtKB-SubCell
  • Fanconi anaemia nuclear complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Fanconi anemia group C protein homologPRO_0000087186Add
BLAST

Proteomic databases

PaxDbiO35870.
PRIDEiO35870.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70. Interacts with ZBTB32. Upon IFNG induction, interacts with STAT1. Interacts with CDK1. Interacts with EIF2AK2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022884.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IK3Y. Eukaryota.
ENOG411225E. LUCA.
HOGENOMiHOG000043097.
HOVERGENiHBG051548.
InParanoidiO35870.
PhylomeDBiO35870.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PTHR16798:SF0. PTHR16798:SF0. 1 hit.
PfamiPF02106. Fanconi_C. 1 hit.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.

Sequencei

Sequence statusi: Complete.

O35870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEPADLAS DYQFWLQKLS AWEQASSKET QRDTCLHLSR FQEFLRQMYE
60 70 80 90 100
LLKEMDSDAI LERFPSIGQL LAKTCWNPLI LAYDESQKIV IWCLCCLMNK
110 120 130 140 150
APRTSAESGR NSWIQGLLSH VLSAFRFDMK EVCLFTKSLG YESIDYYPSL
160 170 180 190 200
LKNMVLSLVS ELRGSHLNGL NTQSRMAPER MMSLSQVCVP LVTLPDIEPL
210 220 230 240 250
VEALLTYHGH EPQEVLSAEF FEAVTEAFLS EKVVLPTSSV VSLWFRHLPS
260 270 280 290 300
LEKATLHLFE KLFSSKRNCL RRMECCIKES LLPQAACQPA IFRIVDEMFR
310 320 330 340 350
FVLLETDGAP AVLAALQIFT SCLVEALRKE NKQLKFALKT YFPYSAPCLT
360 370 380 390 400
AALSQQPEAI PQGHRLQPLL HISQLLREAV EDCTDGSHRN PFESWFLFVH
410 420 430 440 450
FGGWVDLAVE ELLLREEAEP PAGLLWLLVF YYSPQDRSQQ REQSMVELKV
460 470 480 490 500
LVNRLLKLLR SGPLSAMDLL EAAESPREDP RPVCGQLVRR LLLSLLFWTP
510 520 530 540 550
EGHAIVWEAV THMAHTDAVT HEIVGFLDQT LYRSHHLCVE ASRKLARELL

KDLQAQV
Length:557
Mass (Da):63,592
Last modified:January 1, 1998 - v1
Checksum:i891658AE09056902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73586 mRNA. Translation: AAB66675.1.
UniGeneiRn.10798.

Genome annotation databases

UCSCiRGD:2593. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U73586 mRNA. Translation: AAB66675.1.
UniGeneiRn.10798.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022884.

Proteomic databases

PaxDbiO35870.
PRIDEiO35870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2593. rat.

Organism-specific databases

RGDi2593. Fancc.

Phylogenomic databases

eggNOGiENOG410IK3Y. Eukaryota.
ENOG411225E. LUCA.
HOGENOMiHOG000043097.
HOVERGENiHBG051548.
InParanoidiO35870.
PhylomeDBiO35870.

Miscellaneous databases

PROiO35870.

Family and domain databases

InterProiIPR000686. Fanconi.
[Graphical view]
PANTHERiPTHR16798. PTHR16798. 1 hit.
PTHR16798:SF0. PTHR16798:SF0. 1 hit.
PfamiPF02106. Fanconi_C. 1 hit.
[Graphical view]
PIRSFiPIRSF018417. FACC_protein. 1 hit.
PRINTSiPR00494. FANCONICGENE.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the bovine and rat Fanconi anemia group C cDNA."
    Wong J.C.Y., Alon N., Buchwald M.
    Mamm. Genome 8:522-525(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiFANCC_RAT
AccessioniPrimary (citable) accession number: O35870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.