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O35832

- CKD18_RAT

UniProt

O35832 - CKD18_RAT

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Protein
Cyclin-dependent kinase 18
Gene
Cdk18, Pctaire3, Pctk3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501ATP By similarity
Active sitei242 – 2421Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi127 – 1359ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 18 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 18
    PCTAIRE-motif protein kinase 3
    Serine/threonine-protein kinase PCTAIRE-3
    Gene namesi
    Name:Cdk18
    Synonyms:Pctaire3, Pctk3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1309523. Cdk18.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Cyclin-dependent kinase 18
    PRO_0000086493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei51 – 511Phosphoserine1 Publication
    Modified residuei66 – 661Phosphoserine1 Publication
    Modified residuei109 – 1091Phosphoserine By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO35832.
    PRIDEiO35832.

    PTM databases

    PhosphoSiteiO35832.

    Expressioni

    Tissue specificityi

    In brain, kidney, intestine and at a much lower level, in fetal tissues.

    Gene expression databases

    GenevestigatoriO35832.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010976.

    Structurei

    3D structure databases

    ProteinModelPortaliO35832.
    SMRiO35832. Positions 121-404.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini121 – 402282Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiO35832.
    KOiK15596.
    OMAiHDLIHTD.
    OrthoDBiEOG7966H8.
    PhylomeDBiO35832.
    TreeFamiTF106508.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35832-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL    50
    SPGVQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP 100
    LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK 150
    EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD 200
    SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH RDLKPQNLLI 250
    NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 300
    MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE 350
    FRAYNFPRYL PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP 400
    YFQSLGERVH QLDDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI 450
    F 451
    Length:451
    Mass (Da):51,882
    Last modified:January 1, 1998 - v1
    Checksum:iC3E4688F51B142E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005541 mRNA. Translation: BAA21472.1.
    RefSeqiNP_001093976.1. NM_001100506.1.
    XP_006249813.1. XM_006249751.1.
    XP_006249814.1. XM_006249752.1.
    XP_006249815.1. XM_006249753.1.
    UniGeneiRn.219420.

    Genome annotation databases

    EnsembliENSRNOT00000010976; ENSRNOP00000010976; ENSRNOG00000008137.
    GeneIDi289019.
    KEGGirno:289019.
    UCSCiRGD:1309523. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005541 mRNA. Translation: BAA21472.1 .
    RefSeqi NP_001093976.1. NM_001100506.1.
    XP_006249813.1. XM_006249751.1.
    XP_006249814.1. XM_006249752.1.
    XP_006249815.1. XM_006249753.1.
    UniGenei Rn.219420.

    3D structure databases

    ProteinModelPortali O35832.
    SMRi O35832. Positions 121-404.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010976.

    PTM databases

    PhosphoSitei O35832.

    Proteomic databases

    PaxDbi O35832.
    PRIDEi O35832.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010976 ; ENSRNOP00000010976 ; ENSRNOG00000008137 .
    GeneIDi 289019.
    KEGGi rno:289019.
    UCSCi RGD:1309523. rat.

    Organism-specific databases

    CTDi 5129.
    RGDi 1309523. Cdk18.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi O35832.
    KOi K15596.
    OMAi HDLIHTD.
    OrthoDBi EOG7966H8.
    PhylomeDBi O35832.
    TreeFami TF106508.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 5301.

    Miscellaneous databases

    NextBioi 629076.
    PROi O35832.

    Gene expression databases

    Genevestigatori O35832.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."
      Hirose T., Tamaru T., Okumura N., Nagai K., Okada M.
      Eur. J. Biochem. 249:481-488(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCKD18_RAT
    AccessioniPrimary (citable) accession number: O35832
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: April 16, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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