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O35832 (CKD18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 18

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene names
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Tissue specificity

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Cyclin-dependent kinase 18
PRO_0000086493

Regions

Domain121 – 402282Protein kinase
Nucleotide binding127 – 1359ATP By similarity

Sites

Active site2421Proton acceptor By similarity
Binding site1501ATP By similarity

Amino acid modifications

Modified residue511Phosphoserine Ref.2
Modified residue661Phosphoserine Ref.2
Modified residue1091Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O35832 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: C3E4688F51B142E8

FASTA45151,882
        10         20         30         40         50         60 
MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL SPGVQYQQRQ 

        70         80         90        100        110        120 
NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP LTRMSRRASL SDIGFGKLET 

       130        140        150        160        170        180 
YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 

       190        200        210        220        230        240 
TLHDLIHTDR SLTLVFEYLD SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH 

       250        260        270        280        290        300 
RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 

       310        320        330        340        350        360 
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE FRAYNFPRYL 

       370        380        390        400        410        420 
PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP YFQSLGERVH QLDDTASIFS 

       430        440        450 
LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI F 

« Hide

References

« Hide 'large scale' references
[1]"PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."
Hirose T., Tamaru T., Okumura N., Nagai K., Okada M.
Eur. J. Biochem. 249:481-488(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB005541 mRNA. Translation: BAA21472.1.
RefSeqNP_001093976.1. NM_001100506.1.
XP_006249813.1. XM_006249751.1.
XP_006249814.1. XM_006249752.1.
XP_006249815.1. XM_006249753.1.
UniGeneRn.219420.

3D structure databases

ProteinModelPortalO35832.
SMRO35832. Positions 121-404.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010976.

PTM databases

PhosphoSiteO35832.

Proteomic databases

PaxDbO35832.
PRIDEO35832.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000010976; ENSRNOP00000010976; ENSRNOG00000008137.
GeneID289019.
KEGGrno:289019.
UCSCRGD:1309523. rat.

Organism-specific databases

CTD5129.
RGD1309523. Cdk18.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidO35832.
KOK15596.
OMAHDLIHTD.
OrthoDBEOG7966H8.
PhylomeDBO35832.
TreeFamTF106508.

Enzyme and pathway databases

BRENDA2.7.11.22. 5301.

Gene expression databases

GenevestigatorO35832.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629076.
PROO35832.

Entry information

Entry nameCKD18_RAT
AccessionPrimary (citable) accession number: O35832
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families