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O35832

- CKD18_RAT

UniProt

O35832 - CKD18_RAT

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Protein

Cyclin-dependent kinase 18

Gene

Cdk18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501ATPPROSITE-ProRule annotation
Active sitei242 – 2421Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi127 – 1359ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1309523. Cdk18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Cyclin-dependent kinase 18PRO_0000086493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 511Phosphoserine1 Publication
Modified residuei66 – 661Phosphoserine1 Publication
Modified residuei109 – 1091PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35832.
PRIDEiO35832.

PTM databases

PhosphoSiteiO35832.

Expressioni

Tissue specificityi

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Gene expression databases

ExpressionAtlasiO35832. baseline and differential.
GenevestigatoriO35832.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010976.

Structurei

3D structure databases

ProteinModelPortaliO35832.
SMRiO35832. Positions 121-404.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 402282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiO35832.
KOiK15596.
OMAiHDLIHTD.
OrthoDBiEOG7966H8.
PhylomeDBiO35832.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35832-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL
60 70 80 90 100
SPGVQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP
110 120 130 140 150
LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK
160 170 180 190 200
EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD
210 220 230 240 250
SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH RDLKPQNLLI
260 270 280 290 300
NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID
310 320 330 340 350
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE
360 370 380 390 400
FRAYNFPRYL PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP
410 420 430 440 450
YFQSLGERVH QLDDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI

F
Length:451
Mass (Da):51,882
Last modified:January 1, 1998 - v1
Checksum:iC3E4688F51B142E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA. Translation: BAA21472.1.
RefSeqiNP_001093976.1. NM_001100506.1.
XP_006249813.1. XM_006249751.2.
XP_006249814.1. XM_006249752.2.
XP_006249815.1. XM_006249753.2.
XP_008767663.1. XM_008769441.1.
UniGeneiRn.219420.

Genome annotation databases

EnsembliENSRNOT00000010976; ENSRNOP00000010976; ENSRNOG00000008137.
GeneIDi289019.
KEGGirno:289019.
UCSCiRGD:1309523. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA. Translation: BAA21472.1 .
RefSeqi NP_001093976.1. NM_001100506.1.
XP_006249813.1. XM_006249751.2.
XP_006249814.1. XM_006249752.2.
XP_006249815.1. XM_006249753.2.
XP_008767663.1. XM_008769441.1.
UniGenei Rn.219420.

3D structure databases

ProteinModelPortali O35832.
SMRi O35832. Positions 121-404.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010976.

PTM databases

PhosphoSitei O35832.

Proteomic databases

PaxDbi O35832.
PRIDEi O35832.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000010976 ; ENSRNOP00000010976 ; ENSRNOG00000008137 .
GeneIDi 289019.
KEGGi rno:289019.
UCSCi RGD:1309523. rat.

Organism-specific databases

CTDi 5129.
RGDi 1309523. Cdk18.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi O35832.
KOi K15596.
OMAi HDLIHTD.
OrthoDBi EOG7966H8.
PhylomeDBi O35832.
TreeFami TF106508.

Enzyme and pathway databases

BRENDAi 2.7.11.22. 5301.

Miscellaneous databases

NextBioi 629076.
PROi O35832.

Gene expression databases

ExpressionAtlasi O35832. baseline and differential.
Genevestigatori O35832.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."
    Hirose T., Tamaru T., Okumura N., Nagai K., Okada M.
    Eur. J. Biochem. 249:481-488(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
    Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCKD18_RAT
AccessioniPrimary (citable) accession number: O35832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 26, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3