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Protein

Cyclin-dependent kinase 18

Gene

Cdk18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in signal transduction cascades in terminally differentiated cells.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei150ATPPROSITE-ProRule annotation1
Active sitei242Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi127 – 135ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 18 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 18
PCTAIRE-motif protein kinase 3
Serine/threonine-protein kinase PCTAIRE-3
Gene namesi
Name:Cdk18
Synonyms:Pctaire3, Pctk3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309523. Cdk18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000864931 – 451Cyclin-dependent kinase 18Add BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei51PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1
Modified residuei109PhosphoserineBy similarity1
Modified residuei417PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35832.
PRIDEiO35832.

PTM databases

iPTMnetiO35832.
PhosphoSitePlusiO35832.

Expressioni

Tissue specificityi

In brain, kidney, intestine and at a much lower level, in fetal tissues.

Gene expression databases

BgeeiENSRNOG00000008137.
GenevisibleiO35832. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010976.

Structurei

3D structure databases

ProteinModelPortaliO35832.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 402Protein kinasePROSITE-ProRule annotationAdd BLAST282

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiO35832.
KOiK15596.
OrthoDBiEOG091G0CH0.
PhylomeDBiO35832.
TreeFamiTF106508.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35832-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKMKNFKRR LSLSVPRPET IEESLTEFTE QFNQLHTQRN EDGRDEPGQL
60 70 80 90 100
SPGVQYQQRQ NQRRFSMEDL NKRLSLPMDI RLPQEFLQKL QLENPGLPKP
110 120 130 140 150
LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK
160 170 180 190 200
EIRLEHEEGA PCTAIREVSL LKDLKHANIV TLHDLIHTDR SLTLVFEYLD
210 220 230 240 250
SDLKQYLDHC GNLMNMHNVK IFMFQLLRGL AYCHRRKILH RDLKPQNLLI
260 270 280 290 300
NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID
310 320 330 340 350
MWGVGCILYE MATGKPLFPG STVKEELHLI FRLLGTPTEE SWPGVTSISE
360 370 380 390 400
FRAYNFPRYL PQPLLSHAPR LDTEGINLLT SLLLYESKSR MSAEAALSHP
410 420 430 440 450
YFQSLGERVH QLDDTASIFS LKEIQLQKDP GYRGLAFQHP GRGKSRRQSI

F
Length:451
Mass (Da):51,882
Last modified:January 1, 1998 - v1
Checksum:iC3E4688F51B142E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA. Translation: BAA21472.1.
RefSeqiNP_001093976.1. NM_001100506.1.
XP_006249813.1. XM_006249751.3.
UniGeneiRn.219420.

Genome annotation databases

GeneIDi289019.
KEGGirno:289019.
UCSCiRGD:1309523. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB005541 mRNA. Translation: BAA21472.1.
RefSeqiNP_001093976.1. NM_001100506.1.
XP_006249813.1. XM_006249751.3.
UniGeneiRn.219420.

3D structure databases

ProteinModelPortaliO35832.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010976.

PTM databases

iPTMnetiO35832.
PhosphoSitePlusiO35832.

Proteomic databases

PaxDbiO35832.
PRIDEiO35832.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi289019.
KEGGirno:289019.
UCSCiRGD:1309523. rat.

Organism-specific databases

CTDi5129.
RGDi1309523. Cdk18.

Phylogenomic databases

eggNOGiKOG0594. Eukaryota.
ENOG410XPP3. LUCA.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiO35832.
KOiK15596.
OrthoDBiEOG091G0CH0.
PhylomeDBiO35832.
TreeFamiTF106508.

Enzyme and pathway databases

BRENDAi2.7.11.22. 5301.

Miscellaneous databases

PROiO35832.

Gene expression databases

BgeeiENSRNOG00000008137.
GenevisibleiO35832. RN.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKD18_RAT
AccessioniPrimary (citable) accession number: O35832
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.