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O35831

- CDK17_RAT

UniProt

O35831 - CDK17_RAT

Protein

Cyclin-dependent kinase 17

Gene

Cdk17

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1.

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei221 – 2211ATPPROSITE-ProRule annotation
    Active sitei313 – 3131Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.22. 5301.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 17 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 17
    PCTAIRE-motif protein kinase 2
    Serine/threonine-protein kinase PCTAIRE-2
    Gene namesi
    Name:Cdk17
    Synonyms:Pctaire2, Pctk2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1565593. Cdk17.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Cyclin-dependent kinase 17PRO_0000086489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801PhosphoserineBy similarity
    Modified residuei105 – 1051PhosphoserineBy similarity
    Modified residuei137 – 1371Phosphoserine1 Publication
    Modified residuei146 – 1461PhosphoserineBy similarity
    Modified residuei165 – 1651PhosphoserineBy similarity
    Modified residuei180 – 1801PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO35831.
    PRIDEiO35831.

    PTM databases

    PhosphoSiteiO35831.

    Expressioni

    Tissue specificityi

    Brain specific. Within the brain it is concentrated in the neuronal layers of the hippocampus and olfactory bulb, which mostly consist of post-mitotic neurons.

    Gene expression databases

    GenevestigatoriO35831.

    Interactioni

    Subunit structurei

    Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005762.

    Structurei

    3D structure databases

    ProteinModelPortaliO35831.
    SMRiO35831. Positions 200-474.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 473282Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    PhylomeDBiO35831.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT    50
    SHSMHSFLHQ YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN 100
    LKMGSDGESD QASGTSSDEV QSPTGVCLRN RIHRRISMED LNKRLSLPAD 150
    IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS LSEIGFGKME TYIKLEKLGE 200
    GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS LLKDLKHANI 250
    VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGSIMSMHNV KLFLYQILRG 300
    LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 350
    TLWYRPPDVL LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL 400
    IFRLLGTPSQ ETWPGVSSND EFKNYNFPKY KPQPLINHAP RLDSEGIELI 450
    TKFLQYESKK RAPAEEAMKH VYFRSLGPRI HALPESVSIF SLKEIQLQKD 500
    PGFRNSSYPE TGVFVINHFT CRS 523
    Length:523
    Mass (Da):59,432
    Last modified:January 1, 1998 - v1
    Checksum:i1A391555CB3CEF79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005540 mRNA. Translation: BAA22332.1.
    UniGeneiRn.17706.

    Genome annotation databases

    UCSCiRGD:1565593. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005540 mRNA. Translation: BAA22332.1 .
    UniGenei Rn.17706.

    3D structure databases

    ProteinModelPortali O35831.
    SMRi O35831. Positions 200-474.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005762.

    PTM databases

    PhosphoSitei O35831.

    Proteomic databases

    PaxDbi O35831.
    PRIDEi O35831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1565593. rat.

    Organism-specific databases

    RGDi 1565593. Cdk17.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    PhylomeDBi O35831.

    Enzyme and pathway databases

    BRENDAi 2.7.11.22. 5301.

    Miscellaneous databases

    PROi O35831.

    Gene expression databases

    Genevestigatori O35831.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."
      Hirose T., Tamaru T., Okumura N., Nagai K., Okada M.
      Eur. J. Biochem. 249:481-488(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain."
      Hirose T., Kawabuchi M., Tamaru T., Okumura N., Nagai K., Okada M.
      Eur. J. Biochem. 267:2113-2121(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH CDK16 AND TDRD7, INTERACTION WITH TDRD7.
    3. "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCDK17_RAT
    AccessioniPrimary (citable) accession number: O35831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3