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O35831 (CDK17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 17

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 17
PCTAIRE-motif protein kinase 2
Serine/threonine-protein kinase PCTAIRE-2
Gene names
Name:Cdk17
Synonyms:Pctaire2, Pctk2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7. Ref.2

Tissue specificity

Brain specific. Within the brain it is concentrated in the neuronal layers of the hippocampus and olfactory bulb, which mostly consist of post-mitotic neurons.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Cyclin-dependent kinase 17
PRO_0000086489

Regions

Domain192 – 473282Protein kinase
Nucleotide binding198 – 2069ATP By similarity

Sites

Active site3131Proton acceptor By similarity
Binding site2211ATP By similarity

Amino acid modifications

Modified residue801Phosphoserine By similarity
Modified residue1051Phosphoserine By similarity
Modified residue1371Phosphoserine Ref.3
Modified residue1461Phosphoserine By similarity
Modified residue1651Phosphoserine By similarity
Modified residue1801Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O35831 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 1A391555CB3CEF79

FASTA52359,432
        10         20         30         40         50         60 
MKKFKRRLSL TLRGSQTIDE SLSELAEQMT IEESSSKDNE PIVKNGRPPT SHSMHSFLHQ 

        70         80         90        100        110        120 
YTGSFKKPPL RRPHSVIGGS LGSFMAMPRN GSRLDIVHEN LKMGSDGESD QASGTSSDEV 

       130        140        150        160        170        180 
QSPTGVCLRN RIHRRISMED LNKRLSLPAD IRIPDGYLEK LQISSPPFDQ PMSRRSRRAS 

       190        200        210        220        230        240 
LSEIGFGKME TYIKLEKLGE GTYATVYKGR SKLTENLVAL KEIRLEHEEG APCTAIREVS 

       250        260        270        280        290        300 
LLKDLKHANI VTLHDIVHTD KSLTLVFEYL DKDLKQYMDD CGSIMSMHNV KLFLYQILRG 

       310        320        330        340        350        360 
LAYCHRRKVL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV TLWYRPPDVL 

       370        380        390        400        410        420 
LGSSEYSTQI DMWGVGCIFF EMASGRPLFP GSTVEDELHL IFRLLGTPSQ ETWPGVSSND 

       430        440        450        460        470        480 
EFKNYNFPKY KPQPLINHAP RLDSEGIELI TKFLQYESKK RAPAEEAMKH VYFRSLGPRI 

       490        500        510        520 
HALPESVSIF SLKEIQLQKD PGFRNSSYPE TGVFVINHFT CRS 

« Hide

References

« Hide 'large scale' references
[1]"PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons."
Hirose T., Tamaru T., Okumura N., Nagai K., Okada M.
Eur. J. Biochem. 249:481-488(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain."
Hirose T., Kawabuchi M., Tamaru T., Okumura N., Nagai K., Okada M.
Eur. J. Biochem. 267:2113-2121(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH CDK16 AND TDRD7, INTERACTION WITH TDRD7.
[3]"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB005540 mRNA. Translation: BAA22332.1.
UniGeneRn.17706.

3D structure databases

ProteinModelPortalO35831.
SMRO35831. Positions 200-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005762.

PTM databases

PhosphoSiteO35831.

Proteomic databases

PaxDbO35831.
PRIDEO35831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:1565593. rat.

Organism-specific databases

RGD1565593. Cdk17.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
PhylomeDBO35831.

Enzyme and pathway databases

BRENDA2.7.11.22. 5301.

Gene expression databases

GenevestigatorO35831.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROO35831.

Entry information

Entry nameCDK17_RAT
AccessionPrimary (citable) accession number: O35831
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families