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Protein

Amyloid beta A4 precursor protein-binding family B member 3

Gene

Apbb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.

GO - Molecular functioni

  • beta-amyloid binding Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 3
Alternative name(s):
Protein Fe65-like 2
Short name:
Fe65L2
Gene namesi
Name:Apbb3
Synonyms:Fe65l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620853. Apbb3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Amyloid beta A4 precursor protein-binding family B member 3PRO_0000076056Add
BLAST

Proteomic databases

PaxDbiO35827.
PRIDEiO35827.

Expressioni

Tissue specificityi

Expressed predominantly in brain and testis.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.

Protein-protein interaction databases

IntActiO35827. 2 interactions.
STRINGi10116.ENSRNOP00000024313.

Structurei

3D structure databases

ProteinModelPortaliO35827.
SMRiO35827. Positions 31-61, 113-251, 286-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 6133WWPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 278168PID 1PROSITE-ProRule annotationAdd
BLAST
Domaini283 – 438156PID 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 PID domains.PROSITE-ProRule annotation
Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiO35827.
PhylomeDBiO35827.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW
110 120 130 140 150
YNEDSYVRSL EPGAKCFAVR SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ
160 170 180 190 200
ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL NPLDHSLIHC QPLVHIRVWG
210 220 230 240 250
VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR LQGLCAQILS
260 270 280 290 300
ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT
310 320 330 340 350
KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE
360 370 380 390 400
PLWQCPVRLV TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA
410 420 430 440 450
VQAACMVQYQ KCLVASAARG KAWGAQARAR LRLKRTSSMD SPGGPLPPPL
460 470 480 490 500
LKGGVGGAGA APRKRGVFSF LDAFRLKPLF SICPKLILEG WGKRLYTLPV

PRVL
Length:504
Mass (Da):54,907
Last modified:January 1, 1998 - v1
Checksum:iA49CA9E99BDB3A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13413 mRNA. Translation: CAA73837.1.
RefSeqiNP_446409.1. NM_053957.1.
UniGeneiRn.30067.

Genome annotation databases

GeneIDi117026.
KEGGirno:117026.
UCSCiRGD:620853. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13413 mRNA. Translation: CAA73837.1.
RefSeqiNP_446409.1. NM_053957.1.
UniGeneiRn.30067.

3D structure databases

ProteinModelPortaliO35827.
SMRiO35827. Positions 31-61, 113-251, 286-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35827. 2 interactions.
STRINGi10116.ENSRNOP00000024313.

Proteomic databases

PaxDbiO35827.
PRIDEiO35827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117026.
KEGGirno:117026.
UCSCiRGD:620853. rat.

Organism-specific databases

CTDi10307.
RGDi620853. Apbb3.

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiO35827.
PhylomeDBiO35827.

Miscellaneous databases

PROiO35827.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiPS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein."
    Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T.
    Biochem. J. 330:513-519(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAPBB3_RAT
AccessioniPrimary (citable) accession number: O35827
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.