Reviewed, UniProtKB/Swiss-Prot O35827 (APBB3_RAT)

Names and origin

Protein names

Recommended name:
    Amyloid beta A4 precursor protein-binding family B member 3
Alternative name(s):
    Fe65-like protein 2
      Short name=Fe65L2

Gene names

Name:	Apbb3
Synonyms:	Fe65l2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May modulate the internalization of beta-amyloid precursor protein.
Subunit structure	Binds to the intracellular domain of the beta-amyloid precursor protein. Also bind to APP-like proteins.
Tissue specificity	Expressed predominantly in brain and testis.
Sequence similarities	Contains 2 PID domains. Contains 1 WW domain.

Ontologies

Keywords
Domain	Repeat
Gene Ontology (GO)
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APP	P05067	1	EBI-286163,EBI-77613	From a different organism.
App	P08592	1	EBI-286163,EBI-286155

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 504	504	Amyloid beta A4 precursor protein-binding family B member 3
Regions
	Domain	29 – 61	33	WW
	Domain	111 – 278	168	PID 1
	Domain	283 – 438	156	PID 2

Sequences

	Sequence		Length	Mass (Da)
	O35827-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: A49CA9E99BDB3A3A	FASTA	504	54,907
	10 20 30 40 50 60 MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP SGSTQWQRPT 70 80 90 100 110 120 WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW YNEDSYVRSL EPGAKCFAVR 130 140 150 160 170 180 SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL 190 200 210 220 230 240 NPLDHSLIHC QPLVHIRVWG VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR 250 260 270 280 290 300 LQGLCAQILS ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT 310 320 330 340 350 360 KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE PLWQCPVRLV 370 380 390 400 410 420 TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA VQAACMVQYQ KCLVASAARG 430 440 450 460 470 480 KAWGAQARAR LRLKRTSSMD SPGGPLPPPL LKGGVGGAGA APRKRGVFSF LDAFRLKPLF 490 500 SICPKLILEG WGKRLYTLPV PRVL

References

[1]	"Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein." Duilio A., Faraonio R., Minopoli G., Zambrano N., Russo T. Biochem. J. 330:513-519(1998) [PubMed: 9461550] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y13413 mRNA. Translation: CAA73837.1.
RefSeq	NP_446409.1.
UniGene	Rn.30067
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O35827.
Genome annotation databases
Ensembl	ENSRNOG00000017849. Rattus norvegicus. [Contig view]
GeneID	117026.
KEGG	rno:117026.
Organism-specific databases
RGD	620853. Apbb3.
Phylogenomic databases
HOVERGEN	O35827.
Gene expression databases
ArrayExpress	O35827.
GermOnline	ENSRNOG00000017849. Rattus norvegicus.
Family and domain databases
InterPro	IPR011993. PH_type. IPR006020. PTB_PID. IPR001202. WW_Rsp5_WWP. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00640. PID. 2 hits. PF00397. WW. 1 hit. [Graphical view]
SMART	SM00462. PTB. 2 hits. SM00456. WW. 1 hit. [Graphical view]
PROSITE	PS01179. PID. 2 hits. PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProDom	O35827. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

APBB3_RAT

Accession

Primary (citable) accession number: O35827

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 1, 1998
Last modified:	July 22, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)