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Protein

Amyloid beta A4 precursor protein-binding family B member 3

Gene

Apbb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May modulate the internalization of beta-amyloid precursor protein.

GO - Molecular functioni

  • amyloid-beta binding Source: RGD
  • transcription factor binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 3
Alternative name(s):
Protein Fe65-like 2
Short name:
Fe65L2
Gene namesi
Name:Apbb3
Synonyms:Fe65l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620853. Apbb3.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760561 – 504Amyloid beta A4 precursor protein-binding family B member 3Add BLAST504

Proteomic databases

PaxDbiO35827.
PRIDEiO35827.

Expressioni

Tissue specificityi

Expressed predominantly in brain and testis.

Interactioni

Subunit structurei

Binds to the intracellular domain of the beta-amyloid precursor protein. Also binds to APP-like proteins.

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35827. 2 interactors.
STRINGi10116.ENSRNOP00000024313.

Structurei

3D structure databases

ProteinModelPortaliO35827.
SMRiO35827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 61WWPROSITE-ProRule annotationAdd BLAST33
Domaini111 – 278PID 1PROSITE-ProRule annotationAdd BLAST168
Domaini283 – 438PID 2PROSITE-ProRule annotationAdd BLAST156

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA. Eukaryota.
ENOG410YEVS. LUCA.
HOGENOMiHOG000033983.
HOVERGENiHBG050524.
InParanoidiO35827.
PhylomeDBiO35827.

Family and domain databases

CDDicd00201. WW. 1 hit.
Gene3Di2.30.29.30. 2 hits.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF00640. PID. 1 hit.
SMARTiView protein in SMART
SM00462. PTB. 2 hits.
SM00456. WW. 1 hit.
SUPFAMiSSF50729. SSF50729. 2 hits.
SSF51045. SSF51045. 1 hit.
PROSITEiView protein in PROSITE
PS01179. PID. 2 hits.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O35827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKDYMLAI ILVNCDDDLW GDQNLEGETG LPPGWRKIRD AAGTYYWHVP
60 70 80 90 100
SGSTQWQRPT WELAEDPGTG KEGIWELRPP KGRSFSSLDS SLNRSNSLTW
110 120 130 140 150
YNEDSYVRSL EPGAKCFAVR SLGWVEVPEE DLAPGKSSIA VNNCIQQLAQ
160 170 180 190 200
ARNRSQPHDG AWGEGQNMLM VLKKDAMSLL NPLDHSLIHC QPLVHIRVWG
210 220 230 240 250
VGSSKGRDRD FAFVAGDKDS CMLKCHVFRC DVPAKAIASR LQGLCAQILS
260 270 280 290 300
ERVGLSGEAA CCSPDPISPE DFPRQVELLD AVSQAAQKYE ALYMGILPVT
310 320 330 340 350
KAMGMDVLNE AIGTLTGRGD RKTWVPAMLS VSDSLMTAHP IQAEAGAEEE
360 370 380 390 400
PLWQCPVRLV TFIGVGHDPH TFGLIADLGC QSFQCAAFWC QPHAGGLSEA
410 420 430 440 450
VQAACMVQYQ KCLVASAARG KAWGAQARAR LRLKRTSSMD SPGGPLPPPL
460 470 480 490 500
LKGGVGGAGA APRKRGVFSF LDAFRLKPLF SICPKLILEG WGKRLYTLPV

PRVL
Length:504
Mass (Da):54,907
Last modified:January 1, 1998 - v1
Checksum:iA49CA9E99BDB3A3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13413 mRNA. Translation: CAA73837.1.
RefSeqiNP_446409.1. NM_053957.1.
UniGeneiRn.30067.

Genome annotation databases

GeneIDi117026.
KEGGirno:117026.
UCSCiRGD:620853. rat.

Similar proteinsi

Entry informationi

Entry nameiAPBB3_RAT
AccessioniPrimary (citable) accession number: O35827
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome