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Protein

DnaJ homolog subfamily A member 2

Gene

Dnaja2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi143 – 1431Zinc 1By similarity
Metal bindingi146 – 1461Zinc 1By similarity
Metal bindingi159 – 1591Zinc 2By similarity
Metal bindingi162 – 1621Zinc 2By similarity
Metal bindingi186 – 1861Zinc 2By similarity
Metal bindingi189 – 1891Zinc 2By similarity
Metal bindingi202 – 2021Zinc 1By similarity
Metal bindingi205 – 2051Zinc 1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 21485CR-typeAdd
BLAST

GO - Molecular functioni

  • ATP binding Source: InterPro
  • glycoprotein binding Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • carbon tetrachloride metabolic process Source: RGD
  • protein folding Source: InterPro
  • response to heat Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily A member 2
Alternative name(s):
RDJ2
Gene namesi
Name:Dnaja2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71001. Dnaja2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • membrane Source: UniProtKB-SubCell
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409DnaJ homolog subfamily A member 2PRO_0000071013Add
BLAST
Propeptidei410 – 4123Removed in mature formBy similarityPRO_0000396759

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-acetyllysineBy similarity
Modified residuei78 – 781PhosphoserineBy similarity
Modified residuei123 – 1231PhosphoserineCombined sources
Modified residuei152 – 1521N6-acetyllysineBy similarity
Modified residuei391 – 3911PhosphotyrosineBy similarity
Modified residuei394 – 3941PhosphoserineBy similarity
Modified residuei395 – 3951PhosphoserineBy similarity
Modified residuei409 – 4091Cysteine methyl esterBy similarity
Lipidationi409 – 4091S-farnesyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiO35824.
PRIDEiO35824.

PTM databases

iPTMnetiO35824.
PhosphoSiteiO35824.

Interactioni

GO - Molecular functioni

  • glycoprotein binding Source: RGD

Protein-protein interaction databases

IntActiO35824. 3 interactions.
STRINGi10116.ENSRNOP00000022573.

Structurei

3D structure databases

ProteinModelPortaliO35824.
SMRiO35824. Positions 6-70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7063JAdd
BLAST
Repeati143 – 1508CXXCXGXG motif
Repeati159 – 1668CXXCXGXG motif
Repeati186 – 1938CXXCXGXG motif
Repeati202 – 2098CXXCXGXG motif

Sequence similaritiesi

Contains 1 CR-type zinc finger.Curated
Contains 1 J domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri130 – 21485CR-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO35824.
PhylomeDBiO35824.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVADTKLY DILGVPPGAS ENELKKAYRK LAKEYHPDKN PNAGDKFKEI
60 70 80 90 100
SFAYEVLSNP EKRELYDRYG EQGLREGSGG GGGMDDIFSH IFGGGLFGFM
110 120 130 140 150
GNQSRSRNGR RRGEDMMHPL KVSLEDLYNG KTTKLQLSKN VLCSACSGQG
160 170 180 190 200
GKSGAVQKCS ACRGRGVRIM IRQLAPGMVQ QMQSVCSDCN GEGEVINEKD
210 220 230 240 250
RCKKCEGKKV IKEVKILEVH VDKGMKHGQR ITFTGEADQA PGVEPGDIVL
260 270 280 290 300
FVQEKEHEVF QRDGNDLHMT YKIGLVEALC GFQFTFKHLD ARQIVVKYPP
310 320 330 340 350
GKVIEPGCVR VVRGEGMPQY RNPFEKGDLY IKFDVQFPEN NWINPDKLSE
360 370 380 390 400
LEDLLPSRPE VPNVIGETEE VELQEFDSTR GSGGGQRREA YNDSSDEESS
410
SHHGPGVQCA HQ
Length:412
Mass (Da):45,766
Last modified:January 1, 1998 - v1
Checksum:iFAE60601B55C409F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95727 mRNA. Translation: AAB64094.1.
UniGeneiRn.3904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95727 mRNA. Translation: AAB64094.1.
UniGeneiRn.3904.

3D structure databases

ProteinModelPortaliO35824.
SMRiO35824. Positions 6-70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35824. 3 interactions.
STRINGi10116.ENSRNOP00000022573.

PTM databases

iPTMnetiO35824.
PhosphoSiteiO35824.

Proteomic databases

PaxDbiO35824.
PRIDEiO35824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi71001. Dnaja2.

Phylogenomic databases

eggNOGiKOG0712. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000226718.
HOVERGENiHBG066727.
InParanoidiO35824.
PhylomeDBiO35824.

Miscellaneous databases

PROiO35824.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF01556. DnaJ_C. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 3 hits.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a novel farnesylated protein, RDJ2, encoding a DnaJ protein homologue."
    Andres D.A., Shao H., Crick D.C., Finlin B.S.
    Arch. Biochem. Biophys. 346:113-124(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDNJA2_RAT
AccessioniPrimary (citable) accession number: O35824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 1, 1998
Last modified: January 20, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.