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Protein

Myb-binding protein 1A

Gene

Mybbp1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-binding protein 1A
Alternative name(s):
PAR-interacting protein
Short name:
PIP
Gene namesi
Name:Mybbp1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi62062. Mybbp1a.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000962572 – 1344Myb-binding protein 1AAdd BLAST1343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei14PhosphoserineCombined sources1
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei156N6-acetyllysineBy similarity1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1189PhosphoserineBy similarity1
Modified residuei1193PhosphothreonineBy similarity1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1246PhosphoserineBy similarity1
Modified residuei1253PhosphothreonineBy similarity1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1258PhosphothreonineBy similarity1
Modified residuei1280PhosphothreonineBy similarity1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1318PhosphoserineBy similarity1
Modified residuei1322CitrullineBy similarity1
Modified residuei1323PhosphoserineCombined sources1
Modified residuei1325PhosphoserineCombined sources1
Modified residuei1329PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

PaxDbiO35821.
PRIDEiO35821.

PTM databases

iPTMnetiO35821.
PhosphoSitePlusiO35821.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015236.
GenevisibleiO35821. RN.

Interactioni

Subunit structurei

Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with CLOCK and CRY1.By similarity

Protein-protein interaction databases

IntActiO35821. 1 interactor.
STRINGi10116.ENSRNOP00000021134.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 580Interaction with MYBBy similarityAdd BLAST579
Regioni1154 – 1344Required for nuclear and nucleolar localizationBy similarityAdd BLAST191

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 256Nuclear export signal 1By similarityAdd BLAST19
Motifi261 – 279Nuclear export signal 2By similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi694 – 781Glu-richAdd BLAST88

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiO35821.
KOiK02331.
OMAiEDKFPRF.
OrthoDBiEOG091G00YE.
PhylomeDBiO35821.
TreeFamiTF317401.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35821-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEMKSPTKA EPASPAEAPQ GDRRSLLEHS REFLDFFWDI AKPDQETRLR
60 70 80 90 100
ATEKLLEYLR TRPSDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS
110 120 130 140 150
FEDIQLCDIL GQIQEKYNLQ AMNKAMMRPT LFANLFGVLA LFQSGRLVKD
160 170 180 190 200
KEALMKCVRL LKILSHHYNH LQGQPVKALV DILSEVPESM FQEILPKVLK
210 220 230 240 250
GDMKVILSSP KYLELFLLAR QRVPAELESL VGSVDLFSED NIPSLVNILK
260 270 280 290 300
VAANSVKKEQ KLPDVALNLL RLALQENKFE RFWKEVLEEG LLKKPSYTSS
310 320 330 340 350
YMCFRLLGAS LPLLSDEQLQ LVMRGDLIRH FGEHMVVSKS QNPLRFIPEI
360 370 380 390 400
SAYVGTFLEG CQDDPKRQFT VMVAFTAITN QGLPVMPTFW RVTRFLNTEA
410 420 430 440 450
LQNYVTWLRD MFLQPDLDSL VDFSTANQKR VQVASLNVPE RTVFRLRKWI
460 470 480 490 500
IHRLVSLVDH LHLEKDEAVV EQIARFCLFH AFFKTKKATP QIPETKQHFS
510 520 530 540 550
FPLEDGNRGV IVSAFFSLLQ TLSVKFRQTP DLAENGKPWT YRLVQLADML
560 570 580 590 600
LKHNRNVANV TPLTAQQRQA WDQMMSTLKE LEAQSSETRA IAFQHLLLLV
610 620 630 640 650
GLHLFKSPAE SCDVLGDIQT CIKKSMEQNL RRSRSRAKAS QEPVWVEVMV
660 670 680 690 700
EILLSLLAQP SNLMRQVVRS VFGHVCSHLT PRGLQLILAV LNPETNEDEE
710 720 730 740 750
DNVVVTDTDE KQLKHGEDAD SDSEDSKNSE SDVDSEDGEE SEEEDRDKDV
760 770 780 790 800
DPGFRQQLME VLQAGNALGG EEEEEEELGD EAMMALDQNL ASLFAEQKMR
810 820 830 840 850
IQARHEEKNK LQKEKQLRRD FQIRALDLIE VLVTKQPEHP LILELLEPLL
860 870 880 890 900
NIIQRSMRSR GSTKQEQDLL HKTARIFMHH LCRARHYCHE VEPGAEALHA
910 920 930 940 950
QVERLVQQAG NQADASVALY YFNASLYLLR VLKGNTTKRY QDGQKLEGAD
960 970 980 990 1000
IKSEPKDSEV QTTSCLDLDF VTRVYSASLE SLLTKRNSPL TIPMFLDLFS
1010 1020 1030 1040 1050
RYPVICKNLL PIVVQHVAGS SRPRHQAQAC LLLQKALSAR ELRVCFEDPE
1060 1070 1080 1090 1100
WEQLISQVLG KTTQTLQTLG EAQSKGEHQR ELSILELLNT VFRIVNHEKL
1110 1120 1130 1140 1150
SVDLTAFLGM LQGKQQKLQQ NLQQGNHSSG SSRLYDLYWQ AMNLLGVQRP
1160 1170 1180 1190 1200
KSEKKNVKDI PSDSQSPIST KRKKKGFLPE TKKRKKLKSE GTTSEKKAAS
1210 1220 1230 1240 1250
QQDAVTEGAM PAATGKDQPP STGKKRRKRV KANTPSQVNG VTVAKSPAPN
1260 1270 1280 1290 1300
NPTLSPSTPP AKTPKVQKKK EKLSQVNGST PVSPVEPESK KHQKALSTKE
1310 1320 1330 1340
VKRRSSQSAL PKKRARLSLV SRSPSLLQSG IRKRRVARRR VQTP
Length:1,344
Mass (Da):152,286
Last modified:July 19, 2005 - v2
Checksum:iA5721894AD80BDF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137G → A in AAB62878 (Ref. 2) Curated1
Sequence conflicti433V → D in AAB62878 (Ref. 2) Curated1
Sequence conflicti905L → F in AAB62878 (Ref. 2) Curated1
Sequence conflicti1204A → R in AAB62878 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073819 Genomic DNA. No translation available.
U83590 mRNA. Translation: AAB62878.1.
PIRiT32731.
RefSeqiNP_113856.1. NM_031668.1.
XP_006246864.1. XM_006246802.2.
UniGeneiRn.35696.

Genome annotation databases

EnsembliENSRNOT00000021134; ENSRNOP00000021134; ENSRNOG00000015236.
GeneIDi60571.
KEGGirno:60571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03073819 Genomic DNA. No translation available.
U83590 mRNA. Translation: AAB62878.1.
PIRiT32731.
RefSeqiNP_113856.1. NM_031668.1.
XP_006246864.1. XM_006246802.2.
UniGeneiRn.35696.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35821. 1 interactor.
STRINGi10116.ENSRNOP00000021134.

PTM databases

iPTMnetiO35821.
PhosphoSitePlusiO35821.

Proteomic databases

PaxDbiO35821.
PRIDEiO35821.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021134; ENSRNOP00000021134; ENSRNOG00000015236.
GeneIDi60571.
KEGGirno:60571.

Organism-specific databases

CTDi10514.
RGDi62062. Mybbp1a.

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiO35821.
KOiK02331.
OMAiEDKFPRF.
OrthoDBiEOG091G00YE.
PhylomeDBiO35821.
TreeFamiTF317401.

Enzyme and pathway databases

ReactomeiR-RNO-5250924. B-WICH complex positively regulates rRNA expression.

Miscellaneous databases

PROiO35821.

Gene expression databases

BgeeiENSRNOG00000015236.
GenevisibleiO35821. RN.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMBB1A_RAT
AccessioniPrimary (citable) accession number: O35821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.