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O35821

- MBB1A_RAT

UniProt

O35821 - MBB1A_RAT

Protein

Myb-binding protein 1A

Gene

Mybbp1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) By similarity.By similarity

    GO - Molecular functioni

    1. DNA-directed DNA polymerase activity Source: InterPro
    2. sequence-specific DNA binding Source: RGD

    GO - Biological processi

    1. cellular response to glucose starvation Source: Ensembl
    2. intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
    3. negative regulation of transcription, DNA-templated Source: Ensembl
    4. nucleocytoplasmic transport Source: UniProtKB
    5. positive regulation of cell cycle arrest Source: Ensembl
    6. respiratory electron transport chain Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myb-binding protein 1A
    Alternative name(s):
    PAR-interacting protein
    Short name:
    PIP
    Gene namesi
    Name:Mybbp1a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi62062. Mybbp1a.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cytoplasm By similarity
    Note: Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. NLS-dependent protein nuclear import complex Source: UniProtKB
    3. nucleolus Source: UniProtKB
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 13441343Myb-binding protein 1APRO_0000096257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei14 – 141PhosphoserineBy similarity
    Modified residuei69 – 691N6-acetyllysineBy similarity
    Modified residuei156 – 1561N6-acetyllysineBy similarity
    Modified residuei1162 – 11621PhosphoserineBy similarity
    Modified residuei1166 – 11661PhosphoserineBy similarity
    Modified residuei1189 – 11891PhosphoserineBy similarity
    Modified residuei1193 – 11931PhosphothreonineBy similarity
    Modified residuei1221 – 12211PhosphoserineBy similarity
    Modified residuei1246 – 12461PhosphoserineBy similarity
    Modified residuei1255 – 12551PhosphoserineBy similarity
    Modified residuei1280 – 12801PhosphothreonineBy similarity
    Modified residuei1283 – 12831PhosphoserineBy similarity
    Modified residuei1305 – 13051PhosphoserineBy similarity
    Modified residuei1318 – 13181PhosphoserineBy similarity
    Modified residuei1322 – 13221CitrullineBy similarity
    Modified residuei1323 – 13231PhosphoserineBy similarity
    Modified residuei1325 – 13251PhosphoserineBy similarity
    Modified residuei1329 – 13291PhosphoserineBy similarity

    Post-translational modificationi

    Citrullinated by PADI4.By similarity

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    PaxDbiO35821.
    PRIDEiO35821.

    PTM databases

    PhosphoSiteiO35821.

    Expressioni

    Gene expression databases

    GenevestigatoriO35821.

    Interactioni

    Subunit structurei

    Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO35821. 1 interaction.
    STRINGi10116.ENSRNOP00000021134.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 580579Interaction with MYBBy similarityAdd
    BLAST
    Regioni1154 – 1344191Required for nuclear and nucleolar localizationBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi238 – 25619Nuclear export signal 1By similarityAdd
    BLAST
    Motifi261 – 27919Nuclear export signal 2By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi694 – 78188Glu-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG313877.
    GeneTreeiENSGT00390000017457.
    HOGENOMiHOG000113488.
    HOVERGENiHBG081961.
    InParanoidiO35821.
    KOiK02331.
    OMAiHQAQACL.
    OrthoDBiEOG7G7KPN.
    PhylomeDBiO35821.
    TreeFamiTF317401.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR007015. DNA_pol_V.
    [Graphical view]
    PANTHERiPTHR13213. PTHR13213. 1 hit.
    PfamiPF04931. DNA_pol_phi. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 5 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35821-1 [UniParc]FASTAAdd to Basket

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    MAEMKSPTKA EPASPAEAPQ GDRRSLLEHS REFLDFFWDI AKPDQETRLR     50
    ATEKLLEYLR TRPSDSEMKY ALKRLITGLG VGREAARPCY SLALAQLLQS 100
    FEDIQLCDIL GQIQEKYNLQ AMNKAMMRPT LFANLFGVLA LFQSGRLVKD 150
    KEALMKCVRL LKILSHHYNH LQGQPVKALV DILSEVPESM FQEILPKVLK 200
    GDMKVILSSP KYLELFLLAR QRVPAELESL VGSVDLFSED NIPSLVNILK 250
    VAANSVKKEQ KLPDVALNLL RLALQENKFE RFWKEVLEEG LLKKPSYTSS 300
    YMCFRLLGAS LPLLSDEQLQ LVMRGDLIRH FGEHMVVSKS QNPLRFIPEI 350
    SAYVGTFLEG CQDDPKRQFT VMVAFTAITN QGLPVMPTFW RVTRFLNTEA 400
    LQNYVTWLRD MFLQPDLDSL VDFSTANQKR VQVASLNVPE RTVFRLRKWI 450
    IHRLVSLVDH LHLEKDEAVV EQIARFCLFH AFFKTKKATP QIPETKQHFS 500
    FPLEDGNRGV IVSAFFSLLQ TLSVKFRQTP DLAENGKPWT YRLVQLADML 550
    LKHNRNVANV TPLTAQQRQA WDQMMSTLKE LEAQSSETRA IAFQHLLLLV 600
    GLHLFKSPAE SCDVLGDIQT CIKKSMEQNL RRSRSRAKAS QEPVWVEVMV 650
    EILLSLLAQP SNLMRQVVRS VFGHVCSHLT PRGLQLILAV LNPETNEDEE 700
    DNVVVTDTDE KQLKHGEDAD SDSEDSKNSE SDVDSEDGEE SEEEDRDKDV 750
    DPGFRQQLME VLQAGNALGG EEEEEEELGD EAMMALDQNL ASLFAEQKMR 800
    IQARHEEKNK LQKEKQLRRD FQIRALDLIE VLVTKQPEHP LILELLEPLL 850
    NIIQRSMRSR GSTKQEQDLL HKTARIFMHH LCRARHYCHE VEPGAEALHA 900
    QVERLVQQAG NQADASVALY YFNASLYLLR VLKGNTTKRY QDGQKLEGAD 950
    IKSEPKDSEV QTTSCLDLDF VTRVYSASLE SLLTKRNSPL TIPMFLDLFS 1000
    RYPVICKNLL PIVVQHVAGS SRPRHQAQAC LLLQKALSAR ELRVCFEDPE 1050
    WEQLISQVLG KTTQTLQTLG EAQSKGEHQR ELSILELLNT VFRIVNHEKL 1100
    SVDLTAFLGM LQGKQQKLQQ NLQQGNHSSG SSRLYDLYWQ AMNLLGVQRP 1150
    KSEKKNVKDI PSDSQSPIST KRKKKGFLPE TKKRKKLKSE GTTSEKKAAS 1200
    QQDAVTEGAM PAATGKDQPP STGKKRRKRV KANTPSQVNG VTVAKSPAPN 1250
    NPTLSPSTPP AKTPKVQKKK EKLSQVNGST PVSPVEPESK KHQKALSTKE 1300
    VKRRSSQSAL PKKRARLSLV SRSPSLLQSG IRKRRVARRR VQTP 1344
    Length:1,344
    Mass (Da):152,286
    Last modified:July 19, 2005 - v2
    Checksum:iA5721894AD80BDF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti137 – 1371G → A in AAB62878. 1 PublicationCurated
    Sequence conflicti433 – 4331V → D in AAB62878. 1 PublicationCurated
    Sequence conflicti905 – 9051L → F in AAB62878. 1 PublicationCurated
    Sequence conflicti1204 – 12041A → R in AAB62878. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03073819 Genomic DNA. No translation available.
    U83590 mRNA. Translation: AAB62878.1.
    PIRiT32731.
    RefSeqiNP_113856.1. NM_031668.1.
    XP_006246864.1. XM_006246802.1.
    UniGeneiRn.35696.

    Genome annotation databases

    EnsembliENSRNOT00000021134; ENSRNOP00000021134; ENSRNOG00000015236.
    GeneIDi60571.
    KEGGirno:60571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03073819 Genomic DNA. No translation available.
    U83590 mRNA. Translation: AAB62878.1 .
    PIRi T32731.
    RefSeqi NP_113856.1. NM_031668.1.
    XP_006246864.1. XM_006246802.1.
    UniGenei Rn.35696.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O35821. 1 interaction.
    STRINGi 10116.ENSRNOP00000021134.

    PTM databases

    PhosphoSitei O35821.

    Proteomic databases

    PaxDbi O35821.
    PRIDEi O35821.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021134 ; ENSRNOP00000021134 ; ENSRNOG00000015236 .
    GeneIDi 60571.
    KEGGi rno:60571.

    Organism-specific databases

    CTDi 10514.
    RGDi 62062. Mybbp1a.

    Phylogenomic databases

    eggNOGi NOG313877.
    GeneTreei ENSGT00390000017457.
    HOGENOMi HOG000113488.
    HOVERGENi HBG081961.
    InParanoidi O35821.
    KOi K02331.
    OMAi HQAQACL.
    OrthoDBi EOG7G7KPN.
    PhylomeDBi O35821.
    TreeFami TF317401.

    Miscellaneous databases

    NextBioi 612270.
    PROi O35821.

    Gene expression databases

    Genevestigatori O35821.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR007015. DNA_pol_V.
    [Graphical view ]
    PANTHERi PTHR13213. PTHR13213. 1 hit.
    Pfami PF04931. DNA_pol_phi. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 5 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "Isolation of PIP, a 160 kDa nucleolar protein that interacts with the activation domain of PAR transcription factors."
      Comte P.A., Ossipow V., Schibler U.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-1344.

    Entry informationi

    Entry nameiMBB1A_RAT
    AccessioniPrimary (citable) accession number: O35821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3