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Protein

Krueppel-like factor 6

Gene

Klf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cellular response to cycloheximide Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to peptide Source: RGD
  • cytokine-mediated signaling pathway Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • wound healing Source: RGD

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 6
Alternative name(s):
Core promoter element-binding protein
Transcription factor Zf9
Gene namesi
Name:Klf6
Synonyms:Copeb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi62389. Klf6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471731 – 283Krueppel-like factor 6Add BLAST283

Proteomic databases

PaxDbiO35819.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016885.
ExpressionAtlasiO35819. baseline and differential.
GenevisibleiO35819. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023033.

Structurei

3D structure databases

ProteinModelPortaliO35819.
SMRiO35819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000231192.
HOVERGENiHBG000836.
InParanoidiO35819.
PhylomeDBiO35819.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequencei

Sequence statusi: Complete.

O35819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV
60 70 80 90 100
SASEIKFDNQ EDLWTKIILA RERKEESELK ISSSPPEDSL ISSGFNYNLE
110 120 130 140 150
TNSLNSDVSS ESSDSSEELS PTTKFTSDPI GEVLVNSGNL SSSVISTPPS
160 170 180 190 200
SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS GKSGDKGSGD ASPDGRRRVH
210 220 230 240 250
RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH
260 270 280
FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
Length:283
Mass (Da):31,841
Last modified:January 1, 1999 - v2
Checksum:iAAFCF99E927C2F63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001417 mRNA. Translation: AAC40204.1.
BC097306 mRNA. Translation: AAH97306.1.
UniGeneiRn.163355.
Rn.217821.
Rn.227453.
Rn.7947.

Genome annotation databases

EnsembliENSRNOT00000078532; ENSRNOP00000070743; ENSRNOG00000016885.
UCSCiRGD:62389. rat.

Similar proteinsi

Entry informationi

Entry nameiKLF6_RAT
AccessioniPrimary (citable) accession number: O35819
Secondary accession number(s): Q4V8M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1999
Last modified: November 22, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families