O35819 (KLF6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 6

Alternative name(s):
Core promoter element-binding protein
Transcription factor Zf9

Gene names

Name:	Klf6
Synonyms:	Copeb

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development By similarity.
Subcellular location	Nucleus By similarity.
Domain	The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.1. Source: RGD transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW wound healing Inferred from expression pattern Ref.1. Source: RGD
Cellular component	nucleus Inferred from direct assay Ref.1. Source: RGD
Molecular function	double-stranded DNA binding Inferred from direct assay Ref.1. Source: RGD sequence-specific DNA binding transcription factor activity Inferred from direct assay Ref.1. Source: RGD zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Krueppel-like factor 6		PRO_0000047173
Regions
	Zinc finger	200 – 224	25	C2H2-type 1
	Zinc finger	230 – 254	25	C2H2-type 2
	Zinc finger	260 – 282	23	C2H2-type 3

Sequences

	Sequence		Length	Mass (Da)
	O35819 [UniParc]. Last modified January 1, 1999. Version 2. Checksum: AAFCF99E927C2F63	FASTA	283	31,841
	10 20 30 40 50 60 MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDNQ 70 80 90 100 110 120 EDLWTKIILA RERKEESELK ISSSPPEDSL ISSGFNYNLE TNSLNSDVSS ESSDSSEELS 130 140 150 160 170 180 PTTKFTSDPI GEVLVNSGNL SSSVISTPPS SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS 190 200 210 220 230 240 GKSGDKGSGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 250 260 270 280 FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis." Ratziu V., Lalazar A., Wong L., Dang Q., Collins C., Shaulian E., Jensen S., Friedman S.L. Proc. Natl. Acad. Sci. U.S.A. 95:9500-9505(1998) [PubMed: 9689109] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF001417 mRNA. Translation: AAC40204.1. BC097306 mRNA. Translation: AAH97306.1.
IPI	IPI00213025.
RefSeq	NP_113830.1. NM_031642.2.
UniGene	Rn.163355. Rn.217821.
3D structure databases
ProteinModelPortal	O35819.
SMR	O35819. Positions 188-282.
ModBase	Search...
Protein-protein interaction databases
STRING	O35819.
Proteomic databases
PRIDE	O35819.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	58954.
KEGG	rno:58954.
NMPDR	fig|10116.3.peg.13555.
UCSC	NM_031642. rat.
Organism-specific databases
CTD	1316.
RGD	62389. Klf6.
Phylogenomic databases
eggNOG	roNOG13952.
GeneTree	ENSGT00590000082798.
HOVERGEN	HBG000836.
OrthoDB	EOG49079R.
PhylomeDB	O35819.
Gene expression databases
ArrayExpress	O35819.
Genevestigator	O35819.
GermOnline	ENSRNOG00000016885. Rattus norvegicus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
KO	K09207.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	611582.

Entry information

Entry name

KLF6_RAT

Accession

Primary (citable) accession number: O35819
Secondary accession number(s): Q4V8M5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1999
Last modified:	December 14, 2011
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program