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Protein

Krueppel-like factor 6

Gene

Klf6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • double-stranded DNA binding Source: RGD
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

  • cellular response to cycloheximide Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to peptide Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 6
Alternative name(s):
Core promoter element-binding protein
Transcription factor Zf9
Gene namesi
Name:Klf6
Synonyms:Copeb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi62389. Klf6.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471731 – 283Krueppel-like factor 6Add BLAST283

Proteomic databases

PaxDbiO35819.

Expressioni

Gene expression databases

ExpressionAtlasiO35819. baseline and differential.
GenevisibleiO35819. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023033.

Structurei

3D structure databases

ProteinModelPortaliO35819.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 224C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri230 – 254C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri260 – 282C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000231192.
HOVERGENiHBG000836.
InParanoidiO35819.
PhylomeDBiO35819.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35819-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV
60 70 80 90 100
SASEIKFDNQ EDLWTKIILA RERKEESELK ISSSPPEDSL ISSGFNYNLE
110 120 130 140 150
TNSLNSDVSS ESSDSSEELS PTTKFTSDPI GEVLVNSGNL SSSVISTPPS
160 170 180 190 200
SPEVNRESSQ LWGCGPGDLP SPGKVRSGTS GKSGDKGSGD ASPDGRRRVH
210 220 230 240 250
RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR FARSDELTRH
260 270 280
FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL
Length:283
Mass (Da):31,841
Last modified:January 1, 1999 - v2
Checksum:iAAFCF99E927C2F63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001417 mRNA. Translation: AAC40204.1.
BC097306 mRNA. Translation: AAH97306.1.
UniGeneiRn.163355.
Rn.217821.
Rn.227453.
Rn.7947.

Genome annotation databases

EnsembliENSRNOT00000078532; ENSRNOP00000070743; ENSRNOG00000016885.
UCSCiRGD:62389. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001417 mRNA. Translation: AAC40204.1.
BC097306 mRNA. Translation: AAH97306.1.
UniGeneiRn.163355.
Rn.217821.
Rn.227453.
Rn.7947.

3D structure databases

ProteinModelPortaliO35819.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023033.

Proteomic databases

PaxDbiO35819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000078532; ENSRNOP00000070743; ENSRNOG00000016885.
UCSCiRGD:62389. rat.

Organism-specific databases

RGDi62389. Klf6.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000231192.
HOVERGENiHBG000836.
InParanoidiO35819.
PhylomeDBiO35819.

Miscellaneous databases

PROiO35819.

Gene expression databases

ExpressionAtlasiO35819. baseline and differential.
GenevisibleiO35819. RN.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLF6_RAT
AccessioniPrimary (citable) accession number: O35819
Secondary accession number(s): Q4V8M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1999
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.