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Protein
Submitted name:

PHEX protein

Gene

Phex

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM13.091.

Names & Taxonomyi

Protein namesi
Submitted name:
PHEX proteinImported
Gene namesi
Name:PhexImported
Synonyms:PHEXImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi3323. Phex.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4525HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO35812.

PTM databases

iPTMnetiO35812.
PhosphoSiteiO35812.

Expressioni

Gene expression databases

GenevisibleiO35812. RN.

Interactioni

Protein-protein interaction databases

IntActiO35812. 1 interaction.
STRINGi10116.ENSRNOP00000010970.

Structurei

3D structure databases

ProteinModelPortaliO35812.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini76 – 479404Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini538 – 742205Peptidase_M13InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
HOGENOMiHOG000245574.
HOVERGENiHBG005554.
KOiK08636.
PhylomeDBiO35812.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

O35812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEAGSTME TGKGTNRGIR IALALFITGT LVLGTLLFLV SQGLLSFQAK
60 70 80 90 100
QEYCLKPECI EAAAAIMSKV NLSVDPCENF FRFACDGWIS NNPIPEDMPS
110 120 130 140 150
YGVYPWLRHN VDLKLKALLE KSVSRRRDTE AVQKAKILYS SCMNEKAIEK
160 170 180 190 200
ADAKPLLHIL RHSPFRWPVL EANIGPEGVW SERKFSLLQT LATFRGQYSN
210 220 230 240 250
SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDFLDNTT EAKSYRDALY
260 270 280 290 300
KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM
310 320 330 340 350
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDIGPSENVV VRVPQYFKDL
360 370 380 390 400
FRILGAERKK TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL
410 420 430 440 450
PQWDKCVNFI ESALPYVVGK MFVNVHFQED KKEMMEELIE GVRWAFIDML
460 470 480 490 500
EKENEWMDAG TKRKAQEKAR AVLAKVGYPE FIMNDTYVNE DLKAIKFSES
510 520 530 540 550
DYFGNVLQTR KYLAQSDFFW LKKAVPKTEW FTNPTTVNAF YSASTNQIRF
560 570 580 590 600
PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD
610 620 630 640 650
PWWSVDSEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL
660 670 680 690 700
REAFRAYRKW INDRRQGVEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA
710 720 730 740
AREQVQIGAH SPPQFRVNGA ISNFEEFQKA FNCPANSTMN RGADSCRLW
Length:749
Mass (Da):86,306
Last modified:January 1, 1998 - v1
Checksum:i690B8E82609C1A63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001637 mRNA. Translation: CAA04890.1.
RefSeqiNP_037136.1. NM_013004.1.
UniGeneiRn.37861.

Genome annotation databases

GeneIDi25512.
KEGGirno:25512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001637 mRNA. Translation: CAA04890.1.
RefSeqiNP_037136.1. NM_013004.1.
UniGeneiRn.37861.

3D structure databases

ProteinModelPortaliO35812.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35812. 1 interaction.
STRINGi10116.ENSRNOP00000010970.

Protein family/group databases

MEROPSiM13.091.

PTM databases

iPTMnetiO35812.
PhosphoSiteiO35812.

Proteomic databases

PaxDbiO35812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25512.
KEGGirno:25512.

Organism-specific databases

CTDi5251.
RGDi3323. Phex.

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
HOGENOMiHOG000245574.
HOVERGENiHBG005554.
KOiK08636.
PhylomeDBiO35812.

Gene expression databases

GenevisibleiO35812. RN.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Publicationsi

  1. "Genomic organization of the human PEX gene mutated in X-linked dominant hypophosphatemic rickets."
    Francis F., Strom T.M., Hennig S., Boeddrich A., Lorenz B., Brandau O., Mohnike K.L., Cagnoli M., Steffens C., Klages S., Borzym K., Pohl T., Oudet C., Econs M.J., Rowe P.S., Reinhardt R., Meitinger T., Lehrach H.
    Genome Res. 7:573-585(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: IncisorImported.

Entry informationi

Entry nameiO35812_RAT
AccessioniPrimary (citable) accession number: O35812
Entry historyi
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.