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Protein

P2Y purinoceptor 4

Gene

P2ry4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ADP or UDP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417957 P2Y receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 4
Short name:
P2Y4
Gene namesi
Name:P2ry4
Synonyms:P2y4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi61798 P2ry4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 58Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 91Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini92 – 108ExtracellularSequence analysisAdd BLAST17
Transmembranei109 – 127Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 192ExtracellularSequence analysisAdd BLAST22
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 242CytoplasmicSequence analysisAdd BLAST24
Transmembranei243 – 265Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini266 – 283ExtracellularSequence analysisAdd BLAST18
Transmembranei284 – 305Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini306 – 361CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2124
GuidetoPHARMACOLOGYi325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700231 – 361P2Y purinoceptor 4Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35811
PRIDEiO35811

PTM databases

PhosphoSitePlusiO35811

Expressioni

Tissue specificityi

Widely expressed at low levels. In brain, higher expression in the pineal gland and ventricular system.

Gene expression databases

BgeeiENSRNOG00000002953
GenevisibleiO35811 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039027

Chemistry databases

BindingDBiO35811

Structurei

3D structure databases

ProteinModelPortaliO35811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAQ Eukaryota
ENOG410XQNZ LUCA
GeneTreeiENSGT00910000144002
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiO35811
KOiK04271
OMAiEFDHYVH
OrthoDBiEOG091G09D4
PhylomeDBiO35811
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000018 P2Y4
PANTHERiPTHR24231:SF21 PTHR24231:SF21, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01066 P2Y4PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O35811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAESLLFT SLGPSPSSGD GDCRFNEEFK FILLPMSYAV VFVLGLALNA
60 70 80 90 100
PTLWLFLFRL RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG
110 120 130 140 150
TGLCKFVRFL FYWNLYCSVL FLTCISVHRY LGICHPLRAI RWGRPRFASL
160 170 180 190 200
LCLGVWLVVA GCLVPNLFFV TTNANGTTIL CHDTTLPEEF DHYVYFSSAV
210 220 230 240 250
MVLLFGLPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL RTIAVVLTVF
260 270 280 290 300
AVCFVPFHIT RTIYYQARLL QADCHVLNIV NVVYKVTRPL ASANSCLDPV
310 320 330 340 350
LYLFTGDKYR NQLQQLCRGS KPKPRTAASS LALVTLHEES ISRWADTHQD
360
STFSAYEGDR L
Length:361
Mass (Da):40,894
Last modified:January 1, 1998 - v1
Checksum:i0377F96E54B449A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14705 Genomic DNA Translation: CAA75007.1
Y11433 mRNA Translation: CAA72241.1
RefSeqiNP_113868.1, NM_031680.1
XP_006257155.1, XM_006257093.3
XP_006257156.1, XM_006257094.3
XP_006257157.1, XM_006257095.3
XP_017457635.1, XM_017602146.1
XP_017457636.1, XM_017602147.1
UniGeneiRn.30068

Genome annotation databases

EnsembliENSRNOT00000045907; ENSRNOP00000039027; ENSRNOG00000002953
GeneIDi63843
KEGGirno:63843
UCSCiRGD:61798 rat

Similar proteinsi

Entry informationi

Entry nameiP2RY4_RAT
AccessioniPrimary (citable) accession number: O35811
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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