Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2Y purinoceptor 4

Gene

P2ry4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ADP or UDP.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-417957. P2Y receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 4
Short name:
P2Y4
Gene namesi
Name:P2ry4
Synonyms:P2y4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi61798. P2ry4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 58Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 91Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini92 – 108ExtracellularSequence analysisAdd BLAST17
Transmembranei109 – 127Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini128 – 149CytoplasmicSequence analysisAdd BLAST22
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 192ExtracellularSequence analysisAdd BLAST22
Transmembranei193 – 218Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini219 – 242CytoplasmicSequence analysisAdd BLAST24
Transmembranei243 – 265Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini266 – 283ExtracellularSequence analysisAdd BLAST18
Transmembranei284 – 305Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini306 – 361CytoplasmicSequence analysisAdd BLAST56

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • basolateral plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2124.
GuidetoPHARMACOLOGYi325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700231 – 361P2Y purinoceptor 4Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi104 ↔ 181PROSITE-ProRule annotation
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation of Ser-329 and Ser-330 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium-activated kinases (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35811.

PTM databases

PhosphoSitePlusiO35811.

Expressioni

Tissue specificityi

Widely expressed at low levels. In brain, higher expression in the pineal gland and ventricular system.

Gene expression databases

BgeeiENSRNOG00000002953.
GenevisibleiO35811. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039027.

Chemistry databases

BindingDBiO35811.

Structurei

3D structure databases

ProteinModelPortaliO35811.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiO35811.
KOiK04271.
OMAiDATATYM.
OrthoDBiEOG091G09D4.
PhylomeDBiO35811.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4.
[Graphical view]
PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01066. P2Y4PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAESLLFT SLGPSPSSGD GDCRFNEEFK FILLPMSYAV VFVLGLALNA
60 70 80 90 100
PTLWLFLFRL RPWDATATYM FHLALSDTLY VLSLPTLVYY YAARNHWPFG
110 120 130 140 150
TGLCKFVRFL FYWNLYCSVL FLTCISVHRY LGICHPLRAI RWGRPRFASL
160 170 180 190 200
LCLGVWLVVA GCLVPNLFFV TTNANGTTIL CHDTTLPEEF DHYVYFSSAV
210 220 230 240 250
MVLLFGLPFL ITLVCYGLMA RRLYRPLPGA GQSSSRLRSL RTIAVVLTVF
260 270 280 290 300
AVCFVPFHIT RTIYYQARLL QADCHVLNIV NVVYKVTRPL ASANSCLDPV
310 320 330 340 350
LYLFTGDKYR NQLQQLCRGS KPKPRTAASS LALVTLHEES ISRWADTHQD
360
STFSAYEGDR L
Length:361
Mass (Da):40,894
Last modified:January 1, 1998 - v1
Checksum:i0377F96E54B449A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14705 Genomic DNA. Translation: CAA75007.1.
Y11433 mRNA. Translation: CAA72241.1.
RefSeqiNP_113868.1. NM_031680.1.
XP_006257155.1. XM_006257093.3.
XP_006257156.1. XM_006257094.3.
XP_006257157.1. XM_006257095.3.
XP_017457635.1. XM_017602146.1.
XP_017457636.1. XM_017602147.1.
UniGeneiRn.30068.

Genome annotation databases

EnsembliENSRNOT00000045907; ENSRNOP00000039027; ENSRNOG00000002953.
GeneIDi63843.
KEGGirno:63843.
UCSCiRGD:61798. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14705 Genomic DNA. Translation: CAA75007.1.
Y11433 mRNA. Translation: CAA72241.1.
RefSeqiNP_113868.1. NM_031680.1.
XP_006257155.1. XM_006257093.3.
XP_006257156.1. XM_006257094.3.
XP_006257157.1. XM_006257095.3.
XP_017457635.1. XM_017602146.1.
XP_017457636.1. XM_017602147.1.
UniGeneiRn.30068.

3D structure databases

ProteinModelPortaliO35811.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039027.

Chemistry databases

BindingDBiO35811.
ChEMBLiCHEMBL2124.
GuidetoPHARMACOLOGYi325.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO35811.

Proteomic databases

PaxDbiO35811.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045907; ENSRNOP00000039027; ENSRNOG00000002953.
GeneIDi63843.
KEGGirno:63843.
UCSCiRGD:61798. rat.

Organism-specific databases

CTDi5030.
RGDi61798. P2ry4.

Phylogenomic databases

eggNOGiENOG410IIAQ. Eukaryota.
ENOG410XQNZ. LUCA.
GeneTreeiENSGT00760000118784.
HOGENOMiHOG000231307.
HOVERGENiHBG101120.
InParanoidiO35811.
KOiK04271.
OMAiDATATYM.
OrthoDBiEOG091G09D4.
PhylomeDBiO35811.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiR-RNO-417957. P2Y receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiO35811.

Gene expression databases

BgeeiENSRNOG00000002953.
GenevisibleiO35811. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000018. P2Y4.
[Graphical view]
PANTHERiPTHR24231:SF21. PTHR24231:SF21. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01066. P2Y4PRNOCPTR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2RY4_RAT
AccessioniPrimary (citable) accession number: O35811
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.