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O35799

- HFE_RAT

UniProt

O35799 - HFE_RAT

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Protein

Hereditary hemochromatosis protein homolog

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro

GO - Biological processi

  1. acute-phase response Source: RGD
  2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  3. cellular iron ion homeostasis Source: RGD
  4. cellular response to iron ion starvation Source: RGD
  5. female pregnancy Source: RGD
  6. hormone biosynthetic process Source: Ensembl
  7. immune response Source: InterPro
  8. iron ion homeostasis Source: RGD
  9. iron ion import into cell Source: Ensembl
  10. liver regeneration Source: RGD
  11. multicellular organismal iron ion homeostasis Source: Ensembl
  12. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Alternative name(s):
RT1-CAFE
Gene namesi
Name:Hfe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi2793. Hfe.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: RGD
  2. basal part of cell Source: Ensembl
  3. cytoplasmic vesicle Source: Ensembl
  4. early endosome Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. MHC class I protein complex Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: Ensembl
  8. recycling endosome Source: Ensembl
  9. terminal web Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 360335Hereditary hemochromatosis protein homologPRO_0000018895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 200PROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi238 ↔ 295PROSITE-ProRule annotation
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35799.

Expressioni

Gene expression databases

ExpressionAtlasiO35799. baseline.
GenevestigatoriO35799.

Interactioni

Subunit structurei

Binds TFR through the extracellular domain.

Structurei

3D structure databases

ProteinModelPortaliO35799.
SMRiO35799. Positions 32-310.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 319294ExtracellularSequence AnalysisAdd
BLAST
Topological domaini341 – 36020CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 30990Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 127102Alpha-1Add
BLAST
Regioni128 – 21891Alpha-2Add
BLAST
Regioni219 – 31092Alpha-3Add
BLAST
Regioni311 – 3199Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41118.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiO35799.
OMAiNHSKVTK.
OrthoDBiEOG7JT6WQ.
PhylomeDBiO35799.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35799-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP
60 70 80 90 100
FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD
110 120 130 140 150
YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK
160 170 180 190 200
YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC
210 220 230 240 250
PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM
260 270 280 290 300
RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP
310 320 330 340 350
GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT
360
MGDYVLTECE
Length:360
Mass (Da):40,988
Last modified:January 1, 1998 - v1
Checksum:iCC819834EE3240B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981R → K in AAB86597. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqiNP_445753.1. NM_053301.4.
UniGeneiRn.42931.

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneIDi29199.
KEGGirno:29199.
UCSCiRGD:2793. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001517 mRNA. Translation: CAA04799.1 .
AF008587 mRNA. Translation: AAB86597.1 .
RefSeqi NP_445753.1. NM_053301.4.
UniGenei Rn.42931.

3D structure databases

ProteinModelPortali O35799.
SMRi O35799. Positions 32-310.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O35799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000022881 ; ENSRNOP00000022881 ; ENSRNOG00000016967 .
GeneIDi 29199.
KEGGi rno:29199.
UCSCi RGD:2793. rat.

Organism-specific databases

CTDi 3077.
RGDi 2793. Hfe.

Phylogenomic databases

eggNOGi NOG41118.
GeneTreei ENSGT00760000118960.
HOGENOMi HOG000296917.
HOVERGENi HBG016709.
InParanoidi O35799.
OMAi NHSKVTK.
OrthoDBi EOG7JT6WQ.
PhylomeDBi O35799.
TreeFami TF336617.

Miscellaneous databases

NextBioi 608342.
PROi O35799.

Gene expression databases

ExpressionAtlasi O35799. baseline.
Genevestigatori O35799.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Banasch M.W., Schaefer H., Schmidt W.E.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Sawada-Hirai R., Rothenberg B.E.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-303.
    Tissue: Small intestine.

Entry informationi

Entry nameiHFE_RAT
AccessioniPrimary (citable) accession number: O35799
Secondary accession number(s): O35175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3