Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hereditary hemochromatosis protein homolog

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

ReactomeiR-RNO-917977 Transferrin endocytosis and recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Alternative name(s):
RT1-CAFE
Gene namesi
Name:Hfe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2793 Hfe

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 319ExtracellularBy similarityAdd BLAST294
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 360CytoplasmicBy similarityAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001889526 – 360Hereditary hemochromatosis protein homologAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 200PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi238 ↔ 295PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35799
PRIDEiO35799

Expressioni

Gene expression databases

BgeeiENSRNOG00000016967
ExpressionAtlasiO35799 baseline
GenevisibleiO35799 RN

Interactioni

Subunit structurei

Binds TFR through the extracellular domain in a pH-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881

Structurei

3D structure databases

ProteinModelPortaliO35799
SMRiO35799
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 309Ig-like C1-typeAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 127Alpha-1Add BLAST102
Regioni128 – 218Alpha-2Add BLAST91
Regioni219 – 310Alpha-3Add BLAST92
Regioni311 – 319Connecting peptide9

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNV Eukaryota
ENOG4111CQR LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiO35799
OMAiITMKWLK
OrthoDBiEOG091G0K1X
PhylomeDBiO35799
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR031092 HFE
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PANTHERiPTHR16675:SF172 PTHR16675:SF172, 1 hit
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP
60 70 80 90 100
FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD
110 120 130 140 150
YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK
160 170 180 190 200
YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC
210 220 230 240 250
PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM
260 270 280 290 300
RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP
310 320 330 340 350
GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT
360
MGDYVLTECE
Length:360
Mass (Da):40,988
Last modified:January 1, 1998 - v1
Checksum:iCC819834EE3240B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → K in AAB86597 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001517 mRNA Translation: CAA04799.1
AF008587 mRNA Translation: AAB86597.1
RefSeqiNP_445753.1, NM_053301.4
UniGeneiRn.42931

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967
GeneIDi29199
KEGGirno:29199
UCSCiRGD:2793 rat

Similar proteinsi

Entry informationi

Entry nameiHFE_RAT
AccessioniPrimary (citable) accession number: O35799
Secondary accession number(s): O35175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health