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Protein

Hereditary hemochromatosis protein homolog

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Alternative name(s):
RT1-CAFE
Gene namesi
Name:Hfe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2793. Hfe.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 319294ExtracellularBy similarityAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST
Topological domaini341 – 36020CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 360335Hereditary hemochromatosis protein homologPRO_0000018895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi137 ↔ 200PROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi238 ↔ 295PROSITE-ProRule annotation
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35799.

Expressioni

Gene expression databases

ExpressionAtlasiO35799. baseline.
GenevisibleiO35799. RN.

Interactioni

Subunit structurei

Binds TFR through the extracellular domain in a pH-dependent manner.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Structurei

3D structure databases

ProteinModelPortaliO35799.
SMRiO35799. Positions 32-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini220 – 30990Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 127102Alpha-1Add
BLAST
Regioni128 – 21891Alpha-2Add
BLAST
Regioni219 – 31092Alpha-3Add
BLAST
Regioni311 – 3199Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41118.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiO35799.
OMAiNHSKVTK.
OrthoDBiEOG7JT6WQ.
PhylomeDBiO35799.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF139. PTHR16675:SF139. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP
60 70 80 90 100
FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD
110 120 130 140 150
YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK
160 170 180 190 200
YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC
210 220 230 240 250
PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM
260 270 280 290 300
RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP
310 320 330 340 350
GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT
360
MGDYVLTECE
Length:360
Mass (Da):40,988
Last modified:January 1, 1998 - v1
Checksum:iCC819834EE3240B3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981R → K in AAB86597 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqiNP_445753.1. NM_053301.4.
UniGeneiRn.42931.

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneIDi29199.
UCSCiRGD:2793. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqiNP_445753.1. NM_053301.4.
UniGeneiRn.42931.

3D structure databases

ProteinModelPortaliO35799.
SMRiO35799. Positions 32-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Proteomic databases

PRIDEiO35799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneIDi29199.
UCSCiRGD:2793. rat.

Organism-specific databases

CTDi3077.
RGDi2793. Hfe.

Phylogenomic databases

eggNOGiNOG41118.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiO35799.
OMAiNHSKVTK.
OrthoDBiEOG7JT6WQ.
PhylomeDBiO35799.
TreeFamiTF336617.

Miscellaneous databases

NextBioi608342.
PROiO35799.

Gene expression databases

ExpressionAtlasiO35799. baseline.
GenevisibleiO35799. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF139. PTHR16675:SF139. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Banasch M.W., Schaefer H., Schmidt W.E.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. Sawada-Hirai R., Rothenberg B.E.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-303.
    Tissue: Small intestine.

Entry informationi

Entry nameiHFE_RAT
AccessioniPrimary (citable) accession number: O35799
Secondary accession number(s): O35175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 22, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.