Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O35799

- HFE_RAT

UniProt

O35799 - HFE_RAT

Protein

Hereditary hemochromatosis protein homolog

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. cellular iron ion homeostasis Source: RGD
    3. cellular response to iron ion starvation Source: RGD
    4. female pregnancy Source: RGD
    5. hormone biosynthetic process Source: Ensembl
    6. immune response Source: InterPro
    7. iron ion import into cell Source: Ensembl
    8. multicellular organismal iron ion homeostasis Source: Ensembl
    9. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hereditary hemochromatosis protein homolog
    Alternative name(s):
    RT1-CAFE
    Gene namesi
    Name:Hfe
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi2793. Hfe.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: RGD
    2. basal part of cell Source: Ensembl
    3. cytoplasmic vesicle Source: Ensembl
    4. early endosome Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. MHC class I protein complex Source: UniProtKB-KW
    7. perinuclear region of cytoplasm Source: Ensembl
    8. recycling endosome Source: Ensembl

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 360335Hereditary hemochromatosis protein homologPRO_0000018895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi137 ↔ 200PROSITE-ProRule annotation
    Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi238 ↔ 295PROSITE-ProRule annotation
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO35799.

    Expressioni

    Gene expression databases

    GenevestigatoriO35799.

    Interactioni

    Subunit structurei

    Binds TFR through the extracellular domain.

    Structurei

    3D structure databases

    ProteinModelPortaliO35799.
    SMRiO35799. Positions 32-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 319294ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini341 – 36020CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini220 – 30990Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni26 – 127102Alpha-1Add
    BLAST
    Regioni128 – 21891Alpha-2Add
    BLAST
    Regioni219 – 31092Alpha-3Add
    BLAST
    Regioni311 – 3199Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41118.
    GeneTreeiENSGT00750000117285.
    HOGENOMiHOG000296917.
    HOVERGENiHBG016709.
    InParanoidiO35799.
    OMAiNHSKVTK.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiO35799.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35799-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP    50
    FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD 100
    YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK 150
    YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC 200
    PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM 250
    RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP 300
    GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT 350
    MGDYVLTECE 360
    Length:360
    Mass (Da):40,988
    Last modified:January 1, 1998 - v1
    Checksum:iCC819834EE3240B3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981R → K in AAB86597. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001517 mRNA. Translation: CAA04799.1.
    AF008587 mRNA. Translation: AAB86597.1.
    RefSeqiNP_445753.1. NM_053301.4.
    UniGeneiRn.42931.

    Genome annotation databases

    EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
    GeneIDi29199.
    KEGGirno:29199.
    UCSCiRGD:2793. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001517 mRNA. Translation: CAA04799.1 .
    AF008587 mRNA. Translation: AAB86597.1 .
    RefSeqi NP_445753.1. NM_053301.4.
    UniGenei Rn.42931.

    3D structure databases

    ProteinModelPortali O35799.
    SMRi O35799. Positions 32-310.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O35799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000022881 ; ENSRNOP00000022881 ; ENSRNOG00000016967 .
    GeneIDi 29199.
    KEGGi rno:29199.
    UCSCi RGD:2793. rat.

    Organism-specific databases

    CTDi 3077.
    RGDi 2793. Hfe.

    Phylogenomic databases

    eggNOGi NOG41118.
    GeneTreei ENSGT00750000117285.
    HOGENOMi HOG000296917.
    HOVERGENi HBG016709.
    InParanoidi O35799.
    OMAi NHSKVTK.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi O35799.
    TreeFami TF336617.

    Miscellaneous databases

    NextBioi 608342.
    PROi O35799.

    Gene expression databases

    Genevestigatori O35799.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Banasch M.W., Schaefer H., Schmidt W.E.
      Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. Sawada-Hirai R., Rothenberg B.E.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-303.
      Tissue: Small intestine.

    Entry informationi

    Entry nameiHFE_RAT
    AccessioniPrimary (citable) accession number: O35799
    Secondary accession number(s): O35175
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3