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Protein

Hereditary hemochromatosis protein homolog

Gene

Hfe

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Alternative name(s):
RT1-CAFE
Gene namesi
Name:Hfe
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi2793. Hfe.

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 319ExtracellularBy similarityAdd BLAST294
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 360CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001889526 – 360Hereditary hemochromatosis protein homologAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi137 ↔ 200PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi238 ↔ 295PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35799.
PRIDEiO35799.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016967.
ExpressionAtlasiO35799. differential.
GenevisibleiO35799. RN.

Interactioni

Subunit structurei

Binds TFR through the extracellular domain in a pH-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Structurei

3D structure databases

ProteinModelPortaliO35799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 309Ig-like C1-typeAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 127Alpha-1Add BLAST102
Regioni128 – 218Alpha-2Add BLAST91
Regioni219 – 310Alpha-3Add BLAST92
Regioni311 – 319Connecting peptide9

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFNV. Eukaryota.
ENOG4111CQR. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiO35799.
OMAiGCEVHED.
OrthoDBiEOG091G0K1X.
PhylomeDBiO35799.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF172. PTHR16675:SF172. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP
60 70 80 90 100
FFEALGYVDD QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD
110 120 130 140 150
YMFIVDFWTI MGNYNHSKVT KLRVVPESHI LQVILGCEVH EDNSTSGFWK
160 170 180 190 200
YGYDGQDHLE FCPKTLNWSA AEPRAWATKM EWEEHRIRAR QSRDYLQRDC
210 220 230 240 250
PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA LNFFPQNITM
260 270 280 290 300
RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP
310 320 330 340 350
GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT
360
MGDYVLTECE
Length:360
Mass (Da):40,988
Last modified:January 1, 1998 - v1
Checksum:iCC819834EE3240B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198R → K in AAB86597 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqiNP_445753.1. NM_053301.4.
UniGeneiRn.42931.

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneIDi29199.
KEGGirno:29199.
UCSCiRGD:2793. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqiNP_445753.1. NM_053301.4.
UniGeneiRn.42931.

3D structure databases

ProteinModelPortaliO35799.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022881.

Proteomic databases

PaxDbiO35799.
PRIDEiO35799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneIDi29199.
KEGGirno:29199.
UCSCiRGD:2793. rat.

Organism-specific databases

CTDi3077.
RGDi2793. Hfe.

Phylogenomic databases

eggNOGiENOG410IFNV. Eukaryota.
ENOG4111CQR. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiO35799.
OMAiGCEVHED.
OrthoDBiEOG091G0K1X.
PhylomeDBiO35799.
TreeFamiTF336617.

Miscellaneous databases

PROiO35799.

Gene expression databases

BgeeiENSRNOG00000016967.
ExpressionAtlasiO35799. differential.
GenevisibleiO35799. RN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR031092. HFE.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PANTHERiPTHR16675:SF172. PTHR16675:SF172. 1 hit.
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHFE_RAT
AccessioniPrimary (citable) accession number: O35799
Secondary accession number(s): O35175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.