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O35799 (HFE_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hereditary hemochromatosis protein homolog
Alternative name(s):
RT1-CAFE
Gene names
Name:Hfe
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin By similarity.

Subunit structure

Binds TFR through the extracellular domain.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentMembrane
MHC I
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation

Inferred from Biological aspect of Ancestor. Source: RefGenome

antigen processing and presentation of peptide antigen via MHC class I

Inferred from electronic annotation. Source: UniProtKB-KW

cellular iron ion homeostasis

Traceable author statement PubMed 12927914. Source: RGD

cellular response to iron ion starvation

Inferred from expression pattern PubMed 16208485. Source: RGD

female pregnancy

Inferred from expression pattern PubMed 15082582. Source: RGD

hormone biosynthetic process

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

iron ion import into cell

Inferred from Biological aspect of Ancestor. Source: RefGenome

multicellular organismal iron ion homeostasis

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

   Cellular_componentMHC class I protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

apical part of cell

Inferred from direct assay PubMed 16208485. Source: RGD

basal part of cell

Inferred from electronic annotation. Source: Ensembl

cytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

early endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Ensembl

recycling endosome

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionantigen binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

peptide antigen binding

Inferred from electronic annotation. Source: InterPro

receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 360335Hereditary hemochromatosis protein homolog
PRO_0000018895

Regions

Topological domain26 – 319294Extracellular Potential
Transmembrane320 – 34021Helical; Potential
Topological domain341 – 36020Cytoplasmic Potential
Domain220 – 30990Ig-like C1-type
Region26 – 127102Alpha-1
Region128 – 21891Alpha-2
Region219 – 31092Alpha-3
Region311 – 3199Connecting peptide

Amino acid modifications

Glycosylation1151N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2471N-linked (GlcNAc...) Potential
Disulfide bond137 ↔ 200 By similarity
Disulfide bond238 ↔ 295 By similarity

Experimental info

Sequence conflict1981R → K in AAB86597. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O35799 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CC819834EE3240B3

FASTA36040,988
        10         20         30         40         50         60 
MDRSAGLPVR LLLLLLLLLL WSVAPQALRP GSHSLRYLFM GASKPDLGLP FFEALGYVDD 

        70         80         90        100        110        120 
QLFVSYNHES RRAEPRAPWI LGQTSSQLWL QLSQSLKGWD YMFIVDFWTI MGNYNHSKVT 

       130        140        150        160        170        180 
KLRVVPESHI LQVILGCEVH EDNSTSGFWK YGYDGQDHLE FCPKTLNWSA AEPRAWATKM 

       190        200        210        220        230        240 
EWEEHRIRAR QSRDYLQRDC PQQLKQVLEL QRGVLGQQVP TLVKVTRHWA STGTSLRCQA 

       250        260        270        280        290        300 
LNFFPQNITM RWLKDSQPLD AKDVNPENVL PNGDGTYQGW LTLAVAPGEE TRFSCQVEHP 

       310        320        330        340        350        360 
GLDQPLTATW EPSRSQDMII GIISGITICA IFFVGILILV LRKRKVSGGT MGDYVLTECE 

« Hide

References

[1]Banasch M.W., Schaefer H., Schmidt W.E.
Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]Sawada-Hirai R., Rothenberg B.E.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-303.
Tissue: Small intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001517 mRNA. Translation: CAA04799.1.
AF008587 mRNA. Translation: AAB86597.1.
RefSeqNP_445753.1. NM_053301.4.
UniGeneRn.42931.

3D structure databases

ProteinModelPortalO35799.
SMRO35799. Positions 32-310.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEO35799.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000022881; ENSRNOP00000022881; ENSRNOG00000016967.
GeneID29199.
KEGGrno:29199.
UCSCRGD:2793. rat.

Organism-specific databases

CTD3077.
RGD2793. Hfe.

Phylogenomic databases

eggNOGNOG41118.
GeneTreeENSGT00750000117285.
HOGENOMHOG000296917.
HOVERGENHBG016709.
InParanoidO35799.
OMANHSKVTK.
OrthoDBEOG7JT6WQ.
PhylomeDBO35799.
TreeFamTF336617.

Gene expression databases

GenevestigatorO35799.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608342.
PROO35799.

Entry information

Entry nameHFE_RAT
AccessionPrimary (citable) accession number: O35799
Secondary accession number(s): O35175
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families