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Protein

Complement component 1 Q subcomponent-binding protein, mitochondrial

Gene

C1qbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins. May play a role in antibacterial defense. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection (By similarity).By similarity

GO - Molecular functioni

  • adrenergic receptor binding Source: UniProtKB
  • complement component C1q binding Source: RGD
  • hyaluronic acid binding Source: UniProtKB
  • kininogen binding Source: UniProtKB
  • mitochondrial ribosome binding Source: UniProtKB
  • mRNA binding Source: UniProtKB
  • protein kinase C binding Source: RGD
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Apoptosis, Complement pathway, Immunity, Innate immunity, mRNA processing, mRNA splicing, Ribosome biogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-RNO-140837. Intrinsic Pathway of Fibrin Clot Formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component 1 Q subcomponent-binding protein, mitochondrial
Alternative name(s):
GC1q-R protein
Glycoprotein gC1qBP
Short name:
C1qBP
Gene namesi
Name:C1qbp
Synonyms:Gc1qbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2230. C1qbp.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: Ensembl
  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • extracellular space Source: RGD
  • mitochondrial matrix Source: UniProtKB-SubCell
  • nucleolus Source: UniProtKB-SubCell
  • nucleus Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7171MitochondrionBy similarityAdd
BLAST
Chaini72 – 279208Complement component 1 Q subcomponent-binding protein, mitochondrialPRO_0000018592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 891N6-acetyllysineBy similarity
Modified residuei92 – 921N6-acetyllysineBy similarity
Modified residuei185 – 1851PhosphotyrosineBy similarity
Modified residuei198 – 1981PhosphoserineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei211 – 2111PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO35796.
PRIDEiO35796.

PTM databases

iPTMnetiO35796.
PhosphoSiteiO35796.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000006949.
GenevisibleiO35796. RN.

Interactioni

Subunit structurei

Homotrimer; three monomers form a donut-shaped structure with an unusually asymmetric charge distribution on the surface. Interacts with CDK13, HRK, VTN, NFYB, ADRA1B, FOXC1, DDX21, DDX50, NCL, SRSF1, SRSF9 and CDKN2A. Interacts with CD93; the association may represent a cell surface C1q receptor. Interacts with KRT1; the association represents a cell surface kininogen receptor. Interacts with CD209; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with FBL and RRP1; the respective interactions with C1QBP are competetive. Probably associates with the mitoribosome. Interacts with MAVS; the interaction occurs upon viral transfection. Interacts with PPIF. Interacts with U2AF1L4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ADRA1BP188415EBI-915544,EBI-6391008From a different organism.

GO - Molecular functioni

  • adrenergic receptor binding Source: UniProtKB
  • complement component C1q binding Source: RGD
  • kininogen binding Source: UniProtKB
  • protein kinase C binding Source: RGD

Protein-protein interaction databases

BioGridi248302. 2 interactions.
IntActiO35796. 8 interactions.
STRINGi10116.ENSRNOP00000031020.

Structurei

3D structure databases

ProteinModelPortaliO35796.
SMRiO35796. Positions 72-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 9118C1q bindingBy similarityAdd
BLAST
Regioni166 – 21045Interaction with MAVSBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the MAM33 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4024. Eukaryota.
ENOG4111G4Z. LUCA.
GeneTreeiENSGT00390000018406.
HOGENOMiHOG000046272.
HOVERGENiHBG000914.
InParanoidiO35796.
KOiK15414.
OMAiCGCGGLH.
OrthoDBiEOG091G0IZD.
PhylomeDBiO35796.
TreeFamiTF315160.

Family and domain databases

Gene3Di3.10.280.10. 1 hit.
InterProiIPR003428. MAM33.
[Graphical view]
PfamiPF02330. MAM33. 1 hit.
[Graphical view]
SUPFAMiSSF54529. SSF54529. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLRCVPR ALGAAATGLR ASIPAPPLRH LLQPAPRPCL RPFGLLSVRA
60 70 80 90 100
GSARRSGLLQ PPVPCACGCG ALHTEGDKAF VEFLTDEIKE EKKIQKHKSL
110 120 130 140 150
PKMSGDWELE VNGTEAKLLR KVAGEKITVT FNINNSIPPT FDGEEEPSQG
160 170 180 190 200
QKAEEQEPEL TSTPNFVVEV TKTDGKKTLV LDCHYPEDEI GHEDEAESDI
210 220 230 240 250
FSIKEVSFQT TGDSEWRDTN YTLNTDSLDW ALYDHLMDFL ADRGVDNTFA
260 270
DELVELSTAL EHQEYITFLE DLKSFVKSQ
Length:279
Mass (Da):30,997
Last modified:January 9, 2007 - v2
Checksum:i54D238EFBCA6F41B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 642VP → GS in CAA04531 (PubMed:9414106).Curated
Sequence conflicti68 – 703GCG → AA in CAA04531 (PubMed:9414106).Curated
Sequence conflicti107 – 1071W → G in CAA04531 (PubMed:9414106).Curated
Sequence conflicti193 – 1931E → Q in CAA04531 (PubMed:9414106).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001102 mRNA. Translation: CAA04531.1.
BC070510 mRNA. Translation: AAH70510.1.
RefSeqiNP_062132.2. NM_019259.2.
UniGeneiRn.2765.

Genome annotation databases

EnsembliENSRNOT00000037517; ENSRNOP00000031020; ENSRNOG00000006949.
GeneIDi29681.
KEGGirno:29681.
UCSCiRGD:2230. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001102 mRNA. Translation: CAA04531.1.
BC070510 mRNA. Translation: AAH70510.1.
RefSeqiNP_062132.2. NM_019259.2.
UniGeneiRn.2765.

3D structure databases

ProteinModelPortaliO35796.
SMRiO35796. Positions 72-279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248302. 2 interactions.
IntActiO35796. 8 interactions.
STRINGi10116.ENSRNOP00000031020.

PTM databases

iPTMnetiO35796.
PhosphoSiteiO35796.

Proteomic databases

PaxDbiO35796.
PRIDEiO35796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037517; ENSRNOP00000031020; ENSRNOG00000006949.
GeneIDi29681.
KEGGirno:29681.
UCSCiRGD:2230. rat.

Organism-specific databases

CTDi708.
RGDi2230. C1qbp.

Phylogenomic databases

eggNOGiKOG4024. Eukaryota.
ENOG4111G4Z. LUCA.
GeneTreeiENSGT00390000018406.
HOGENOMiHOG000046272.
HOVERGENiHBG000914.
InParanoidiO35796.
KOiK15414.
OMAiCGCGGLH.
OrthoDBiEOG091G0IZD.
PhylomeDBiO35796.
TreeFamiTF315160.

Enzyme and pathway databases

ReactomeiR-RNO-140837. Intrinsic Pathway of Fibrin Clot Formation.

Miscellaneous databases

PROiO35796.

Gene expression databases

BgeeiENSRNOG00000006949.
GenevisibleiO35796. RN.

Family and domain databases

Gene3Di3.10.280.10. 1 hit.
InterProiIPR003428. MAM33.
[Graphical view]
PfamiPF02330. MAM33. 1 hit.
[Graphical view]
SUPFAMiSSF54529. SSF54529. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC1QBP_RAT
AccessioniPrimary (citable) accession number: O35796
Secondary accession number(s): Q6IRS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.