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Protein

Gremlin-1

Gene

Grem1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Gremlin-1
Alternative name(s):
Cysteine knot superfamily 1, BMP antagonist 1
Down-regulated in Mos-transformed cells protein
Gene namesi
Name:Grem1
Synonyms:Cktsf1b1, Drm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2359. Grem1.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: RGD
  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi42 – 443NDS → IEA: No interaction with SLIT1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 184160Gremlin-1PRO_0000006717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 144By similarity
Disulfide bondi108 ↔ 158By similarity
Disulfide bondi118 ↔ 176By similarity
Disulfide bondi122 ↔ 178By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35793.

Expressioni

Tissue specificityi

Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine.1 Publication

Inductioni

Down-regulated in cells transformed by oncogenes.1 Publication

Gene expression databases

BgeeiENSRNOG00000026053.
GenevisibleiO35793. RN.

Interactioni

Subunit structurei

Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.1 Publication

Protein-protein interaction databases

IntActiO35793. 1 interaction.
STRINGi10116.ENSRNOP00000035888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 18491CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the DAN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG3Z. Eukaryota.
ENOG4111HEF. LUCA.
GeneTreeiENSGT00510000046909.
HOGENOMiHOG000237358.
HOVERGENiHBG051837.
InParanoidiO35793.
OMAiRVKECRC.
OrthoDBiEOG091G0GL9.
PhylomeDBiO35793.
TreeFamiTF106445.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR004133. DAN.
IPR017159. Gremlin-1/2.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF037254. Gremlin_precursor. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTAYTVGA LLLLLGTLLP AAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP
60 70 80 90 100
PQPGSRTRGR GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK
110 120 130 140 150
QTIHEEGCNS RTIINRFCYG QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT
160 170 180
TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS IDLD
Length:184
Mass (Da):20,680
Last modified:January 1, 1998 - v1
Checksum:i90AC99749B1AD8F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10019 mRNA. Translation: CAA71126.1.
RefSeqiNP_062155.1. NM_019282.3.
UniGeneiRn.42929.

Genome annotation databases

EnsembliENSRNOT00000037895; ENSRNOP00000035888; ENSRNOG00000026053.
GeneIDi50566.
KEGGirno:50566.
UCSCiRGD:2359. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10019 mRNA. Translation: CAA71126.1.
RefSeqiNP_062155.1. NM_019282.3.
UniGeneiRn.42929.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35793. 1 interaction.
STRINGi10116.ENSRNOP00000035888.

Proteomic databases

PaxDbiO35793.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037895; ENSRNOP00000035888; ENSRNOG00000026053.
GeneIDi50566.
KEGGirno:50566.
UCSCiRGD:2359. rat.

Organism-specific databases

CTDi26585.
RGDi2359. Grem1.

Phylogenomic databases

eggNOGiENOG410IG3Z. Eukaryota.
ENOG4111HEF. LUCA.
GeneTreeiENSGT00510000046909.
HOGENOMiHOG000237358.
HOVERGENiHBG051837.
InParanoidiO35793.
OMAiRVKECRC.
OrthoDBiEOG091G0GL9.
PhylomeDBiO35793.
TreeFamiTF106445.

Miscellaneous databases

PROiO35793.

Gene expression databases

BgeeiENSRNOG00000026053.
GenevisibleiO35793. RN.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR004133. DAN.
IPR017159. Gremlin-1/2.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
PIRSFiPIRSF037254. Gremlin_precursor. 1 hit.
SMARTiSM00041. CT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGREM1_RAT
AccessioniPrimary (citable) accession number: O35793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 1, 1998
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.