Unreviewed, UniProtKB/TrEMBL O35791 (O35791_RAT)

Names and origin

Protein names

Submitted name:
    RhoA EMBL BAA20863.1

Gene names

Name:	Rhoa RGD 619921
Synonyms:	rhoA EMBL BAA20863.1

Organism

Rattus norvegicus (Rat) EMBL BAA20863.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	174 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the small GTPase superfamily. Rho family. RuleBase RU003317V0

Ontologies

Keywords
Cellular component	Membrane Spearmint SPM003578
Ligand	GTP-binding Spearmint SPM003578 RuleBase RU003312V0 Nucleotide-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Traceable author statement. Source: RGD negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: RGD negative regulation of calcium ion transport via voltage-gated calcium channel activity Inferred from mutant phenotype. Source: RGD negative regulation of neuron differentiation Inferred from mutant phenotype. Source: RGD neuron projection morphogenesis Inferred from expression pattern. Source: RGD positive regulation of actin filament polymerization Inferred from mutant phenotype. Source: RGD positive regulation of caspase activity Inferred from mutant phenotype. Source: RGD positive regulation of cell adhesion Inferred from expression pattern. Source: RGD positive regulation of cell growth Inferred from expression pattern. Source: RGD positive regulation of cell migration Inferred from expression pattern. Source: RGD positive regulation of neuron apoptosis Inferred from mutant phenotype. Source: RGD positive regulation of neuron differentiation Inferred from mutant phenotype. Source: MGI positive regulation of translation Inferred from expression pattern. Source: RGD positive regulation of vasoconstriction Inferred from expression pattern. Source: RGD regulation of dendrite development Inferred from mutant phenotype. Source: RGD response to amino acid stimulus Inferred from expression pattern. Source: RGD response to drug Inferred from direct assay. Source: RGD response to ethanol Inferred from expression pattern. Source: RGD response to glucocorticoid stimulus Inferred from expression pattern. Source: RGD response to glucose stimulus Inferred from expression pattern. Source: RGD response to hypoxia Inferred from expression pattern. Source: RGD response to mechanical stimulus Inferred from expression pattern. Source: RGD small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro stress-activated protein kinase signaling pathway Inferred from mutant phenotype. Source: RGD
Cellular component	axon Inferred from direct assay. Source: RGD cytoplasm Inferred from direct assay. Source: RGD membrane fraction Inferred from direct assay. Source: RGD nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara soluble fraction Inferred from direct assay. Source: RGD
Molecular function	GTP binding Traceable author statement. Source: RGD GTPase activity Non-traceable author statement. Source: RGD protein binding Inferred from physical interaction. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAA20863.1
	Non-terminal residue	174	1	EMBL BAA20863.1

Sequences

	Sequence		Length	Mass (Da)
	O35791-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 49C778E3FCBA614E	FASTA	174	19,686
	10 20 30 40 50 60 VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR 70 80 90 100 110 120 PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD LRNDEHTRRE 130 140 150 160 170 LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRG

References

[1]	"Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation." Yoshimura S., Sakai H., Nakashima S., Nozawa Y., Shinoda J., Sakai N., Yamada H. Brain Res. Mol. Brain Res. 45:90-98(1997) [PubMed: 9105674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D84477 mRNA. Translation: BAA20863.1.
IPI	IPI00201699.
UniGene	Rn.107401
3D structure databases
HSSP	HSSP built from PDB template 1A2B based on UniProtKB P61586.
SMR	O35791. Positions 1-171.
ModBase	Search...
Protein-protein interaction databases
STRING	O35791.
Genome annotation databases
Ensembl	ENSRNOT00000017254; ENSRNOP00000017254; ENSRNOG00000012630; Rattus norvegicus. [Genome view]
Phylogenomic databases
HOVERGEN	O35791.
Gene expression databases
ArrayExpress	O35791.
Genevestigator	O35791.
Family and domain databases
InterPro	IPR003578. GTPase_Rho. IPR013753. Ras. IPR001806. Ras_GTPase. IPR005225. Small_GTP_bd. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00174. RHO. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51420. RHO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O35791_RAT

Accession

Primary (citable) accession number: O35791

Entry history

Integrated into UniProtKB/TrEMBL:	January 1, 1998
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)