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Protein

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Gene

Pigl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.1 Publication

Catalytic activityi

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate.

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • GPI anchor biosynthetic process Source: RGD

Keywordsi

Molecular functionHydrolase
Biological processGPI-anchor biosynthesis

Enzyme and pathway databases

BRENDAi3.5.1.89 5301
ReactomeiR-RNO-162710 Synthesis of glycosylphosphatidylinositol (GPI)
UniPathwayiUPA00196

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC:3.5.1.89)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class L protein
Short name:
PIG-L
Gene namesi
Name:Pigl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620437 Pigl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 252CytoplasmicSequence analysisAdd BLAST230

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071681 – 252N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseAdd BLAST252

Proteomic databases

PaxDbiO35790

Expressioni

Gene expression databases

BgeeiENSRNOG00000003070
GenevisibleiO35790 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004113

Structurei

3D structure databases

ProteinModelPortaliO35790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3332 Eukaryota
COG2120 LUCA
GeneTreeiENSGT00390000018434
HOGENOMiHOG000176611
HOVERGENiHBG019149
InParanoidiO35790
KOiK03434
OMAiLVWFRWL
OrthoDBiEOG091G0HS4
PhylomeDBiO35790
TreeFamiTF315150

Family and domain databases

Gene3Di3.40.50.10320, 1 hit
InterProiView protein in InterPro
IPR003737 GlcNAc_PI_deacetylase-related
IPR024078 LmbE-like_dom_sf
PANTHERiPTHR12993 PTHR12993, 1 hit
PfamiView protein in Pfam
PF02585 PIG-L, 1 hit
SUPFAMiSSF102588 SSF102588, 1 hit

Sequencei

Sequence statusi: Complete.

O35790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVVGLLCVA VAVLTWGFLR VWNSAERMRS PEQAGLPGAG SRALVVIAHP
60 70 80 90 100
DDEAMFFAPT ILGLARLKQQ VSLLCFSSGN YYNQGEIRKK ELLQSCAVLG
110 120 130 140 150
IPPSRVMIID KREFPDDPEV QWDTEHVAST ILQHIHANAT DLVVTFDAEG
160 170 180 190 200
VSGHSNHIAL YKAVRALHSG GKLPEGCSVL TLQSVNVLRK YVFLLDLPWT
210 220 230 240 250
LLSPQGVLFV LTSKEVAQAK KAMSCHRSQL LWFRHLYTVF SRYMSVNSLQ

LL
Length:252
Mass (Da):27,984
Last modified:January 1, 1998 - v1
Checksum:i73AD9AA7A79DBFCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88364 mRNA Translation: BAA20869.1
BC074020 mRNA Translation: AAH74020.1
RefSeqiNP_620256.1, NM_138901.2
UniGeneiRn.10774

Genome annotation databases

EnsembliENSRNOT00000004113; ENSRNOP00000004113; ENSRNOG00000003070
GeneIDi192263
KEGGirno:192263
UCSCiRGD:620437 rat

Similar proteinsi

Entry informationi

Entry nameiPIGL_RAT
AccessioniPrimary (citable) accession number: O35790
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health