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Protein

Kinesin-like protein KIF1C

Gene

Kif1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable motor protein.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 103ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: GO_Central
  • motor activity Source: RGD

GO - Biological processi

  • anterograde neuronal dense core vesicle transport Source: ARUK-UCL
  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • microtubule-based movement Source: GO_Central
  • microtubule-based process Source: RGD
  • retrograde neuronal dense core vesicle transport Source: ARUK-UCL

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Alternative name(s):
Kinesin-like protein KIF1D
Gene namesi
Name:Kif1c
Synonyms:Kif1d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70928 Kif1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254121 – 1097Kinesin-like protein KIF1CAdd BLAST1097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294PhosphoserineBy similarity1
Modified residuei491PhosphoserineBy similarity1
Modified residuei671PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei911PhosphoserineBy similarity1
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1036Omega-N-methylarginineBy similarity1
Modified residuei1077PhosphothreonineBy similarity1
Modified residuei1086PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiO35787
PRIDEiO35787

PTM databases

iPTMnetiO35787
PhosphoSitePlusiO35787

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiO35787, 1 interactor
MINTiO35787
STRINGi10116.ENSRNOP00000045754

Structurei

3D structure databases

ProteinModelPortaliO35787
SMRiO35787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 347Kinesin motorPROSITE-ProRule annotationAdd BLAST343
Domaini520 – 587FHAAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili358 – 380Sequence analysisAdd BLAST23
Coiled coili437 – 478Sequence analysisAdd BLAST42
Coiled coili630 – 671Sequence analysisAdd BLAST42
Coiled coili824 – 868Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi961 – 1079Pro-richAdd BLAST119

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
HOGENOMiHOG000231453
HOVERGENiHBG057158
InParanoidiO35787
KOiK10392
PhylomeDBiO35787

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR027640 Kinesin-like_fam
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00498 FHA, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

O35787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSRMFLKAS
60 70 80 90 100
FDYSYWSHTS VEDPQFASQQ QVYRDIGEEM LLHAFEGYNV CIFAYGQTGA
110 120 130 140 150
GKSYTMMGRQ EPGQQGIVPQ LCEDLFSRVN VNQSAQLSYS VEVSYMEIYC
160 170 180 190 200
ERVRDLLNPK SRGSLRVREH PILGPYVQDL SKLAVTSYAD IADLMDCGNK
210 220 230 240 250
ARTVAATNMN ETSSRSHAVF TIVFTQRSHD QLTGLDSEKV SKISLVNLAG
260 270 280 290 300
SERADSSGAR GMRLKEGANI NKSLTTLGKV ISALADLQSK KRKSDFIPYR
310 320 330 340 350
DSVLTWLLKE NLGGNSRTAM IAALSPADIN YEETLSTLRY ADRTKQIRCN
360 370 380 390 400
AVINEDPNAR LIRELQEEVA RLRELLMAQG LSASALGGLK VEEGSPGGVL
410 420 430 440 450
PAASSPPAPA SPSSPPPHNG ELEPSFSPSA EPQIGPEEAM ERLQETEKII
460 470 480 490 500
AELNETWEEK LRKTEALRME REALLAEMGS PGGWRTVGVF SPKKTPHLVN
510 520 530 540 550
LNEDPLMSEC LLYHIKDGVT RVGQVDVDIK LTGQFIREQH CLFRSIPQPD
560 570 580 590 600
GEVMVTLEPC EGAETYVNGK LVTEPLVLKS GNRIVMGKNH VFRFNHPEQA
610 620 630 640 650
RLERERGVPP PPGPPSEPVD WNFAQKDWLE QQGIDIKLEM EKRLQDLENQ
660 670 680 690 700
YRKEKEEADL LLEQQRLYAD SDSGEDSDKR SCEESWRLIS SLRDELPPNT
710 720 730 740 750
VQTIVKRCGL PSSGKRRAPR RVYQIPQRRR LQGKDPRWAT MADLKMQAVK
760 770 780 790 800
EICYEVALAD FRHGRAEIEA LAALKMRELC RTYGKPEGPG DAWRAVARDV
810 820 830 840 850
WDTVGEEEGC GGGGGGGEEG ARGAEVEDLR AHIDKLTGIL QEVKLQNSSK
860 870 880 890 900
DRELQALRDR MLRMERVIPL TQDLEDDNEE SGLVTWAPPE GSEAVEEAVS
910 920 930 940 950
NDHSPAVRPS SPPQSSWERV SRLMEEDPAF RRGRLRWLKQ EQLRLQGLQG
960 970 980 990 1000
SGGRGGGLRR PPARFVPPHD CKLRFPFKSN PQHRESWPGM GSGEAPGPQP
1010 1020 1030 1040 1050
PEEVTAPPPP PNRRPPSPRR PHRPRRNSLD GGSRSRGGGS TQPEPQHLRP
1060 1070 1080 1090
QKHNSYPQQP QPYPAQRPGP RYPPYTTPPR MRRQRSAPDL KESGAAV
Length:1,097
Mass (Da):122,334
Last modified:January 1, 1998 - v1
Checksum:i8EF40B1C7579BA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000696 mRNA Translation: CAA04248.1
RefSeqiNP_665884.1, NM_145877.1
UniGeneiRn.89698

Genome annotation databases

GeneIDi113886
KEGGirno:113886
UCSCiRGD:70928 rat

Similar proteinsi

Entry informationi

Entry nameiKIF1C_RAT
AccessioniPrimary (citable) accession number: O35787
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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