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Protein

Kinesin-like protein KIF1C

Gene

Kif1c

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable motor protein.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi96 – 1038ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: InterPro
  • motor activity Source: RGD

GO - Biological processi

  • microtubule-based movement Source: InterPro
  • microtubule-based process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF1C
Alternative name(s):
Kinesin-like protein KIF1D
Gene namesi
Name:Kif1c
Synonyms:Kif1d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70928. Kif1c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: RGD
  • microtubule Source: UniProtKB-KW
  • microtubule associated complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10971097Kinesin-like protein KIF1CPRO_0000125412Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei491 – 4911PhosphoserineBy similarity
Modified residuei671 – 6711PhosphoserineCombined sources
Modified residuei673 – 6731PhosphoserineCombined sources
Modified residuei911 – 9111PhosphoserineBy similarity
Modified residuei1028 – 10281PhosphoserineCombined sources
Modified residuei1077 – 10771PhosphothreonineBy similarity
Modified residuei1086 – 10861PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35787.
PRIDEiO35787.

PTM databases

iPTMnetiO35787.
PhosphoSiteiO35787.

Interactioni

Protein-protein interaction databases

IntActiO35787. 1 interaction.
MINTiMINT-7899659.
STRINGi10116.ENSRNOP00000045754.

Structurei

3D structure databases

ProteinModelPortaliO35787.
SMRiO35787. Positions 4-346, 495-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 347343Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Domaini520 – 58768FHAAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili358 – 38023Sequence analysisAdd
BLAST
Coiled coili437 – 47842Sequence analysisAdd
BLAST
Coiled coili630 – 67142Sequence analysisAdd
BLAST
Coiled coili824 – 86845Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi961 – 1079119Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000231453.
HOVERGENiHBG057158.
InParanoidiO35787.
KOiK10392.
PhylomeDBiO35787.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGASVKVAV RVRPFNARET SQDAKCVVSM QGNTTSIINP KQSRMFLKAS
60 70 80 90 100
FDYSYWSHTS VEDPQFASQQ QVYRDIGEEM LLHAFEGYNV CIFAYGQTGA
110 120 130 140 150
GKSYTMMGRQ EPGQQGIVPQ LCEDLFSRVN VNQSAQLSYS VEVSYMEIYC
160 170 180 190 200
ERVRDLLNPK SRGSLRVREH PILGPYVQDL SKLAVTSYAD IADLMDCGNK
210 220 230 240 250
ARTVAATNMN ETSSRSHAVF TIVFTQRSHD QLTGLDSEKV SKISLVNLAG
260 270 280 290 300
SERADSSGAR GMRLKEGANI NKSLTTLGKV ISALADLQSK KRKSDFIPYR
310 320 330 340 350
DSVLTWLLKE NLGGNSRTAM IAALSPADIN YEETLSTLRY ADRTKQIRCN
360 370 380 390 400
AVINEDPNAR LIRELQEEVA RLRELLMAQG LSASALGGLK VEEGSPGGVL
410 420 430 440 450
PAASSPPAPA SPSSPPPHNG ELEPSFSPSA EPQIGPEEAM ERLQETEKII
460 470 480 490 500
AELNETWEEK LRKTEALRME REALLAEMGS PGGWRTVGVF SPKKTPHLVN
510 520 530 540 550
LNEDPLMSEC LLYHIKDGVT RVGQVDVDIK LTGQFIREQH CLFRSIPQPD
560 570 580 590 600
GEVMVTLEPC EGAETYVNGK LVTEPLVLKS GNRIVMGKNH VFRFNHPEQA
610 620 630 640 650
RLERERGVPP PPGPPSEPVD WNFAQKDWLE QQGIDIKLEM EKRLQDLENQ
660 670 680 690 700
YRKEKEEADL LLEQQRLYAD SDSGEDSDKR SCEESWRLIS SLRDELPPNT
710 720 730 740 750
VQTIVKRCGL PSSGKRRAPR RVYQIPQRRR LQGKDPRWAT MADLKMQAVK
760 770 780 790 800
EICYEVALAD FRHGRAEIEA LAALKMRELC RTYGKPEGPG DAWRAVARDV
810 820 830 840 850
WDTVGEEEGC GGGGGGGEEG ARGAEVEDLR AHIDKLTGIL QEVKLQNSSK
860 870 880 890 900
DRELQALRDR MLRMERVIPL TQDLEDDNEE SGLVTWAPPE GSEAVEEAVS
910 920 930 940 950
NDHSPAVRPS SPPQSSWERV SRLMEEDPAF RRGRLRWLKQ EQLRLQGLQG
960 970 980 990 1000
SGGRGGGLRR PPARFVPPHD CKLRFPFKSN PQHRESWPGM GSGEAPGPQP
1010 1020 1030 1040 1050
PEEVTAPPPP PNRRPPSPRR PHRPRRNSLD GGSRSRGGGS TQPEPQHLRP
1060 1070 1080 1090
QKHNSYPQQP QPYPAQRPGP RYPPYTTPPR MRRQRSAPDL KESGAAV
Length:1,097
Mass (Da):122,334
Last modified:January 1, 1998 - v1
Checksum:i8EF40B1C7579BA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000696 mRNA. Translation: CAA04248.1.
RefSeqiNP_665884.1. NM_145877.1.
UniGeneiRn.89698.

Genome annotation databases

GeneIDi113886.
KEGGirno:113886.
UCSCiRGD:70928. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000696 mRNA. Translation: CAA04248.1.
RefSeqiNP_665884.1. NM_145877.1.
UniGeneiRn.89698.

3D structure databases

ProteinModelPortaliO35787.
SMRiO35787. Positions 4-346, 495-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO35787. 1 interaction.
MINTiMINT-7899659.
STRINGi10116.ENSRNOP00000045754.

PTM databases

iPTMnetiO35787.
PhosphoSiteiO35787.

Proteomic databases

PaxDbiO35787.
PRIDEiO35787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113886.
KEGGirno:113886.
UCSCiRGD:70928. rat.

Organism-specific databases

CTDi10749.
RGDi70928. Kif1c.

Phylogenomic databases

eggNOGiKOG0245. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000231453.
HOVERGENiHBG057158.
InParanoidiO35787.
KOiK10392.
PhylomeDBiO35787.

Miscellaneous databases

NextBioi617952.
PROiO35787.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR032405. Kinesin_assoc.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00498. FHA. 1 hit.
PF00225. Kinesin. 1 hit.
PF16183. Kinesin_assoc. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The secretory epithelial cells of the choroid plexus employ a novel kinesin-related protein."
    Rogers K.R., Griffin M., Brophy P.J.
    Brain Res. Mol. Brain Res. 55:355-355(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-671; SER-673 AND SER-1028, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKIF1C_RAT
AccessioniPrimary (citable) accession number: O35787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.