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Protein

Chemokine-like receptor 1

Gene

Cmklr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled chemoattractant receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Chemokine-like receptor 1
Alternative name(s):
G-protein coupled chemoattractant-like receptor
G-protein coupled receptor DEZ
Gene namesi
Name:Cmklr1
Synonyms:Dez
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69359. Cmklr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6223Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 7311CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9522Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini96 – 11217ExtracellularSequence analysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15219CytoplasmicSequence analysisAdd
BLAST
Transmembranei153 – 17422Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini175 – 22248ExtracellularSequence analysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 25916CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini281 – 29818ExtracellularSequence analysisAdd
BLAST
Transmembranei299 – 31820Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini319 – 37153CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Chemokine-like receptor 1PRO_0000069309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Modified residuei337 – 3371PhosphoserineCombined sources
Modified residuei340 – 3401PhosphothreonineCombined sources
Modified residuei347 – 3471PhosphoserineCombined sources
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei370 – 3701PhosphothreonineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO35786.

PTM databases

iPTMnetiO35786.
PhosphoSiteiO35786.

Expressioni

Tissue specificityi

High expression in heart and lung, low in small intestines, colon, kidney, liver, uterus and brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000893.

Structurei

3D structure databases

ProteinModelPortaliO35786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiO35786.
PhylomeDBiO35786.

Family and domain databases

InterProiIPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYEGYNDSS IYGEEYSDGS DYIVDLEEAG PLEAKVAEVF LVVIYSLVCF
60 70 80 90 100
LGILGNGLVI VIATFKMKKT VNTVWFVNLA VADFLFNIFL PIHITYAAMD
110 120 130 140 150
YHWVFGKAMC KISSFLLSHN MYTSVFLLTV ISFDRCISVL LPVWSQNHRS
160 170 180 190 200
VRLAYMTCVV VWVWLSSESP PSLVFGHVST SHGKITCFNN FSLAAPEPFS
210 220 230 240 250
HSTHPRTDPV GYSRHVAVTV TRFLCGFLIP VFIITACYLT IVFKLQRNRQ
260 270 280 290 300
AKTKKPFKII ITIIITFFLC WCPYHTLYLL ELHHTAVPAS VFSLGLPLAT
310 320 330 340 350
AVAIANSCMN PILYVFMGHD FKKFKVALFS RLVNALSEDT GPSSYPSHRS
360 370
FTKMSSLIEK ASVNEKETST L
Length:371
Mass (Da):41,723
Last modified:January 1, 1998 - v1
Checksum:i3AE308603FEC7801
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002745 mRNA. Translation: CAA05715.1.
PIRiJC5796.
UniGeneiRn.44465.

Genome annotation databases

UCSCiRGD:69359. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002745 mRNA. Translation: CAA05715.1.
PIRiJC5796.
UniGeneiRn.44465.

3D structure databases

ProteinModelPortaliO35786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000893.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO35786.
PhosphoSiteiO35786.

Proteomic databases

PaxDbiO35786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:69359. rat.

Organism-specific databases

RGDi69359. Cmklr1.

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
HOGENOMiHOG000234122.
HOVERGENiHBG107927.
InParanoidiO35786.
PhylomeDBiO35786.

Miscellaneous databases

PROiO35786.

Family and domain databases

InterProiIPR002258. DEZorph_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01126. DEZORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and tissue distribution of cDNA encoding a novel chemoattractant-like receptor."
    Owman C.S.O., LoLait S.J., Santen S., Olde B.
    Biochem. Biophys. Res. Commun. 241:390-394(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Albino.
    Tissue: Pituitary anterior lobe.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337; THR-340; SER-347 AND SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCML1_RAT
AccessioniPrimary (citable) accession number: O35786
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.