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Protein

Natural killer cells antigen CD94

Gene

Klrd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural killer cells antigen CD94
Alternative name(s):
Killer cell lectin-like receptor subfamily D member 1
CD_antigen: CD94
Gene namesi
Name:Klrd1
Synonyms:Cd94
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2978. Klrd1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence analysis
Transmembranei11 – 3121Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini32 – 179148ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Natural killer cells antigen CD94PRO_0000378459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi58 ↔ 70PROSITE-ProRule annotation
Disulfide bondi59 – 59Interchain (with C-116 in NGK2A)PROSITE-ProRule annotation
Disulfide bondi61 ↔ 72PROSITE-ProRule annotation
Disulfide bondi89 ↔ 174PROSITE-ProRule annotation
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi152 ↔ 166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35778.

Expressioni

Gene expression databases

GenevisibleiO35778. RN.

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with NKG2 family members.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052682.

Structurei

3D structure databases

ProteinModelPortaliO35778.
SMRiO35778. Positions 59-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 175108C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
InParanoidiO35778.
KOiK06516.
OMAiDESCETK.
OrthoDBiEOG71CFP0.
PhylomeDBiO35778.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVSRITRWR LMSMFFGIKC LFLIVALGVL VKNSFTIQNI QSTPSSTPIV
60 70 80 90 100
EFQKVSKCCA CLEKWIGHQC SCYFISKEEK SWKGSREFCA SQNSSLLQLQ
110 120 130 140 150
TRNELSFMSS SQAFFWIGIH YNEERSAWLW EDGTFPSKDL FPEFSKFRQD
160 170
HCIGYSISRE ISSESCENKN RFICKQLPT
Length:179
Mass (Da):20,781
Last modified:January 1, 1998 - v1
Checksum:i11E6A55C670EE84C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009133 mRNA. Translation: AAC10220.1.
BC086393 mRNA. Translation: AAH86393.1.
RefSeqiNP_036877.1. NM_012745.2.
UniGeneiRn.6025.

Genome annotation databases

EnsembliENSRNOT00000082064; ENSRNOP00000074715; ENSRNOG00000060246.
GeneIDi25110.
KEGGirno:25110.
UCSCiRGD:2978. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009133 mRNA. Translation: AAC10220.1.
BC086393 mRNA. Translation: AAH86393.1.
RefSeqiNP_036877.1. NM_012745.2.
UniGeneiRn.6025.

3D structure databases

ProteinModelPortaliO35778.
SMRiO35778. Positions 59-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052682.

Proteomic databases

PaxDbiO35778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000082064; ENSRNOP00000074715; ENSRNOG00000060246.
GeneIDi25110.
KEGGirno:25110.
UCSCiRGD:2978. rat.

Organism-specific databases

CTDi3824.
RGDi2978. Klrd1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00730000110282.
HOGENOMiHOG000220925.
InParanoidiO35778.
KOiK06516.
OMAiDESCETK.
OrthoDBiEOG71CFP0.
PhylomeDBiO35778.
TreeFamiTF336674.

Enzyme and pathway databases

ReactomeiR-RNO-2172127. DAP12 interactions.
R-RNO-2424491. DAP12 signaling.

Miscellaneous databases

PROiO35778.

Gene expression databases

GenevisibleiO35778. RN.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of a gene in the rat homologous to human CD94."
    Dissen E., Berg S.F., Westgaard I.H., Fossum S.
    Eur. J. Immunol. 27:2080-2086(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiKLRD1_RAT
AccessioniPrimary (citable) accession number: O35778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.