Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Magnesium transporter protein 1

Gene

Magt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in N-glycosylation through its association with N-oligosaccharyl transferase. May be involved in Mg2+ transport in epithelial cells.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter protein 1
Short name:
MagT1
Alternative name(s):
Implantation-associated protein
Short name:
IAP
Gene namesi
Name:Magt1
Synonyms:Iag2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620094. Magt1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 184ExtracellularSequence analysisAdd BLAST155
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 209CytoplasmicSequence analysis4
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 270ExtracellularSequence analysisAdd BLAST40
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 300CytoplasmicSequence analysis9
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000021530130 – 335Magnesium transporter protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi87 ↔ 90Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35777.
PeptideAtlasiO35777.
PRIDEiO35777.

Interactioni

Subunit structurei

Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.By similarity

Protein-protein interaction databases

MINTiMINT-4567080.
STRINGi10116.ENSRNOP00000062502.

Structurei

3D structure databases

ProteinModelPortaliO35777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 175ThioredoxinAdd BLAST129

Sequence similaritiesi

Belongs to the OST3/OST6 family.Curated
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
HOGENOMiHOG000231301.
HOVERGENiHBG002493.
InParanoidiO35777.
KOiK19478.
PhylomeDBiO35777.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006844. Mg_transporter-1.
IPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12692:SF2. PTHR12692:SF2. 1 hit.
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRWLWCV CATAAVTLLL VSKVPSASAQ RKKEKVLVEK VIQLMEWTNQ
60 70 80 90 100
RPVIRMNGDK FRPLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL
110 120 130 140 150
ANFWRYSSAF TNRIFFAMVD FDEGSDVFQM LNMNSAPTFI NFPPKGKPKR
160 170 180 190 200
ADTYELQVRG FSAEQIARWI ADRTDVNIRV IRPPNYAGPL MLGLLLAVIG
210 220 230 240 250
GLVYLRRSNM EFLFNKTGWA FAALCFVLAM TSGQMWNHIR GPPYAHKNPH
260 270 280 290 300
TGHVNYIHGS SQAQFVAETH IVLLFNGGVT LGMVLLCEAA ASDMDIGKRR
310 320 330
MMCIAGIGLV VLFFSWMLSI FRSKYHGYPY SFLMS
Length:335
Mass (Da):37,993
Last modified:May 1, 1999 - v2
Checksum:iAFB9DB35F1A06091
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008554 mRNA. Translation: AAB63294.2.
RefSeqiNP_446398.1. NM_053946.1.
UniGeneiRn.43578.

Genome annotation databases

GeneIDi116967.
KEGGirno:116967.
UCSCiRGD:620094. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008554 mRNA. Translation: AAB63294.2.
RefSeqiNP_446398.1. NM_053946.1.
UniGeneiRn.43578.

3D structure databases

ProteinModelPortaliO35777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4567080.
STRINGi10116.ENSRNOP00000062502.

Proteomic databases

PaxDbiO35777.
PeptideAtlasiO35777.
PRIDEiO35777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116967.
KEGGirno:116967.
UCSCiRGD:620094. rat.

Organism-specific databases

CTDi84061.
RGDi620094. Magt1.

Phylogenomic databases

eggNOGiKOG2603. Eukaryota.
ENOG410XR1F. LUCA.
HOGENOMiHOG000231301.
HOVERGENiHBG002493.
InParanoidiO35777.
KOiK19478.
PhylomeDBiO35777.

Miscellaneous databases

PROiO35777.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006844. Mg_transporter-1.
IPR021149. OligosaccharylTrfase_OST3/OST6.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12692:SF2. PTHR12692:SF2. 1 hit.
PfamiPF04756. OST3_OST6. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMAGT1_RAT
AccessioniPrimary (citable) accession number: O35777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.