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Protein

A-kinase anchor protein 4

Gene

Akap4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major structural component of sperm fibrous sheath. May play a role in sperm motility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 4
Short name:
AKAP-4
Alternative name(s):
75 kDa fibrous sheath protein
Major sperm fibrous sheath protein
Protein kinase A-anchoring protein 4
Short name:
PRKA4
Gene namesi
Name:Akap4Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620828 Akap4

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00002482321 – 187Sequence analysisAdd BLAST187
ChainiPRO_0000248233188 – 847A-kinase anchor protein 4By similarityAdd BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95PhosphoserineCombined sources1
Modified residuei129PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei203PhosphoserineCombined sources1
Modified residuei206PhosphothreonineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei300PhosphotyrosineBy similarity1
Modified residuei301PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei491PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei505PhosphothreonineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei700PhosphoserineCombined sources1
Modified residuei729PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO35774
PRIDEiO35774

PTM databases

iPTMnetiO35774
PhosphoSitePlusiO35774

Expressioni

Tissue specificityi

Expressed in flagella of epididymal sperm.1 Publication

Interactioni

Subunit structurei

Interacts with PRKAR1A and PRKAR2A. Interacts with ENO4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003939

Structurei

3D structure databases

SMRiO35774
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni218 – 231Interaction with Prkar1a and Prkar2aBy similarityAdd BLAST14
Regioni334 – 343PKA-RI subunit binding domainBy similarity10

Domaini

RI-alpha binding site, predicted to form an amphipathic helix that is required for binding to Prkar1a.By similarity

Sequence similaritiesi

Belongs to the AKAP110 family.Curated

Phylogenomic databases

HOGENOMiHOG000220883
HOVERGENiHBG050478
InParanoidiO35774
KOiK16521
PhylomeDBiO35774

Family and domain databases

InterProiView protein in InterPro
IPR020799 AKAP_110
IPR018292 AKAP_110_C
IPR018459 RII_binding_1
IPR008382 SPHK1-interactor_AKAP_110
PANTHERiPTHR10226 PTHR10226, 1 hit
PfamiView protein in Pfam
PF05716 AKAP_110, 3 hits
PF10522 RII_binding_1, 1 hit
SMARTiView protein in SMART
SM00807 AKAP_110, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAYCGTTKM SDDIDWLHSR RGVCKVDLYS PEGQQDQDRK VICFVDVSTL
60 70 80 90 100
NVEDDSKGAA GPRSDGELNL ENLEEKEIIV IKDTEKQDQP KTEGSVCLFK
110 120 130 140 150
QAPSDPISVL NWLLNDLQKY ALGFQHALSP SASSCKHKVG DLEGDYHKIP
160 170 180 190 200
SENCYSVYAD QVNLDYLNKG PQNLRLEMAA SKNTNNNQSP SNPATKSPSN
210 220 230 240 250
QRSVATPDGE CSMDDLSYYV NRLSSLVIQM ARKEIKDKLE GGNKCLHHSM
260 270 280 290 300
YTSGEKGKTS PRSAVSKIAS EMAHEAVELT SSEMRGNGEE GRDGRKTFLY
310 320 330 340 350
SELSNKNKCG EKQQMCPKDS KEFADSISKG LMVYANQVAS DMMVSVMKTL
360 370 380 390 400
KVHSCGKPIP ACVVLKRVLL KHTKEIVSDL IDSCMKNLHN ITGVLMTDSD
410 420 430 440 450
FVSAVKRNLF NHGKQNAADI MEAMLKRLVS ALLGEKKETK SQSLAYATLK
460 470 480 490 500
AGTHDPKCKN QSLEFSAMKA EMKGKDKGKT KGDPCCKSLT SAERVSEHIL
510 520 530 540 550
KESLTMWNNQ KQGTQGRVPN KVCPSKDEKR EKISPSTDSL AKDLIVSALM
560 570 580 590 600
LIQYHLTQQA KGKDPCEEEC PGSSMGYMSQ SAQYEKSGGG QSSKSLSMKH
610 620 630 640 650
FESRGAPGPS TCAKENQLES QKMDMSNMVL SLIQKLLSES PFSCDELSES
660 670 680 690 700
ENKRCCDSRS KQAAPVAKRP EDQSQDSTEM DFISGMKQMN RQFIDQLVES
710 720 730 740 750
VMKLCLIMAK YSNNGAALAE LEEQAALASN GPRCGREAVM SQSYLETPGP
760 770 780 790 800
EVIVNNQCST SNLQKQLQAV LQWIAASQFN VPMLYFMGDD DGQLEKLPEV
810 820 830 840
SAKAAEKGYS VGDLLQEVMK FAKERQLDEA VGNMARKQLL DWLLANL
Length:847
Mass (Da):93,494
Last modified:January 1, 1998 - v1
Checksum:iA8F3DB78EA2C3914
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008114 mRNA Translation: AAB62877.1
RefSeqiNP_077378.1, NM_024402.1
UniGeneiRn.10777

Genome annotation databases

GeneIDi79254
KEGGirno:79254
UCSCiRGD:620828 rat

Similar proteinsi

Entry informationi

Entry nameiAKAP4_RAT
AccessioniPrimary (citable) accession number: O35774
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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