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Protein

Neuronal pentraxin receptor

Gene

Nptxr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi341 – 3411Calcium 1By similarity
Metal bindingi419 – 4191Calcium 1By similarity
Metal bindingi419 – 4191Calcium 2By similarity
Metal bindingi420 – 4201Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi421 – 4211Calcium 1By similarity
Metal bindingi421 – 4211Calcium 2By similarity
Metal bindingi431 – 4311Calcium 2By similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • pentraxin receptor activity Source: RGD
  • protein complex binding Source: RGD

GO - Biological processi

  • response to hydrogen peroxide Source: RGD
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin receptor
Gene namesi
Name:Nptxr
Synonyms:Npr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628898. Nptxr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence analysis
Transmembranei3 – 2321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini24 – 494471ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Neuronal pentraxin receptorPRO_0000162508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.
Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.By similarity

Keywords - PTMi

Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiO35764.
PRIDEiO35764.

PTM databases

UniCarbKBiO35764.

Expressioni

Tissue specificityi

Brain specific.

Interactioni

Subunit structurei

Interacts with KLHL2 (By similarity). Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2).By similarity2 Publications

GO - Molecular functioni

  • protein complex binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004703.

Structurei

3D structure databases

ProteinModelPortaliO35764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 494205PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KD04. Eukaryota.
ENOG410XTA3. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO35764.
PhylomeDBiO35764.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.

Sequencei

Sequence statusi: Complete.

O35764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGT DNASAASAAG
60 70 80 90 100
APGPQRSLSA LQGAGGSAGP SVLPGEPAAS VFPPPPGPLL SRFLCTPLAA
110 120 130 140 150
ACPSGAEQGD AAGERAELLL LQSTAEQLRQ TALQQEARIR ADRDTIRELT
160 170 180 190 200
GKLGRCESGL PRGLQDAGPR RDTMADGAWD SPALLVELEN AVRALRDRIE
210 220 230 240 250
RIEQELPARG NLSSSAPAPA VPTALHSKMD ELEGQLLAKV LALEKERAAL
260 270 280 290 300
SHGSHQQRQE VEKELDALQG RVAELEHGSS AYSPPDAFKV SIPIRNNYMY
310 320 330 340 350
ARVRKAVPEL YAFTACMWLR SRSGGSGQGT PFSYSVPGQA NEIVLLEAGL
360 370 380 390 400
EPMELLINDK VAQLPLSLKD SNWHHICIAW TTRDGLWSAY QDGELRGSGE
410 420 430 440 450
NLAAWHPIKP HGILILGQEQ DTLGGRFDAT QAFVGDIAQF NLWDHALTPA
460 470 480 490
QVLGIANCTG PLMGNVLPWE DKLVEAFGGA KKAAFDVCKR RAKA
Length:494
Mass (Da):52,371
Last modified:January 1, 1998 - v1
Checksum:iFEC996CA311E40E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005099 mRNA. Translation: AAB62885.1.
UniGeneiRn.34907.

Genome annotation databases

UCSCiRGD:628898. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005099 mRNA. Translation: AAB62885.1.
UniGeneiRn.34907.

3D structure databases

ProteinModelPortaliO35764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004703.

PTM databases

UniCarbKBiO35764.

Proteomic databases

PaxDbiO35764.
PRIDEiO35764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:628898. rat.

Organism-specific databases

RGDi628898. Nptxr.

Phylogenomic databases

eggNOGiENOG410KD04. Eukaryota.
ENOG410XTA3. LUCA.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiO35764.
PhylomeDBiO35764.

Miscellaneous databases

PROiO35764.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49."
    Dodds D.C., Omeis I.A., Cushman S.J., Helms J.A., Perin M.S.
    J. Biol. Chem. 272:21488-21494(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, SUBUNIT.
    Tissue: Brain.
  2. "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2."
    Kirkpatrick L.L., Matzuk M.M., Dodds D.C., Perin M.S.
    J. Biol. Chem. 275:17786-17792(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.

Entry informationi

Entry nameiNPTXR_RAT
AccessioniPrimary (citable) accession number: O35764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: January 20, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.