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Protein

Neuronal pentraxin receptor

Gene

Nptxr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi341Calcium 1By similarity1
Metal bindingi419Calcium 1By similarity1
Metal bindingi419Calcium 2PROSITE-ProRule annotation1
Metal bindingi420Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi421Calcium 1By similarity1
Metal bindingi421Calcium 2PROSITE-ProRule annotation1
Metal bindingi431Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • pentraxin receptor activity Source: RGD
  • protein-containing complex binding Source: RGD

GO - Biological processi

  • response to hydrogen peroxide Source: RGD

Keywordsi

Molecular functionReceptor
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin receptor
Gene namesi
Name:Nptxr
Synonyms:Npr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628898 Nptxr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini24 – 494ExtracellularSequence analysisAdd BLAST471

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625081 – 494Neuronal pentraxin receptorAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi211N-linked (HexNAc...) asparagine; alternateCombined sources1
Disulfide bondi316 ↔ 377PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.
Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing KLHL2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiO35764
PRIDEiO35764

PTM databases

UniCarbKBiO35764

Expressioni

Tissue specificityi

Brain specific.

Interactioni

Subunit structurei

Interacts with KLHL2 (By similarity). Heteropentamer with NPTX1 and/or NPTX2. Also binds taipoxin-associated calcium-binding protein 49 (TCBP49/RCN2).By similarity2 Publications

Protein-protein interaction databases

CORUMiO35764
STRINGi10116.ENSRNOP00000004703

Structurei

3D structure databases

ProteinModelPortaliO35764
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini286 – 488Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KD04 Eukaryota
ENOG410XTA3 LUCA
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiO35764
PhylomeDBiO35764

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O35764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLAVLLAA GMLAFLGAVI CIIASVPLAA SPARALPGGT DNASAASAAG
60 70 80 90 100
APGPQRSLSA LQGAGGSAGP SVLPGEPAAS VFPPPPGPLL SRFLCTPLAA
110 120 130 140 150
ACPSGAEQGD AAGERAELLL LQSTAEQLRQ TALQQEARIR ADRDTIRELT
160 170 180 190 200
GKLGRCESGL PRGLQDAGPR RDTMADGAWD SPALLVELEN AVRALRDRIE
210 220 230 240 250
RIEQELPARG NLSSSAPAPA VPTALHSKMD ELEGQLLAKV LALEKERAAL
260 270 280 290 300
SHGSHQQRQE VEKELDALQG RVAELEHGSS AYSPPDAFKV SIPIRNNYMY
310 320 330 340 350
ARVRKAVPEL YAFTACMWLR SRSGGSGQGT PFSYSVPGQA NEIVLLEAGL
360 370 380 390 400
EPMELLINDK VAQLPLSLKD SNWHHICIAW TTRDGLWSAY QDGELRGSGE
410 420 430 440 450
NLAAWHPIKP HGILILGQEQ DTLGGRFDAT QAFVGDIAQF NLWDHALTPA
460 470 480 490
QVLGIANCTG PLMGNVLPWE DKLVEAFGGA KKAAFDVCKR RAKA
Length:494
Mass (Da):52,371
Last modified:January 1, 1998 - v1
Checksum:iFEC996CA311E40E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005099 mRNA Translation: AAB62885.1
UniGeneiRn.34907

Genome annotation databases

UCSCiRGD:628898 rat

Similar proteinsi

Entry informationi

Entry nameiNPTXR_RAT
AccessioniPrimary (citable) accession number: O35764
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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