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Protein

Short stature homeobox protein 2

Gene

Shox2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi46 – 105HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Short stature homeobox protein 2
Alternative name(s):
Paired family homeodomain protein Prx3
Gene namesi
Name:Shox2
Synonyms:Prx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3674. Shox2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000049294‹1 – 237Short stature homeobox protein 2Add BLAST›237

Proteomic databases

PaxDbiO35750.
PRIDEiO35750.

Expressioni

Tissue specificityi

Expression restricted to a few regions in the brain: thalamic, tectal and brainstem structures that include relay nuclei of the visual and auditory systems as well as other ascending systems conveying somatosensory information. Not expressed in kidney, heart, lung, tongue and adrenal gland.

Developmental stagei

Neural expression in lateral and medial geniculate complex, superior and inferior colliculus, superficial gray layer of the superior colliculus, pontine reticular formation and inferior olive. Also expressed in non-neuronal structures around the oral cavity and in hip and shoulder regions.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016843.

Structurei

3D structure databases

ProteinModelPortaliO35750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 232OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG007233.
InParanoidiO35750.
KOiK09331.
PhylomeDBiO35750.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Fragment.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O35750-1) [UniParc]FASTAAdd to basket
Also known as: SHOX2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
RELDMGAAER SREPGSPRLT EVSPELKDRK EDAKGMEDEG QTKIKQRRSR
60 70 80 90 100
TNFTLEQLNE LERLFDETHY PDAFMREELS QRLGLSEARV QVWFQNRRAK
110 120 130 140 150
CRKQENQLHK GVLIGAASQF EACRVAPYVN VGALRMPFQQ DSHCNVTPLS
160 170 180 190 200
FQVQAHVQLD SAVRAAHHHL HPHLAAHGPY MMFPAPPFGL PLATLAADSA
210 220 230
SAASVVAAAA AAKTTSKNSS IADLRLKAKK HAAALGL
Length:237
Mass (Da):26,221
Last modified:September 26, 2001 - v2
Checksum:i96702BF3A25A144A
GO
Isoform 2 (identifier: O35750-2) [UniParc]FASTAAdd to basket
Also known as: SHOX2B

The sequence of this isoform differs from the canonical sequence as follows:
     141-152: Missing.

Show »
Length:225
Mass (Da):24,891
Checksum:iD626B9FE26F78206
GO

Sequence cautioni

The sequence CAA05283 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA05284 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti11 – 21SREPGSPRLTE → HTCGPSVVPSS in CAA05285 (PubMed:9371788).CuratedAdd BLAST11
Sequence conflicti172P → G in CAA05285 (PubMed:9371788).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002290141 – 152Missing in isoform 2. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002258 mRNA. Translation: CAA05283.1. Different initiation.
AJ002259 mRNA. Translation: CAA05284.1. Different initiation.
AJ002260 mRNA. Translation: CAA05285.1.
RefSeqiNP_037160.1. NM_013028.1.
UniGeneiRn.11258.

Genome annotation databases

GeneIDi25546.
KEGGirno:25546.
UCSCiRGD:3674. rat. [O35750-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002258 mRNA. Translation: CAA05283.1. Different initiation.
AJ002259 mRNA. Translation: CAA05284.1. Different initiation.
AJ002260 mRNA. Translation: CAA05285.1.
RefSeqiNP_037160.1. NM_013028.1.
UniGeneiRn.11258.

3D structure databases

ProteinModelPortaliO35750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016843.

Proteomic databases

PaxDbiO35750.
PRIDEiO35750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25546.
KEGGirno:25546.
UCSCiRGD:3674. rat. [O35750-1]

Organism-specific databases

CTDi6474.
RGDi3674. Shox2.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
HOGENOMiHOG000231518.
HOVERGENiHBG007233.
InParanoidiO35750.
KOiK09331.
PhylomeDBiO35750.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHOX2_RAT
AccessioniPrimary (citable) accession number: O35750
Secondary accession number(s): O35749, O35751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 5, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.