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Protein

GDNF family receptor alpha

Gene

Gfra1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alphaUniRule annotation
Gene namesi
Name:Gfra1Imported
ORF Names:rCG_57678Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2681 Gfra1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24UniRule annotationAdd BLAST24
ChainiPRO_501343307825 – 463GDNF family receptor alphaUniRule annotationAdd BLAST439

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 111GDNFInterPro annotationAdd BLAST83
Domaini149 – 228GDNFInterPro annotationAdd BLAST80
Domaini238 – 332GDNFInterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the GDNFR family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410IU4F Eukaryota
ENOG410XPTA LUCA
HOGENOMiHOG000008695
HOVERGENiHBG051725

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
IPR003503 GDNF_rcpt_A1
IPR017372 Glial_neurotroph_fac_rcpt_a1/2
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 3 hits
PIRSFiPIRSF038071 GDNF_family_receptor_alpha, 1 hit
PRINTSiPR01317 GDNFRALPHA1
PR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 3 hits
SUPFAMiSSF110035 SSF110035, 1 hit

Sequencei

Sequence statusi: Complete.

O35748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLATLYFAL PLLDLLMSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR
60 70 80 90 100
QCVAGKETNF SLTSGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL
110 120 130 140 150
RIYWSMYQSL QGNDLLEDSP YEPVNSRLSD IFRAVPFISV EHISKGNNCL
160 170 180 190 200
DAAKACNLDD TCKKYRSAYI TPCTTSMSNE VCNRRKCHKA LRQFFDKVPA
210 220 230 240 250
KHSYGMLFCS CRDIACTERR RQTIVPVCSY EERERPNCLS LQDSCKTNYI
260 270 280 290 300
CRSRLADFFT NCQPESRSVS NCLKENYADC LLAYSGLIGT VMTPNYVDSS
310 320 330 340 350
SLSVAPWCDC SNSGNDLEDC LKFLNFFKDN TCLKNAIQAF GNGSDVTMWQ
360 370 380 390 400
PAPPVQTTTA TTTTAFRVKN KPLGPAGSEN EIPTHVLPPC ANLQAQKLKS
410 420 430 440 450
NVSGSTHLCL SDSDFGKDGL AGASSHITTK SMAAPPSCSL SSLPVLMLTA
460
LAALLSVSLA ETS
Length:463
Mass (Da):51,032
Last modified:January 1, 1998 - v1
Checksum:iCCC9583ACE7353CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ002072 mRNA Translation: CAA05171.1
CH473986 Genomic DNA Translation: EDL94531.1
CH473986 Genomic DNA Translation: EDL94532.1
CH473986 Genomic DNA Translation: EDL94533.1
PIRiS69080
RefSeqiXP_008758736.1, XM_008760514.2
UniGeneiRn.88489

Genome annotation databases

GeneIDi25454

Similar proteinsi

Entry informationi

Entry nameiO35748_RAT
AccessioniPrimary (citable) accession number: O35748
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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