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Protein

Cbp/p300-interacting transactivator 2

Gene

Cited2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.7 Publications

GO - Molecular functioni

  • chromatin binding Source: UniProtKB
  • histone acetyltransferase binding Source: MGI
  • LBD domain binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: BHF-UCL
  • RNA polymerase II transcription coactivator activity Source: MGI
  • RNA polymerase II transcription corepressor activity Source: MGI
  • SMAD binding Source: MGI
  • transcription coactivator activity Source: UniProtKB
  • transcription cofactor activity Source: MGI
  • transcription corepressor activity Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • adrenal cortex formation Source: UniProtKB
  • adrenal gland development Source: MGI
  • blood vessel development Source: MGI
  • bone morphogenesis Source: MGI
  • cardiac neural crest cell development involved in heart development Source: MGI
  • cardiac septum morphogenesis Source: MGI
  • cell aging Source: Ensembl
  • cell proliferation Source: UniProtKB
  • central nervous system development Source: MGI
  • cranial nerve morphogenesis Source: MGI
  • decidualization Source: MGI
  • determination of heart left/right asymmetry Source: MGI
  • determination of left/right symmetry Source: UniProtKB
  • embryonic camera-type eye morphogenesis Source: MGI
  • embryonic heart tube left/right pattern formation Source: BHF-UCL
  • embryonic placenta development Source: MGI
  • embryonic process involved in female pregnancy Source: MGI
  • endocardial cushion development Source: MGI
  • erythrocyte development Source: MGI
  • granulocyte differentiation Source: MGI
  • heart development Source: UniProtKB
  • heart looping Source: MGI
  • hematopoietic progenitor cell differentiation Source: MGI
  • in utero embryonic development Source: MGI
  • left/right axis specification Source: BHF-UCL
  • lens morphogenesis in camera-type eye Source: MGI
  • leukocyte differentiation Source: MGI
  • liver development Source: BHF-UCL
  • male gonad development Source: MGI
  • negative regulation of apoptotic process Source: BHF-UCL
  • negative regulation of cell migration Source: MGI
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: MGI
  • neural tube closure Source: MGI
  • neural tube formation Source: MGI
  • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
  • outflow tract morphogenesis Source: BHF-UCL
  • peripheral nervous system development Source: MGI
  • positive regulation of cell-cell adhesion Source: BHF-UCL
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of male gonad development Source: UniProtKB
  • positive regulation of peroxisome proliferator activated receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • pulmonary artery morphogenesis Source: MGI
  • regulation of nucleic acid-templated transcription Source: MGI
  • regulation of organ formation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to estrogen Source: UniProtKB
  • response to fluid shear stress Source: MGI
  • response to hypoxia Source: UniProtKB
  • response to mechanical stimulus Source: Ensembl
  • sex determination Source: UniProtKB
  • skeletal muscle cell differentiation Source: MGI
  • spleen development Source: BHF-UCL
  • thymus development Source: MGI
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • trophectodermal cell differentiation Source: MGI
  • vasculature development Source: MGI
  • vasculogenesis Source: MGI
  • ventricular septum development Source: MGI
  • ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-1234158. Regulation of gene expression by Hypoxia-inducible Factor.

Names & Taxonomyi

Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 2
Alternative name(s):
MSG-related protein 1
Short name:
MRG-1
P35srj
Gene namesi
Name:Cited2
Synonyms:Mrg1, Msg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1306784. Cited2.

Subcellular locationi

  • Nucleus

  • Note: Colocalizes with EP300 in dot-like structures.By similarity

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nuclear chromatin Source: BHF-UCL
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice embryos die during gestation with left-right patterning defects and severe developmental abnormalities, including cardiac malformations, exencephaly and adrenal agenesis. Show also impaired mesonephric tubules and adrenal cortex development in embryos.5 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Cbp/p300-interacting transactivator 2PRO_0000144727Add
BLAST

Proteomic databases

MaxQBiO35740.
PaxDbiO35740.
PRIDEiO35740.

PTM databases

iPTMnetiO35740.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Developmental stagei

Expressed in the embryonic heart. Expressed in the ventral node, cardiac crescent and blood islands at 7.5 dpc. Expressed in the cardiac crescent, anterior lateral mesoderm and in trunk paraxial mesoderm at 8 dpc. Expressed in forebrain-midbrain boundary, branchial arches 1 and 2, heart and somites at 9.5 dpc (at protein level). Expressed in the coelomic epithelium and in cells in the underlying nephrogenic mesenchyme of the genital ridge at 10 dpc. Expressed in the genital ridge and the presumptive adrenal area at 10.5 dpc. Expressed in the gonad and in the adrenal anlagen at 12 dpc. Expressed in the cells of the adrenal cortex at 14 dpc. Expressed throughout the embryonic heart, as well as in the node and the lateral plate mesoderm (LPM), that are responsible for initiating and maintaining left-right patterning. Expressed in the crown cells of the node.4 Publications

Gene expression databases

GenevisibleiO35740. MM.

Interactioni

Subunit structurei

Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C (By similarity). Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 isoform 1 and isoform 3.By similarity3 Publications

GO - Molecular functioni

  • histone acetyltransferase binding Source: MGI
  • LBD domain binding Source: MGI
  • RNA polymerase II activating transcription factor binding Source: BHF-UCL
  • SMAD binding Source: MGI

Protein-protein interaction databases

BioGridi201524. 6 interactions.
MINTiMINT-365410.
STRINGi10090.ENSMUSP00000038405.

Structurei

3D structure databases

ProteinModelPortaliO35740.
SMRiO35740. Positions 219-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 5737His-richAdd
BLAST
Compositional biasi162 – 19736Gly-richAdd
BLAST
Compositional biasi218 – 25740Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the CITED family.Curated

Phylogenomic databases

eggNOGiENOG410IH9P. Eukaryota.
ENOG410Y09Y. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiO35740.
OMAiDHIHYGA.
OrthoDBiEOG72NRRB.
TreeFamiTF331915.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 2 hits.
PfamiPF04487. CITED. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O35740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA
60 70 80 90 100
LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG
110 120 130 140 150
PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP TAGHQMNGTN
160 170 180 190 200
QHFRDCNPKH SGGSSTPGGA GGSGTPGGSG GTSGGAGGSS AGGSGGGSTM
210 220 230 240 250
PASVAHVPAA MLPPNVIDTD FIDEEVLMSL VIEMGLDRIK ELPELWLGQN
260
EFDFMTDFVC KQQPSRVSC
Length:269
Mass (Da):28,321
Last modified:October 3, 2012 - v2
Checksum:i0FFCD8C21E4E3D81
GO
Isoform 2 (identifier: O35740-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-158: Missing.

Show »
Length:248
Mass (Da):25,964
Checksum:i19D4847D7205947E
GO
Isoform 3 (identifier: O35740-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-213: Missing.

Show »
Length:214
Mass (Da):23,859
Checksum:iABA833F5CFA85270
GO
Isoform 4 (identifier: O35740-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-213: Missing.

Show »
Length:258
Mass (Da):27,247
Checksum:i3D8803D5F9393903
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1952SG → TC in CAA75432 (PubMed:9533950).Curated
Sequence conflicti194 – 1952SG → TC in CAA75435 (PubMed:9533950).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei138 – 15821Missing in isoform 2. 1 PublicationVSP_001090Add
BLAST
Alternative sequencei159 – 21355Missing in isoform 3. 2 PublicationsVSP_001091Add
BLAST
Alternative sequencei203 – 21311Missing in isoform 4. 1 PublicationVSP_001092Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15163 mRNA. Translation: CAA75432.1.
Y15163 mRNA. Translation: CAA75433.1.
Y15163 mRNA. Translation: CAA75434.1.
Y15163 mRNA. Translation: CAA75435.1.
U86445 mRNA. Translation: AAC39945.1.
AK131664 mRNA. Translation: BAE20751.1.
AK133791 mRNA. Translation: BAE21844.1.
AC105167 Genomic DNA. No translation available.
CH466562 Genomic DNA. Translation: EDL03481.1.
BC057126 mRNA. Translation: AAH57126.1.
CCDSiCCDS23708.1. [O35740-1]
RefSeqiNP_034958.2. NM_010828.3. [O35740-1]
XP_006512639.1. XM_006512576.2. [O35740-1]
UniGeneiMm.272321.

Genome annotation databases

EnsembliENSMUST00000038107; ENSMUSP00000038405; ENSMUSG00000039910. [O35740-1]
GeneIDi17684.
KEGGimmu:17684.
UCSCiuc007elt.2. mouse. [O35740-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15163 mRNA. Translation: CAA75432.1.
Y15163 mRNA. Translation: CAA75433.1.
Y15163 mRNA. Translation: CAA75434.1.
Y15163 mRNA. Translation: CAA75435.1.
U86445 mRNA. Translation: AAC39945.1.
AK131664 mRNA. Translation: BAE20751.1.
AK133791 mRNA. Translation: BAE21844.1.
AC105167 Genomic DNA. No translation available.
CH466562 Genomic DNA. Translation: EDL03481.1.
BC057126 mRNA. Translation: AAH57126.1.
CCDSiCCDS23708.1. [O35740-1]
RefSeqiNP_034958.2. NM_010828.3. [O35740-1]
XP_006512639.1. XM_006512576.2. [O35740-1]
UniGeneiMm.272321.

3D structure databases

ProteinModelPortaliO35740.
SMRiO35740. Positions 219-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201524. 6 interactions.
MINTiMINT-365410.
STRINGi10090.ENSMUSP00000038405.

PTM databases

iPTMnetiO35740.

Proteomic databases

MaxQBiO35740.
PaxDbiO35740.
PRIDEiO35740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038107; ENSMUSP00000038405; ENSMUSG00000039910. [O35740-1]
GeneIDi17684.
KEGGimmu:17684.
UCSCiuc007elt.2. mouse. [O35740-1]

Organism-specific databases

CTDi10370.
MGIiMGI:1306784. Cited2.

Phylogenomic databases

eggNOGiENOG410IH9P. Eukaryota.
ENOG410Y09Y. LUCA.
GeneTreeiENSGT00530000063624.
HOGENOMiHOG000231079.
HOVERGENiHBG075182.
InParanoidiO35740.
OMAiDHIHYGA.
OrthoDBiEOG72NRRB.
TreeFamiTF331915.

Enzyme and pathway databases

ReactomeiR-MMU-1234158. Regulation of gene expression by Hypoxia-inducible Factor.

Miscellaneous databases

PROiO35740.
SOURCEiSearch...

Gene expression databases

GenevisibleiO35740. MM.

Family and domain databases

InterProiIPR007576. CITED.
[Graphical view]
PANTHERiPTHR17045. PTHR17045. 2 hits.
PfamiPF04487. CITED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Msg1 and Mrg1, founding members of a gene family, show distinct patterns of gene expression during mouse embryogenesis."
    Dunwoodie S.L., Rodriguez T.A., Beddington R.S.P.
    Mech. Dev. 72:27-40(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: C57BL/6 X DBA.
  2. "MSG1 and its related protein MRG1 share a transcription activating domain."
    Shioda T., Fenner M.H., Isselbacher K.J.
    Gene 204:235-241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  7. "MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression."
    Glenn D.J., Maurer R.A.
    J. Biol. Chem. 274:36159-36167(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LHX2.
  8. "Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator."
    Bamforth S.D., Braganca J., Eloranta J.J., Murdoch J.N., Marques F.I., Kranc K.R., Farza H., Henderson D.J., Hurst H.C., Bhattacharya S.
    Nat. Genet. 29:469-474(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  9. "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator."
    Tien E.S., Davis J.W., Vanden Heuvel J.P.
    J. Biol. Chem. 279:24053-24063(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. Cited for: FUNCTION, ASSOCIATION WITH CHROMATIN, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  11. "Cited2 modulates TGF-beta-mediated upregulation of MMP9."
    Chou Y.T., Wang H., Chen Y., Danielpour D., Yang Y.C.
    Oncogene 25:5547-5560(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMAD2 AND SMAD3.
  12. "Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development."
    Weninger W.J., Lopes Floro K., Bennett M.B., Withington S.L., Preis J.I., Barbera J.P., Mohun T.J., Dunwoodie S.L.
    Development 132:1337-1348(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  13. "Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage."
    Val P., Martinez-Barbera J.P., Swain A.
    Development 134:2349-2358(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH WT1, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  14. "The transcription co-factor CITED2 functions during sex determination and early gonad development."
    Buaas F.W., Val P., Swain A.
    Hum. Mol. Genet. 18:2989-3001(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  15. "Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis."
    Lopes Floro K., Artap S.T., Preis J.I., Fatkin D., Chapman G., Furtado M.B., Harvey R.P., Hamada H., Sparrow D.B., Dunwoodie S.L.
    Hum. Mol. Genet. 20:1097-1110(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiCITE2_MOUSE
AccessioniPrimary (citable) accession number: O35740
Secondary accession number(s): O35741
, O35742, O35743, O55198, Q6PGA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.