ID   KLF9_MOUSE              Reviewed;         244 AA.
AC   O35739;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Krueppel-like factor 9;
DE   AltName: Full=Basic transcription element-binding protein 1;
DE            Short=BTE-binding protein 1;
DE   AltName: Full=GC-box-binding protein 1;
DE   AltName: Full=Transcription factor BTEB1;
GN   Name=Klf9; Synonyms=Bteb, Bteb-1, Bteb1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=9858544; DOI=10.1128/mcb.19.1.194;
RA   Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R.,
RA   Buettner R.;
RT   "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-
RT   2rep, a novel wt-1/egr-related zinc finger repressor.";
RL   Mol. Cell. Biol. 19:194-204(1999).
CC   -!- FUNCTION: Transcription factor that binds to GC box promoter elements.
CC       Selectively activates mRNA synthesis from genes containing tandem
CC       repeats of GC boxes but represses genes with a single GC box. Acts as
CC       an epidermal circadian transcription factor regulating keratinocyte
CC       proliferation. {ECO:0000250|UniProtKB:Q13886}.
CC   -!- SUBUNIT: Interacts with ZZEF1. {ECO:0000250|UniProtKB:Q13886}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13886}.
CC   -!- SIMILARITY: Belongs to the Sp1 C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; Y14296; CAA74671.1; -; mRNA.
DR   CCDS; CCDS29706.1; -.
DR   AlphaFoldDB; O35739; -.
DR   SMR; O35739; -.
DR   IntAct; O35739; 2.
DR   STRING; 10090.ENSMUSP00000045639; -.
DR   iPTMnet; O35739; -.
DR   PhosphoSitePlus; O35739; -.
DR   PaxDb; 10090-ENSMUSP00000045639; -.
DR   PeptideAtlas; O35739; -.
DR   ProteomicsDB; 264769; -.
DR   AGR; MGI:1333856; -.
DR   MGI; MGI:1333856; Klf9.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; O35739; -.
DR   PhylomeDB; O35739; -.
DR   ChiTaRS; Klf9; mouse.
DR   PRO; PR:O35739; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O35739; Protein.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; ISS:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0071387; P:cellular response to cortisol stimulus; ISS:UniProtKB.
DR   GO; GO:0007566; P:embryo implantation; IDA:MGI.
DR   GO; GO:0010839; P:negative regulation of keratinocyte proliferation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0050847; P:progesterone receptor signaling pathway; IDA:MGI.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IDA:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   CDD; cd21578; KLF9_N; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR23235:SF132; KRUEPPEL-LIKE FACTOR 9; 1.
DR   PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Biological rhythms; DNA-binding; Metal-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..244
FT                   /note="Krueppel-like factor 9"
FT                   /id="PRO_0000047155"
FT   ZN_FING         143..167
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         173..197
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         203..225
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          26..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13886"
SQ   SEQUENCE   244 AA;  27170 MW;  BBDF607FFA218D5A CRC64;
     MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PEAERLRLPE REVTKEHGDP GDTWKDYCTL
     VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDIGSDSDVT TESGSSPSHS PEERQDSGSA
     PSPLSLLHSG VASKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC
     LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTVFHP SMIKRSKKAL
     ACPL
//