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O35739

- KLF9_MOUSE

UniProt

O35739 - KLF9_MOUSE

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Protein

Krueppel-like factor 9

Gene
Klf9, Bteb, Bteb-1, Bteb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16725C2H2-type 1Add
BLAST
Zinc fingeri173 – 19725C2H2-type 2Add
BLAST
Zinc fingeri203 – 22523C2H2-type 3Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. embryo implantation Source: MGI
  2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  3. progesterone receptor signaling pathway Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 9
Alternative name(s):
Basic transcription element-binding protein 1
Short name:
BTE-binding protein 1
GC-box-binding protein 1
Transcription factor BTEB1
Gene namesi
Name:Klf9
Synonyms:Bteb, Bteb-1, Bteb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1333856. Klf9.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Krueppel-like factor 9PRO_0000047155Add
BLAST

Proteomic databases

PRIDEiO35739.

PTM databases

PhosphoSiteiO35739.

Expressioni

Gene expression databases

CleanExiMM_KLF9.
GenevestigatoriO35739.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045639.

Structurei

3D structure databases

ProteinModelPortaliO35739.
SMRiO35739. Positions 76-110, 140-225.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi84 – 11633Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiO35739.
PhylomeDBiO35739.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35739-1 [UniParc]FASTAAdd to Basket

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MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PEAERLRLPE REVTKEHGDP    50
GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDIGSDSDVT 100
TESGSSPSHS PEERQDSGSA PSPLSLLHSG VASKGKHASE KRHKCPYSGC 150
GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE 200
KQFRCPLCEK RFMRSDHLTK HARRHTVFHP SMIKRSKKAL ACPL 244
Length:244
Mass (Da):27,170
Last modified:January 1, 1998 - v1
Checksum:iBBDF607FFA218D5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14296 mRNA. Translation: CAA74671.1.
CCDSiCCDS29706.1.
UniGeneiMm.291595.
Mm.392684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14296 mRNA. Translation: CAA74671.1 .
CCDSi CCDS29706.1.
UniGenei Mm.291595.
Mm.392684.

3D structure databases

ProteinModelPortali O35739.
SMRi O35739. Positions 76-110, 140-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000045639.

PTM databases

PhosphoSitei O35739.

Proteomic databases

PRIDEi O35739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1333856. Klf9.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000233575.
HOVERGENi HBG050746.
InParanoidi O35739.
PhylomeDBi O35739.

Miscellaneous databases

ChiTaRSi KLF9. mouse.
PROi O35739.
SOURCEi Search...

Gene expression databases

CleanExi MM_KLF9.
Genevestigatori O35739.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
    Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
    Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.

Entry informationi

Entry nameiKLF9_MOUSE
AccessioniPrimary (citable) accession number: O35739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi