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O35739

- KLF9_MOUSE

UniProt

O35739 - KLF9_MOUSE

Protein

Krueppel-like factor 9

Gene

Klf9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. embryo implantation Source: MGI
    2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    3. progesterone receptor signaling pathway Source: MGI
    4. regulation of transcription, DNA-templated Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 9
    Alternative name(s):
    Basic transcription element-binding protein 1
    Short name:
    BTE-binding protein 1
    GC-box-binding protein 1
    Transcription factor BTEB1
    Gene namesi
    Name:Klf9
    Synonyms:Bteb, Bteb-1, Bteb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1333856. Klf9.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Krueppel-like factor 9PRO_0000047155Add
    BLAST

    Proteomic databases

    PRIDEiO35739.

    PTM databases

    PhosphoSiteiO35739.

    Expressioni

    Gene expression databases

    CleanExiMM_KLF9.
    GenevestigatoriO35739.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000045639.

    Structurei

    3D structure databases

    ProteinModelPortaliO35739.
    SMRiO35739. Positions 76-110, 140-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi84 – 11633Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri143 – 16725C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri173 – 19725C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri203 – 22523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000233575.
    HOVERGENiHBG050746.
    InParanoidiO35739.
    PhylomeDBiO35739.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAAAYMDFV AAQCLVSISN RAAVPEHGGA PEAERLRLPE REVTKEHGDP    50
    GDTWKDYCTL VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDIGSDSDVT 100
    TESGSSPSHS PEERQDSGSA PSPLSLLHSG VASKGKHASE KRHKCPYSGC 150
    GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC LKKFSRSDEL TRHYRTHTGE 200
    KQFRCPLCEK RFMRSDHLTK HARRHTVFHP SMIKRSKKAL ACPL 244
    Length:244
    Mass (Da):27,170
    Last modified:January 1, 1998 - v1
    Checksum:iBBDF607FFA218D5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14296 mRNA. Translation: CAA74671.1.
    CCDSiCCDS29706.1.
    UniGeneiMm.291595.
    Mm.392684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14296 mRNA. Translation: CAA74671.1 .
    CCDSi CCDS29706.1.
    UniGenei Mm.291595.
    Mm.392684.

    3D structure databases

    ProteinModelPortali O35739.
    SMRi O35739. Positions 76-110, 140-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000045639.

    PTM databases

    PhosphoSitei O35739.

    Proteomic databases

    PRIDEi O35739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1333856. Klf9.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000233575.
    HOVERGENi HBG050746.
    InParanoidi O35739.
    PhylomeDBi O35739.

    Miscellaneous databases

    ChiTaRSi KLF9. mouse.
    PROi O35739.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_KLF9.
    Genevestigatori O35739.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
      Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
      Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.

    Entry informationi

    Entry nameiKLF9_MOUSE
    AccessioniPrimary (citable) accession number: O35739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3