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O35738

- KLF12_MOUSE

UniProt

O35738 - KLF12_MOUSE

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Protein

Krueppel-like factor 12

Gene

Klf12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  5. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:Klf12
Synonyms:Ap2rep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1333796. Klf12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Krueppel-like factor 12PRO_0000047183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei313 – 3131N6-methylated lysine; by EHMT2By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiO35738.
PRIDEiO35738.

PTM databases

PhosphoSiteiO35738.

Expressioni

Gene expression databases

BgeeiO35738.
CleanExiMM_KLF12.
GenevestigatoriO35738.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094844.

Structurei

3D structure databases

ProteinModelPortaliO35738.
SMRiO35738. Positions 306-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiO35738.
KOiK09205.
OMAiSLPLMYT.
OrthoDBiEOG747PJ4.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD
60 70 80 90 100
MEAVPLLLNN VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP
110 120 130 140 150
VSMTASASSP SSTSTSSSSS SRPASSPTVI TSVSSASSSS TVLSPGPLVA
160 170 180 190 200
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV
210 220 230 240 250
RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS DDDDLPNVTL
260 270 280 290 300
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST
310 320 330 340 350
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT
360 370 380 390 400
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM

LV
Length:402
Mass (Da):44,105
Last modified:July 27, 2011 - v2
Checksum:iB80D73C2123F1FF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051A → G in CAA74670. (PubMed:9858544)Curated
Sequence conflicti135 – 1351S → R in CAA74670. (PubMed:9858544)Curated
Sequence conflicti359 – 3591A → G in CAA74670. (PubMed:9858544)Curated
Sequence conflicti385 – 3851S → R in CAA74670. (PubMed:9858544)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14295 mRNA. Translation: CAA74670.1.
BC067408 mRNA. Translation: AAH67408.1.
CCDSiCCDS36998.1.
RefSeqiNP_034766.2. NM_010636.3.
XP_006518686.1. XM_006518623.1.
XP_006518687.1. XM_006518624.1.
UniGeneiMm.396499.
Mm.458816.

Genome annotation databases

EnsembliENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294.
GeneIDi16597.
KEGGimmu:16597.
UCSCiuc007uvh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14295 mRNA. Translation: CAA74670.1 .
BC067408 mRNA. Translation: AAH67408.1 .
CCDSi CCDS36998.1.
RefSeqi NP_034766.2. NM_010636.3.
XP_006518686.1. XM_006518623.1.
XP_006518687.1. XM_006518624.1.
UniGenei Mm.396499.
Mm.458816.

3D structure databases

ProteinModelPortali O35738.
SMRi O35738. Positions 306-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000094844.

PTM databases

PhosphoSitei O35738.

Proteomic databases

MaxQBi O35738.
PRIDEi O35738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097079 ; ENSMUSP00000094844 ; ENSMUSG00000072294 .
GeneIDi 16597.
KEGGi mmu:16597.
UCSCi uc007uvh.2. mouse.

Organism-specific databases

CTDi 11278.
MGIi MGI:1333796. Klf12.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118998.
HOGENOMi HOG000232138.
HOVERGENi HBG003941.
InParanoidi O35738.
KOi K09205.
OMAi SLPLMYT.
OrthoDBi EOG747PJ4.
TreeFami TF350556.

Miscellaneous databases

ChiTaRSi Klf12. mouse.
NextBioi 290165.
PROi O35738.
SOURCEi Search...

Gene expression databases

Bgeei O35738.
CleanExi MM_KLF12.
Genevestigatori O35738.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
    Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
    Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1.
    Tissue: Neural stem cell.

Entry informationi

Entry nameiKLF12_MOUSE
AccessioniPrimary (citable) accession number: O35738
Secondary accession number(s): Q6NWV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3