SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35738

- KLF12_MOUSE

UniProt

O35738 - KLF12_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Krueppel-like factor 12
Gene
Klf12, Ap2rep
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri317 – 34125C2H2-type 1
Add
BLAST
Zinc fingeri347 – 37125C2H2-type 2
Add
BLAST
Zinc fingeri377 – 39923C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  3. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
  4. metal ion binding Source: UniProtKB-KW
  5. protein binding Source: BHF-UCL
  6. sequence-specific DNA binding transcription factor activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene namesi
Name:Klf12
Synonyms:Ap2rep
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1333796. Klf12.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Krueppel-like factor 12
PRO_0000047183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021Phosphoserine By similarity
Modified residuei313 – 3131N6-methylated lysine; by EHMT2 By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiO35738.

PTM databases

PhosphoSiteiO35738.

Expressioni

Gene expression databases

BgeeiO35738.
CleanExiMM_KLF12.
GenevestigatoriO35738.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094844.

Structurei

3D structure databases

ProteinModelPortaliO35738.
SMRiO35738. Positions 306-402.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00750000117621.
HOGENOMiHOG000232138.
HOVERGENiHBG003941.
InParanoidiQ6NWV9.
KOiK09205.
OMAiSLPLMYT.
OrthoDBiEOG747PJ4.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35738-1 [UniParc]FASTAAdd to Basket

« Hide

MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD    50
MEAVPLLLNN VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP 100
VSMTASASSP SSTSTSSSSS SRPASSPTVI TSVSSASSSS TVLSPGPLVA 150
SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV 200
RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS DDDDLPNVTL 250
DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST 300
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT 350
WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM 400
LV 402
Length:402
Mass (Da):44,105
Last modified:July 27, 2011 - v2
Checksum:iB80D73C2123F1FF5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1051A → G in CAA74670. 1 Publication
Sequence conflicti135 – 1351S → R in CAA74670. 1 Publication
Sequence conflicti359 – 3591A → G in CAA74670. 1 Publication
Sequence conflicti385 – 3851S → R in CAA74670. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14295 mRNA. Translation: CAA74670.1.
BC067408 mRNA. Translation: AAH67408.1.
CCDSiCCDS36998.1.
RefSeqiNP_034766.2. NM_010636.3.
XP_006518686.1. XM_006518623.1.
XP_006518687.1. XM_006518624.1.
UniGeneiMm.396499.
Mm.458816.

Genome annotation databases

EnsembliENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294.
GeneIDi16597.
KEGGimmu:16597.
UCSCiuc007uvh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14295 mRNA. Translation: CAA74670.1 .
BC067408 mRNA. Translation: AAH67408.1 .
CCDSi CCDS36998.1.
RefSeqi NP_034766.2. NM_010636.3.
XP_006518686.1. XM_006518623.1.
XP_006518687.1. XM_006518624.1.
UniGenei Mm.396499.
Mm.458816.

3D structure databases

ProteinModelPortali O35738.
SMRi O35738. Positions 306-402.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000094844.

PTM databases

PhosphoSitei O35738.

Proteomic databases

PRIDEi O35738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097079 ; ENSMUSP00000094844 ; ENSMUSG00000072294 .
GeneIDi 16597.
KEGGi mmu:16597.
UCSCi uc007uvh.2. mouse.

Organism-specific databases

CTDi 11278.
MGIi MGI:1333796. Klf12.

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00750000117621.
HOGENOMi HOG000232138.
HOVERGENi HBG003941.
InParanoidi Q6NWV9.
KOi K09205.
OMAi SLPLMYT.
OrthoDBi EOG747PJ4.
TreeFami TF350556.

Miscellaneous databases

ChiTaRSi KLF12. mouse.
NextBioi 290165.
PROi O35738.
SOURCEi Search...

Gene expression databases

Bgeei O35738.
CleanExi MM_KLF12.
Genevestigatori O35738.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
    Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
    Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1.
    Tissue: Neural stem cell.

Entry informationi

Entry nameiKLF12_MOUSE
AccessioniPrimary (citable) accession number: O35738
Secondary accession number(s): Q6NWV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi