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O35738 (KLF12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 12
Alternative name(s):
Transcriptional repressor AP-2rep
Gene names
Name:Klf12
Synonyms:Ap2rep
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Krueppel-like factor 12
PRO_0000047183

Regions

Zinc finger317 – 34125C2H2-type 1
Zinc finger347 – 37125C2H2-type 2
Zinc finger377 – 39923C2H2-type 3

Amino acid modifications

Modified residue2021Phosphoserine By similarity
Modified residue3131N6-methylated lysine; by EHMT2 By similarity

Experimental info

Sequence conflict1051A → G in CAA74670. Ref.1
Sequence conflict1351S → R in CAA74670. Ref.1
Sequence conflict3591A → G in CAA74670. Ref.1
Sequence conflict3851S → R in CAA74670. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35738 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B80D73C2123F1FF5

FASTA40244,105
        10         20         30         40         50         60 
MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD MEAVPLLLNN 

        70         80         90        100        110        120 
VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP VSMTASASSP SSTSTSSSSS 

       130        140        150        160        170        180 
SRPASSPTVI TSVSSASSSS TVLSPGPLVA SASGVGGQQF LHIIHPVPPS SPMNLQSNKL 

       190        200        210        220        230        240 
SHVHRIPVVV QSVPVVYTAV RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS 

       250        260        270        280        290        300 
DDDDLPNVTL DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST 

       310        320        330        340        350        360 
RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT WEGCTWKFAR 

       370        380        390        400 
SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM LV 

« Hide

References

« Hide 'large scale' references
[1]"Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CD-1.
Tissue: Neural stem cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14295 mRNA. Translation: CAA74670.1.
BC067408 mRNA. Translation: AAH67408.1.
CCDSCCDS36998.1.
RefSeqNP_034766.2. NM_010636.3.
XP_006518686.1. XM_006518623.1.
XP_006518687.1. XM_006518624.1.
UniGeneMm.396499.
Mm.458816.

3D structure databases

ProteinModelPortalO35738.
SMRO35738. Positions 306-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000094844.

PTM databases

PhosphoSiteO35738.

Proteomic databases

PRIDEO35738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294.
GeneID16597.
KEGGmmu:16597.
UCSCuc007uvh.2. mouse.

Organism-specific databases

CTD11278.
MGIMGI:1333796. Klf12.

Phylogenomic databases

eggNOGCOG5048.
GeneTreeENSGT00750000117621.
HOGENOMHOG000232138.
HOVERGENHBG003941.
InParanoidQ6NWV9.
KOK09205.
OMASLPLMYT.
OrthoDBEOG747PJ4.
TreeFamTF350556.

Gene expression databases

BgeeO35738.
CleanExMM_KLF12.
GenevestigatorO35738.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF12. mouse.
NextBio290165.
PROO35738.
SOURCESearch...

Entry information

Entry nameKLF12_MOUSE
AccessionPrimary (citable) accession number: O35738
Secondary accession number(s): Q6NWV9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot