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O35738

- KLF12_MOUSE

UniProt

O35738 - KLF12_MOUSE

Protein

Krueppel-like factor 12

Gene

Klf12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: BHF-UCL
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    5. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. regulation of transcription, DNA-templated Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 12
    Alternative name(s):
    Transcriptional repressor AP-2rep
    Gene namesi
    Name:Klf12
    Synonyms:Ap2rep
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1333796. Klf12.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Krueppel-like factor 12PRO_0000047183Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei202 – 2021PhosphoserineBy similarity
    Modified residuei313 – 3131N6-methylated lysine; by EHMT2By similarity

    Keywords - PTMi

    Methylation, Phosphoprotein

    Proteomic databases

    PRIDEiO35738.

    PTM databases

    PhosphoSiteiO35738.

    Expressioni

    Gene expression databases

    BgeeiO35738.
    CleanExiMM_KLF12.
    GenevestigatoriO35738.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000094844.

    Structurei

    3D structure databases

    ProteinModelPortaliO35738.
    SMRiO35738. Positions 306-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri317 – 34125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 37125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri377 – 39923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00750000117621.
    HOGENOMiHOG000232138.
    HOVERGENiHBG003941.
    InParanoidiQ6NWV9.
    KOiK09205.
    OMAiSLPLMYT.
    OrthoDBiEOG747PJ4.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35738-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIHMKRKTI KNLSALENRM LMLDGMPAVR VKTELVESEQ GSPNVHNYPD    50
    MEAVPLLLNN VKGEPPEDSL PVDHFQTQTE PVDLSINKAR TSPTAASSSP 100
    VSMTASASSP SSTSTSSSSS SRPASSPTVI TSVSSASSSS TVLSPGPLVA 150
    SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV 200
    RSPGNVNNTI VVPLLEDGRS HGKAQMEPRG LSPRQSKSDS DDDDLPNVTL 250
    DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFAC SISPFSIEST 300
    RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT 350
    WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM 400
    LV 402
    Length:402
    Mass (Da):44,105
    Last modified:July 27, 2011 - v2
    Checksum:iB80D73C2123F1FF5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti105 – 1051A → G in CAA74670. (PubMed:9858544)Curated
    Sequence conflicti135 – 1351S → R in CAA74670. (PubMed:9858544)Curated
    Sequence conflicti359 – 3591A → G in CAA74670. (PubMed:9858544)Curated
    Sequence conflicti385 – 3851S → R in CAA74670. (PubMed:9858544)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14295 mRNA. Translation: CAA74670.1.
    BC067408 mRNA. Translation: AAH67408.1.
    CCDSiCCDS36998.1.
    RefSeqiNP_034766.2. NM_010636.3.
    XP_006518686.1. XM_006518623.1.
    XP_006518687.1. XM_006518624.1.
    UniGeneiMm.396499.
    Mm.458816.

    Genome annotation databases

    EnsembliENSMUST00000097079; ENSMUSP00000094844; ENSMUSG00000072294.
    GeneIDi16597.
    KEGGimmu:16597.
    UCSCiuc007uvh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14295 mRNA. Translation: CAA74670.1 .
    BC067408 mRNA. Translation: AAH67408.1 .
    CCDSi CCDS36998.1.
    RefSeqi NP_034766.2. NM_010636.3.
    XP_006518686.1. XM_006518623.1.
    XP_006518687.1. XM_006518624.1.
    UniGenei Mm.396499.
    Mm.458816.

    3D structure databases

    ProteinModelPortali O35738.
    SMRi O35738. Positions 306-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000094844.

    PTM databases

    PhosphoSitei O35738.

    Proteomic databases

    PRIDEi O35738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097079 ; ENSMUSP00000094844 ; ENSMUSG00000072294 .
    GeneIDi 16597.
    KEGGi mmu:16597.
    UCSCi uc007uvh.2. mouse.

    Organism-specific databases

    CTDi 11278.
    MGIi MGI:1333796. Klf12.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00750000117621.
    HOGENOMi HOG000232138.
    HOVERGENi HBG003941.
    InParanoidi Q6NWV9.
    KOi K09205.
    OMAi SLPLMYT.
    OrthoDBi EOG747PJ4.
    TreeFami TF350556.

    Miscellaneous databases

    ChiTaRSi KLF12. mouse.
    NextBioi 290165.
    PROi O35738.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35738.
    CleanExi MM_KLF12.
    Genevestigatori O35738.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor."
      Imhof A., Schuierer M., Werner O., Moser M., Roth C., Bauer R., Buettner R.
      Mol. Cell. Biol. 19:194-204(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CD-1.
      Tissue: Neural stem cell.

    Entry informationi

    Entry nameiKLF12_MOUSE
    AccessioniPrimary (citable) accession number: O35738
    Secondary accession number(s): Q6NWV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3