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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

Hnrnph1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.
R-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H
Short name:
hnRNP H
Cleaved into the following chain:
Gene namesi
Name:Hnrnph1
Synonyms:Hnrph, Hnrph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1891925. Hnrnph1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Heterogeneous nuclear ribonucleoprotein HPRO_0000367120Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 449448Heterogeneous nuclear ribonucleoprotein H, N-terminally processedPRO_0000081858Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei233 – 2331Dimethylated arginine; alternateBy similarity
Modified residuei233 – 2331Omega-N-methylarginine; alternateBy similarity
Modified residuei246 – 2461PhosphotyrosineBy similarity
Modified residuei310 – 3101PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiO35737.
PaxDbiO35737.
PeptideAtlasiO35737.
PRIDEiO35737.

2D gel databases

REPRODUCTION-2DPAGEIPI00133916.
O35737.

PTM databases

iPTMnetiO35737.
PhosphoSiteiO35737.
SwissPalmiO35737.

Expressioni

Gene expression databases

BgeeiENSMUSG00000007850.
ExpressionAtlasiO35737. baseline and differential.
GenevisibleiO35737. MM.

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent (By similarity).By similarity

Protein-protein interaction databases

BioGridi208484. 8 interactions.
IntActiO35737. 13 interactions.
MINTiMINT-1864374.
STRINGi10090.ENSMUSP00000070503.

Structurei

3D structure databases

ProteinModelPortaliO35737.
SMRiO35737. Positions 7-193, 283-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9080RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18878RRM 2PROSITE-ProRule annotationAdd
BLAST
Repeati234 – 249161-1Add
BLAST
Domaini289 – 36476RRM 3PROSITE-ProRule annotationAdd
BLAST
Repeati354 – 372192-1Add
BLAST
Repeati374 – 392192-2Add
BLAST
Repeati418 – 433161-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 4332002 X 16 AA Gly-rich approximate repeatsAdd
BLAST
Regioni354 – 392392 X 19 AA perfect repeatsAdd
BLAST

Domaini

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiO35737.
KOiK12898.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGAEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Length:449
Mass (Da):49,199
Last modified:January 23, 2007 - v3
Checksum:iBF6138CA982D5484
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14196 mRNA. Translation: CAA74583.1.
BC056224 mRNA. Translation: AAH56224.1.
CCDSiCCDS24634.1.
RefSeqiNP_067485.1. NM_021510.2.
UniGeneiMm.21740.

Genome annotation databases

EnsembliENSMUST00000069304; ENSMUSP00000070503; ENSMUSG00000007850.
ENSMUST00000109142; ENSMUSP00000104770; ENSMUSG00000007850.
GeneIDi59013.
KEGGimmu:59013.
UCSCiuc007isj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14196 mRNA. Translation: CAA74583.1.
BC056224 mRNA. Translation: AAH56224.1.
CCDSiCCDS24634.1.
RefSeqiNP_067485.1. NM_021510.2.
UniGeneiMm.21740.

3D structure databases

ProteinModelPortaliO35737.
SMRiO35737. Positions 7-193, 283-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208484. 8 interactions.
IntActiO35737. 13 interactions.
MINTiMINT-1864374.
STRINGi10090.ENSMUSP00000070503.

PTM databases

iPTMnetiO35737.
PhosphoSiteiO35737.
SwissPalmiO35737.

2D gel databases

REPRODUCTION-2DPAGEIPI00133916.
O35737.

Proteomic databases

EPDiO35737.
PaxDbiO35737.
PeptideAtlasiO35737.
PRIDEiO35737.

Protocols and materials databases

DNASUi59013.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069304; ENSMUSP00000070503; ENSMUSG00000007850.
ENSMUST00000109142; ENSMUSP00000104770; ENSMUSG00000007850.
GeneIDi59013.
KEGGimmu:59013.
UCSCiuc007isj.1. mouse.

Organism-specific databases

CTDi3187.
MGIiMGI:1891925. Hnrnph1.

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiO35737.
KOiK12898.

Enzyme and pathway databases

ReactomeiR-MMU-6803529. FGFR2 alternative splicing.
R-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiHnrnph1. mouse.
PROiO35737.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007850.
ExpressionAtlasiO35737. baseline and differential.
GenevisibleiO35737. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH1_MOUSE
AccessioniPrimary (citable) accession number: O35737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.