ID   CP4AE_MOUSE             Reviewed;         507 AA.
AC   O35728; A2A975; Q3UER2; Q5EBH0;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 67.
DE   RecName: Full=Cytochrome P450 4A14;
DE   AltName: Full=CYPIVA14;
DE   AltName: Full=Lauric acid omega-hydroxylase 3;
DE            EC=1.14.15.3;
DE   AltName: Full=P450-LA-omega 3;
DE   Flags: Precursor;
GN   Name=Cyp4a14;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=C57BL/6 X CBA;
RX   MEDLINE=97373526; PubMed=9271096;
RA   Heng Y.M., Kuo C.-W.S., Jones P.S., Savory R., Shultz R.M.,
RA   Tomlinson S.R., Gray T.J.B., Bell D.R.;
RT   "A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and
RT   Cyp4b, but not of CYP4F, genes in mouse and humans.";
RL   Biochem. J. 325:741-749(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney, and Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RG   The mouse genome sequencing consortium;
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
CC       monooxygenases. In liver microsomes, this enzyme is involved in an
CC       NADPH-dependent electron transport pathway. It oxidizes a variety
CC       of structurally unrelated compounds, including steroids, fatty
CC       acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY: Octane + reduced rubredoxin + O(2) = 1-octanol
CC       + oxidized rubredoxin + H(2)O.
CC   -!- COFACTOR: Heme group (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: Very low level in liver, kidney and spleen.
CC   -!- INDUCTION: By peroxisome proliferator methylclofenapate; 1000-fold
CC       in liver, 10-fold in kidney.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BC089609; Type=Erroneous termination; Positions=365; Note=Translated as Gln;
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DR   EMBL; Y11638; CAA72345.1; -; Genomic_DNA.
DR   EMBL; Y11639; CAA72345.1; JOINED; Genomic_DNA.
DR   EMBL; Y11640; CAA72345.1; JOINED; Genomic_DNA.
DR   EMBL; Y11641; CAA72345.1; JOINED; Genomic_DNA.
DR   EMBL; Y11642; CAA72345.1; JOINED; Genomic_DNA.
DR   EMBL; AK149392; BAE28849.1; -; mRNA.
DR   EMBL; AK165452; BAE38193.1; -; mRNA.
DR   EMBL; AL627182; CAM21089.1; -; Genomic_DNA.
DR   EMBL; BC089609; -; NOT_ANNOTATED_CDS; mRNA.
DR   IPI; IPI00133877; -.
DR   RefSeq; NP_031848.1; -.
DR   UniGene; Mm.250901; -.
DR   Ensembl; ENSMUSG00000028715; Mus musculus.
DR   GeneID; 13119; -.
DR   KEGG; mmu:13119; -.
DR   MGI; MGI:1096550; Cyp4a14.
DR   HOGENOM; O35728; -.
DR   HOVERGEN; O35728; -.
DR   OMA; O35728; RSIPKGI.
DR   BRENDA; 1.14.15.3; 244.
DR   NextBio; 283150; -.
DR   ArrayExpress; O35728; -.
DR   Bgee; O35728; -.
DR   GermOnline; ENSMUSG00000028715; Mus musculus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0018685; F:alkane 1-monooxygenase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017973; Cyt_P450_C.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   Gene3D; G3DSA:1.10.630.10; Cyt_P450; 1.
DR   PANTHER; PTHR19383; Cyt_P450; 1.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Phosphoprotein.
FT   PROPEP        1      4       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000046058.
FT   CHAIN         5    507       Cytochrome P450 4A14.
FT                                /FTId=PRO_0000046059.
FT   METAL       454    454       Iron (heme axial ligand) (By similarity).
FT   BINDING     318    318       Heme (covalent; via 1 link) (By
FT                                similarity).
FT   MOD_RES     437    437       Phosphoserine (By similarity).
FT   CONFLICT    231    231       N -> D (in Ref. 2; BAE28849).
FT   CONFLICT    278    278       Q -> R (in Ref. 4; BC089609).
FT   CONFLICT    401    401       S -> F (in Ref. 4; BC089609).
SQ   SEQUENCE   507 AA;  58720 MW;  EB46205838D4549C CRC64;
     MGFFLFSPTR YLDGISGFFQ WAFLLSLFLV LFKAVQFYLR RQWLLKTLQH FPCMPSHWLW
     GHHLKDKELQ QILIWVEKFP SACLQCLSGS NIRVLLYDPD YVKVVLGRSD PKASGIYQFF
     APWIGYGLLL LNGKKWFQHR RMLTPAFHYD ILKPYVKIMA DSVNIMLDKW EKLDGQDHPL
     EIFHCVSLMT LDTVMKCAFS YQGSVQLDEN SKLYTKAVED LNNLTFFRLR NAFYKYNIIY
     NMSSDGRLSH HACQIAHEHT DGVIKMRKSQ LQNEEELQKA RKKRHLDFLD ILLFARMEDR
     NSLSDEDLRA EVDTFMFEGH DTTASGISWI FYALATHPEH QQRCREEVQS ILGDGTSVTW
     DHLGQMPYTT MCIKEALRLY PPVISVSREL SSPVTFPDGR SIPKGITATI SIYGLHHNPR
     FWPNPKVFDP SRFAPDSSHH SHAYLPFSGG SRNCIGKQFA MNELKVAVAL TLLRFELLPD
     PTRIPVPIAR LVLKSKNGIH LCLKKLR
//