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Protein

DnaJ homolog subfamily B member 3

Gene

Dnajb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.Curated

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily B member 3
Short name:
DnaJ protein homolog 3
Alternative name(s):
Heat shock protein J3
Short name:
HSJ-3
MSJ-1
Gene namesi
Name:Dnajb3
Synonyms:Hsj3, Msj1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1306822. Dnajb3.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242DnaJ homolog subfamily B member 3PRO_0000071020Add
BLAST

Proteomic databases

EPDiO35723.
PaxDbiO35723.
PRIDEiO35723.

2D gel databases

REPRODUCTION-2DPAGEIPI00133874.
O35723.

PTM databases

iPTMnetiO35723.

Expressioni

Tissue specificityi

Testis specific. Expression is confined to the germline without any contribution of the somatic components.

Developmental stagei

Its expression occurs in the postmeiotic phase of male germ cell development. First detected in 30 days old mice and thereafter into adulthood. Barely detectable in 20 days old mice and absent before this period.

Gene expression databases

CleanExiMM_DNAJB3.

Interactioni

Protein-protein interaction databases

BioGridi200447. 1 interaction.
STRINGi10090.ENSMUSP00000112703.

Structurei

3D structure databases

ProteinModelPortaliO35723.
SMRiO35723. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6969JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiO35723.
KOiK09509.
PhylomeDBiO35723.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDYYEVLGV PRQASAEAIR KAYRKLALKW HPDKNPEHKE EAERRFKQVA
60 70 80 90 100
QAYEVLSDVR KREVYDRCGE VGEVGGGGAA GSPFHDAFQY VFSFRDPAEV
110 120 130 140 150
FREFFGGHDP FSFDFFGGDP LENFFGDRRS TRGSRSRGAV PFSTSFTEFP
160 170 180 190 200
GFGGGFASLD TGFTSFGSPG NSGLSSFSMS CGGGAAGNYK SVSTSTEIIN
210 220 230 240
GKKITTKRIV ENGQERVEVE EDGELKSLII NGREQLLRIN TQ
Length:242
Mass (Da):26,679
Last modified:January 1, 1998 - v1
Checksum:i5F54F48A00094D84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711V → M in BAB24186 (PubMed:16141072).Curated
Sequence conflicti149 – 1491F → I in BAB24188 (PubMed:16141072).Curated
Sequence conflicti233 – 2331R → K in BAB24188 (PubMed:16141072).Curated
Sequence conflicti233 – 2331R → K in BAB24186 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95607 mRNA. Translation: AAC13944.1.
AK005690 mRNA. Translation: BAB24188.1.
AK005688 mRNA. Translation: BAB24186.1.
CCDSiCCDS15142.1.
RefSeqiNP_032325.2. NM_008299.3.
UniGeneiMm.439983.

Genome annotation databases

GeneIDi15504.
KEGGimmu:15504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95607 mRNA. Translation: AAC13944.1.
AK005690 mRNA. Translation: BAB24188.1.
AK005688 mRNA. Translation: BAB24186.1.
CCDSiCCDS15142.1.
RefSeqiNP_032325.2. NM_008299.3.
UniGeneiMm.439983.

3D structure databases

ProteinModelPortaliO35723.
SMRiO35723. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200447. 1 interaction.
STRINGi10090.ENSMUSP00000112703.

PTM databases

iPTMnetiO35723.

2D gel databases

REPRODUCTION-2DPAGEIPI00133874.
O35723.

Proteomic databases

EPDiO35723.
PaxDbiO35723.
PRIDEiO35723.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15504.
KEGGimmu:15504.

Organism-specific databases

CTDi414061.
MGIiMGI:1306822. Dnajb3.

Phylogenomic databases

eggNOGiKOG0714. Eukaryota.
COG0484. LUCA.
HOGENOMiHOG000111538.
HOVERGENiHBG066998.
InParanoidiO35723.
KOiK09509.
PhylomeDBiO35723.

Miscellaneous databases

PROiO35723.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DNAJB3.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "MSJ-1, a new member of the DNAJ family of proteins, is a male germ cell-specific gene product."
    Berruti G., Perego L., Borgonovo B., Martegani E.
    Exp. Cell Res. 239:430-441(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiDNJB3_MOUSE
AccessioniPrimary (citable) accession number: O35723
Secondary accession number(s): Q9DAN3, Q9DAN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.