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Protein

Suppressor of cytokine signaling 2

Gene

Socs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI
  • insulin-like growth factor receptor binding Source: UniProtKB

GO - Biological processi

  • cellular response to hormone stimulus Source: MGI
  • growth hormone receptor signaling pathway Source: MGI
  • intracellular signal transduction Source: MGI
  • lactation Source: MGI
  • mammary gland alveolus development Source: MGI
  • negative regulation of JAK-STAT cascade Source: MGI
  • negative regulation of multicellular organism growth Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • protein ubiquitination Source: UniProtKB-UniPathway
  • regulation of cell growth Source: InterPro
  • regulation of multicellular organism growth Source: MGI
  • response to estradiol Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Growth regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-982772. Growth hormone receptor signaling.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of cytokine signaling 2
Short name:
SOCS-2
Alternative name(s):
Cytokine-inducible SH2 protein 2
Short name:
CIS-2
Gene namesi
Name:Socs2
Synonyms:Cis2, Cish2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1201787. Socs2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Suppressor of cytokine signaling 2PRO_0000181239Add
BLAST

Proteomic databases

EPDiO35717.
PaxDbiO35717.
PRIDEiO35717.

Expressioni

Tissue specificityi

Expressed primarily in the testis, some expression in liver and lung.

Developmental stagei

In the developing brain, expressed at relatively high levels from E10 stages to young adulthood (P25) with peak levels from E14 to P8. Levels of SOCS2 increase dramatically between E10 and E12. At E12, high expression found in the olfactory epithelium with moderate expression in the neuroepithelium of the neocortex, presumptive striatum, hippocampus and septum. Low expression in the retina. At E14, in the cortical wall, levels increase in the cortical plate and decrease in the intermediate zone. High expression also in the hippocampus, fimbria, thalamic neuroepithelium and innermost layer of the retina. At P8, high expression in the neurons of the hippocampus. Lower levels found in the dentate gyrus. Levels of expression decrease between P8 and P15 and remain constant until P25. In adulthood, levels decrease. In the peripheral nervous system, expression found at low levels at E14 in a subpopulation of neurons in the dorsal root ganglion.1 Publication

Gene expression databases

BgeeiO35717.
CleanExiMM_SOCS2.
ExpressionAtlasiO35717. baseline and differential.
GenevisibleiO35717. MM.

Interactioni

Subunit structurei

Associates with the Elongin BC complex.By similarity

GO - Molecular functioni

  • growth hormone receptor binding Source: MGI
  • insulin-like growth factor receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi229727. 13 interactions.
IntActiO35717. 3 interactions.
MINTiMINT-2577241.
STRINGi10090.ENSMUSP00000020215.

Structurei

3D structure databases

ProteinModelPortaliO35717.
SMRiO35717. Positions 32-198.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 156109SH2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 19747SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SOCS box domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiO35717.
KOiK04695.
OMAiWETERIC.
PhylomeDBiO35717.
TreeFamiTF321368.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028410. SOCS2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF75. PTHR24369:SF75. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW
60 70 80 90 100
GSMTVNEAKE KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ
110 120 130 140 150
DGKFRLDSII CVKSKLKQFD SVVHLIDYYV QMCKDKRTGP EAPRNGTVHL
160 170 180 190
YLTKPLYTSA PTLQHFCRLA INKCTGTIWG LPLPTRLKDY LEEYKFQV
Length:198
Mass (Da):22,434
Last modified:January 1, 1998 - v1
Checksum:iC9051AE9C84BA7F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88327 mRNA. Translation: AAB62402.1.
CCDSiCCDS24136.1.
RefSeqiNP_001162126.1. NM_001168655.1.
NP_001162127.1. NM_001168656.1.
NP_001162128.1. NM_001168657.1.
NP_031732.1. NM_007706.4.
XP_011241712.1. XM_011243410.1.
UniGeneiMm.474283.
Mm.490329.

Genome annotation databases

EnsembliENSMUST00000020215; ENSMUSP00000020215; ENSMUSG00000020027.
ENSMUST00000119917; ENSMUSP00000113378; ENSMUSG00000020027.
ENSMUST00000170690; ENSMUSP00000129331; ENSMUSG00000020027.
ENSMUST00000172070; ENSMUSP00000131875; ENSMUSG00000020027.
GeneIDi216233.
KEGGimmu:216233.
UCSCiuc007gwg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88327 mRNA. Translation: AAB62402.1.
CCDSiCCDS24136.1.
RefSeqiNP_001162126.1. NM_001168655.1.
NP_001162127.1. NM_001168656.1.
NP_001162128.1. NM_001168657.1.
NP_031732.1. NM_007706.4.
XP_011241712.1. XM_011243410.1.
UniGeneiMm.474283.
Mm.490329.

3D structure databases

ProteinModelPortaliO35717.
SMRiO35717. Positions 32-198.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229727. 13 interactions.
IntActiO35717. 3 interactions.
MINTiMINT-2577241.
STRINGi10090.ENSMUSP00000020215.

Proteomic databases

EPDiO35717.
PaxDbiO35717.
PRIDEiO35717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020215; ENSMUSP00000020215; ENSMUSG00000020027.
ENSMUST00000119917; ENSMUSP00000113378; ENSMUSG00000020027.
ENSMUST00000170690; ENSMUSP00000129331; ENSMUSG00000020027.
ENSMUST00000172070; ENSMUSP00000131875; ENSMUSG00000020027.
GeneIDi216233.
KEGGimmu:216233.
UCSCiuc007gwg.2. mouse.

Organism-specific databases

CTDi8835.
MGIiMGI:1201787. Socs2.

Phylogenomic databases

eggNOGiKOG4566. Eukaryota.
ENOG4111V4J. LUCA.
HOGENOMiHOG000236320.
HOVERGENiHBG002457.
InParanoidiO35717.
KOiK04695.
OMAiWETERIC.
PhylomeDBiO35717.
TreeFamiTF321368.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-MMU-982772. Growth hormone receptor signaling.

Miscellaneous databases

PROiO35717.
SOURCEiSearch...

Gene expression databases

BgeeiO35717.
CleanExiMM_SOCS2.
ExpressionAtlasiO35717. baseline and differential.
GenevisibleiO35717. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR028410. SOCS2.
IPR001496. SOCS_box.
[Graphical view]
PANTHERiPTHR24369:SF75. PTHR24369:SF75. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF07525. SOCS_box. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50225. SOCS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Expression of 'suppressor of cytokine signaling' (SOCS) genes in the developing and adult mouse nervous system."
    Polizzotto M.N., Bartlett P.F., Turnley A.M.
    J. Comp. Neurol. 423:348-358(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSOCS2_MOUSE
AccessioniPrimary (citable) accession number: O35717
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice deficient in SOCS2 exhibit considerable weight increase (30-40% more than normal) after 3 weeks of age. This is attributable to increase in visceral organ weight, carcass weight, long bone length and body length. In addition there is a thickening of the dermis due to excess collagen accumulation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.