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O35710 (NOCT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nocturnin

EC=3.1.13.4
Alternative name(s):
Carbon catabolite repression 4-like protein
Circadian deadenylase NOC
Gene names
Name:Ccrn4l
Synonyms:Ccr4, Noc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length429 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the circadian clock or downstream effector of clock function. Exhibits a high amplitude circadian rhythm with maximal levels in early evening. In constant darkness or constant light, the amplitude of the rhythm decreases By similarity.

Catalytic activity

Exonucleolytic cleavage of poly(A) to 5'-AMP.

Cofactor

Magnesium By similarity.

Tissue specificity

Ubiquitous. Ref.2 Ref.3

Miscellaneous

When animals were kept on a 12 hours light/dark cycle expression was highest after 12 hours, at the time when the light was switched off.

Sequence similarities

Belongs to the CCR4/nocturin family.

Sequence caution

The sequence AAB62717.1 differs from that shown. Reason: Frameshift at position 125.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O35710-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O35710-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 429429Nocturnin
PRO_0000218569

Sites

Active site1931 By similarity
Active site3751 By similarity
Active site4121 By similarity
Metal binding1931Magnesium 1 By similarity
Metal binding3221Magnesium 2 By similarity
Metal binding3241Magnesium 2 By similarity
Metal binding4121Magnesium 2 By similarity

Natural variations

Alternative sequence1 – 6464Missing in isoform 2.
VSP_016677

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 2, 2001. Version 3.
Checksum: CB9FB55D84E13942

FASTA42948,301
        10         20         30         40         50         60 
MYQSPRRLCS ALLLRDAPGL RRTLVPGPRR TLAPPVLGSR PKSPQLQAAA ASGAARSRPR 

        70         80         90        100        110        120 
TVSSMGNGTS RLYSALAKTV NSSAAAQHPE YLVSTDPEHL EPIDPKELLE ECRAVLHTRP 

       130        140        150        160        170        180 
PRYQRDFVDL RTDCSSSHSP IRVMQWNILA QALGEGKDNF VQCPVEALKW EERKCLILEE 

       190        200        210        220        230        240 
ILAYQPDILC LQEVDHYFDT FQPLLSRLGY QGTFFPKPWS PCLDVEHNNG PDGCALFFLQ 

       250        260        270        280        290        300 
NRFKLISSTN IRLTAMTLKT NQVAIAQTLE CKESGRQFCI AVTHLKARTG WERFRSAQGC 

       310        320        330        340        350        360 
DLLQNLQNIT QGAKIPLIVC GDFNAEPTEE VYKHFASSSL NLNSAYKLLS PDGQSEPPYT 

       370        380        390        400        410        420 
TWKIRTSGEC RHTLDYIWYS RHALSVTSAL DLLTEEQIGP NRLPSFHYPS DHLSLVCDFS 


FNEEPHELF 

« Hide

Isoform 2 [UniParc].

Checksum: 762CA86E0F907EB8
Show »

FASTA36541,500

References

« Hide 'large scale' references
[1]"Characterization of two age-induced intracisternal A-particle-related transcripts in the mouse liver. Transcriptional read-through into an open reading frame with similarities to the yeast ccr4 transcription factor."
Puech A., Dupressoir A., Loireau M.-P., Mattei M.-G., Heidmann T.
J. Biol. Chem. 272:5995-6003(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: DBA/2J.
Tissue: Liver.
[2]"Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion."
Dupressoir A., Barbot W., Loireau M.-P., Heidmann T.
J. Biol. Chem. 274:31068-31075(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Brain.
[3]"Rhythmic expression of nocturnin mRNA in multiple tissues of the mouse."
Wang Y., Osterbur D.L., Megaw P.L., Tosini G., Fukuhara C., Green C.B., Besharse J.C.
BMC Dev. Biol. 1:9-9(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CIRCADIAN EXPRESSION, TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Retina.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U70139 mRNA. Translation: AAB62717.1. Frameshift.
AF183960 mRNA. Translation: AAD56547.1.
AF199491 mRNA. Translation: AAG01384.1.
AK087790 mRNA. Translation: BAC40004.1.
RefSeqNP_033964.1. NM_009834.2.
XP_006501020.1. XM_006500957.1.
UniGeneMm.86541.

3D structure databases

ProteinModelPortalO35710.
SMRO35710. Positions 120-422.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60436N.

PTM databases

PhosphoSiteO35710.

Proteomic databases

PaxDbO35710.
PRIDEO35710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023849; ENSMUSP00000023849; ENSMUSG00000023087. [O35710-1]
ENSMUST00000167780; ENSMUSP00000130347; ENSMUSG00000023087. [O35710-1]
GeneID12457.
KEGGmmu:12457.
UCSCuc008pdm.2. mouse. [O35710-1]

Organism-specific databases

CTD25819.
MGIMGI:109382. Ccrn4l.

Phylogenomic databases

eggNOGCOG5239.
GeneTreeENSGT00550000074364.
HOGENOMHOG000237357.
HOVERGENHBG006512.
InParanoidO35710.
OMAHPEYLVS.
OrthoDBEOG7Z95MC.
PhylomeDBO35710.
TreeFamTF323175.

Enzyme and pathway databases

BRENDA3.1.13.4. 3474.

Gene expression databases

ArrayExpressO35710.
BgeeO35710.
CleanExMM_CCR4.
GenevestigatorO35710.

Family and domain databases

Gene3D3.60.10.10. 1 hit.
InterProIPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PfamPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMSSF56219. SSF56219. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCCRN4L. mouse.
NextBio281308.
PROO35710.
SOURCESearch...

Entry information

Entry nameNOCT_MOUSE
AccessionPrimary (citable) accession number: O35710
Secondary accession number(s): Q9QZG9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 2, 2001
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot