ID   PHX2B_MOUSE             Reviewed;         314 AA.
AC   O35690;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   24-JAN-2024, entry version 163.
DE   RecName: Full=Paired mesoderm homeobox protein 2B;
DE   AltName: Full=Neuroblastoma Phox;
DE            Short=NBPhox;
DE   AltName: Full=PHOX2B homeodomain protein;
DE   AltName: Full=Paired-like homeobox 2B;
GN   Name=Phox2b; Synonyms=Pmx2b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9374403; DOI=10.1242/dev.124.20.4065;
RA   Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.-F.;
RT   "Expression and interactions of the two closely related homeobox genes
RT   Phox2a and Phox2b during neurogenesis.";
RL   Development 124:4065-4075(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10395798; DOI=10.1006/geno.1999.5845;
RA   Yokoyama M., Watanabe H., Nakamura M.;
RT   "Genomic structure and functional characterization of NBPhox (PMX2B), a
RT   homeodomain protein specific to catecholaminergic cells that is involved in
RT   second messenger-mediated transcriptional activation.";
RL   Genomics 59:40-50(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH TRIM11.
RX   PubMed=18275850; DOI=10.1016/j.bbrc.2008.01.165;
RA   Hong S.J., Chae H., Lardaro T., Hong S., Kim K.S.;
RT   "Trim11 increases expression of dopamine beta-hydroxylase gene by
RT   interacting with Phox2b.";
RL   Biochem. Biophys. Res. Commun. 368:650-655(2008).
CC   -!- SUBUNIT: Interacts with TRIM11. {ECO:0000269|PubMed:18275850}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Y14493; CAA74833.1; -; mRNA.
DR   EMBL; AB015672; BAA82671.1; -; Genomic_DNA.
DR   EMBL; BC079610; AAH79610.1; -; mRNA.
DR   CCDS; CCDS19316.1; -.
DR   RefSeq; NP_032914.1; NM_008888.3.
DR   AlphaFoldDB; O35690; -.
DR   SMR; O35690; -.
DR   BioGRID; 202270; 2.
DR   STRING; 10090.ENSMUSP00000012664; -.
DR   PhosphoSitePlus; O35690; -.
DR   MaxQB; O35690; -.
DR   PaxDb; 10090-ENSMUSP00000012664; -.
DR   PeptideAtlas; O35690; -.
DR   ProteomicsDB; 289556; -.
DR   Antibodypedia; 11895; 226 antibodies from 33 providers.
DR   DNASU; 18935; -.
DR   Ensembl; ENSMUST00000012664.11; ENSMUSP00000012664.8; ENSMUSG00000012520.11.
DR   GeneID; 18935; -.
DR   KEGG; mmu:18935; -.
DR   UCSC; uc008xpm.1; mouse.
DR   AGR; MGI:1100882; -.
DR   CTD; 8929; -.
DR   MGI; MGI:1100882; Phox2b.
DR   VEuPathDB; HostDB:ENSMUSG00000012520; -.
DR   eggNOG; KOG0484; Eukaryota.
DR   GeneTree; ENSGT00940000159958; -.
DR   HOGENOM; CLU_081152_0_0_1; -.
DR   InParanoid; O35690; -.
DR   OMA; QSQGWAT; -.
DR   OrthoDB; 2901226at2759; -.
DR   PhylomeDB; O35690; -.
DR   TreeFam; TF351612; -.
DR   BioGRID-ORCS; 18935; 2 hits in 78 CRISPR screens.
DR   PRO; PR:O35690; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; O35690; Protein.
DR   Bgee; ENSMUSG00000012520; Expressed in migratory enteric neural crest cell and 80 other cell types or tissues.
DR   ExpressionAtlas; O35690; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:MGI.
DR   GO; GO:0048483; P:autonomic nervous system development; ISO:MGI.
DR   GO; GO:0003360; P:brainstem development; IEA:Ensembl.
DR   GO; GO:0048468; P:cell development; IMP:MGI.
DR   GO; GO:0021533; P:cell differentiation in hindbrain; IMP:MGI.
DR   GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR   GO; GO:0071773; P:cellular response to BMP stimulus; IDA:MGI.
DR   GO; GO:0071244; P:cellular response to carbon dioxide; IEA:Ensembl.
DR   GO; GO:0071542; P:dopaminergic neuron differentiation; IMP:BHF-UCL.
DR   GO; GO:0048894; P:efferent axon development in a lateral line nerve; IMP:MGI.
DR   GO; GO:0048484; P:enteric nervous system development; IMP:BHF-UCL.
DR   GO; GO:0010001; P:glial cell differentiation; IMP:MGI.
DR   GO; GO:0021934; P:hindbrain tangential cell migration; IMP:MGI.
DR   GO; GO:0048839; P:inner ear development; IMP:MGI.
DR   GO; GO:0021723; P:medullary reticular formation development; IEP:BHF-UCL.
DR   GO; GO:0051899; P:membrane depolarization; IEA:Ensembl.
DR   GO; GO:0097475; P:motor neuron migration; IMP:MGI.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.
DR   GO; GO:1904691; P:negative regulation of type B pancreatic cell proliferation; IMP:MGI.
DR   GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IMP:BHF-UCL.
DR   GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR   GO; GO:0003358; P:noradrenergic neuron development; IMP:UniProtKB.
DR   GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:BHF-UCL.
DR   GO; GO:0048486; P:parasympathetic nervous system development; IMP:BHF-UCL.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IGI:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR   GO; GO:0010468; P:regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0002087; P:regulation of respiratory gaseous exchange by nervous system process; IMP:BHF-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR   GO; GO:0060541; P:respiratory system development; IMP:BHF-UCL.
DR   GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR   GO; GO:0061452; P:retrotrapezoid nucleus neuron differentiation; IMP:BHF-UCL.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR   GO; GO:0061549; P:sympathetic ganglion development; IMP:UniProtKB.
DR   GO; GO:0048485; P:sympathetic nervous system development; IMP:BHF-UCL.
DR   GO; GO:0044342; P:type B pancreatic cell proliferation; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR   PANTHER; PTHR24329:SF301; PAIRED MESODERM HOMEOBOX PROTEIN 2B; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; O35690; MM.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..314
FT                   /note="Paired mesoderm homeobox protein 2B"
FT                   /id="PRO_0000049263"
FT   DNA_BIND        98..157
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          162..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  31621 MW;  40737F71948B595A CRC64;
     MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL
     TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET
     HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR
     DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG
     AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR
     PNGAKAALVK SSMF
//