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O35690

- PHX2B_MOUSE

UniProt

O35690 - PHX2B_MOUSE

Protein

Paired mesoderm homeobox protein 2B

Gene

Phox2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi98 – 15760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brainstem development Source: Ensembl
    2. cell development Source: MGI
    3. cell differentiation in hindbrain Source: MGI
    4. cellular response to BMP stimulus Source: MGI
    5. dopaminergic neuron differentiation Source: BHF-UCL
    6. efferent axon development in a lateral line nerve Source: MGI
    7. enteric nervous system development Source: BHF-UCL
    8. glial cell differentiation Source: MGI
    9. hindbrain tangential cell migration Source: MGI
    10. inner ear development Source: MGI
    11. medullary reticular formation development Source: BHF-UCL
    12. negative regulation of cell proliferation Source: MGI
    13. negative regulation of neuron differentiation Source: MGI
    14. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
    15. neuron differentiation Source: MGI
    16. neuron migration Source: MGI
    17. noradrenergic neuron development Source: UniProtKB
    18. noradrenergic neuron differentiation Source: BHF-UCL
    19. parasympathetic nervous system development Source: BHF-UCL
    20. positive regulation of neuron differentiation Source: MGI
    21. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    22. regulation of gene expression Source: UniProtKB
    23. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
    24. respiratory system development Source: BHF-UCL
    25. retrotrapezoid nucleus neuron differentiation Source: BHF-UCL
    26. skeletal muscle cell differentiation Source: MGI
    27. sympathetic ganglion development Source: UniProtKB
    28. sympathetic nervous system development Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired mesoderm homeobox protein 2B
    Alternative name(s):
    Neuroblastoma Phox
    Short name:
    NBPhox
    PHOX2B homeodomain protein
    Paired-like homeobox 2B
    Gene namesi
    Name:Phox2b
    Synonyms:Pmx2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1100882. Phox2b.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Paired mesoderm homeobox protein 2BPRO_0000049263Add
    BLAST

    Proteomic databases

    PRIDEiO35690.

    PTM databases

    PhosphoSiteiO35690.

    Expressioni

    Gene expression databases

    BgeeiO35690.
    CleanExiMM_PHOX2B.
    GenevestigatoriO35690.

    Interactioni

    Subunit structurei

    Interacts with TRIM11.1 Publication

    Protein-protein interaction databases

    BioGridi202270. 1 interaction.
    STRINGi10090.ENSMUSP00000012664.

    Structurei

    3D structure databases

    ProteinModelPortaliO35690.
    SMRiO35690. Positions 100-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi159 – 1679Poly-Ala
    Compositional biasi212 – 2176Poly-Gly
    Compositional biasi241 – 26020Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the paired homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG301263.
    GeneTreeiENSGT00750000117318.
    HOGENOMiHOG000013060.
    HOVERGENiHBG094678.
    InParanoidiO35690.
    KOiK09330.
    OMAiLVKTSMF.
    OrthoDBiEOG7C2R1F.
    PhylomeDBiO35690.
    TreeFamiTF351612.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35690-1 [UniParc]FASTAAdd to Basket

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    MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT    50
    FGATSGCPSL TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR 100
    IRTTFTSAQL KELERVFAET HYPDIYTREE LALKIDLTEA RVQVWFQNRR 150
    AKFRKQERAA AAAAAAAKNG SSGKKSDSSR DDESKEAKST DPDSTGGPGP 200
    NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG AAAAAAAAAA 250
    AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR 300
    PNGAKAALVK SSMF 314
    Length:314
    Mass (Da):31,621
    Last modified:January 1, 1998 - v1
    Checksum:i40737F71948B595A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14493 mRNA. Translation: CAA74833.1.
    AB015672 Genomic DNA. Translation: BAA82671.1.
    BC079610 mRNA. Translation: AAH79610.1.
    CCDSiCCDS19316.1.
    RefSeqiNP_032914.1. NM_008888.3.
    UniGeneiMm.62505.

    Genome annotation databases

    EnsembliENSMUST00000012664; ENSMUSP00000012664; ENSMUSG00000012520.
    GeneIDi18935.
    KEGGimmu:18935.
    UCSCiuc008xpm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y14493 mRNA. Translation: CAA74833.1 .
    AB015672 Genomic DNA. Translation: BAA82671.1 .
    BC079610 mRNA. Translation: AAH79610.1 .
    CCDSi CCDS19316.1.
    RefSeqi NP_032914.1. NM_008888.3.
    UniGenei Mm.62505.

    3D structure databases

    ProteinModelPortali O35690.
    SMRi O35690. Positions 100-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202270. 1 interaction.
    STRINGi 10090.ENSMUSP00000012664.

    PTM databases

    PhosphoSitei O35690.

    Proteomic databases

    PRIDEi O35690.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000012664 ; ENSMUSP00000012664 ; ENSMUSG00000012520 .
    GeneIDi 18935.
    KEGGi mmu:18935.
    UCSCi uc008xpm.1. mouse.

    Organism-specific databases

    CTDi 8929.
    MGIi MGI:1100882. Phox2b.

    Phylogenomic databases

    eggNOGi NOG301263.
    GeneTreei ENSGT00750000117318.
    HOGENOMi HOG000013060.
    HOVERGENi HBG094678.
    InParanoidi O35690.
    KOi K09330.
    OMAi LVKTSMF.
    OrthoDBi EOG7C2R1F.
    PhylomeDBi O35690.
    TreeFami TF351612.

    Miscellaneous databases

    NextBioi 295256.
    PROi O35690.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35690.
    CleanExi MM_PHOX2B.
    Genevestigatori O35690.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis."
      Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.-F.
      Development 124:4065-4075(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation."
      Yokoyama M., Watanabe H., Nakamura M.
      Genomics 59:40-50(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b."
      Hong S.J., Chae H., Lardaro T., Hong S., Kim K.S.
      Biochem. Biophys. Res. Commun. 368:650-655(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRIM11.

    Entry informationi

    Entry nameiPHX2B_MOUSE
    AccessioniPrimary (citable) accession number: O35690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3