Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O35690 (PHX2B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired mesoderm homeobox protein 2B
Alternative name(s):
Neuroblastoma Phox
Short name=NBPhox
PHOX2B homeodomain protein
Paired-like homeobox 2B
Gene names
Name:Phox2b
Synonyms:Pmx2b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with TRIM11. Ref.4

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the paired homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrainstem development

Inferred from electronic annotation. Source: Ensembl

cell development

Inferred from mutant phenotype PubMed 15733675. Source: MGI

cell differentiation in hindbrain

Inferred from mutant phenotype PubMed 17922007. Source: MGI

cellular response to BMP stimulus

Inferred from direct assay PubMed 19793887. Source: MGI

dopaminergic neuron differentiation

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

efferent axon development in a lateral line nerve

Inferred from mutant phenotype PubMed 12885554. Source: MGI

enteric nervous system development

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

glial cell differentiation

Inferred from mutant phenotype PubMed 18506029. Source: MGI

hindbrain tangential cell migration

Inferred from mutant phenotype PubMed 21068058. Source: MGI

inner ear development

Inferred from mutant phenotype PubMed 12885554. Source: MGI

medullary reticular formation development

Inferred from expression pattern Ref.1. Source: BHF-UCL

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 18506029. Source: MGI

negative regulation of neuron differentiation

Inferred from genetic interaction PubMed 17922007. Source: MGI

neural crest cell migration involved in autonomic nervous system development

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

neuron differentiation

Inferred from mutant phenotype PubMed 18506029. Source: MGI

neuron migration

Inferred from mutant phenotype PubMed 16319924. Source: MGI

noradrenergic neuron development

Inferred from mutant phenotype PubMed 18094025. Source: UniProtKB

noradrenergic neuron differentiation

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

parasympathetic nervous system development

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

positive regulation of neuron differentiation

Inferred from genetic interaction PubMed 17922007. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay Ref.2. Source: BHF-UCL

regulation of gene expression

Inferred from mutant phenotype PubMed 18094025. Source: UniProtKB

regulation of respiratory gaseous exchange by neurological system process

Inferred from mutant phenotype PubMed 19940179. Source: BHF-UCL

respiratory system development

Inferred from mutant phenotype PubMed 19940179. Source: BHF-UCL

retrotrapezoid nucleus neuron differentiation

Inferred from mutant phenotype PubMed 19940179. Source: BHF-UCL

skeletal muscle cell differentiation

Inferred from mutant phenotype PubMed 22147266. Source: MGI

sympathetic ganglion development

Inferred from mutant phenotype PubMed 18094025. Source: UniProtKB

sympathetic nervous system development

Inferred from mutant phenotype PubMed 10360575. Source: BHF-UCL

   Cellular_componentnuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 10536054PubMed 16854219PubMed 9758704. Source: MGI

   Molecular_functionRNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Paired mesoderm homeobox protein 2B
PRO_0000049263

Regions

DNA binding98 – 15760Homeobox
Compositional bias159 – 1679Poly-Ala
Compositional bias212 – 2176Poly-Gly
Compositional bias241 – 26020Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
O35690 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: 40737F71948B595A

FASTA31431,621
        10         20         30         40         50         60 
MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL 

        70         80         90        100        110        120 
TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET 

       130        140        150        160        170        180 
HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR 

       190        200        210        220        230        240 
DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG 

       250        260        270        280        290        300 
AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR 

       310 
PNGAKAALVK SSMF 

« Hide

References

« Hide 'large scale' references
[1]"Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis."
Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.-F.
Development 124:4065-4075(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation."
Yokoyama M., Watanabe H., Nakamura M.
Genomics 59:40-50(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b."
Hong S.J., Chae H., Lardaro T., Hong S., Kim K.S.
Biochem. Biophys. Res. Commun. 368:650-655(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TRIM11.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y14493 mRNA. Translation: CAA74833.1.
AB015672 Genomic DNA. Translation: BAA82671.1.
BC079610 mRNA. Translation: AAH79610.1.
CCDSCCDS19316.1.
RefSeqNP_032914.1. NM_008888.3.
UniGeneMm.62505.

3D structure databases

ProteinModelPortalO35690.
SMRO35690. Positions 100-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202270. 1 interaction.
STRING10090.ENSMUSP00000012664.

PTM databases

PhosphoSiteO35690.

Proteomic databases

PRIDEO35690.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000012664; ENSMUSP00000012664; ENSMUSG00000012520.
GeneID18935.
KEGGmmu:18935.
UCSCuc008xpm.1. mouse.

Organism-specific databases

CTD8929.
MGIMGI:1100882. Phox2b.

Phylogenomic databases

eggNOGNOG301263.
GeneTreeENSGT00750000117318.
HOGENOMHOG000013060.
HOVERGENHBG094678.
InParanoidO35690.
KOK09330.
OMALVKTSMF.
OrthoDBEOG7C2R1F.
PhylomeDBO35690.
TreeFamTF351612.

Gene expression databases

BgeeO35690.
CleanExMM_PHOX2B.
GenevestigatorO35690.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295256.
PROO35690.
SOURCESearch...

Entry information

Entry namePHX2B_MOUSE
AccessionPrimary (citable) accession number: O35690
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot