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O35690

- PHX2B_MOUSE

UniProt

O35690 - PHX2B_MOUSE

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Protein
Paired mesoderm homeobox protein 2B
Gene
Phox2b, Pmx2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi98 – 15760Homeobox
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. brainstem development Source: Ensembl
  2. cell development Source: MGI
  3. cell differentiation in hindbrain Source: MGI
  4. cellular response to BMP stimulus Source: MGI
  5. dopaminergic neuron differentiation Source: BHF-UCL
  6. efferent axon development in a lateral line nerve Source: MGI
  7. enteric nervous system development Source: BHF-UCL
  8. glial cell differentiation Source: MGI
  9. hindbrain tangential cell migration Source: MGI
  10. inner ear development Source: MGI
  11. medullary reticular formation development Source: BHF-UCL
  12. negative regulation of cell proliferation Source: MGI
  13. negative regulation of neuron differentiation Source: MGI
  14. neural crest cell migration involved in autonomic nervous system development Source: BHF-UCL
  15. neuron differentiation Source: MGI
  16. neuron migration Source: MGI
  17. noradrenergic neuron development Source: UniProtKB
  18. noradrenergic neuron differentiation Source: BHF-UCL
  19. parasympathetic nervous system development Source: BHF-UCL
  20. positive regulation of neuron differentiation Source: MGI
  21. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  22. regulation of gene expression Source: UniProtKB
  23. regulation of respiratory gaseous exchange by neurological system process Source: BHF-UCL
  24. respiratory system development Source: BHF-UCL
  25. retrotrapezoid nucleus neuron differentiation Source: BHF-UCL
  26. skeletal muscle cell differentiation Source: MGI
  27. sympathetic ganglion development Source: UniProtKB
  28. sympathetic nervous system development Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Paired mesoderm homeobox protein 2B
Alternative name(s):
Neuroblastoma Phox
Short name:
NBPhox
PHOX2B homeodomain protein
Paired-like homeobox 2B
Gene namesi
Name:Phox2b
Synonyms:Pmx2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1100882. Phox2b.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Paired mesoderm homeobox protein 2B
PRO_0000049263Add
BLAST

Proteomic databases

PRIDEiO35690.

PTM databases

PhosphoSiteiO35690.

Expressioni

Gene expression databases

BgeeiO35690.
CleanExiMM_PHOX2B.
GenevestigatoriO35690.

Interactioni

Subunit structurei

Interacts with TRIM11.1 Publication

Protein-protein interaction databases

BioGridi202270. 1 interaction.
STRINGi10090.ENSMUSP00000012664.

Structurei

3D structure databases

ProteinModelPortaliO35690.
SMRiO35690. Positions 100-157.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi159 – 1679Poly-Ala
Compositional biasi212 – 2176Poly-Gly
Compositional biasi241 – 26020Poly-Ala
Add
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG301263.
GeneTreeiENSGT00750000117318.
HOGENOMiHOG000013060.
HOVERGENiHBG094678.
InParanoidiO35690.
KOiK09330.
OMAiLVKTSMF.
OrthoDBiEOG7C2R1F.
PhylomeDBiO35690.
TreeFamiTF351612.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35690-1 [UniParc]FASTAAdd to Basket

« Hide

MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT    50
FGATSGCPSL TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR 100
IRTTFTSAQL KELERVFAET HYPDIYTREE LALKIDLTEA RVQVWFQNRR 150
AKFRKQERAA AAAAAAAKNG SSGKKSDSSR DDESKEAKST DPDSTGGPGP 200
NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG AAAAAAAAAA 250
AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR 300
PNGAKAALVK SSMF 314
Length:314
Mass (Da):31,621
Last modified:January 1, 1998 - v1
Checksum:i40737F71948B595A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14493 mRNA. Translation: CAA74833.1.
AB015672 Genomic DNA. Translation: BAA82671.1.
BC079610 mRNA. Translation: AAH79610.1.
CCDSiCCDS19316.1.
RefSeqiNP_032914.1. NM_008888.3.
UniGeneiMm.62505.

Genome annotation databases

EnsembliENSMUST00000012664; ENSMUSP00000012664; ENSMUSG00000012520.
GeneIDi18935.
KEGGimmu:18935.
UCSCiuc008xpm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14493 mRNA. Translation: CAA74833.1 .
AB015672 Genomic DNA. Translation: BAA82671.1 .
BC079610 mRNA. Translation: AAH79610.1 .
CCDSi CCDS19316.1.
RefSeqi NP_032914.1. NM_008888.3.
UniGenei Mm.62505.

3D structure databases

ProteinModelPortali O35690.
SMRi O35690. Positions 100-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202270. 1 interaction.
STRINGi 10090.ENSMUSP00000012664.

PTM databases

PhosphoSitei O35690.

Proteomic databases

PRIDEi O35690.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000012664 ; ENSMUSP00000012664 ; ENSMUSG00000012520 .
GeneIDi 18935.
KEGGi mmu:18935.
UCSCi uc008xpm.1. mouse.

Organism-specific databases

CTDi 8929.
MGIi MGI:1100882. Phox2b.

Phylogenomic databases

eggNOGi NOG301263.
GeneTreei ENSGT00750000117318.
HOGENOMi HOG000013060.
HOVERGENi HBG094678.
InParanoidi O35690.
KOi K09330.
OMAi LVKTSMF.
OrthoDBi EOG7C2R1F.
PhylomeDBi O35690.
TreeFami TF351612.

Miscellaneous databases

NextBioi 295256.
PROi O35690.
SOURCEi Search...

Gene expression databases

Bgeei O35690.
CleanExi MM_PHOX2B.
Genevestigatori O35690.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis."
    Pattyn A., Morin X., Cremer H., Goridis C., Brunet J.-F.
    Development 124:4065-4075(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation."
    Yokoyama M., Watanabe H., Nakamura M.
    Genomics 59:40-50(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Trim11 increases expression of dopamine beta-hydroxylase gene by interacting with Phox2b."
    Hong S.J., Chae H., Lardaro T., Hong S., Kim K.S.
    Biochem. Biophys. Res. Commun. 368:650-655(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRIM11.

Entry informationi

Entry nameiPHX2B_MOUSE
AccessioniPrimary (citable) accession number: O35690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi