Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear migration protein nudC

Gene

Nudc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.
R-MMU-68884. Mitotic Telophase/Cytokinesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear migration protein nudC
Alternative name(s):
Nuclear distribution protein C homolog
Silica-induced gene 92 protein
Short name:
SIG-92
Gene namesi
Name:Nudc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:106014. Nudc.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Nucleus By similarity

  • Note: A small proportion is nuclear, in a punctate pattern (By similarity). In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579911 – 332Nuclear migration protein nudCAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108PhosphothreonineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei240N6-acetyllysineBy similarity1
Modified residuei261PhosphoserineBy similarity1
Modified residuei275PhosphoserineBy similarity1
Modified residuei278PhosphoserineBy similarity1
Modified residuei286PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1

Post-translational modificationi

Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-275 and Ser-327 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO35685.
MaxQBiO35685.
PaxDbiO35685.
PeptideAtlasiO35685.
PRIDEiO35685.

2D gel databases

REPRODUCTION-2DPAGEO35685.

PTM databases

iPTMnetiO35685.
PhosphoSitePlusiO35685.

Expressioni

Tissue specificityi

Detected in fetal and adult brain, in particular in the ventricular zone of the embryonic forebrain and in the embryonic cortical plate. Highly expressed in brain cortex from new born and adult mice. Detected in the choroid plexus and in ependymal cells in embryonic brain.2 Publications

Inductioni

Up-regulated in silica-treated macrophages.1 Publication

Gene expression databases

BgeeiENSMUSG00000028851.
CleanExiMM_NUDC.
GenevisibleiO35685. MM.

Interactioni

Subunit structurei

Binds PLK1 (By similarity). Binds PAFAH1B1. Part of a complex containing PLK1, NUDC, dynein and dynactin.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kif5bQ617684EBI-911192,EBI-776129
Pafah1b2Q612062EBI-911192,EBI-7445518

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201876. 4 interactors.
IntActiO35685. 10 interactors.
MINTiMINT-4104807.
STRINGi10090.ENSMUSP00000030665.

Structurei

Secondary structure

1332
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi172 – 177Combined sources6
Beta strandi179 – 186Combined sources8
Beta strandi198 – 204Combined sources7
Beta strandi207 – 212Combined sources6
Beta strandi223 – 225Combined sources3
Turni229 – 231Combined sources3
Beta strandi233 – 237Combined sources5
Turni238 – 240Combined sources3
Beta strandi241 – 251Combined sources11
Beta strandi258 – 261Combined sources4
Beta strandi268 – 271Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFINMR-A171-288[»]
2CR0NMR-A161-268[»]
ProteinModelPortaliO35685.
SMRiO35685.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 259CSPROSITE-ProRule annotationAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili60 – 134Sequence analysisAdd BLAST75

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 74Nuclear localization signalSequence analysis7

Sequence similaritiesi

Belongs to the nudC family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000182245.
HOVERGENiHBG052690.
InParanoidiO35685.
OMAiTEESVWV.
OrthoDBiEOG091G0BZ5.
PhylomeDBiO35685.
TreeFamiTF300147.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR032572. NuDC.
IPR025934. NudC_N_dom.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF16273. NuDC. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGEQEEERF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFIGGEEGM
60 70 80 90 100
AEKLITQTFN HHNQLAQKAR REKRARQETE RREKAERAAR LAKEAKAETP
110 120 130 140 150
GPQIKELTDE EAERLQLEID QKKDAEDQEA QLKNGSLDSP GKQDAEDEED
160 170 180 190 200
EEDEKDKGKL KPNLGNGADL PNYRWTQTLA ELDLAVPFRV SFRLKGKDVV
210 220 230 240 250
VDIQRRHLRV GLKGQPPVVD GELYNEVKVE ESSWLIEDGK VVTVHLEKIN
260 270 280 290 300
KMEWWNRLVT SDPEINTKKI NPENSKLSDL DSETRSMVEK MMYDQRQKSM
310 320 330
GLPTSDEQKK QEILKKFMDQ HPEMDFSKAK FN
Length:332
Mass (Da):38,358
Last modified:January 1, 1998 - v1
Checksum:i83F30F2D8E013E3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81443 mRNA. Translation: CAA57201.1.
Y15522 mRNA. Translation: CAA75677.1.
AK032673 mRNA. Translation: BAC27981.1.
AK146323 mRNA. Translation: BAE27078.1.
BC011253 mRNA. Translation: AAH11253.1.
CCDSiCCDS18750.1.
RefSeqiNP_035078.1. NM_010948.3.
UniGeneiMm.393592.
Mm.69.

Genome annotation databases

EnsembliENSMUST00000030665; ENSMUSP00000030665; ENSMUSG00000028851.
GeneIDi18221.
KEGGimmu:18221.
UCSCiuc012dmm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81443 mRNA. Translation: CAA57201.1.
Y15522 mRNA. Translation: CAA75677.1.
AK032673 mRNA. Translation: BAC27981.1.
AK146323 mRNA. Translation: BAE27078.1.
BC011253 mRNA. Translation: AAH11253.1.
CCDSiCCDS18750.1.
RefSeqiNP_035078.1. NM_010948.3.
UniGeneiMm.393592.
Mm.69.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFINMR-A171-288[»]
2CR0NMR-A161-268[»]
ProteinModelPortaliO35685.
SMRiO35685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201876. 4 interactors.
IntActiO35685. 10 interactors.
MINTiMINT-4104807.
STRINGi10090.ENSMUSP00000030665.

PTM databases

iPTMnetiO35685.
PhosphoSitePlusiO35685.

2D gel databases

REPRODUCTION-2DPAGEO35685.

Proteomic databases

EPDiO35685.
MaxQBiO35685.
PaxDbiO35685.
PeptideAtlasiO35685.
PRIDEiO35685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030665; ENSMUSP00000030665; ENSMUSG00000028851.
GeneIDi18221.
KEGGimmu:18221.
UCSCiuc012dmm.1. mouse.

Organism-specific databases

CTDi10726.
MGIiMGI:106014. Nudc.

Phylogenomic databases

eggNOGiKOG2265. Eukaryota.
ENOG410XQVU. LUCA.
GeneTreeiENSGT00530000063486.
HOGENOMiHOG000182245.
HOVERGENiHBG052690.
InParanoidiO35685.
OMAiTEESVWV.
OrthoDBiEOG091G0BZ5.
PhylomeDBiO35685.
TreeFamiTF300147.

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-68877. Mitotic Prometaphase.
R-MMU-68884. Mitotic Telophase/Cytokinesis.

Miscellaneous databases

EvolutionaryTraceiO35685.
PROiO35685.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028851.
CleanExiMM_NUDC.
GenevisibleiO35685. MM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR032572. NuDC.
IPR025934. NudC_N_dom.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF16273. NuDC. 1 hit.
PF14050. Nudc_N. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUDC_MOUSE
AccessioniPrimary (citable) accession number: O35685
Secondary accession number(s): Q3UJS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.