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Protein

Neuroserpin

Gene

Serpini1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3632Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serine protease inhibitor 17
Serpin I1
Gene namesi
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1194506. Serpini1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 410394NeuroserpinPRO_0000032522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO35684.
PaxDbiO35684.
PRIDEiO35684.

PTM databases

PhosphoSiteiO35684.

Expressioni

Tissue specificityi

During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.

Gene expression databases

BgeeiO35684.
ExpressionAtlasiO35684. baseline and differential.
GenevisibleiO35684. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029423.

Structurei

Secondary structure

1
410
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 338Combined sources
Turni34 – 385Combined sources
Beta strandi39 – 413Combined sources
Beta strandi46 – 483Combined sources
Helixi50 – 6011Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi108 – 11710Combined sources
Helixi122 – 13110Combined sources
Beta strandi136 – 1394Combined sources
Helixi144 – 15815Combined sources
Turni169 – 1713Combined sources
Beta strandi178 – 19013Combined sources
Beta strandi200 – 2045Combined sources
Beta strandi212 – 2209Combined sources
Beta strandi224 – 2296Combined sources
Beta strandi238 – 24811Combined sources
Beta strandi251 – 2577Combined sources
Helixi264 – 2663Combined sources
Turni267 – 2704Combined sources
Helixi273 – 2775Combined sources
Helixi279 – 2813Combined sources
Beta strandi289 – 2935Combined sources
Beta strandi296 – 2994Combined sources
Helixi303 – 3086Combined sources
Beta strandi334 – 34310Combined sources
Beta strandi346 – 35813Combined sources
Beta strandi369 – 3713Combined sources
Beta strandi376 – 3827Combined sources
Turni383 – 3853Combined sources
Beta strandi388 – 3958Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684.
SMRiO35684. Positions 22-400.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35684.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO35684.
OMAiDETITEW.
PhylomeDBiO35684.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYLELLALL ALQSVVTGAT FPDETITEWS VNMYNHLRGT GEDENILFSP
60 70 80 90 100
LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE
110 120 130 140 150
ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS
160 170 180 190 200
INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR
210 220 230 240 250
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE
260 270 280 290 300
ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE
310 320 330 340 350
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE
360 370 380 390 400
AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM
410
NTSGHDFEEL
Length:410
Mass (Da):46,348
Last modified:January 1, 1998 - v1
Checksum:iDA3AF6F5195EBB7C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → G in AAH06776 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001700 mRNA. Translation: CAA04939.1.
AK032152 mRNA. Translation: BAC27727.1.
AK051756 mRNA. Translation: BAC34756.1.
BC006776 mRNA. Translation: AAH06776.1.
CCDSiCCDS17415.1.
RefSeqiNP_033276.1. NM_009250.2.
UniGeneiMm.41560.

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
GeneIDi20713.
KEGGimmu:20713.
UCSCiuc008pne.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001700 mRNA. Translation: CAA04939.1.
AK032152 mRNA. Translation: BAC27727.1.
AK051756 mRNA. Translation: BAC34756.1.
BC006776 mRNA. Translation: AAH06776.1.
CCDSiCCDS17415.1.
RefSeqiNP_033276.1. NM_009250.2.
UniGeneiMm.41560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684.
SMRiO35684. Positions 22-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029423.

Protein family/group databases

MEROPSiI04.025.

PTM databases

PhosphoSiteiO35684.

Proteomic databases

MaxQBiO35684.
PaxDbiO35684.
PRIDEiO35684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
GeneIDi20713.
KEGGimmu:20713.
UCSCiuc008pne.2. mouse.

Organism-specific databases

CTDi5274.
MGIiMGI:1194506. Serpini1.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO35684.
OMAiDETITEW.
PhylomeDBiO35684.
TreeFamiTF352620.

Miscellaneous databases

EvolutionaryTraceiO35684.
NextBioi299293.
PROiO35684.
SOURCEiSearch...

Gene expression databases

BgeeiO35684.
ExpressionAtlasiO35684. baseline and differential.
GenevisibleiO35684. MM.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse."
    Krueger S.R., Ghisu G.-P., Cinelli P., Gschwend T.P., Osterwalder T., Wolfer D.P., Sonderegger P.
    J. Neurosci. 17:8984-8996(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Structure of the mouse gene for the serine protease inhibitor neuroserpin (PI12)."
    Berger P., Kozlov S.V., Krueger S.R., Sonderegger P.
    Gene 214:25-33(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
  5. "The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin."
    Osterwalder T., Cinelli P., Baici A., Pennella A., Krueger S.R., Schrimpf S.P., Meins M., Sonderegger P.
    J. Biol. Chem. 273:2312-2321(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease."
    Briand C., Kozlov S.V., Sonderegger P., Gruetter M.G.
    FEBS Lett. 505:18-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS).

Entry informationi

Entry nameiNEUS_MOUSE
AccessioniPrimary (citable) accession number: O35684
Secondary accession number(s): Q543F7, Q922U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: June 24, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.