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Protein

Neuroserpin

Gene

Serpini1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362 – 363Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serine protease inhibitor 17
Serpin I1
Gene namesi
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1194506. Serpini1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000003252217 – 410NeuroserpinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157N-linked (GlcNAc...)Sequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO35684.
MaxQBiO35684.
PaxDbiO35684.
PeptideAtlasiO35684.
PRIDEiO35684.

PTM databases

PhosphoSitePlusiO35684.

Expressioni

Tissue specificityi

During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000027834.
ExpressionAtlasiO35684. baseline and differential.
GenevisibleiO35684. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029423.

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 33Combined sources8
Turni34 – 38Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi46 – 48Combined sources3
Helixi50 – 60Combined sources11
Beta strandi103 – 105Combined sources3
Beta strandi108 – 117Combined sources10
Helixi122 – 131Combined sources10
Beta strandi136 – 139Combined sources4
Helixi144 – 158Combined sources15
Turni169 – 171Combined sources3
Beta strandi178 – 190Combined sources13
Beta strandi200 – 204Combined sources5
Beta strandi212 – 220Combined sources9
Beta strandi224 – 229Combined sources6
Beta strandi238 – 248Combined sources11
Beta strandi251 – 257Combined sources7
Helixi264 – 266Combined sources3
Turni267 – 270Combined sources4
Helixi273 – 277Combined sources5
Helixi279 – 281Combined sources3
Beta strandi289 – 293Combined sources5
Beta strandi296 – 299Combined sources4
Helixi303 – 308Combined sources6
Beta strandi334 – 343Combined sources10
Beta strandi346 – 358Combined sources13
Beta strandi369 – 371Combined sources3
Beta strandi376 – 382Combined sources7
Turni383 – 385Combined sources3
Beta strandi388 – 395Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684.
SMRiO35684.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35684.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO35684.
OrthoDBiEOG091G0ION.
PhylomeDBiO35684.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYLELLALL ALQSVVTGAT FPDETITEWS VNMYNHLRGT GEDENILFSP
60 70 80 90 100
LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE
110 120 130 140 150
ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS
160 170 180 190 200
INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR
210 220 230 240 250
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE
260 270 280 290 300
ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE
310 320 330 340 350
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE
360 370 380 390 400
AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM
410
NTSGHDFEEL
Length:410
Mass (Da):46,348
Last modified:January 1, 1998 - v1
Checksum:iDA3AF6F5195EBB7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5E → G in AAH06776 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001700 mRNA. Translation: CAA04939.1.
AK032152 mRNA. Translation: BAC27727.1.
AK051756 mRNA. Translation: BAC34756.1.
BC006776 mRNA. Translation: AAH06776.1.
CCDSiCCDS17415.1.
RefSeqiNP_033276.1. NM_009250.2.
UniGeneiMm.41560.

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
GeneIDi20713.
KEGGimmu:20713.
UCSCiuc008pne.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001700 mRNA. Translation: CAA04939.1.
AK032152 mRNA. Translation: BAC27727.1.
AK051756 mRNA. Translation: BAC34756.1.
BC006776 mRNA. Translation: AAH06776.1.
CCDSiCCDS17415.1.
RefSeqiNP_033276.1. NM_009250.2.
UniGeneiMm.41560.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684.
SMRiO35684.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029423.

Protein family/group databases

MEROPSiI04.025.

PTM databases

PhosphoSitePlusiO35684.

Proteomic databases

EPDiO35684.
MaxQBiO35684.
PaxDbiO35684.
PeptideAtlasiO35684.
PRIDEiO35684.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
GeneIDi20713.
KEGGimmu:20713.
UCSCiuc008pne.2. mouse.

Organism-specific databases

CTDi5274.
MGIiMGI:1194506. Serpini1.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118839.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO35684.
OrthoDBiEOG091G0ION.
PhylomeDBiO35684.
TreeFamiTF352620.

Miscellaneous databases

EvolutionaryTraceiO35684.
PROiO35684.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027834.
ExpressionAtlasiO35684. baseline and differential.
GenevisibleiO35684. MM.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEUS_MOUSE
AccessioniPrimary (citable) accession number: O35684
Secondary accession number(s): Q543F7, Q922U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.