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O35684

- NEUS_MOUSE

UniProt

O35684 - NEUS_MOUSE

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Protein
Neuroserpin
Gene
Serpini1, Pi12, Spi17
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei362 – 3632Reactive bond By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of cell adhesion Source: Ensembl
  3. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.025.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serine protease inhibitor 17
Serpin I1
Gene namesi
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1194506. Serpini1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 410394Neuroserpin
PRO_0000032522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi157 – 1571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi321 – 3211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi401 – 4011N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO35684.
PaxDbiO35684.
PRIDEiO35684.

PTM databases

PhosphoSiteiO35684.

Expressioni

Tissue specificityi

During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.

Gene expression databases

ArrayExpressiO35684.
BgeeiO35684.
GenevestigatoriO35684.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 338
Turni34 – 385
Beta strandi39 – 413
Beta strandi46 – 483
Helixi50 – 6011
Beta strandi103 – 1053
Beta strandi108 – 11710
Helixi122 – 13110
Beta strandi136 – 1394
Helixi144 – 15815
Turni169 – 1713
Beta strandi178 – 19013
Beta strandi200 – 2045
Beta strandi212 – 2209
Beta strandi224 – 2296
Beta strandi238 – 24811
Beta strandi251 – 2577
Helixi264 – 2663
Turni267 – 2704
Helixi273 – 2775
Helixi279 – 2813
Beta strandi289 – 2935
Beta strandi296 – 2994
Helixi303 – 3086
Beta strandi334 – 34310
Beta strandi346 – 35813
Beta strandi369 – 3713
Beta strandi376 – 3827
Turni383 – 3853
Beta strandi388 – 3958

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684.
SMRiO35684. Positions 22-400.

Miscellaneous databases

EvolutionaryTraceiO35684.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00740000115014.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO35684.
OMAiVENHTNN.
PhylomeDBiO35684.
TreeFamiTF352620.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35684-1 [UniParc]FASTAAdd to Basket

« Hide

MTYLELLALL ALQSVVTGAT FPDETITEWS VNMYNHLRGT GEDENILFSP    50
LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE 100
ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS 150
INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR 200
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE 250
ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE 300
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE 350
AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM 400
NTSGHDFEEL 410
Length:410
Mass (Da):46,348
Last modified:January 1, 1998 - v1
Checksum:iDA3AF6F5195EBB7C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51E → G in AAH06776. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001700 mRNA. Translation: CAA04939.1.
AK032152 mRNA. Translation: BAC27727.1.
AK051756 mRNA. Translation: BAC34756.1.
BC006776 mRNA. Translation: AAH06776.1.
CCDSiCCDS17415.1.
RefSeqiNP_033276.1. NM_009250.2.
UniGeneiMm.41560.

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
GeneIDi20713.
KEGGimmu:20713.
UCSCiuc008pne.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001700 mRNA. Translation: CAA04939.1 .
AK032152 mRNA. Translation: BAC27727.1 .
AK051756 mRNA. Translation: BAC34756.1 .
BC006776 mRNA. Translation: AAH06776.1 .
CCDSi CCDS17415.1.
RefSeqi NP_033276.1. NM_009250.2.
UniGenei Mm.41560.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JJO X-ray 3.06 A/B 25-64 [» ]
C/D 101-361 [» ]
E/F 367-397 [» ]
ProteinModelPortali O35684.
SMRi O35684. Positions 22-400.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I04.025.

PTM databases

PhosphoSitei O35684.

Proteomic databases

MaxQBi O35684.
PaxDbi O35684.
PRIDEi O35684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029423 ; ENSMUSP00000029423 ; ENSMUSG00000027834 .
GeneIDi 20713.
KEGGi mmu:20713.
UCSCi uc008pne.2. mouse.

Organism-specific databases

CTDi 5274.
MGIi MGI:1194506. Serpini1.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00740000115014.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi O35684.
OMAi VENHTNN.
PhylomeDBi O35684.
TreeFami TF352620.

Miscellaneous databases

EvolutionaryTracei O35684.
NextBioi 299293.
PROi O35684.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35684.
Bgeei O35684.
Genevestigatori O35684.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse."
    Krueger S.R., Ghisu G.-P., Cinelli P., Gschwend T.P., Osterwalder T., Wolfer D.P., Sonderegger P.
    J. Neurosci. 17:8984-8996(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Structure of the mouse gene for the serine protease inhibitor neuroserpin (PI12)."
    Berger P., Kozlov S.V., Krueger S.R., Sonderegger P.
    Gene 214:25-33(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE STRUCTURE.
  5. "The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin."
    Osterwalder T., Cinelli P., Baici A., Pennella A., Krueger S.R., Schrimpf S.P., Meins M., Sonderegger P.
    J. Biol. Chem. 273:2312-2321(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease."
    Briand C., Kozlov S.V., Sonderegger P., Gruetter M.G.
    FEBS Lett. 505:18-22(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS).

Entry informationi

Entry nameiNEUS_MOUSE
AccessioniPrimary (citable) accession number: O35684
Secondary accession number(s): Q543F7, Q922U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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