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Protein

Neuroserpin

Gene

Serpini1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9364046, PubMed:11557034). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).Curated2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei362 – 363Reactive bond1 Publication2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.025

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroserpin
Alternative name(s):
Peptidase inhibitor 12
Short name:
PI-12
Serine protease inhibitor 17
Serpin I1
Gene namesi
Name:Serpini1
Synonyms:Pi12, Spi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1194506 Serpini1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000003252217 – 410NeuroserpinAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO35684
MaxQBiO35684
PaxDbiO35684
PeptideAtlasiO35684
PRIDEiO35684

PTM databases

PhosphoSitePlusiO35684

Expressioni

Tissue specificityi

Detected in neurons in embryonic brain cortex (at protein level) (PubMed:17040209). During embryonic development mostly expressed in CNS (PubMed:9364046). In adult expressed in brain and much less in spinal cord, heart, kidney and testis (PubMed:9364046).2 Publications

Gene expression databases

BgeeiENSMUSG00000027834
ExpressionAtlasiO35684 baseline and differential
GenevisibleiO35684 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029423

Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 33Combined sources8
Turni34 – 38Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi46 – 48Combined sources3
Helixi50 – 60Combined sources11
Beta strandi103 – 105Combined sources3
Beta strandi108 – 117Combined sources10
Helixi122 – 131Combined sources10
Beta strandi136 – 139Combined sources4
Helixi144 – 158Combined sources15
Turni169 – 171Combined sources3
Beta strandi178 – 190Combined sources13
Beta strandi200 – 204Combined sources5
Beta strandi212 – 220Combined sources9
Beta strandi224 – 229Combined sources6
Beta strandi238 – 248Combined sources11
Beta strandi251 – 257Combined sources7
Helixi264 – 266Combined sources3
Turni267 – 270Combined sources4
Helixi273 – 277Combined sources5
Helixi279 – 281Combined sources3
Beta strandi289 – 293Combined sources5
Beta strandi296 – 299Combined sources4
Helixi303 – 308Combined sources6
Beta strandi334 – 343Combined sources10
Beta strandi346 – 358Combined sources13
Beta strandi369 – 371Combined sources3
Beta strandi376 – 382Combined sources7
Turni383 – 385Combined sources3
Beta strandi388 – 395Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JJOX-ray3.06A/B25-64[»]
C/D101-361[»]
E/F367-397[»]
ProteinModelPortaliO35684
SMRiO35684
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO35684

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00900000140788
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiO35684
OMAiVQNGFHV
OrthoDBiEOG091G0ION
PhylomeDBiO35684
TreeFamiTF352620

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYLELLALL ALQSVVTGAT FPDETITEWS VNMYNHLRGT GEDENILFSP
60 70 80 90 100
LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE
110 120 130 140 150
ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS
160 170 180 190 200
INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR
210 220 230 240 250
TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE
260 270 280 290 300
ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE
310 320 330 340 350
IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE
360 370 380 390 400
AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM
410
NTSGHDFEEL
Length:410
Mass (Da):46,348
Last modified:January 1, 1998 - v1
Checksum:iDA3AF6F5195EBB7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5E → G in AAH06776 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001700 mRNA Translation: CAA04939.1
AK032152 mRNA Translation: BAC27727.1
AK051756 mRNA Translation: BAC34756.1
BC006776 mRNA Translation: AAH06776.1
CCDSiCCDS17415.1
RefSeqiNP_033276.1, NM_009250.2
UniGeneiMm.41560

Genome annotation databases

EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834
GeneIDi20713
KEGGimmu:20713
UCSCiuc008pne.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNEUS_MOUSE
AccessioniPrimary (citable) accession number: O35684
Secondary accession number(s): Q543F7, Q922U6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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