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O35684

- NEUS_MOUSE

UniProt

O35684 - NEUS_MOUSE

Protein

Neuroserpin

Gene

Serpini1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei362 – 3632Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of cell adhesion Source: Ensembl
    3. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroserpin
    Alternative name(s):
    Peptidase inhibitor 12
    Short name:
    PI-12
    Serine protease inhibitor 17
    Serpin I1
    Gene namesi
    Name:Serpini1
    Synonyms:Pi12, Spi17
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1194506. Serpini1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 410394NeuroserpinPRO_0000032522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi157 – 1571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi321 – 3211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO35684.
    PaxDbiO35684.
    PRIDEiO35684.

    PTM databases

    PhosphoSiteiO35684.

    Expressioni

    Tissue specificityi

    During embryonic development mostly expressed in CNS. In adult expressed in brain and much less in spinal cord, heart, kidney and testis.

    Gene expression databases

    ArrayExpressiO35684.
    BgeeiO35684.
    GenevestigatoriO35684.

    Structurei

    Secondary structure

    1
    410
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi26 – 338
    Turni34 – 385
    Beta strandi39 – 413
    Beta strandi46 – 483
    Helixi50 – 6011
    Beta strandi103 – 1053
    Beta strandi108 – 11710
    Helixi122 – 13110
    Beta strandi136 – 1394
    Helixi144 – 15815
    Turni169 – 1713
    Beta strandi178 – 19013
    Beta strandi200 – 2045
    Beta strandi212 – 2209
    Beta strandi224 – 2296
    Beta strandi238 – 24811
    Beta strandi251 – 2577
    Helixi264 – 2663
    Turni267 – 2704
    Helixi273 – 2775
    Helixi279 – 2813
    Beta strandi289 – 2935
    Beta strandi296 – 2994
    Helixi303 – 3086
    Beta strandi334 – 34310
    Beta strandi346 – 35813
    Beta strandi369 – 3713
    Beta strandi376 – 3827
    Turni383 – 3853
    Beta strandi388 – 3958

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JJOX-ray3.06A/B25-64[»]
    C/D101-361[»]
    E/F367-397[»]
    ProteinModelPortaliO35684.
    SMRiO35684. Positions 22-400.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO35684.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115014.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiO35684.
    OMAiVENHTNN.
    PhylomeDBiO35684.
    TreeFamiTF352620.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35684-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYLELLALL ALQSVVTGAT FPDETITEWS VNMYNHLRGT GEDENILFSP    50
    LSIALAMGMM ELGAQGSTRK EIRHSMGYEG LKGGEEFSFL RDFSNMASAE 100
    ENQYVMKLAN SLFVQNGFHV NEEFLQMLKM YFNAEVNHVD FSQNVAVANS 150
    INKWVENYTN SLLKDLVSPE DFDGVTNLAL INAVYFKGNW KSQFRPENTR 200
    TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE 250
    ISMMLALSRQ EVPLATLEPL LKAQLIEEWA NSVKKQKVEV YLPRFTVEQE 300
    IDLKDILKAL GVTEIFIKDA NLTAMSDKKE LFLSKAVHKS CIEVNEEGSE 350
    AAAASGMIAI SRMAVLYPQV IVDHPFLYLI RNRKSGIILF MGRVMNPETM 400
    NTSGHDFEEL 410
    Length:410
    Mass (Da):46,348
    Last modified:January 1, 1998 - v1
    Checksum:iDA3AF6F5195EBB7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51E → G in AAH06776. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001700 mRNA. Translation: CAA04939.1.
    AK032152 mRNA. Translation: BAC27727.1.
    AK051756 mRNA. Translation: BAC34756.1.
    BC006776 mRNA. Translation: AAH06776.1.
    CCDSiCCDS17415.1.
    RefSeqiNP_033276.1. NM_009250.2.
    UniGeneiMm.41560.

    Genome annotation databases

    EnsembliENSMUST00000029423; ENSMUSP00000029423; ENSMUSG00000027834.
    GeneIDi20713.
    KEGGimmu:20713.
    UCSCiuc008pne.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001700 mRNA. Translation: CAA04939.1 .
    AK032152 mRNA. Translation: BAC27727.1 .
    AK051756 mRNA. Translation: BAC34756.1 .
    BC006776 mRNA. Translation: AAH06776.1 .
    CCDSi CCDS17415.1.
    RefSeqi NP_033276.1. NM_009250.2.
    UniGenei Mm.41560.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JJO X-ray 3.06 A/B 25-64 [» ]
    C/D 101-361 [» ]
    E/F 367-397 [» ]
    ProteinModelPortali O35684.
    SMRi O35684. Positions 22-400.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I04.025.

    PTM databases

    PhosphoSitei O35684.

    Proteomic databases

    MaxQBi O35684.
    PaxDbi O35684.
    PRIDEi O35684.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029423 ; ENSMUSP00000029423 ; ENSMUSG00000027834 .
    GeneIDi 20713.
    KEGGi mmu:20713.
    UCSCi uc008pne.2. mouse.

    Organism-specific databases

    CTDi 5274.
    MGIi MGI:1194506. Serpini1.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115014.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi O35684.
    OMAi VENHTNN.
    PhylomeDBi O35684.
    TreeFami TF352620.

    Miscellaneous databases

    EvolutionaryTracei O35684.
    NextBioi 299293.
    PROi O35684.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35684.
    Bgeei O35684.
    Genevestigatori O35684.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse."
      Krueger S.R., Ghisu G.-P., Cinelli P., Gschwend T.P., Osterwalder T., Wolfer D.P., Sonderegger P.
      J. Neurosci. 17:8984-8996(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb and Spinal ganglion.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Structure of the mouse gene for the serine protease inhibitor neuroserpin (PI12)."
      Berger P., Kozlov S.V., Krueger S.R., Sonderegger P.
      Gene 214:25-33(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE.
    5. "The axonally secreted serine proteinase inhibitor, neuroserpin, inhibits plasminogen activators and plasmin but not thrombin."
      Osterwalder T., Cinelli P., Baici A., Pennella A., Krueger S.R., Schrimpf S.P., Meins M., Sonderegger P.
      J. Biol. Chem. 273:2312-2321(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease."
      Briand C., Kozlov S.V., Sonderegger P., Gruetter M.G.
      FEBS Lett. 505:18-22(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.06 ANGSTROMS).

    Entry informationi

    Entry nameiNEUS_MOUSE
    AccessioniPrimary (citable) accession number: O35684
    Secondary accession number(s): Q543F7, Q922U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3