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O35683

- NDUA1_MOUSE

UniProt

O35683 - NDUA1_MOUSE

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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene
Ndufa1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:Ndufa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1929511. Ndufa1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain complex I Source: Ensembl
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1PRO_0000118818Add
BLAST

Proteomic databases

PaxDbiO35683.
PRIDEiO35683.

PTM databases

PhosphoSiteiO35683.

Expressioni

Gene expression databases

ArrayExpressiO35683.
BgeeiO35683.
GenevestigatoriO35683.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016571.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79354.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiO35683.
KOiK03945.
OMAiVARVQYQ.
OrthoDBiEOG7NGQFC.
PhylomeDBiO35683.
TreeFamiTF333394.

Family and domain databases

InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view]
PANTHERiPTHR17098. PTHR17098. 1 hit.
PIRSFiPIRSF038095. NDUA1. 1 hit.

Sequencei

Sequence statusi: Complete.

O35683-1 [UniParc]FASTAAdd to Basket

« Hide

MWFEILPGLA IMGVCLVIPG VSTAYIHKFT NGGKEKRVAR VQYQWYLMER   50
DRRISGVNRY YVSKGLENID 70
Length:70
Mass (Da):8,139
Last modified:January 1, 1998 - v1
Checksum:i58CB30E72A275734
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07708 mRNA. Translation: CAA68977.1.
BC024364 mRNA. Translation: AAH24364.1.
CCDSiCCDS40928.1.
RefSeqiNP_062316.1. NM_019443.2.
UniGeneiMm.34869.

Genome annotation databases

EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427.
GeneIDi54405.
KEGGimmu:54405.
UCSCiuc009syi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07708 mRNA. Translation: CAA68977.1 .
BC024364 mRNA. Translation: AAH24364.1 .
CCDSi CCDS40928.1.
RefSeqi NP_062316.1. NM_019443.2.
UniGenei Mm.34869.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000016571.

PTM databases

PhosphoSitei O35683.

Proteomic databases

PaxDbi O35683.
PRIDEi O35683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016571 ; ENSMUSP00000016571 ; ENSMUSG00000016427 .
GeneIDi 54405.
KEGGi mmu:54405.
UCSCi uc009syi.1. mouse.

Organism-specific databases

CTDi 4694.
MGIi MGI:1929511. Ndufa1.

Phylogenomic databases

eggNOGi NOG79354.
HOGENOMi HOG000010206.
HOVERGENi HBG000813.
InParanoidi O35683.
KOi K03945.
OMAi VARVQYQ.
OrthoDBi EOG7NGQFC.
PhylomeDBi O35683.
TreeFami TF333394.

Miscellaneous databases

ChiTaRSi NDUFA1. mouse.
NextBioi 311272.
PROi O35683.
SOURCEi Search...

Gene expression databases

ArrayExpressi O35683.
Bgeei O35683.
Genevestigatori O35683.

Family and domain databases

InterProi IPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view ]
PANTHERi PTHR17098. PTHR17098. 1 hit.
PIRSFi PIRSF038095. NDUA1. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Frattini A., Faranda S., Bagnasco L., Patrosso C., Nulli P., Vezzoni P.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNDUA1_MOUSE
AccessioniPrimary (citable) accession number: O35683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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