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O35683

- NDUA1_MOUSE

UniProt

O35683 - NDUA1_MOUSE

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

Ndufa1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
    Alternative name(s):
    Complex I-MWFE
    Short name:
    CI-MWFE
    NADH-ubiquinone oxidoreductase MWFE subunit
    Gene namesi
    Name:Ndufa1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1929511. Ndufa1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain complex I Source: Ensembl
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1PRO_0000118818Add
    BLAST

    Proteomic databases

    PaxDbiO35683.
    PRIDEiO35683.

    PTM databases

    PhosphoSiteiO35683.

    Expressioni

    Gene expression databases

    ArrayExpressiO35683.
    BgeeiO35683.
    GenevestigatoriO35683.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000016571.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFA1 subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG79354.
    HOGENOMiHOG000010206.
    HOVERGENiHBG000813.
    InParanoidiO35683.
    KOiK03945.
    OMAiVARVQYQ.
    OrthoDBiEOG7NGQFC.
    PhylomeDBiO35683.
    TreeFamiTF333394.

    Family and domain databases

    InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
    [Graphical view]
    PANTHERiPTHR17098. PTHR17098. 1 hit.
    PIRSFiPIRSF038095. NDUA1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O35683-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWFEILPGLA IMGVCLVIPG VSTAYIHKFT NGGKEKRVAR VQYQWYLMER   50
    DRRISGVNRY YVSKGLENID 70
    Length:70
    Mass (Da):8,139
    Last modified:January 1, 1998 - v1
    Checksum:i58CB30E72A275734
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07708 mRNA. Translation: CAA68977.1.
    BC024364 mRNA. Translation: AAH24364.1.
    CCDSiCCDS40928.1.
    RefSeqiNP_062316.1. NM_019443.2.
    UniGeneiMm.34869.

    Genome annotation databases

    EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427.
    GeneIDi54405.
    KEGGimmu:54405.
    UCSCiuc009syi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07708 mRNA. Translation: CAA68977.1 .
    BC024364 mRNA. Translation: AAH24364.1 .
    CCDSi CCDS40928.1.
    RefSeqi NP_062316.1. NM_019443.2.
    UniGenei Mm.34869.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000016571.

    PTM databases

    PhosphoSitei O35683.

    Proteomic databases

    PaxDbi O35683.
    PRIDEi O35683.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016571 ; ENSMUSP00000016571 ; ENSMUSG00000016427 .
    GeneIDi 54405.
    KEGGi mmu:54405.
    UCSCi uc009syi.1. mouse.

    Organism-specific databases

    CTDi 4694.
    MGIi MGI:1929511. Ndufa1.

    Phylogenomic databases

    eggNOGi NOG79354.
    HOGENOMi HOG000010206.
    HOVERGENi HBG000813.
    InParanoidi O35683.
    KOi K03945.
    OMAi VARVQYQ.
    OrthoDBi EOG7NGQFC.
    PhylomeDBi O35683.
    TreeFami TF333394.

    Miscellaneous databases

    ChiTaRSi NDUFA1. mouse.
    NextBioi 311272.
    PROi O35683.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35683.
    Bgeei O35683.
    Genevestigatori O35683.

    Family and domain databases

    InterProi IPR017384. NADH_Ub_cplx-1_asu_su-1.
    [Graphical view ]
    PANTHERi PTHR17098. PTHR17098. 1 hit.
    PIRSFi PIRSF038095. NDUA1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Frattini A., Faranda S., Bagnasco L., Patrosso C., Nulli P., Vezzoni P.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiNDUA1_MOUSE
    AccessioniPrimary (citable) accession number: O35683
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3