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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

Gene

Ndufa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Alternative name(s):
Complex I-MWFE
Short name:
CI-MWFE
NADH-ubiquinone oxidoreductase MWFE subunit
Gene namesi
Name:Ndufa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1929511. Ndufa1.

Subcellular locationi

Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity; Matrix side By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: MGI
  3. mitochondrial respiratory chain complex I Source: MGI
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1PRO_0000118818Add
BLAST

Proteomic databases

MaxQBiO35683.
PaxDbiO35683.
PRIDEiO35683.

PTM databases

PhosphoSiteiO35683.

Expressioni

Gene expression databases

BgeeiO35683.
ExpressionAtlasiO35683. baseline and differential.
GenevestigatoriO35683.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016571.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA1 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG79354.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiO35683.
KOiK03945.
OMAiWYLMERD.
OrthoDBiEOG7NGQFC.
PhylomeDBiO35683.
TreeFamiTF333394.

Family and domain databases

InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view]
PANTHERiPTHR17098. PTHR17098. 1 hit.
PIRSFiPIRSF038095. NDUA1. 1 hit.

Sequencei

Sequence statusi: Complete.

O35683-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWFEILPGLA IMGVCLVIPG VSTAYIHKFT NGGKEKRVAR VQYQWYLMER
60 70
DRRISGVNRY YVSKGLENID
Length:70
Mass (Da):8,139
Last modified:January 1, 1998 - v1
Checksum:i58CB30E72A275734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07708 mRNA. Translation: CAA68977.1.
BC024364 mRNA. Translation: AAH24364.1.
CCDSiCCDS40928.1.
RefSeqiNP_062316.1. NM_019443.2.
UniGeneiMm.34869.

Genome annotation databases

EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427.
GeneIDi54405.
KEGGimmu:54405.
UCSCiuc009syi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07708 mRNA. Translation: CAA68977.1.
BC024364 mRNA. Translation: AAH24364.1.
CCDSiCCDS40928.1.
RefSeqiNP_062316.1. NM_019443.2.
UniGeneiMm.34869.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016571.

PTM databases

PhosphoSiteiO35683.

Proteomic databases

MaxQBiO35683.
PaxDbiO35683.
PRIDEiO35683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016571; ENSMUSP00000016571; ENSMUSG00000016427.
GeneIDi54405.
KEGGimmu:54405.
UCSCiuc009syi.1. mouse.

Organism-specific databases

CTDi4694.
MGIiMGI:1929511. Ndufa1.

Phylogenomic databases

eggNOGiNOG79354.
HOGENOMiHOG000010206.
HOVERGENiHBG000813.
InParanoidiO35683.
KOiK03945.
OMAiWYLMERD.
OrthoDBiEOG7NGQFC.
PhylomeDBiO35683.
TreeFamiTF333394.

Enzyme and pathway databases

ReactomeiREACT_262523. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiNdufa1. mouse.
NextBioi311272.
PROiO35683.
SOURCEiSearch...

Gene expression databases

BgeeiO35683.
ExpressionAtlasiO35683. baseline and differential.
GenevestigatoriO35683.

Family and domain databases

InterProiIPR017384. NADH_Ub_cplx-1_asu_su-1.
[Graphical view]
PANTHERiPTHR17098. PTHR17098. 1 hit.
PIRSFiPIRSF038095. NDUA1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Frattini A., Faranda S., Bagnasco L., Patrosso C., Nulli P., Vezzoni P.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNDUA1_MOUSE
AccessioniPrimary (citable) accession number: O35683
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.