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O35681

- SYT3_MOUSE

UniProt

O35681 - SYT3_MOUSE

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Protein

Synaptotagmin-3

Gene
Syt3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi327 – 3271Calcium 1 By similarity
Metal bindingi327 – 3271Calcium 2 By similarity
Metal bindingi333 – 3331Calcium 1 By similarity
Metal bindingi385 – 3851Calcium 1 By similarity
Metal bindingi385 – 3851Calcium 2 By similarity
Metal bindingi386 – 3861Calcium 1; via carbonyl oxygen By similarity
Metal bindingi387 – 3871Calcium 1 By similarity
Metal bindingi387 – 3871Calcium 2 By similarity
Metal bindingi387 – 3871Calcium 3 By similarity
Metal bindingi390 – 3901Calcium 3 By similarity
Metal bindingi393 – 3931Calcium 2 By similarity
Metal bindingi393 – 3931Calcium 3 By similarity

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. protein heterodimerization activity Source: UniProtKB
  5. protein homodimerization activity Source: BHF-UCL
  6. transporter activity Source: InterPro

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name:
SytIII
Gene namesi
Name:Syt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:99665. Syt3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454Vesicular Reviewed predictionAdd
BLAST
Transmembranei55 – 7521Helical; Reviewed predictionAdd
BLAST
Topological domaini76 – 587512Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Synaptotagmin-3PRO_0000183946Add
BLAST

Proteomic databases

PaxDbiO35681.
PRIDEiO35681.

PTM databases

PhosphoSiteiO35681.

Expressioni

Gene expression databases

CleanExiMM_SYT3.
GenevestigatoriO35681.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers with SYT6.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-457995,EBI-457995
Syt10Q9R0N42EBI-457995,EBI-5239459
Syt6Q9R0N82EBI-457995,EBI-5239378
Syt9Q9R0N92EBI-457995,EBI-458006

Protein-protein interaction databases

IntActiO35681. 5 interactions.
MINTiMINT-4136576.

Structurei

3D structure databases

ProteinModelPortaliO35681.
SMRiO35681. Positions 294-572.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini298 – 399102C2 1Add
BLAST
Domaini430 – 533104C2 2Add
BLAST

Domaini

The first C2 domain mediates Ca2+-dependent phospholipid binding.

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiO35681.
PhylomeDBiO35681.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view]
PANTHERiPTHR10024:SF176. PTHR10024:SF176. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35681-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNELR IRGYPRGPDA    50
DISVSLLSVI VTFCGIVLLG VSLFVSWKLC WVPWRDKGGS AVGGGPLRKD 100
LAPGVGLAGL VGGGGHHLGA SLGGHPLLGG PHHHGHTAHH PPFAELLEPG 150
GLGGSEPPEP SYLDMDSYPE AAVASVVAAG VKPSQTSPEL PSEGGTGSGL 200
LLLPPSGGGL PSAQSHQQVT SLAPTTRYPA LPRPLTQQTL TTQADPSTEE 250
RPPALPLPLP GGEEKAKLIG QIKPELYQGT GPGGRRGGGS GEAGAPCGRI 300
SFALRYLYGS DHLVVRILQA LDLPAKDSNG FSDPYVKIYL LPDRKKKFQT 350
KVHRKTLNPI FNETFQFSVP LAELAQRKLH FSVYDFDRFS RHDLIGQVVL 400
DNLLELAEQP PDRPLWRDIL EGGSEKADLG ELNFSLCYLP TAGRLTVTII 450
KASNLKAMDL TGFSDPYVKA SLISEGRRLK KRKTSIKKNT LNPTYNEALV 500
FDVAPESVEN VGLSIAVVDY DCIGHNEVIG VCRVGPEAAD PHGREHWAEM 550
LANPRKPVEH WHQLVEEKTL SSFTKGGKGL SEKENSE 587
Length:587
Mass (Da):63,254
Last modified:July 19, 2003 - v2
Checksum:i87EAEAADF22D5A4C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111V → L in BAA08292. 1 Publication
Sequence conflicti232 – 2321P → A in BAA08292. 1 Publication
Sequence conflicti312 – 3121H → Q in BAA08292. 1 Publication
Sequence conflicti312 – 3121H → Q in BAA19204. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45858 mRNA. Translation: BAA08292.1.
AB000893 mRNA. Translation: BAA19204.1.
BC051969 mRNA. Translation: AAH51969.1.
CCDSiCCDS21205.1.
RefSeqiNP_001107588.1. NM_001114116.1.
NP_057872.3. NM_016663.3.
UniGeneiMm.4824.

Genome annotation databases

GeneIDi20981.
KEGGimmu:20981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45858 mRNA. Translation: BAA08292.1 .
AB000893 mRNA. Translation: BAA19204.1 .
BC051969 mRNA. Translation: AAH51969.1 .
CCDSi CCDS21205.1.
RefSeqi NP_001107588.1. NM_001114116.1.
NP_057872.3. NM_016663.3.
UniGenei Mm.4824.

3D structure databases

ProteinModelPortali O35681.
SMRi O35681. Positions 294-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O35681. 5 interactions.
MINTi MINT-4136576.

PTM databases

PhosphoSitei O35681.

Proteomic databases

PaxDbi O35681.
PRIDEi O35681.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20981.
KEGGi mmu:20981.

Organism-specific databases

CTDi 84258.
MGIi MGI:99665. Syt3.

Phylogenomic databases

eggNOGi COG5038.
HOGENOMi HOG000232128.
HOVERGENi HBG005010.
InParanoidi O35681.
PhylomeDBi O35681.

Miscellaneous databases

NextBioi 299972.
PROi O35681.
SOURCEi Search...

Gene expression databases

CleanExi MM_SYT3.
Genevestigatori O35681.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view ]
PANTHERi PTHR10024:SF176. PTHR10024:SF176. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kataoka M.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X."
    Fukuda M., Kanno E., Mikoshiba K.
    J. Biol. Chem. 274:31421-31427(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "A novel alternatively spliced variant of synaptotagmin VI lacking a transmembrane domain. Implications for distinct functions of the two isoforms."
    Fukuda M., Mikoshiba K.
    J. Biol. Chem. 274:31428-31434(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: HETERODIMERIZATION.
    Strain: ICR.
    Tissue: Cerebellum.

Entry informationi

Entry nameiSYT3_MOUSE
AccessioniPrimary (citable) accession number: O35681
Secondary accession number(s): P97791, Q80WV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 19, 2003
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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