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Protein

28S ribosomal protein S12, mitochondrial

Gene

Mrps12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Gene namesi
Name:Mrps12
Synonyms:Rpms12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1346333. Mrps12.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial ribosome Source: GO_Central
  • mitochondrial small ribosomal subunit Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionSequence analysisAdd BLAST29
ChainiPRO_000003060730 – 13928S ribosomal protein S12, mitochondrialAdd BLAST110

Proteomic databases

EPDiO35680.
MaxQBiO35680.
PaxDbiO35680.
PeptideAtlasiO35680.
PRIDEiO35680.

PTM databases

iPTMnetiO35680.
PhosphoSitePlusiO35680.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045948.
CleanExiMM_MRPS12.
ExpressionAtlasiO35680. baseline and differential.
GenevisibleiO35680. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062066.

Structurei

3D structure databases

ProteinModelPortaliO35680.
SMRiO35680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1750. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO35680.
KOiK02950.
OMAiMHRQGKP.
OrthoDBiEOG091G0U3U.
PhylomeDBiO35680.
TreeFamiTF315095.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWPGLLYGL TTSLSRGLAL APQLWAARSM ATLNQMHRLG PRKEPPKRLG
60 70 80 90 100
PTEGRPQLKG VVLRTFIRKP KKPNSANRKC CRVRLSTGKE AVCFIPGEGH
110 120 130
TLQEHHVVLV EGGRTQDLPG VKLKVVRGKY DCGHVQKKK
Length:139
Mass (Da):15,437
Last modified:January 1, 1998 - v1
Checksum:iB365FE940025EA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA. Translation: CAA72378.1.
BC012679 mRNA. Translation: AAH12679.1.
BC027522 mRNA. Translation: AAH27522.1.
CCDSiCCDS21052.1.
RefSeqiNP_036015.1. NM_011885.4.
XP_006539971.1. XM_006539908.2.
UniGeneiMm.358650.

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948.
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
GeneIDi24030.
KEGGimmu:24030.
UCSCiuc009fzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA. Translation: CAA72378.1.
BC012679 mRNA. Translation: AAH12679.1.
BC027522 mRNA. Translation: AAH27522.1.
CCDSiCCDS21052.1.
RefSeqiNP_036015.1. NM_011885.4.
XP_006539971.1. XM_006539908.2.
UniGeneiMm.358650.

3D structure databases

ProteinModelPortaliO35680.
SMRiO35680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062066.

PTM databases

iPTMnetiO35680.
PhosphoSitePlusiO35680.

Proteomic databases

EPDiO35680.
MaxQBiO35680.
PaxDbiO35680.
PeptideAtlasiO35680.
PRIDEiO35680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948.
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
GeneIDi24030.
KEGGimmu:24030.
UCSCiuc009fzo.1. mouse.

Organism-specific databases

CTDi6183.
MGIiMGI:1346333. Mrps12.

Phylogenomic databases

eggNOGiKOG1750. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO35680.
KOiK02950.
OMAiMHRQGKP.
OrthoDBiEOG091G0U3U.
PhylomeDBiO35680.
TreeFamiTF315095.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiO35680.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045948.
CleanExiMM_MRPS12.
ExpressionAtlasiO35680. baseline and differential.
GenevisibleiO35680. MM.

Family and domain databases

CDDicd03368. Ribosomal_S12. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRT12_MOUSE
AccessioniPrimary (citable) accession number: O35680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.