O35680 (RT12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S12, mitochondrial
Short name=MRP-S12
Short name=S12mt

Alternative name(s):
MT-RPS12

Gene names

Name:	Mrps12
Synonyms:	Rpms12

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S12P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI small ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 29	29	Mitochondrion Potential
	Chain	30 – 139	110	28S ribosomal protein S12, mitochondrial		PRO_0000030607

Sequences

	Sequence		Length	Mass (Da)
	O35680 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B365FE940025EA08	FASTA	139	15,437
	10 20 30 40 50 60 MSWPGLLYGL TTSLSRGLAL APQLWAARSM ATLNQMHRLG PRKEPPKRLG PTEGRPQLKG 70 80 90 100 110 120 VVLRTFIRKP KKPNSANRKC CRVRLSTGKE AVCFIPGEGH TLQEHHVVLV EGGRTQDLPG 130 VKLKVVRGKY DCGHVQKKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Metazoan nuclear genes for mitoribosomal protein S12." Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T. Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II and FVB/N. Tissue: Colon and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y11682 mRNA. Translation: CAA72378.1. BC012679 mRNA. Translation: AAH12679.1. BC027522 mRNA. Translation: AAH27522.1.
IPI	IPI00132932.
RefSeq	NP_036015.1. NM_011885.4.
UniGene	Mm.358650.
3D structure databases
ProteinModelPortal	O35680.
SMR	O35680. Positions 12-139.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000062066.
PTM databases
PhosphoSite	O35680.
Proteomic databases
PaxDb	O35680.
PRIDE	O35680.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948. ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
GeneID	24030.
KEGG	mmu:24030.
UCSC	uc009fzo.1. mouse.
Organism-specific databases
CTD	6183.
MGI	MGI:1346333. Mrps12.
Phylogenomic databases
eggNOG	COG0048.
GeneTree	ENSGT00550000075103.
HOGENOM	HOG000040063.
HOVERGEN	HBG001525.
InParanoid	O35680.
KO	K02950.
OMA	LNQMHRQ.
OrthoDB	EOG4MGS8W.
Gene expression databases
ArrayExpress	O35680.
Bgee	O35680.
CleanEx	MM_MRPS12.
Genevestigator	O35680.
GermOnline	ENSMUSG00000045948. Mus musculus.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR006032. Ribosomal_S12/S23. IPR005679. Ribosomal_S12_bac. [Graphical view]
PANTHER	PTHR11652. PTHR11652. 1 hit.
Pfam	PF00164. Ribosomal_S12. 1 hit. [Graphical view]
PIRSF	PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTS	PR01034. RIBOSOMALS12.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00981. rpsL_bact. 1 hit.
PROSITE	PS00055. RIBOSOMAL_S12. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	303963.
SOURCE	Search...

Entry information

Entry name

RT12_MOUSE

Accession

Primary (citable) accession number: O35680

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program