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Protein

28S ribosomal protein S12, mitochondrial

Gene

Mrps12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: MGI
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S12, mitochondrial
Short name:
MRP-S12
Short name:
S12mt
Alternative name(s):
MT-RPS12
Gene namesi
Name:Mrps12
Synonyms:Rpms12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1346333. Mrps12.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. small ribosomal subunit Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence AnalysisAdd
BLAST
Chaini30 – 13911028S ribosomal protein S12, mitochondrialPRO_0000030607Add
BLAST

Proteomic databases

MaxQBiO35680.
PaxDbiO35680.
PRIDEiO35680.

PTM databases

PhosphoSiteiO35680.

Expressioni

Gene expression databases

BgeeiO35680.
CleanExiMM_MRPS12.
ExpressionAtlasiO35680. baseline and differential.
GenevestigatoriO35680.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062066.

Structurei

3D structure databases

ProteinModelPortaliO35680.
SMRiO35680. Positions 31-139.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0048.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO35680.
KOiK02950.
OMAiQMHRTGP.
OrthoDBiEOG7Z69F2.
PhylomeDBiO35680.
TreeFamiTF315095.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWPGLLYGL TTSLSRGLAL APQLWAARSM ATLNQMHRLG PRKEPPKRLG
60 70 80 90 100
PTEGRPQLKG VVLRTFIRKP KKPNSANRKC CRVRLSTGKE AVCFIPGEGH
110 120 130
TLQEHHVVLV EGGRTQDLPG VKLKVVRGKY DCGHVQKKK
Length:139
Mass (Da):15,437
Last modified:January 1, 1998 - v1
Checksum:iB365FE940025EA08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA. Translation: CAA72378.1.
BC012679 mRNA. Translation: AAH12679.1.
BC027522 mRNA. Translation: AAH27522.1.
CCDSiCCDS21052.1.
RefSeqiNP_036015.1. NM_011885.4.
XP_006539971.1. XM_006539908.1.
UniGeneiMm.358650.

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948.
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
GeneIDi24030.
KEGGimmu:24030.
UCSCiuc009fzo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11682 mRNA. Translation: CAA72378.1.
BC012679 mRNA. Translation: AAH12679.1.
BC027522 mRNA. Translation: AAH27522.1.
CCDSiCCDS21052.1.
RefSeqiNP_036015.1. NM_011885.4.
XP_006539971.1. XM_006539908.1.
UniGeneiMm.358650.

3D structure databases

ProteinModelPortaliO35680.
SMRiO35680. Positions 31-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062066.

PTM databases

PhosphoSiteiO35680.

Proteomic databases

MaxQBiO35680.
PaxDbiO35680.
PRIDEiO35680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948.
ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
GeneIDi24030.
KEGGimmu:24030.
UCSCiuc009fzo.1. mouse.

Organism-specific databases

CTDi6183.
MGIiMGI:1346333. Mrps12.

Phylogenomic databases

eggNOGiCOG0048.
GeneTreeiENSGT00550000075103.
HOGENOMiHOG000040063.
HOVERGENiHBG001525.
InParanoidiO35680.
KOiK02950.
OMAiQMHRTGP.
OrthoDBiEOG7Z69F2.
PhylomeDBiO35680.
TreeFamiTF315095.

Enzyme and pathway databases

ReactomeiREACT_270125. Mitochondrial translation elongation.
REACT_270158. Mitochondrial translation termination.
REACT_271096. Mitochondrial translation initiation.

Miscellaneous databases

NextBioi303963.
PROiO35680.
SOURCEiSearch...

Gene expression databases

BgeeiO35680.
CleanExiMM_MRPS12.
ExpressionAtlasiO35680. baseline and differential.
GenevestigatoriO35680.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Metazoan nuclear genes for mitoribosomal protein S12."
    Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T.
    Gene 204:55-62(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Colon and Lung.

Entry informationi

Entry nameiRT12_MOUSE
AccessioniPrimary (citable) accession number: O35680
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.