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Protein

Serine protease inhibitor Kazal-type 4

Gene

Spink4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei48 – 49Reactive bondPROSITE-ProRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.970.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease inhibitor Kazal-type 4
Alternative name(s):
MPGC60 protein
Peptide PEC-60 homolog
Gene namesi
Name:Spink4
Synonyms:Mpgc60
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1341848. Spink4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001657027 – 86Serine protease inhibitor Kazal-type 4Add BLAST60

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 68PROSITE-ProRule annotation
Disulfide bondi46 ↔ 65PROSITE-ProRule annotation
Disulfide bondi54 ↔ 86PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO35679.
PRIDEiO35679.

Expressioni

Tissue specificityi

Expressed in the intestinal tract.

Gene expression databases

BgeeiENSMUSG00000028415.
CleanExiMM_SPINK4.
GenevisibleiO35679. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030122.

Structurei

3D structure databases

ProteinModelPortaliO35679.
SMRiO35679.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 86Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00530000064269.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiO35679.
OMAiTCSQTSN.
OrthoDBiEOG091G12CJ.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35679-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMHLWLVTL TLVPLLGMDR ELMVSAGSLV FPRMPFCEHM AELPNCPQTP
60 70 80
NLICGTDGLT YENECHLCLT RMKTMKDIQI MKDGQC
Length:86
Mass (Da):9,729
Last modified:October 3, 2012 - v2
Checksum:iBC6D5E6204A597A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13V → G in CAA72282 (PubMed:9810707).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11505 mRNA. Translation: CAA72282.1.
AL837521 Genomic DNA. Translation: CAM19842.1.
CH466538 Genomic DNA. Translation: EDL05424.1.
BC117048 mRNA. Translation: AAI17049.1.
BC117050 mRNA. Translation: AAI17051.1.
CCDSiCCDS18052.1.
RefSeqiNP_035593.2. NM_011463.2.
UniGeneiMm.25246.

Genome annotation databases

EnsembliENSMUST00000030122; ENSMUSP00000030122; ENSMUSG00000028415.
GeneIDi20731.
KEGGimmu:20731.
UCSCiuc008shy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11505 mRNA. Translation: CAA72282.1.
AL837521 Genomic DNA. Translation: CAM19842.1.
CH466538 Genomic DNA. Translation: EDL05424.1.
BC117048 mRNA. Translation: AAI17049.1.
BC117050 mRNA. Translation: AAI17051.1.
CCDSiCCDS18052.1.
RefSeqiNP_035593.2. NM_011463.2.
UniGeneiMm.25246.

3D structure databases

ProteinModelPortaliO35679.
SMRiO35679.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030122.

Protein family/group databases

MEROPSiI01.970.

Proteomic databases

PaxDbiO35679.
PRIDEiO35679.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030122; ENSMUSP00000030122; ENSMUSG00000028415.
GeneIDi20731.
KEGGimmu:20731.
UCSCiuc008shy.1. mouse.

Organism-specific databases

CTDi27290.
MGIiMGI:1341848. Spink4.

Phylogenomic databases

eggNOGiKOG3649. Eukaryota.
ENOG410YC3T. LUCA.
GeneTreeiENSGT00530000064269.
HOGENOMiHOG000090244.
HOVERGENiHBG006182.
InParanoidiO35679.
OMAiTCSQTSN.
OrthoDBiEOG091G12CJ.

Miscellaneous databases

PROiO35679.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028415.
CleanExiMM_SPINK4.
GenevisibleiO35679. MM.

Family and domain databases

InterProiIPR002350. Kazal_dom.
[Graphical view]
PfamiPF00050. Kazal_1. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS00282. KAZAL_1. 1 hit.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISK4_MOUSE
AccessioniPrimary (citable) accession number: O35679
Secondary accession number(s): Q149Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.