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O35660

- GSTM6_MOUSE

UniProt

O35660 - GSTM6_MOUSE

Protein

Glutathione S-transferase Mu 6

Gene

Gstm6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 3 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161SubstrateBy similarity

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Enzyme and pathway databases

    ReactomeiREACT_215316. Glutathione conjugation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase Mu 6 (EC:2.5.1.18)
    Alternative name(s):
    GST class-mu 6
    Glutathione-S-transferase class M5
    Gene namesi
    Name:Gstm6
    Synonyms:Gstm5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1309467. Gstm6.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Glutathione S-transferase Mu 6PRO_0000185830Add
    BLAST

    Proteomic databases

    PaxDbiO35660.
    PRIDEiO35660.

    PTM databases

    PhosphoSiteiO35660.

    Expressioni

    Tissue specificityi

    Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung.1 Publication

    Gene expression databases

    BgeeiO35660.
    CleanExiMM_GSTM5.
    MM_GSTM6.
    GenevestigatoriO35660.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    MINTiMINT-1869645.

    Structurei

    3D structure databases

    ProteinModelPortaliO35660.
    SMRiO35660. Positions 2-215.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8888GST N-terminalAdd
    BLAST
    Domaini90 – 208119GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 82Glutathione bindingBy similarity
    Regioni46 – 505Glutathione bindingBy similarity
    Regioni59 – 602Glutathione bindingBy similarity
    Regioni72 – 732Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Mu family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiNOG05174.
    GeneTreeiENSGT00550000074559.
    HOGENOMiHOG000115735.
    HOVERGENiHBG106842.
    KOiK00799.
    OrthoDBiEOG7KH9M3.
    PhylomeDBiO35660.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view]
    PRINTSiPR01267. GSTRNSFRASEM.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35660-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVTLGYWDI RGLGHAIRLL LEYTETGYEE RRYAMGDAPD YDRSQWLNDK    50
    FKLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDIL 100
    ENRVMDTRIQ MGMLCYSADF EKRKPEFLKG LPDQLKLYSE FLGKQPWFAG 150
    DKITFADFLV YDVLDQHRMF EPTCLDAFPN LKDFMARFEG LRKISAYMKT 200
    SRFLPSPVYL KQATWGNE 218
    Length:218
    Mass (Da):25,605
    Last modified:August 16, 2004 - v3
    Checksum:iDBACBEBCFB3AF314
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311R → K in AAH31818. (PubMed:15489334)Curated
    Sequence conflicti54 – 541G → D in AAH31818. (PubMed:15489334)Curated
    Sequence conflicti102 – 1032NR → KQ in AAH31818. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000413 mRNA. Translation: CAA04061.1.
    AJ000412 Genomic DNA. Translation: CAA04060.1.
    BC031818 mRNA. Translation: AAH31818.1.
    CCDSiCCDS38596.1.
    RefSeqiNP_032210.3. NM_008184.3.
    UniGeneiMm.458154.

    Genome annotation databases

    EnsembliENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762.
    GeneIDi14867.
    KEGGimmu:14867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ000413 mRNA. Translation: CAA04061.1 .
    AJ000412 Genomic DNA. Translation: CAA04060.1 .
    BC031818 mRNA. Translation: AAH31818.1 .
    CCDSi CCDS38596.1.
    RefSeqi NP_032210.3. NM_008184.3.
    UniGenei Mm.458154.

    3D structure databases

    ProteinModelPortali O35660.
    SMRi O35660. Positions 2-215.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1869645.

    PTM databases

    PhosphoSitei O35660.

    Proteomic databases

    PaxDbi O35660.
    PRIDEi O35660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106685 ; ENSMUSP00000102296 ; ENSMUSG00000068762 .
    GeneIDi 14867.
    KEGGi mmu:14867.

    Organism-specific databases

    CTDi 14867.
    MGIi MGI:1309467. Gstm6.

    Phylogenomic databases

    eggNOGi NOG05174.
    GeneTreei ENSGT00550000074559.
    HOGENOMi HOG000115735.
    HOVERGENi HBG106842.
    KOi K00799.
    OrthoDBi EOG7KH9M3.
    PhylomeDBi O35660.

    Enzyme and pathway databases

    Reactomei REACT_215316. Glutathione conjugation.

    Miscellaneous databases

    ChiTaRSi GSTM5. mouse.
    NextBioi 287125.
    PROi O35660.
    SOURCEi Search...

    Gene expression databases

    Bgeei O35660.
    CleanExi MM_GSTM5.
    MM_GSTM6.
    Genevestigatori O35660.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR003081. GST_mu.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF02798. GST_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01267. GSTRNSFRASEM.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel murine glutathione S-transferase class mu gene."
      De Bruin W.C.C., te Morsche R.H.M., Wagenmans M.J.M., Alferink J.C., Townsend A.J., Wieringa B., Peters W.H.M.
      Biochem. J. 330:623-626(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
      Strain: 129/Sv, C57BL/6 and FVB.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTM6_MOUSE
    AccessioniPrimary (citable) accession number: O35660
    Secondary accession number(s): O35661, Q8K0C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 104 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3