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Protein

Glutathione S-transferase Mu 6

Gene

Gstm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 6 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 6
Glutathione-S-transferase class M5
Gene namesi
Name:Gstm6
Synonyms:Gstm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1309467. Gstm6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858301 – 218Glutathione S-transferase Mu 6Add BLAST218

Proteomic databases

PaxDbiO35660.
PRIDEiO35660.

PTM databases

iPTMnetiO35660.
PhosphoSitePlusiO35660.

Expressioni

Tissue specificityi

Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung.1 Publication

Gene expression databases

BgeeiENSMUSG00000068762.
CleanExiMM_GSTM5.
MM_GSTM6.
ExpressionAtlasiO35660. baseline and differential.
GenevisibleiO35660. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1869645.
STRINGi10090.ENSMUSP00000102296.

Structurei

3D structure databases

ProteinModelPortaliO35660.
SMRiO35660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GST N-terminalAdd BLAST88
Domaini90 – 208GST C-terminalAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 8Glutathione bindingBy similarity2
Regioni46 – 50Glutathione bindingBy similarity5
Regioni59 – 60Glutathione bindingBy similarity2
Regioni72 – 73Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiO35660.
KOiK00799.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVTLGYWDI RGLGHAIRLL LEYTETGYEE KRYAMGDAPD YDRSQWLNDK
60 70 80 90 100
FKLDLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
EKQVMDTRIQ MGMLCYSADF EKRKPEFLKG LPDQLKLYSE FLGKQPWFAG
160 170 180 190 200
DKITFADFLV YDVLDQHRMF EPTCLDAFPN LKDFMARFEG LRKISAYMKT
210
SRFLPSPVYL KQATWGNE
Length:218
Mass (Da):25,621
Last modified:April 29, 2015 - v4
Checksum:iDEA0AF7056F88638
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31K → R in CAA04060 (PubMed:9480867).Curated1
Sequence conflicti31K → R in CAA04061 (PubMed:9480867).Curated1
Sequence conflicti54D → G in CAA04060 (PubMed:9480867).Curated1
Sequence conflicti102 – 103KQ → NR in CAA04061 (PubMed:9480867).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000413 mRNA. Translation: CAA04061.1.
AJ000412 Genomic DNA. Translation: CAA04060.1.
AC079042 Genomic DNA. No translation available.
BC031818 mRNA. Translation: AAH31818.1.
CCDSiCCDS38596.1.
RefSeqiNP_032210.3. NM_008184.3.
UniGeneiMm.458154.

Genome annotation databases

EnsembliENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762.
GeneIDi14867.
KEGGimmu:14867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000413 mRNA. Translation: CAA04061.1.
AJ000412 Genomic DNA. Translation: CAA04060.1.
AC079042 Genomic DNA. No translation available.
BC031818 mRNA. Translation: AAH31818.1.
CCDSiCCDS38596.1.
RefSeqiNP_032210.3. NM_008184.3.
UniGeneiMm.458154.

3D structure databases

ProteinModelPortaliO35660.
SMRiO35660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1869645.
STRINGi10090.ENSMUSP00000102296.

PTM databases

iPTMnetiO35660.
PhosphoSitePlusiO35660.

Proteomic databases

PaxDbiO35660.
PRIDEiO35660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762.
GeneIDi14867.
KEGGimmu:14867.

Organism-specific databases

CTDi14867.
MGIiMGI:1309467. Gstm6.

Phylogenomic databases

eggNOGiENOG410IN5J. Eukaryota.
ENOG4110YU0. LUCA.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiO35660.
KOiK00799.

Miscellaneous databases

ChiTaRSiGstm5. mouse.
PROiO35660.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068762.
CleanExiMM_GSTM5.
MM_GSTM6.
ExpressionAtlasiO35660. baseline and differential.
GenevisibleiO35660. MM.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTM6_MOUSE
AccessioniPrimary (citable) accession number: O35660
Secondary accession number(s): O35661, Q8K0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: April 29, 2015
Last modified: November 2, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.