Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O35660

- GSTM6_MOUSE

UniProt

O35660 - GSTM6_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutathione S-transferase Mu 6

Gene

Gstm6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161SubstrateBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_215316. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase Mu 6 (EC:2.5.1.18)
Alternative name(s):
GST class-mu 6
Glutathione-S-transferase class M5
Gene namesi
Name:Gstm6
Synonyms:Gstm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1309467. Gstm6.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Glutathione S-transferase Mu 6PRO_0000185830Add
BLAST

Proteomic databases

PaxDbiO35660.
PRIDEiO35660.

PTM databases

PhosphoSiteiO35660.

Expressioni

Tissue specificityi

Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung.1 Publication

Gene expression databases

BgeeiO35660.
CleanExiMM_GSTM5.
MM_GSTM6.
ExpressionAtlasiO35660. baseline and differential.
GenevestigatoriO35660.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1869645.

Structurei

3D structure databases

ProteinModelPortaliO35660.
SMRiO35660. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8888GST N-terminalAdd
BLAST
Domaini90 – 208119GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 82Glutathione bindingBy similarity
Regioni46 – 505Glutathione bindingBy similarity
Regioni59 – 602Glutathione bindingBy similarity
Regioni72 – 732Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Mu family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115735.
HOVERGENiHBG106842.
InParanoidiO35660.
KOiK00799.
OrthoDBiEOG7KH9M3.
PhylomeDBiO35660.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01267. GSTRNSFRASEM.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O35660-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVTLGYWDI RGLGHAIRLL LEYTETGYEE RRYAMGDAPD YDRSQWLNDK
60 70 80 90 100
FKLGLDFPNL PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDIL
110 120 130 140 150
ENRVMDTRIQ MGMLCYSADF EKRKPEFLKG LPDQLKLYSE FLGKQPWFAG
160 170 180 190 200
DKITFADFLV YDVLDQHRMF EPTCLDAFPN LKDFMARFEG LRKISAYMKT
210
SRFLPSPVYL KQATWGNE
Length:218
Mass (Da):25,605
Last modified:August 16, 2004 - v3
Checksum:iDBACBEBCFB3AF314
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311R → K in AAH31818. (PubMed:15489334)Curated
Sequence conflicti54 – 541G → D in AAH31818. (PubMed:15489334)Curated
Sequence conflicti102 – 1032NR → KQ in AAH31818. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000413 mRNA. Translation: CAA04061.1.
AJ000412 Genomic DNA. Translation: CAA04060.1.
BC031818 mRNA. Translation: AAH31818.1.
CCDSiCCDS38596.1.
RefSeqiNP_032210.3. NM_008184.3.
UniGeneiMm.458154.

Genome annotation databases

EnsembliENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762.
GeneIDi14867.
KEGGimmu:14867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000413 mRNA. Translation: CAA04061.1 .
AJ000412 Genomic DNA. Translation: CAA04060.1 .
BC031818 mRNA. Translation: AAH31818.1 .
CCDSi CCDS38596.1.
RefSeqi NP_032210.3. NM_008184.3.
UniGenei Mm.458154.

3D structure databases

ProteinModelPortali O35660.
SMRi O35660. Positions 2-215.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1869645.

PTM databases

PhosphoSitei O35660.

Proteomic databases

PaxDbi O35660.
PRIDEi O35660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106685 ; ENSMUSP00000102296 ; ENSMUSG00000068762 .
GeneIDi 14867.
KEGGi mmu:14867.

Organism-specific databases

CTDi 14867.
MGIi MGI:1309467. Gstm6.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115735.
HOVERGENi HBG106842.
InParanoidi O35660.
KOi K00799.
OrthoDBi EOG7KH9M3.
PhylomeDBi O35660.

Enzyme and pathway databases

Reactomei REACT_215316. Glutathione conjugation.

Miscellaneous databases

ChiTaRSi GSTM5. mouse.
NextBioi 287125.
PROi O35660.
SOURCEi Search...

Gene expression databases

Bgeei O35660.
CleanExi MM_GSTM5.
MM_GSTM6.
ExpressionAtlasi O35660. baseline and differential.
Genevestigatori O35660.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01267. GSTRNSFRASEM.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel murine glutathione S-transferase class mu gene."
    De Bruin W.C.C., te Morsche R.H.M., Wagenmans M.J.M., Alferink J.C., Townsend A.J., Wieringa B., Peters W.H.M.
    Biochem. J. 330:623-626(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Strain: 129/Sv, C57BL/6 and FVB.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiGSTM6_MOUSE
AccessioniPrimary (citable) accession number: O35660
Secondary accession number(s): O35661, Q8K0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3