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O35660 (GSTM6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase Mu 6

EC=2.5.1.18
Alternative name(s):
GST class-mu 6
Glutathione-S-transferase class M5
Gene names
Name:Gstm6
Synonyms:Gstm5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in liver, stomach and small intestine. Not expressed in spleen, kidney, colon, heart, muscle, brain or lung. Ref.1

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Glutathione S-transferase Mu 6
PRO_0000185830

Regions

Domain1 – 8888GST N-terminal
Domain90 – 208119GST C-terminal
Region7 – 82Glutathione binding By similarity
Region46 – 505Glutathione binding By similarity
Region59 – 602Glutathione binding By similarity
Region72 – 732Glutathione binding By similarity

Sites

Binding site1161Substrate By similarity

Experimental info

Sequence conflict311R → K in AAH31818. Ref.2
Sequence conflict541G → D in AAH31818. Ref.2
Sequence conflict102 – 1032NR → KQ in AAH31818. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O35660 [UniParc].

Last modified August 16, 2004. Version 3.
Checksum: DBACBEBCFB3AF314

FASTA21825,605
        10         20         30         40         50         60 
MPVTLGYWDI RGLGHAIRLL LEYTETGYEE RRYAMGDAPD YDRSQWLNDK FKLGLDFPNL 

        70         80         90        100        110        120 
PYLIDGSHKV TQSNAILRYL GRKHNLCGET EEERIRVDIL ENRVMDTRIQ MGMLCYSADF 

       130        140        150        160        170        180 
EKRKPEFLKG LPDQLKLYSE FLGKQPWFAG DKITFADFLV YDVLDQHRMF EPTCLDAFPN 

       190        200        210 
LKDFMARFEG LRKISAYMKT SRFLPSPVYL KQATWGNE 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel murine glutathione S-transferase class mu gene."
De Bruin W.C.C., te Morsche R.H.M., Wagenmans M.J.M., Alferink J.C., Townsend A.J., Wieringa B., Peters W.H.M.
Biochem. J. 330:623-626(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
Strain: 129/Sv, C57BL/6 and FVB.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ000413 mRNA. Translation: CAA04061.1.
AJ000412 Genomic DNA. Translation: CAA04060.1.
BC031818 mRNA. Translation: AAH31818.1.
CCDSCCDS38596.1.
RefSeqNP_032210.3. NM_008184.3.
UniGeneMm.458154.

3D structure databases

ProteinModelPortalO35660.
SMRO35660. Positions 2-215.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1869645.

PTM databases

PhosphoSiteO35660.

Proteomic databases

PaxDbO35660.
PRIDEO35660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106685; ENSMUSP00000102296; ENSMUSG00000068762.
GeneID14867.
KEGGmmu:14867.

Organism-specific databases

CTD14867.
MGIMGI:1309467. Gstm6.

Phylogenomic databases

eggNOGNOG05174.
GeneTreeENSGT00550000074559.
HOGENOMHOG000115735.
HOVERGENHBG106842.
KOK00799.
OrthoDBEOG7KH9M3.
PhylomeDBO35660.

Gene expression databases

BgeeO35660.
CleanExMM_GSTM5.
MM_GSTM6.
GenevestigatorO35660.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGSTM5. mouse.
NextBio287125.
PROO35660.
SOURCESearch...

Entry information

Entry nameGSTM6_MOUSE
AccessionPrimary (citable) accession number: O35660
Secondary accession number(s): O35661, Q8K0C3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot