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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: InterPro
  • receptor activity Source: MGI

GO - Biological processi

  • cAMP-mediated signaling Source: MGI
  • cell surface receptor signaling pathway Source: InterPro
  • learning or memory Source: UniProtKB
  • neuropeptide signaling pathway Source: MGI
  • positive regulation of blood pressure Source: CACAO
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of heart contraction Source: UniProtKB
  • response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:99571. Glp1r.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 145ExtracellularSequence analysisAdd BLAST124
Transmembranei146 – 168Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini169 – 176CytoplasmicSequence analysis8
Transmembranei177 – 196Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini197 – 227ExtracellularSequence analysisAdd BLAST31
Transmembranei228 – 252Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini253 – 264CytoplasmicSequence analysisAdd BLAST12
Transmembranei265 – 288Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini289 – 303ExtracellularSequence analysisAdd BLAST15
Transmembranei304 – 329Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini330 – 351CytoplasmicSequence analysisAdd BLAST22
Transmembranei352 – 372Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini373 – 387ExtracellularSequence analysisAdd BLAST15
Transmembranei388 – 408Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini409 – 463CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075290.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001283622 – 463Glucagon-like peptide 1 receptorAdd BLAST442

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi226 ↔ 296By similarity
Modified residuei341ADP-ribosylcysteineBy similarity1
Modified residuei348ADP-ribosylarginineBy similarity1

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO35659.
PRIDEiO35659.

PTM databases

iPTMnetiO35659.
PhosphoSitePlusiO35659.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024027.
CleanExiMM_GLP1R.
GenevisibleiO35659. MM.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110221.

Chemistry databases

BindingDBiO35659.

Structurei

3D structure databases

ProteinModelPortaliO35659.
SMRiO35659.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO35659.
KOiK04581.
OMAiSECEESK.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35659-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGLW LHKDNSSLPW RDLSECEESK RGERNFPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ MEFRKCWERW RLEHLNIQRD CSMKPLKCPT SSVSSGATVG
460
SSVYAATCQS SYS
Length:463
Mass (Da):53,028
Last modified:October 16, 2013 - v2
Checksum:iFBA3D9D79A30E9C3
GO

Sequence cautioni

The sequence CAA04930 differs from that shown. Reason: Frameshift at position 450.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1.
AY293742 mRNA. Translation: AAQ54583.1.
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1.
BC139466 mRNA. Translation: AAI39467.1.
CCDSiCCDS37542.1.
RefSeqiNP_067307.2. NM_021332.2.
UniGeneiMm.390969.

Genome annotation databases

EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
GeneIDi14652.
KEGGimmu:14652.
UCSCiuc008bud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1.
AY293742 mRNA. Translation: AAQ54583.1.
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1.
BC139466 mRNA. Translation: AAI39467.1.
CCDSiCCDS37542.1.
RefSeqiNP_067307.2. NM_021332.2.
UniGeneiMm.390969.

3D structure databases

ProteinModelPortaliO35659.
SMRiO35659.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110221.

Chemistry databases

BindingDBiO35659.
ChEMBLiCHEMBL1075290.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO35659.
PhosphoSitePlusiO35659.

Proteomic databases

PaxDbiO35659.
PRIDEiO35659.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
GeneIDi14652.
KEGGimmu:14652.
UCSCiuc008bud.1. mouse.

Organism-specific databases

CTDi2740.
MGIiMGI:99571. Glp1r.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO35659.
KOiK04581.
OMAiSECEESK.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiO35659.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024027.
CleanExiMM_GLP1R.
GenevisibleiO35659. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLP1R_MOUSE
AccessioniPrimary (citable) accession number: O35659
Secondary accession number(s): Q1JQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.