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O35659

- GLP1R_MOUSE

UniProt

O35659 - GLP1R_MOUSE

Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (16 Oct 2013)
      Previous versions | rss
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    Functioni

    This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. glucagon receptor activity Source: InterPro
    2. receptor activity Source: MGI

    GO - Biological processi

    1. learning or memory Source: UniProtKB
    2. neuropeptide signaling pathway Source: MGI
    3. regulation of heart contraction Source: UniProtKB
    4. response to stress Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucagon-like peptide 1 receptor
    Short name:
    GLP-1 receptor
    Short name:
    GLP-1-R
    Short name:
    GLP-1R
    Gene namesi
    Name:Glp1r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:99571. Glp1r.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 463442Glucagon-like peptide 1 receptorPRO_0000012836Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 71By similarity
    Disulfide bondi62 ↔ 104By similarity
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 126By similarity
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi226 ↔ 296By similarity
    Modified residuei341 – 3411ADP-ribosylcysteineBy similarity
    Modified residuei348 – 3481ADP-ribosylarginineBy similarity

    Post-translational modificationi

    N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

    Keywords - PTMi

    ADP-ribosylation, Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO35659.

    PTM databases

    PhosphoSiteiO35659.

    Expressioni

    Gene expression databases

    CleanExiMM_GLP1R.
    GenevestigatoriO35659.

    Interactioni

    Subunit structurei

    May form homodimers and heterodimers with GIPR.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO35659.
    SMRiO35659. Positions 29-131, 143-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 145124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini169 – 1768CytoplasmicSequence Analysis
    Topological domaini197 – 22731ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini253 – 26412CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini289 – 30315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 35122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini373 – 38715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini409 – 46355CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 16823Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 25225Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei265 – 28824Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32926Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei352 – 37221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei388 – 40821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263329.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    InParanoidiO35659.
    KOiK04581.
    OMAiCIVVSKL.
    OrthoDBiEOG7TF78W.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003290. GPCR_2_GLP1/glucagon_rcpt.
    IPR003292. GPCR_2_GLP1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01353. GLUCAGNFAMLY.
    PR01355. GLUCAGNLIKER.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O35659-1 [UniParc]FASTAAdd to Basket

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    MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL    50
    TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV 100
    YRFCTAEGLW LHKDNSSLPW RDLSECEESK RGERNFPEEQ LLSLYIIYTV 150
    GYALSFSALV IASAILVGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA 200
    LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY 250
    LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN 300
    SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA 350
    KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI 400
    LYCFVNNEVQ MEFRKCWERW RLEHLNIQRD CSMKPLKCPT SSVSSGATVG 450
    SSVYAATCQS SYS 463
    Length:463
    Mass (Da):53,028
    Last modified:October 16, 2013 - v2
    Checksum:iFBA3D9D79A30E9C3
    GO

    Sequence cautioni

    The sequence CAA04930.1 differs from that shown. Reason: Frameshift at position 450.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
    DQ093397 mRNA. Translation: AAZ83365.1.
    AY293742 mRNA. Translation: AAQ54583.1.
    AC165951 Genomic DNA. No translation available.
    BC139464 mRNA. Translation: AAI39465.1.
    BC139466 mRNA. Translation: AAI39467.1.
    CCDSiCCDS37542.1.
    RefSeqiNP_067307.2. NM_021332.2.
    UniGeneiMm.390969.

    Genome annotation databases

    EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
    GeneIDi14652.
    KEGGimmu:14652.
    UCSCiuc008bud.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001692 mRNA. Translation: CAA04930.1 . Frameshift.
    DQ093397 mRNA. Translation: AAZ83365.1 .
    AY293742 mRNA. Translation: AAQ54583.1 .
    AC165951 Genomic DNA. No translation available.
    BC139464 mRNA. Translation: AAI39465.1 .
    BC139466 mRNA. Translation: AAI39467.1 .
    CCDSi CCDS37542.1.
    RefSeqi NP_067307.2. NM_021332.2.
    UniGenei Mm.390969.

    3D structure databases

    ProteinModelPortali O35659.
    SMRi O35659. Positions 29-131, 143-412.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1075290.
    GuidetoPHARMACOLOGYi 249.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O35659.

    Proteomic databases

    PRIDEi O35659.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114574 ; ENSMUSP00000110221 ; ENSMUSG00000024027 .
    GeneIDi 14652.
    KEGGi mmu:14652.
    UCSCi uc008bud.1. mouse.

    Organism-specific databases

    CTDi 2740.
    MGIi MGI:99571. Glp1r.

    Phylogenomic databases

    eggNOGi NOG263329.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    InParanoidi O35659.
    KOi K04581.
    OMAi CIVVSKL.
    OrthoDBi EOG7TF78W.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 286510.
    PROi O35659.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GLP1R.
    Genevestigatori O35659.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003290. GPCR_2_GLP1/glucagon_rcpt.
    IPR003292. GPCR_2_GLP1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01353. GLUCAGNFAMLY.
    PR01355. GLUCAGNLIKER.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."
      Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.
      Diabetes 47:646-652(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. "Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r)."
      Kumar K.G., Poole A.C., York B., Volaufova J., Zuberi A., Richards B.K.
      Am. J. Physiol. 292:R207-R216(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Intestine.
    3. "Identification and characterization of glucagon-like peptide-1 receptors in a pituitary ACTH-secreting cell line."
      Watanabe K., Doran A.C., Tibaduiza E.C., Chen C., Beinborn M.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: LAF1.
      Tissue: Pituitary.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGLP1R_MOUSE
    AccessioniPrimary (citable) accession number: O35659
    Secondary accession number(s): Q1JQR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 16, 2013
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3