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O35659

- GLP1R_MOUSE

UniProt

O35659 - GLP1R_MOUSE

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Protein
Glucagon-like peptide 1 receptor
Gene
Glp1r
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: InterPro
  2. receptor activity Source: MGI

GO - Biological processi

  1. learning or memory Source: UniProtKB
  2. neuropeptide signaling pathway Source: MGI
  3. regulation of heart contraction Source: UniProtKB
  4. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:99571. Glp1r.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 145124Extracellular Reviewed prediction
Add
BLAST
Transmembranei146 – 16823Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini169 – 1768Cytoplasmic Reviewed prediction
Transmembranei177 – 19620Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini197 – 22731Extracellular Reviewed prediction
Add
BLAST
Transmembranei228 – 25225Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini253 – 26412Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei265 – 28824Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini289 – 30315Extracellular Reviewed prediction
Add
BLAST
Transmembranei304 – 32926Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini330 – 35122Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei352 – 37221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini373 – 38715Extracellular Reviewed prediction
Add
BLAST
Transmembranei388 – 40821Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini409 – 46355Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 463442Glucagon-like peptide 1 receptor
PRO_0000012836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 71 By similarity
Disulfide bondi62 ↔ 104 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi85 ↔ 126 By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi226 ↔ 296 By similarity
Modified residuei341 – 3411ADP-ribosylcysteine By similarity
Modified residuei348 – 3481ADP-ribosylarginine By similarity

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35659.

PTM databases

PhosphoSiteiO35659.

Expressioni

Gene expression databases

CleanExiMM_GLP1R.
GenevestigatoriO35659.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR By similarity.

Structurei

3D structure databases

ProteinModelPortaliO35659.
SMRiO35659. Positions 29-131, 143-412.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263329.
GeneTreeiENSGT00740000115231.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO35659.
KOiK04581.
OMAiCIVVSKL.
OrthoDBiEOG7TF78W.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35659-1 [UniParc]FASTAAdd to Basket

« Hide

MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL    50
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV 100
YRFCTAEGLW LHKDNSSLPW RDLSECEESK RGERNFPEEQ LLSLYIIYTV 150
GYALSFSALV IASAILVGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA 200
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY 250
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN 300
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA 350
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI 400
LYCFVNNEVQ MEFRKCWERW RLEHLNIQRD CSMKPLKCPT SSVSSGATVG 450
SSVYAATCQS SYS 463
Length:463
Mass (Da):53,028
Last modified:October 16, 2013 - v2
Checksum:iFBA3D9D79A30E9C3
GO

Sequence cautioni

The sequence CAA04930.1 differs from that shown. Reason: Frameshift at position 450.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1.
AY293742 mRNA. Translation: AAQ54583.1.
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1.
BC139466 mRNA. Translation: AAI39467.1.
CCDSiCCDS37542.1.
RefSeqiNP_067307.2. NM_021332.2.
UniGeneiMm.390969.

Genome annotation databases

EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
GeneIDi14652.
KEGGimmu:14652.
UCSCiuc008bud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001692 mRNA. Translation: CAA04930.1 . Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1 .
AY293742 mRNA. Translation: AAQ54583.1 .
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1 .
BC139466 mRNA. Translation: AAI39467.1 .
CCDSi CCDS37542.1.
RefSeqi NP_067307.2. NM_021332.2.
UniGenei Mm.390969.

3D structure databases

ProteinModelPortali O35659.
SMRi O35659. Positions 29-131, 143-412.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075290.
GuidetoPHARMACOLOGYi 249.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O35659.

Proteomic databases

PRIDEi O35659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114574 ; ENSMUSP00000110221 ; ENSMUSG00000024027 .
GeneIDi 14652.
KEGGi mmu:14652.
UCSCi uc008bud.1. mouse.

Organism-specific databases

CTDi 2740.
MGIi MGI:99571. Glp1r.

Phylogenomic databases

eggNOGi NOG263329.
GeneTreei ENSGT00740000115231.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi O35659.
KOi K04581.
OMAi CIVVSKL.
OrthoDBi EOG7TF78W.
TreeFami TF315710.

Miscellaneous databases

NextBioi 286510.
PROi O35659.
SOURCEi Search...

Gene expression databases

CleanExi MM_GLP1R.
Genevestigatori O35659.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."
    Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.
    Diabetes 47:646-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r)."
    Kumar K.G., Poole A.C., York B., Volaufova J., Zuberi A., Richards B.K.
    Am. J. Physiol. 292:R207-R216(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  3. "Identification and characterization of glucagon-like peptide-1 receptors in a pituitary ACTH-secreting cell line."
    Watanabe K., Doran A.C., Tibaduiza E.C., Chen C., Beinborn M.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LAF1.
    Tissue: Pituitary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGLP1R_MOUSE
AccessioniPrimary (citable) accession number: O35659
Secondary accession number(s): Q1JQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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