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O35659

- GLP1R_MOUSE

UniProt

O35659 - GLP1R_MOUSE

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Protein

Glucagon-like peptide 1 receptor

Gene

Glp1r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: InterPro
  2. receptor activity Source: MGI

GO - Biological processi

  1. cAMP-mediated signaling Source: Ensembl
  2. learning or memory Source: UniProtKB
  3. neuropeptide signaling pathway Source: MGI
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  5. regulation of heart contraction Source: UniProtKB
  6. response to stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
Gene namesi
Name:Glp1r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:99571. Glp1r.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 463442Glucagon-like peptide 1 receptorPRO_0000012836Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 71By similarity
Disulfide bondi62 ↔ 104By similarity
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi85 ↔ 126By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi226 ↔ 296By similarity
Modified residuei341 – 3411ADP-ribosylcysteineBy similarity
Modified residuei348 – 3481ADP-ribosylarginineBy similarity

Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO35659.

PTM databases

PhosphoSiteiO35659.

Expressioni

Gene expression databases

CleanExiMM_GLP1R.
ExpressionAtlasiO35659. baseline and differential.
GenevestigatoriO35659.

Interactioni

Subunit structurei

May form homodimers and heterodimers with GIPR.By similarity

Structurei

3D structure databases

ProteinModelPortaliO35659.
SMRiO35659. Positions 29-131, 143-412.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 145124ExtracellularSequence AnalysisAdd
BLAST
Topological domaini169 – 1768CytoplasmicSequence Analysis
Topological domaini197 – 22731ExtracellularSequence AnalysisAdd
BLAST
Topological domaini253 – 26412CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini289 – 30315ExtracellularSequence AnalysisAdd
BLAST
Topological domaini330 – 35122CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini373 – 38715ExtracellularSequence AnalysisAdd
BLAST
Topological domaini409 – 46355CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei146 – 16823Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei177 – 19620Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei228 – 25225Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei265 – 28824Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei304 – 32926Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei352 – 37221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei388 – 40821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263329.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO35659.
KOiK04581.
OMAiCIVVSKL.
OrthoDBiEOG7TF78W.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O35659-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL
60 70 80 90 100
TEAPLLATGL FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV
110 120 130 140 150
YRFCTAEGLW LHKDNSSLPW RDLSECEESK RGERNFPEEQ LLSLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILVGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ MEFRKCWERW RLEHLNIQRD CSMKPLKCPT SSVSSGATVG
460
SSVYAATCQS SYS
Length:463
Mass (Da):53,028
Last modified:October 16, 2013 - v2
Checksum:iFBA3D9D79A30E9C3
GO

Sequence cautioni

The sequence CAA04930.1 differs from that shown. Reason: Frameshift at position 450.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1.
AY293742 mRNA. Translation: AAQ54583.1.
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1.
BC139466 mRNA. Translation: AAI39467.1.
CCDSiCCDS37542.1.
RefSeqiNP_067307.2. NM_021332.2.
UniGeneiMm.390969.

Genome annotation databases

EnsembliENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
GeneIDi14652.
KEGGimmu:14652.
UCSCiuc008bud.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001692 mRNA. Translation: CAA04930.1 . Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1 .
AY293742 mRNA. Translation: AAQ54583.1 .
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1 .
BC139466 mRNA. Translation: AAI39467.1 .
CCDSi CCDS37542.1.
RefSeqi NP_067307.2. NM_021332.2.
UniGenei Mm.390969.

3D structure databases

ProteinModelPortali O35659.
SMRi O35659. Positions 29-131, 143-412.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1075290.
GuidetoPHARMACOLOGYi 249.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O35659.

Proteomic databases

PRIDEi O35659.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114574 ; ENSMUSP00000110221 ; ENSMUSG00000024027 .
GeneIDi 14652.
KEGGi mmu:14652.
UCSCi uc008bud.1. mouse.

Organism-specific databases

CTDi 2740.
MGIi MGI:99571. Glp1r.

Phylogenomic databases

eggNOGi NOG263329.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi O35659.
KOi K04581.
OMAi CIVVSKL.
OrthoDBi EOG7TF78W.
TreeFami TF315710.

Miscellaneous databases

NextBioi 286510.
PROi O35659.
SOURCEi Search...

Gene expression databases

CleanExi MM_GLP1R.
ExpressionAtlasi O35659. baseline and differential.
Genevestigatori O35659.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."
    Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.
    Diabetes 47:646-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. "Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r)."
    Kumar K.G., Poole A.C., York B., Volaufova J., Zuberi A., Richards B.K.
    Am. J. Physiol. 292:R207-R216(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  3. "Identification and characterization of glucagon-like peptide-1 receptors in a pituitary ACTH-secreting cell line."
    Watanabe K., Doran A.C., Tibaduiza E.C., Chen C., Beinborn M.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: LAF1.
    Tissue: Pituitary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGLP1R_MOUSE
AccessioniPrimary (citable) accession number: O35659
Secondary accession number(s): Q1JQR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3