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O35659 (GLP1R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucagon-like peptide 1 receptor

Short name=GLP-1 receptor
Short name=GLP-1-R
Short name=GLP-1R
Gene names
Name:Glp1r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subunit structure

May form homodimers and heterodimers with GIPR By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence caution

The sequence CAA04930.1 differs from that shown. Reason: Frameshift at position 450.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 463442Glucagon-like peptide 1 receptor
PRO_0000012836

Regions

Topological domain22 – 145124Extracellular Potential
Transmembrane146 – 16823Helical; Name=1; Potential
Topological domain169 – 1768Cytoplasmic Potential
Transmembrane177 – 19620Helical; Name=2; Potential
Topological domain197 – 22731Extracellular Potential
Transmembrane228 – 25225Helical; Name=3; Potential
Topological domain253 – 26412Cytoplasmic Potential
Transmembrane265 – 28824Helical; Name=4; Potential
Topological domain289 – 30315Extracellular Potential
Transmembrane304 – 32926Helical; Name=5; Potential
Topological domain330 – 35122Cytoplasmic Potential
Transmembrane352 – 37221Helical; Name=6; Potential
Topological domain373 – 38715Extracellular Potential
Transmembrane388 – 40821Helical; Name=7; Potential
Topological domain409 – 46355Cytoplasmic Potential

Amino acid modifications

Modified residue3411ADP-ribosylcysteine By similarity
Modified residue3481ADP-ribosylarginine By similarity
Glycosylation631N-linked (GlcNAc...) Potential
Glycosylation821N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 71 By similarity
Disulfide bond62 ↔ 104 By similarity
Disulfide bond85 ↔ 126 By similarity
Disulfide bond226 ↔ 296 By similarity

Sequences

Sequence LengthMass (Da)Tools
O35659 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: FBA3D9D79A30E9C3

FASTA46353,028
        10         20         30         40         50         60 
MASTPSLLRL ALLLLGAVGR AGPRPQGTTV SLSETVQKWR EYRRQCQRFL TEAPLLATGL 

        70         80         90        100        110        120 
FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV YRFCTAEGLW LHKDNSSLPW 

       130        140        150        160        170        180 
RDLSECEESK RGERNFPEEQ LLSLYIIYTV GYALSFSALV IASAILVGFR HLHCTRNYIH 

       190        200        210        220        230        240 
LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN 

       250        260        270        280        290        300 
YYWLLVEGVY LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN 

       310        320        330        340        350        360 
SNMNYWLIIR LPILFAIGVN FLIFIRVICI VVSKLKANLM CKTDIKCRLA KSTLTLIPLL 

       370        380        390        400        410        420 
GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI LYCFVNNEVQ MEFRKCWERW 

       430        440        450        460 
RLEHLNIQRD CSMKPLKCPT SSVSSGATVG SSVYAATCQS SYS 

« Hide

References

« Hide 'large scale' references
[1]"Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene."
Flamez D., van Breusegem A., Scrocchi L.A., Quartier E., Pipeleers D., Drucker D.J., Schuit F.
Diabetes 47:646-652(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[2]"Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r)."
Kumar K.G., Poole A.C., York B., Volaufova J., Zuberi A., Richards B.K.
Am. J. Physiol. 292:R207-R216(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Intestine.
[3]"Identification and characterization of glucagon-like peptide-1 receptors in a pituitary ACTH-secreting cell line."
Watanabe K., Doran A.C., Tibaduiza E.C., Chen C., Beinborn M.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: LAF1.
Tissue: Pituitary.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001692 mRNA. Translation: CAA04930.1. Frameshift.
DQ093397 mRNA. Translation: AAZ83365.1.
AY293742 mRNA. Translation: AAQ54583.1.
AC165951 Genomic DNA. No translation available.
BC139464 mRNA. Translation: AAI39465.1.
BC139466 mRNA. Translation: AAI39467.1.
CCDSCCDS37542.1.
RefSeqNP_067307.2. NM_021332.2.
UniGeneMm.390969.

3D structure databases

ProteinModelPortalO35659.
SMRO35659. Positions 29-131, 143-412.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1075290.
GuidetoPHARMACOLOGY249.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO35659.

Proteomic databases

PRIDEO35659.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000114574; ENSMUSP00000110221; ENSMUSG00000024027.
GeneID14652.
KEGGmmu:14652.
UCSCuc008bud.1. mouse.

Organism-specific databases

CTD2740.
MGIMGI:99571. Glp1r.

Phylogenomic databases

eggNOGNOG263329.
GeneTreeENSGT00740000115231.
HOGENOMHOG000008250.
HOVERGENHBG008318.
InParanoidO35659.
KOK04581.
OMACIVVSKL.
OrthoDBEOG7TF78W.
TreeFamTF315710.

Gene expression databases

CleanExMM_GLP1R.
GenevestigatorO35659.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003290. GPCR_2_GLP1/glucagon_rcpt.
IPR003292. GPCR_2_GLP1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR01353. GLUCAGNFAMLY.
PR01355. GLUCAGNLIKER.
PR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286510.
PROO35659.
SOURCESearch...

Entry information

Entry nameGLP1R_MOUSE
AccessionPrimary (citable) accession number: O35659
Secondary accession number(s): Q1JQR8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries