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O35654

- DPOD2_MOUSE

UniProt

O35654 - DPOD2_MOUSE

Protein

DNA polymerase delta subunit 2

Gene

Pold2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    The function of the small subunit is not yet clear.

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase delta subunit 2 (EC:2.7.7.7)
    Alternative name(s):
    DNA polymerase delta subunit p50
    Gene namesi
    Name:Pold2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1097163. Pold2.

    Subcellular locationi

    GO - Cellular componenti

    1. delta DNA polymerase complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469DNA polymerase delta subunit 2PRO_0000096167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO35654.
    PaxDbiO35654.
    PRIDEiO35654.

    PTM databases

    PhosphoSiteiO35654.

    Expressioni

    Gene expression databases

    ArrayExpressiO35654.
    BgeeiO35654.
    GenevestigatoriO35654.

    Interactioni

    Subunit structurei

    Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD13/POLDIP1, POLDIP2, POLDIP3. Interacts with WRNIP1 and KCTD10. Interacts with POLD4 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi202291. 1 interaction.
    IntActiO35654. 2 interactions.
    MINTiMINT-1565891.
    STRINGi10090.ENSMUSP00000099986.

    Structurei

    3D structure databases

    ProteinModelPortaliO35654.
    SMRiO35654. Positions 1-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1311.
    GeneTreeiENSGT00390000006780.
    HOGENOMiHOG000189057.
    HOVERGENiHBG051396.
    InParanoidiQ99J61.
    KOiK02328.
    OMAiATRLIQM.
    OrthoDBiEOG7RZ5PQ.
    TreeFamiTF101073.

    Family and domain databases

    InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
    IPR024826. DNA_pol_delta/II_ssu.
    [Graphical view]
    PANTHERiPTHR10416. PTHR10416. 1 hit.
    PfamiPF04042. DNA_pol_E_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O35654-1 [UniParc]FASTAAdd to Basket

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    MFSEQAAQRA HTLLAPPSAS NATFARVPVA TYTNSSQPFR LGERSFNRQY    50
    AHIYATRLIQ MRPFLVSRAQ QHWGSRVEVK KLCELQPGEQ CCVVGTLFKA 100
    MSLQPSILRE ISEEHNLVPQ PPRSKYIHPD DELVLEDELQ RIKLKGTIDV 150
    SKLVTGTVLA VLGSAKDDGR FQVEDHCFAD LAPQKPVPPL DTDRFVLLVS 200
    GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR VILAGNLLSH 250
    NTQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD 300
    PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS 350
    DIFRYSSMED HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH 400
    VYFCGNTPSF GSKIIRGPED QVVLLVAVPD FSSTQTACLV NLRSLACQPI 450
    SFAGFGAEQE DLEGLGLGP 469
    Length:469
    Mass (Da):51,355
    Last modified:July 27, 2011 - v2
    Checksum:i1203465743C80900
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671S → T in CAA96567. (PubMed:9286699)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72486 mRNA. Translation: CAA96567.1.
    AL627069 Genomic DNA. Translation: CAI25442.1.
    CH466574 Genomic DNA. Translation: EDL40563.1.
    BC003342 mRNA. Translation: AAH03342.1.
    CCDSiCCDS24407.1.
    RefSeqiNP_032920.2. NM_008894.2.
    XP_006514650.1. XM_006514587.1.
    UniGeneiMm.35788.

    Genome annotation databases

    EnsembliENSMUST00000102922; ENSMUSP00000099986; ENSMUSG00000020471.
    GeneIDi18972.
    KEGGimmu:18972.
    UCSCiuc007hxk.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z72486 mRNA. Translation: CAA96567.1 .
    AL627069 Genomic DNA. Translation: CAI25442.1 .
    CH466574 Genomic DNA. Translation: EDL40563.1 .
    BC003342 mRNA. Translation: AAH03342.1 .
    CCDSi CCDS24407.1.
    RefSeqi NP_032920.2. NM_008894.2.
    XP_006514650.1. XM_006514587.1.
    UniGenei Mm.35788.

    3D structure databases

    ProteinModelPortali O35654.
    SMRi O35654. Positions 1-458.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202291. 1 interaction.
    IntActi O35654. 2 interactions.
    MINTi MINT-1565891.
    STRINGi 10090.ENSMUSP00000099986.

    PTM databases

    PhosphoSitei O35654.

    Proteomic databases

    MaxQBi O35654.
    PaxDbi O35654.
    PRIDEi O35654.

    Protocols and materials databases

    DNASUi 18972.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102922 ; ENSMUSP00000099986 ; ENSMUSG00000020471 .
    GeneIDi 18972.
    KEGGi mmu:18972.
    UCSCi uc007hxk.2. mouse.

    Organism-specific databases

    CTDi 5425.
    MGIi MGI:1097163. Pold2.

    Phylogenomic databases

    eggNOGi COG1311.
    GeneTreei ENSGT00390000006780.
    HOGENOMi HOG000189057.
    HOVERGENi HBG051396.
    InParanoidi Q99J61.
    KOi K02328.
    OMAi ATRLIQM.
    OrthoDBi EOG7RZ5PQ.
    TreeFami TF101073.

    Enzyme and pathway databases

    Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Miscellaneous databases

    ChiTaRSi POLD2. mouse.
    NextBioi 295324.
    PROi O35654.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O35654.
    Bgeei O35654.
    Genevestigatori O35654.

    Family and domain databases

    InterProi IPR007185. DNA_pol_alpha/epsilon_bsu.
    IPR024826. DNA_pol_delta/II_ssu.
    [Graphical view ]
    PANTHERi PTHR10416. PTHR10416. 1 hit.
    Pfami PF04042. DNA_pol_E_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)."
      Hindges R., Huebscher U.
      Genomics 44:45-51(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRI.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiDPOD2_MOUSE
    AccessioniPrimary (citable) accession number: O35654
    Secondary accession number(s): Q99J61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3