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O35654 (DPOD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA polymerase delta subunit 2

EC=2.7.7.7
Alternative name(s):
DNA polymerase delta subunit p50
Gene names
Name:Pold2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The function of the small subunit is not yet clear.

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Subunit structure

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with KCTD13/POLDIP1, POLDIP2, POLDIP3. Interacts with WRNIP1 and KCTD10. Interacts with POLD4 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the DNA polymerase delta/II small subunit family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   Molecular functionDNA-directed DNA polymerase
Nucleotidyltransferase
Transferase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentdelta DNA polymerase complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

DNA-directed DNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469DNA polymerase delta subunit 2
PRO_0000096167

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict671S → T in CAA96567. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O35654 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 1203465743C80900

FASTA46951,355
        10         20         30         40         50         60 
MFSEQAAQRA HTLLAPPSAS NATFARVPVA TYTNSSQPFR LGERSFNRQY AHIYATRLIQ 

        70         80         90        100        110        120 
MRPFLVSRAQ QHWGSRVEVK KLCELQPGEQ CCVVGTLFKA MSLQPSILRE ISEEHNLVPQ 

       130        140        150        160        170        180 
PPRSKYIHPD DELVLEDELQ RIKLKGTIDV SKLVTGTVLA VLGSAKDDGR FQVEDHCFAD 

       190        200        210        220        230        240 
LAPQKPVPPL DTDRFVLLVS GLGLGGGGGE SLLGTQLLVD VVTGQLGDEG EQCSAAHVSR 

       250        260        270        280        290        300 
VILAGNLLSH NTQSRDSINK AKYLTKKTQA ASVEAVKMLD EILLQLSASV PVDVMPGEFD 

       310        320        330        340        350        360 
PTNYTLPQQP LHPCMFPLAT AYSTLQLVTN PYQATIDGVR FLGTSGQNVS DIFRYSSMED 

       370        380        390        400        410        420 
HLEILEWTLR VRHISPTAPD TLGCYPFYKT DPFIFPECPH VYFCGNTPSF GSKIIRGPED 

       430        440        450        460 
QVVLLVAVPD FSSTQTACLV NLRSLACQPI SFAGFGAEQE DLEGLGLGP 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)."
Hindges R., Huebscher U.
Genomics 44:45-51(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z72486 mRNA. Translation: CAA96567.1.
AL627069 Genomic DNA. Translation: CAI25442.1.
CH466574 Genomic DNA. Translation: EDL40563.1.
BC003342 mRNA. Translation: AAH03342.1.
RefSeqNP_032920.2. NM_008894.2.
XP_006514650.1. XM_006514587.1.
UniGeneMm.35788.

3D structure databases

ProteinModelPortalO35654.
SMRO35654. Positions 1-458.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid202291. 1 interaction.
IntActO35654. 2 interactions.
MINTMINT-1565891.
STRING10090.ENSMUSP00000099986.

PTM databases

PhosphoSiteO35654.

Proteomic databases

PaxDbO35654.
PRIDEO35654.

Protocols and materials databases

DNASU18972.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102922; ENSMUSP00000099986; ENSMUSG00000020471.
GeneID18972.
KEGGmmu:18972.
UCSCuc007hxk.2. mouse.

Organism-specific databases

CTD5425.
MGIMGI:1097163. Pold2.

Phylogenomic databases

eggNOGCOG1311.
GeneTreeENSGT00390000006780.
HOGENOMHOG000189057.
HOVERGENHBG051396.
InParanoidQ99J61.
KOK02328.
OMAATRLIQM.
OrthoDBEOG7RZ5PQ.
TreeFamTF101073.

Gene expression databases

ArrayExpressO35654.
BgeeO35654.
GenevestigatorO35654.

Family and domain databases

InterProIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERPTHR10416. PTHR10416. 1 hit.
PfamPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPOLD2. mouse.
NextBio295324.
PROO35654.
SOURCESearch...

Entry information

Entry nameDPOD2_MOUSE
AccessionPrimary (citable) accession number: O35654
Secondary accession number(s): Q99J61
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: March 19, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot